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https://read.qxmd.com/read/30877409/bdnf-mediated-mitophagy-alleviates-high-glucose-induced-brain-microvascular-endothelial-cell-injury
#1
Hong Jin, Yi Zhu, Yiping Li, Xiuyu Ding, Wenqi Ma, Xiqiong Han, Bilei Wang
Endothelial cell dysfunction and diabetic vascular complications are intrinsically linked. Although BDNF plays a protective role in cerebral microvascular complications caused by diabetes, the mechanisms of this activity are not fully clear. In this study, we investigated the role of BDNF in the hyperglycemic injury of BMECs and its associated intracellular signal transduction pathways. BMECs were treated with 33 mM glucose to imitate the endothelium under hyperglycemic conditions. The high-glucose treatment caused cell dysfunction, as evaluated by oxidative stress and cell apoptosis, which could be alleviated by BDNF...
March 15, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30875566/preclinical-prevention-trial-of-calcitriol-impact-of-stage-of-intervention-and-duration-of-treatment-on-oral-carcinogenesis
#2
Vui King Vincent-Chong, Hendrik DeJong, Kristopher Attwood, Pamela A Hershberger, Mukund Seshadri
The anticancer activity of 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 or calcitriol) has been widely reported in preclinical models. However, systematic investigation into the chemopreventive potential of calcitriol against the spectrum of oral carcinogenesis has not been performed. To address this gap in knowledge, we conducted a preclinical prevention trial of calcitriol in the 4-nitroquinoline-1-oxide (4NQO) oral carcinogenesis model. C57BL/6 mice were exposed to the carcinogen 4NQO in drinking water for 16 weeks and randomized to control (4NQO only) or calcitriol arms...
March 12, 2019: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/30873880/effects-of-graphene-oxide-and-graphene-oxide-quantum-dots-on-the-osteogenic-differentiation-of-stem-cells-from-human-exfoliated-deciduous-teeth
#3
Xin Yang, Qi Zhao, Yijing Chen, Yuanxiang Fu, Shushen Lu, Xinlin Yu, Dongsheng Yu, Wei Zhao
Graphene and its derivatives, graphene oxide (GO) and graphene oxide quantum dots (GOQDs), have recently attracted much attention as bioactive factors in differentiating stem cells towards osteoblastic lineage. The stem cells from human exfoliated deciduous teeth (SHEDs) possess the properties of self-renewal, extensive proliferation, and multiple differentiation potential, and have gradually become one of the most promising mesenchymal stem cells (MSCs) in bone tissue engineering. The purpose of this study was to explore the effects of GO and GOQDs on the osteogenic differentiation of SHEDs...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
https://read.qxmd.com/read/30872062/characterization-of-the-cellular-effects-of-myeloperoxidase-derived-oxidants-on-h9c2-cardiac-myoblasts
#4
Leila Reyes, Clare L Hawkins, Benjamin S Rayner
Oxidative stress is a major hallmark of cardiac ischemia/reperfusion (I/R) injury, which is in part due to the release of the enzyme myeloperoxidase (MPO) from activated infiltrating leukocytes, and the subsequent production of the oxidants hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). Although exposure of various cell types to either oxidant is known to cause cellular dysfunction within a variety of pathological settings, the precise role of HOCl and HOSCN in the initiation of tissue damage evident following cardiac I/R injury remains unclear...
March 11, 2019: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/30865134/management-of-treatment-related-toxicities-in-advanced-medullary-thyroid-cancer
#5
Venessa H M Tsang
PURPOSE OF REVIEW: Tyrosine kinase inhibitors (TKI), predominantly vandetanib and cabozantinib, are increasingly used for management of advanced medullary thyroid cancer. This review aims to discuss the major and serious adverse events associated with TKI. RECENT FINDINGS: The choice of TKI depends on the patient's existing comorbidities. Patients who have long QT interval should avoid vandetanib and those at risk of gastrointestinal perforation should avoid cabozantinib...
March 8, 2019: Current Opinion in Oncology
https://read.qxmd.com/read/30864013/the-transcription-factor-myb15-is-essential-for-basal-immunity-pti-in-chinese-wild-grape
#6
Yangyang Luo, Ru Bai, Jing Li, Weidong Yang, Ruixiang Li, Qingyang Wang, Guifang Zhao, Dong Duan
MYB15 promoter of Vitis quinquangularis has potential as a target for disease resistance breeding, and its involvement in PTI is associated with a range of defense mechanisms. China is a center of origin for Vitis and is home to diverse wild Vitis genotypes, some of which show superior pathogen resistance, although the underlying molecular basis for this has not yet been elucidated. In the current study, we identified a transcription factor, MYB15, from the Chinese wild grape, Vitis quinquangularis, whose promoter region (pVqMYB15) was shown to be induced by basal immunity (also called PAMP-triggered immunity, PTI) triggered by flg22, following heterologous expression in Nicotiana benthamiana and homologous expression in grapevine...
