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https://read.qxmd.com/read/30786280/age-related-alterations-in-retinal-tissue-perfusion-and-volumetric-vessel-density
#1
Ying Lin, Hong Jiang, Yi Liu, Giovana Rosa Gameiro, Giovanni Gregori, Chuanhui Dong, Tatjana Rundek, Jianhua Wang
Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. The RTP was calculated as the blood flow supplying the macular area (ϕ 2.5 mm) divided by the perfused tissue volume of the inner retina from the inner limiting membrane to the outer plexiform layer...
February 1, 2019: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/30783942/three-dimensional-analysis-of-morphologic-changes-and-visual-outcomes-in-diabetic-macular-edema
#2
Hyungwoo Lee, Kyung Eun Kang, Hyewon Chung, Hyung Chan Kim
PURPOSE: To investigate the association of retinal fluid volume with the visual and anatomic outcomes of patients with diabetic macular edema (DME) after treatment with bevacizumab. STUDY DESIGN: Retrospective observational study. METHODS: We retrospectively analyzed 65 eyes of 58 DME patients treated with bevacizumab. The volumes of the inner intraretinal fluid (IRF) in the inner nuclear layer (INL), outer IRF in the outer plexiform layer (OPL)/outer nuclear layer (ONL), and subretinal fluid (SRF) were calculated...
February 19, 2019: Japanese Journal of Ophthalmology
https://read.qxmd.com/read/30783941/treatment-of-macular-hemorrhage-in-retinal-arterial-microaneurysm-anatomic-site-oriented-therapy
#3
Yorihisa Kitagawa, Akiyo Kawamorita, Hiroyuki Shimada, Hiroyuki Nakashizuka
PURPOSE: To investigate the usefulness of anatomic site-oriented therapy for macular hemorrhage secondary to retinal arterial macroaneurysm (RAM). STUDY DESIGN: Retrospective observational study, clinical case series METHODS: Twenty-seven consecutive patients (27 eyes) with macular hemorrhage secondary to RAM were classified according to the retinal layer(s) with hemorrhage identified by optical coherence tomography into 4 types and treated differentially. Vitrectomy was conducted for subinternal limiting membrane hemorrhage (SILMH), intravitreal gas injection for subretinal hemorrhage (SRH) or intraretinal hemorrhage (IRH), and vitrectomy and intravitreal air/gas exchange for multilevel hemorrhage (at least 2 among SILMH/SRH/IRH)...
February 19, 2019: Japanese Journal of Ophthalmology
https://read.qxmd.com/read/30777956/epiretinal-membrane-profile-on-spectral-domain-optical-coherence-tomography-in-patients-with-uveitis
#4
Puja Maitra, Dhivya Ashok Kumar, Amar Agarwal
Purpose: To study the epiretinal membrane (ERM) profile on the spectral-domain optical coherence tomography (SDOCT) in eyes with uveitis. Methods: In this prospective observational study, macula of uveitic eyes were evaluated by SDOCT (Cirrus, model 5000) for ERM. ERM was quantified (in microns) and were followed up along with the best-corrected visual acuity (BCVA) and treatment profile for 1 year. ERM morphology (focal, global, or mixed) and characteristics (thickness at fovea, maximum thickness, and location of maximum thickness in relation to fovea) were documented...
March 2019: Indian Journal of Ophthalmology
https://read.qxmd.com/read/30768230/macular-hole-complicating-familial-exudative-vitreoretinopathy-due-to-lrp5-mutation-in-an-adolescent
#5
Francis L Munier, Alejandra Daruich
A 17-year-old boy, previously diagnosed with familial exudative vitreoretinopathy (FEVR) due to LRP5 mutation, complained of left eye decreased vision. Serial imaging by optical coherence tomography showed vitreomacular traction that progressed to lamellar macular hole (MH), and further evolved to full-thickness MH 3 weeks later. Visual acuity (VA) was 20/200. Pars plana vitrectomy with encircling buckle, internal limiting membrane peeling, and gas tamponade were performed. Three months postoperatively, VA had increased to 20/25 and the MH remained closed...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/30768228/topical-aqueous-suppression-and-closure-of-idiopathic-full-thickness-macular-holes
#6
Daniel Su, Anthony Obeid, Jason Hsu
Hydration of retinal tissue has been proposed as a potential model of macular hole (MH) formation in addition to tractional forces of the vitreous and internal limiting membrane (ILM). Carbonic anhydrase inhibitors have previously been utilized in the treatment of cystoid macular edema in outer retinal diseases. There has been recent interest in the use of topical aqueous suppression as a potential medical therapy for MHs. In this case series, four eyes with small (< 300 μm) full-thickness MHs were treated with topical dorzolamide-timolol for 1 month...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/30766732/epiretinal-membrane-surgery-in-daily-clinical-practice-results-of-a-proposed-management-scheme
#7
Jesús Pareja, Alba Coronado, Inés Contreras
Purpose: To report the results of the epiretinal membrane (ERM) management guidelines followed in our center. Methods: Patients with ERM seen between 2014 and 2015, with ≥2 years follow-up or who had undergone ERM surgery, were included. Corrected visual acuity (VA), lens status, and ERM configuration were recorded at each visit. Our guidelines for ERM are if VA is ≥20/30, observation is recommended unless there is moderate/intense metamorphopsia. Vitrectomy is recommended during follow-up if there is a drop >one line in VA with changes in ERM configuration...