March 12, 2019: Planta
https://read.qxmd.com/read/30858090/anabolic-androgen-steroids-effects-on-bioenergetics-responsiveness-of-synaptic-and-extrasynaptic-mitochondria
#7
Randhall B Carteri, Afonso Kopzynski, Lizia Nardi Menegassi, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Luis Valmor Portela
We hypothesized that supraphysiological administration of the anabolic-androgenic steroids (AAS) like testosterone (TEST) and nandrolone decanoate (NAND) might differentially affect synaptic and extrasynaptic components of mitochondrial bioenergetics, thereby resulting in memory impairment. Oil (VEH), NAND or TEST (15 mg/Kg) were daily administered to male CF-1 albino mice for 19-days. We evaluated in the synaptosomes and extrasynaptic mitochondria, Ca2+ influx/efflux, membrane potential ΔѰm, oxidative respiratory states, dehydrogenases activity, H2O2 production, Tau phosphorylation, and spatial memory in the Morris water maze (MWM)...
March 8, 2019: Toxicology Letters
https://read.qxmd.com/read/30856562/geochemical-simulation-of-the-stabilization-process-of-vanadium-contaminated-soil-remediated-with-calcium-oxide-and-ferrous-sulfate
#8
Quan Zou, De'an Li, Jianguo Jiang, Aikelaimu Aihemaiti, Yuchen Gao, Nuo Liu, Jiwei Liu
Vanadium (V)-contaminated soil poses health risks to plants, animals, and humans via both direct exposure and through the food chain. Stabilization treatment of metal-contaminated soil can chemically convert metal contaminants into less soluble, mobile, and toxic forms. However, the stabilization mechanisms of V-contaminated soil have not been thoroughly investigated. Therefore, we performed geochemical modeling of V-contaminated soil stabilized with the common binders calcium oxide (CaO) and ferrous sulfate (FeSO4 ), as well as their mixture, using Visual MINTEQ software...
March 8, 2019: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30854505/pollutant-composition-modification-of-the-effect-of-air-pollution-on-progression-of-coronary-artery-calcium-the-multi-ethnic-study-of-atherosclerosis
#9
Joshua P Keller, Timothy V Larson, Elena Austin, R Graham Barr, Lianne Sheppard, Sverre Vedal, Joel D Kaufman, Adam A Szpiro
Background: Differences in traffic-related air pollution (TRAP) composition may cause heterogeneity in associations between air pollution exposure and cardiovascular health outcomes. Clustering multi-pollutant measurements allows investigation of effect modification by TRAP profiles. Methods: We measured TRAP components with fixed-site and on-road instruments for two two-week periods in Baltimore, Maryland. We created representative TRAP profiles for cold and warm seasons using predictive k -means clustering...
September 2018: Environmental Epidemiology
https://read.qxmd.com/read/30853557/map4k4-inhibition-promotes-survival-of-human-stem-cell-derived-cardiomyocytes-and-reduces-infarct-size-in-vivo
#10
Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Pelin Arabacilar Golforoush, Mohamed Bellahcene, Michela Noseda, Dörte Faust, Ashley Jarvis, Gary Newton, Marta Abreu Paiva, Mutsuo Harada, Daniel J Stuckey, Weihua Song, Josef Habib, Priyanka Narasimham, Rehan Aqil, Devika Sanmugalingam, Robert Yan, Lorenzo Pavanello, Motoaki Sano, Sam C Wang, Robert D Sampson, Sunthar Kanayaganam, George E Taffet, Lloyd H Michael, Mark L Entman, Tse-Hua Tan, Sian E Harding, Caroline M R Low, Catherine Tralau-Stewart, Trevor Perrior, Michael D Schneider
Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways. Therapeutic progress has been hampered by lack of preclinical human validation. Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) is activated in failing human hearts and relevant rodent models. Using human induced-pluripotent-stem-cell-derived cardiomyocytes (hiPSC-CMs) and MAP4K4 gene silencing, we demonstrate that death induced by oxidative stress requires MAP4K4...
March 1, 2019: Cell Stem Cell
https://read.qxmd.com/read/30852764/medicinal-plants-and-their-isolated-phytochemicals-for-the-management-of-chemotherapy-induced-neuropathy-therapeutic-targets-and-clinical-perspective
#11
Vahideh Oveissi, Mahboobe Ram, Roodabeh Bahramsoltani, Farnaz Ebrahimi, Roja Rahimi, Rozita Naseri, Tarun Belwal, Hari Prasad Devkota, Zahra Abbasabadi, Mohammad Hosein Farzaei
BACKGROUND: Chemotherapy, as one of the main approaches of cancer treatment, is accompanied with several adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Since current methods to control the condition are not completely effective, new treatment options should be introduced. Medicinal plants can be suitable candidates to be assessed regarding their effects in CIPN. Current paper reviews the available preclinical and clinical studies on the efficacy of herbal medicines in CIPN...
March 9, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30852746/the-association-between-iron-calcium-and-oxidative-stress-in-seminal-plasma-and-sperm-quality
#12
Oumaima Ammar, Zohra Houas, Meriem Mehdi
The present study aimed to determine the level of iron and calcium in the seminal plasma of men with different fertility potentials and to examine its relationship with oxidative stress. Seventy-nine sub-fertile patients with asthenoteratozoospermia (AT), n 27; teratoleucozoospermia (TL), n 20; teratozoospermia (Terato), n 32; and 29 healthy donors were included. The ability of spermatozoa to produce reactive oxygen species (ROS) was evaluated by using nitroblue tetrazolium (NBT) staining. The lipid peroxidation end product, malondialdehyde (MDA), and the trace element levels (iron and calcium) were measured spectrophotometrically...
March 9, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30851408/lactate-accelerates-calcification-in-vsmcs-through-suppression-of-bnip3-mediated-mitophagy
#13
Yi Zhu, Jing-Jing Ji, Rui Yang, Xi-Qiong Han, Xue-Jiao Sun, Wen-Qi Ma, Nai-Feng Liu
Arterial media calcification is one of the major complications of diabetes mellitus, which is related to oxidative stress and apoptosis. Mitophagy is a special regulation of mitochondrial homeostasis and takes control of intracellular ROS generation and apoptotic pathways. High circulating levels of lactate usually accompanies diabetes. The potential link between lactate, mitophagy and vascular calcification is investigated in this study. Lactate treatment accelerated VSMC calcification, evaluated by measuring the calcium content, ALP activity, RUNX2, BMP-2 protein levels, and Alizarin red S staining...
March 6, 2019: Cellular Signalling
https://read.qxmd.com/read/30849447/an-inhibitor-of-the-mitochondrial-permeability-transition-pore-lacks-therapeutic-efficacy-following-neonatal-hypoxia-ischemia-in-mice
#14
Jing Fang, Raul Chavez-Valdez, Debbie L Flock, Oliver Avaritt, Manda Saraswati, Courtney Robertson, Lee J Martin, Frances J Northington
Neonatal hypoxic ischemic (HI) brain injury causes lifelong neurologic disability. Therapeutic hypothermia (TH) is the only approved therapy that partially mitigates mortality and morbidity. Therapies specifically targeting HI-induced brain cell death are currently lacking. Intracellular calcium dysregulation, oxidative stress, and mitochondrial dysfunction through the formation of the mitochondrial permeability transition pore (mPTP) are drivers of HI cellular injury. GNX-4728, a small molecule direct inhibitor of the mPTP that increases mitochondrial calcium retention capacity, is highly effective in adult neurodegenerative disease models and could have potential as a therapy in neonatal HI...
March 5, 2019: Neuroscience
https://read.qxmd.com/read/30848428/modulating-effect-of-tiron-on-the-capability-of-mitochondrial-oxidative-phosphorylation-in-the-brain-of-rats-exposed-to-radiation-or-manganese-toxicity
#15
Nadia Abdel-Magied, Nahed Abdel-Aziz, Shereen M Shedid, Amal G Ahmed
The brain is an important organ rich in mitochondria and more susceptible to oxidative stress. Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) is a potent antioxidant. This study aims to evaluate the effect of tiron on the impairment of brain mitochondria induced by exposure to radiation or manganese (Mn) toxicity. We assessed the capability of oxidative phosphorylation (OXPHOS) through determination of mitochondrial redox state, the activity of electron transport chain (ETC), and Krebs cycle as well as the level of adenosine triphosphate (ATP) production...