2019: Journal of Ophthalmology
https://read.qxmd.com/read/30765957/inverted-internal-limiting-membrane-technique-maintains-macular-hole-closure-in-retinal-detachment-following-macular-hole-repair
#8
Ogugua N Okonkwo, Michael E Gyasi, Adekunle O Hassan, Olufemi Oderinlo
Recent advances in macular hole surgery have significantly improved the rates of anatomical success. One important advance is the dye-assisted peeling of the internal limiting membrane (ILM) around the hole. In large holes (<400 μ), sometimes, ILM peeling alone is not enough to achieve closure, and this may be improved by inverting part of the peeled membrane and using it to cover the macular hole or inverting and tucking the ILM flap into the hole. In this case report, a patient with large full-thickness macular hole underwent a hole repair with an inverted ILM flap technique...
July 2018: Middle East African Journal of Ophthalmology
https://read.qxmd.com/read/30754662/is-retinal-metabolic-dysfunction-at-the-center-of-the-pathogenesis-of-age-related-macular-degeneration
#9
REVIEW
Thierry Léveillard, Nancy J Philp, Florian Sennlaub
The retinal pigment epithelium (RPE) forms the outer blood⁻retina barrier and facilitates the transepithelial transport of glucose into the outer retina via GLUT1. Glucose is metabolized in photoreceptors via the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS) but also by aerobic glycolysis to generate glycerol for the synthesis of phospholipids for the renewal of their outer segments. Aerobic glycolysis in the photoreceptors also leads to a high rate of production of lactate which is transported out of the subretinal space to the choroidal circulation by the RPE...
February 11, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30748126/concise-review-update-on-retinal-pigment-epithelium-transplantation-for-age-related-macular-degeneration
#10
REVIEW
Marco Zarbin, Ilene Sugino, Ellen Townes-Anderson
Retinal cell therapy can have the objectives of rescue (i.e., modulation of metabolic abnormalities primarily for sight preservation) as well as replacement (i.e., replace cells lost due to injury or disease for sight restoration as well as preservation). The first clinical trials of retinal pigment epithelium (RPE) transplantation for vision-threatening complications of age-related macular degeneration (AMD) have begun with some preliminary signs of success (e.g., improvement in vision in some patients, anatomic evidence of transplant-host integration with some evidence of host photoreceptor recovery, long-term survival of autologous induced pluripotent stem cell-derived RPE transplants without immune suppression) as well as limitations (e...
February 12, 2019: Stem Cells Translational Medicine
https://read.qxmd.com/read/30746303/predictive-model-for-macular-hole-closure-speed-insights-from-intraoperative-optical-coherence-tomography
#11
Justis P Ehlers, Atsuro Uchida, Sunil K Srivastava, Ming Hu
Purpose: To establish a predictive model of macular hole (MH) closure speed. Methods: This study was a post hoc analysis of eyes that underwent full-thickness MH repair in the prospective PIONEER intraoperative optical coherence tomography (iOCT) study. The Bioptigen SDOIS system was used for iOCT imaging. All patients underwent standard small-gauge vitrectomy with internal limiting membrane (ILM) peeling, gas tamponade, and postoperative facedown positioning. Before vitrectomy and after ILM peeling, various quantitative OCT measures related to MH were obtained, including MH geometry alterations and outer retinal features...
January 2019: Translational Vision Science & Technology
https://read.qxmd.com/read/30739141/efficacy-of-novel-selective-nlrp3-inhibitors-in-human-and-murine-retinal-pigment-epithelial-cells
#12
Luping Wang, Sarah Schmidt, Petra P Larsen, Johanna H Meyer, William R Roush, Eicke Latz, Frank G Holz, Tim U Krohne
NLRP3 inflammasome activation in the retinal pigment epithelium (RPE) is observed in atrophic age-related macular degeneration (AMD), and pharmacological NLRP3 inhibition may provide a therapeutic strategy to halt disease progression. We tested selective NLRP3 inhibitors (IFM-514, IFM-632, and CRID3) for their efficacy in human and murine RPE cells. Inflammasome activation was induced in primary human RPE cells and ARPE-19 cells following priming with IL-1α by different stimuli, including lysosomal membrane permeabilization by leucyl-leucine methyl ester (Leu-Leu-OMe), oxidative damage induced by hydrogen peroxide, lipofuscin-mediated photooxidative damage induced by incubation with 4-hydroxynonenal-modified photoreceptor outer segments and subsequent blue light irradiation, and P2X7 receptor activation by benzoylbenzoyl-ATP...
February 10, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30739110/a-double-inverted-flap-surgical-technique-for-the-treatment-of-idiopathic-lamellar-macular-hole-associated-with-atypical-epiretinal-membrane
#13
Rino Frisina, Raffaele Parrozzani, Elisabetta Pilotto, Edoardo Midena
OBJECTIVES: To propose a new technique of a double inverted epiretinal membrane (ERM) and internal limiting membrane (ILM) flap (double flap group) for the treatment of idiopathic lamellar macular hole (LMH) with atypical ERM (AERM) and to compare surgical outcomes to those of the standard technique of ERM and ILM peeling of the fovea including LMH (control group). METHODS: AERM was tomographically defined as a medium reflective thickened membrane above the retinal fiber layers without retinal traction signs...
February 8, 2019: Ophthalmologica. Journal International D'ophtalmologie
https://read.qxmd.com/read/30736075/-comparative-clinical-and-ultrastructural-analysis-of-the-results-from-ranibizumab-and-aflibercept-in-patients-with-pdr
#14
Christina Nicolaeva Vidinova, Pravoslava Tz Gouguchkova, Tzvetomir Dimitrov, Kalin Nicolaev Vidinov, Hristina Nocheva
PURPOSE: Diabetic retinopathy is one of the worst complications of diabetes and can threaten sight. The aim of our study is to compare the clinical outcomes and ultrastructural changes in diabetic retinopathy patients after intravitreal admission of either ranibizumab (Lucentis) or aflibercept (Eylea). METHODS: In our prospective study, 27 patients with PDR were enrolled. They were divided into two groups - 14 PDR patients treated with ranibizumab and 13 PDR patients treated with aflibercept...
February 8, 2019: Klinische Monatsblätter Für Augenheilkunde
https://read.qxmd.com/read/30733209/long-term-outcomes-of-penetrating-keratoplasty-for-corneal-complications-of-herpes-zoster-ophthalmicus
#15
Thaís Shiota Tanaka, Christopher Thomas Hood, Matthias Frank Kriegel, Leslie Niziol, H Kaz Soong
BACKGROUND/AIM: To review the long-term outcomes of penetrating keratoplasty (PKP) for corneal complications of herpes zoster ophthalmicus (HZO). METHODS: We reviewed the medical records of 53 eyes of 53 patients who underwent PKP due to corneal complications of HZO at the Kellogg Eye Center. RESULTS: The mean age of patients at the time of PKP was 68.0±16.4 years, with a follow-up of 4.0±3.8 years and quiescent period of 6.5±5.3 years from active HZO to PKP...
February 7, 2019: British Journal of Ophthalmology
https://read.qxmd.com/read/30723562/optical-coherence-tomography-angiography-evolution-of-choroidal-neovascular-membrane-in-choroidal-rupture-managed-by-intravitreal-bevacizumab
#16
Massimo Lorusso, Luisa Micelli Ferrari, Eleni Nikolopoulou, Tommaso Micelli Ferrari
Purpose: To describe a case of a 25-year-old man with choroidal neovascularization (CNV) secondary to traumatic choroidal rupture treated with intravitreal bevacizumab and to evaluate the vascular structure of the area near the traumatic choroidal rupture. Methods: The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity (BCVA), intraocular pressure, anterior segment and funds examination, and optical coherence tomography angiography (OCTA) at baseline and on each follow-up visit...