March 8, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30847871/relationships-between-thyroid-hormones-insulin-like-growth-factor-1-and-antioxidant-levels-in-hypothalamic-amenorrhea-and-impact-on-bone-metabolism
#16
Antonio Mancini, Edoardo Vergani, Carmine Bruno, Angelina Barini, Andrea Silvestrini, Elisabetta Meucci, Calogero Messana, Daniela Romualdi, Rosanna Apa, Antonio Lanzone
Reduced bone mineral density (BMD) in Functional Hypothalamic Amenorrhea (FHA) is mainly related to hypoestrogenism, but other hormonal derangement (reduced conversion of T4-T3 and GH resistance) can play a role. These hormones are involved in antioxidant systems regulation. We evaluated the impact of hormonal alterations, with special focus on low T3 and IGF-1 levels, on antioxidant systems as a link with osteoporosis in FHA. Forty-three FHA patients, 15-34 years, with BMI range 17.3-23.4 kg/m2 , were divided in 2 groups according to fT3 levels; group A (n=22), low fT3 (<2...
March 7, 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30847816/controllable-synthesis-of-fe-3-o-4-wollastonite-adsorbents-for-efficient-heavy-metal-ions-oxyanions-removal
#17
Jelena D Rusmirović, Nina Obradović, Jovana Perendija, Ana Umićević, Ana Kapidžić, Branislav Vlahović, Vera Pavlović, Aleksandar D Marinković, Vladimir B Pavlović
Iron oxide, in the form of magnetite (MG)-functionalized porous wollastonite (WL), was used as an adsorbent for heavy metal ions (cadmium and nickel) and oxyanions (chromate and phosphate) removal from water. The porous WL was synthesized from calcium carbonate and siloxane by controlled sintering process using low molecular weight submicrosized poly(methyl methacrylate) as a pore-forming agent. The precipitation of MG nanoparticles was carried out directly by a polyol-medium solvothermal method or via branched amino/carboxylic acid cross-linker by solvent/nonsolvent method producing WL/MG and WL-γ-APS/MG adsorbents, respectively...
March 7, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30846885/siderophile-element-constraints-on-the-thermal-history-of-the-h-chondrite-parent-body
#18
Gregory J Archer, Richard J Walker, Jonathan Tino, Terrence Blackburn, Thomas S Kruijer, Jan L Hellmann
The abundances of highly siderophile elements (HSE: Re, Os, Ir, Ru, Pt, Pd), as well as 187 Re-187 Os and 182 Hf-182 W isotopic systematics were determined for separated metal, slightly magnetic, and nonmagnetic fractions from seven H4 to H6 ordinary chondrites. The HSE are too abundant in nonmagnetic fractions to reflect metal-silicate equilibration. The disequilibrium was likely a primary feature, as 187 Re-187 Os data indicate only minor open-system behavior of the HSE in the slightly and non-magnetic fractions...
January 15, 2019: Geochimica et Cosmochimica Acta
https://read.qxmd.com/read/30845148/graphene-oxide-in-zinc-alginate-films-antibacterial-activity-cytotoxicity-zinc-release-water-sorption-diffusion-wettability-and-opacity
#19
Belén Frígols, Miguel Martí, Beatriz Salesa, Carolina Hernández-Oliver, Olav Aarstad, Ann-Sissel Teialeret Ulset, Gerd Inger Sӕtrom, Finn Lillelund Aachmann, Ángel Serrano-Aroca
Alginate is considered an exceptional biomaterial due to its hydrophilicity, biocompatibility, biodegradability, nontoxicity and low-cost in comparison with other biopolymers. We have recently demonstrated that the incorporation of 1% graphene oxide (GO) into alginate films crosslinked with Ca2+ cations provides antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and no cytotoxicity for human keratinocyte HaCaT cells. However, many other reports in literature have shown controversial results about the toxicity of GO demanding further investigation...
2019: PloS One
https://read.qxmd.com/read/30844782/properties-of-vaterite-containing-tricalcium-silicate-composited-graphene-oxide-for-biomaterials
#20
Jun Tang, Weijing Cao, Yin Zhang, Jiapan Luan, Feng Jiang, Xiang Zhou, Mingming Li
The properties of vaterite-containing tricalcium silicate (referred as V-C3S) bone cement can be significantly affected by graphene oxide (GO) added. The composited bone cement can overcome the problem of poor mechanical properties and low cellular activity of calcium silicate-based bone cement. The material properties, mineralization and cell compatibility were characterized. The results demonstrated that GO/V-C3S had good curing ability, mechanical properties and higher injectability. In general, V-C3S adding with 0...
March 7, 2019: Biomedical Materials
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