2019: Case Reports in Ophthalmological Medicine
https://read.qxmd.com/read/30711606/autologous-retinal-transplant-for-refractory-macular-holes-multicenter-international-collaborative-study-group
#17
Dilraj S Grewal, Steve Charles, Barbara Parolini, Kazuaki Kadonosono, Tamer H Mahmoud
PURPOSE: To report the structural and functional outcomes of the autologous neurosensory retinal transplant for closure of refractory large macular holes. DESIGN: Multicenter retrospective consecutive case series PARTICIPANTS: Forty-one eyes of 41 patients (27 female and 14 male) with a full thickness macular hole refractory to prior vitrectomy with internal limiting membrane peel and tamponade. METHODS: All patients underwent pars-plana vitrectomy, autologous neurosensory retinal transplant with either gas, silicone oil tamponade, or short-term Perfluoro-n-octane heavy-liquid tamponade...
January 31, 2019: Ophthalmology
https://read.qxmd.com/read/30711487/complement-factor-h-mutation-w1206r-causes-retinal-thrombosis-and-ischemic-retinopathy-in-mice
#18
Delu Song, Yoshiyasu Ueda, Rupak Bhuyan, Imran Mohammed, Takashi Miwa, Damodar Gullipali, Hangsoo Kim, Lin Zhou, Ying Song, Hannah Schultz, Albert Bargoud, Joshua L Dunaief, Wen-Chao Song
Single nucleotide polymorphisms and rare mutations in Factor H (FH; official name CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thrombotic microangiopathy. Mice with the FH W1206R mutation (FHR/R ) share features with human atypical hemolytic uremic syndrome. Here, we report that FHR/R mice exhibited retinal vascular occlusion and ischemia. Retinal fluorescein angiography demonstrated delayed perfusion and vascular leakage in FHR/R mice. Optical coherence tomography imaging of FHR/R mice showed retinal degeneration, edema, and detachment...
January 31, 2019: American Journal of Pathology
https://read.qxmd.com/read/30707718/axial-length-and-its-associations-in-a-russian-population-the-ural-eye-and-medical-study
#19
Mukharram M Bikbov, Gyulli M Kazakbaeva, Timur R Gilmanshin, Rinat M Zainullin, Inga I Arslangareeva, Venera F Salavatova, Guzel M Bikbova, Songhomitra Panda-Jonas, Nikolai A Nikitin, Artur F Zaynetdinov, Ildar F Nuriev, Renat I Khikmatullin, Yulia V Uzianbaeva, Dilya F Yakupova, Said K Aminev, Jost B Jonas
PURPOSE: To assess the normal distribution of axial length and its associations in a population of Russia. METHODS: The population-based Ural Eye and Medical Study included 5,899 (80.5%) individuals out of 7328 eligible individuals aged 40+ years. The participants underwent an ocular and systemic examination. Axial length was measured sonographically (Ultra-compact A/B/P ultrasound system, Quantel Medical, Cournon d'Auvergne, France). RESULTS: Biometric data were available for 5707 (96...
2019: PloS One
https://read.qxmd.com/read/30707219/apolipoprotein-a-i-mimetic-peptide-l-4f-removes-bruch-s-membrane-lipids-in-aged-nonhuman-primates
#20
Martin Rudolf, Christine A Curcio, Ursula Schlötzer-Schrehardt, Armin Mir Mohi Sefat, Aysegül Tura, Zouhair Aherrahrou, Max Brinkmann, Salvatore Grisanti, Yoko Miura, Mahdy Ranjbar
Purpose: Multiple evidence lines support Bruch's membrane lipid deposition as a major precursor of soft drusen and age-related macular degeneration as including a potentially treatable atherosclerosis-like progression in the subretinal pigment epithelium (RPE)-basal lamina space. We evaluated the effect of anti-inflammatory, antiatherogenic peptide L-4F on Bruch's membrane of aged nonhuman primates in a dose-escalating study. Methods: Macaca fascicularis ≥20 years of age evaluated by color fundus photography and optical coherence tomography received monocular intravitreal injections of L-4F (n = 7) or a placebo-scrambled peptide (n = 2) in 6 doses of 25 to 175 μg over 6 months...
February 1, 2019: Investigative Ophthalmology & Visual Science
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