Xian-Zhe Fan, Jia-Qi Song, Li-Jun Zhang, Rong Wang, Ting Liu, Wen-Jing Bai, Xiang-Qian Kong, Ya-Si Huang, Hong Liang, Hai-Bing Liao
Picrachinentins A-F ( 1 - 6 , respectively), six novel cyclopeptide alkaloid-type burpitides (CPABs), were isolated and fully elucidated from the EtOH extract of the stems and leaves of Picrasma chinensis . Structurally, compounds 1 - 6 have a 14-membered paracyclophane ring system that was closed through an ether bond between the β-hydroxy amino acid and tyrosine and modified with a 4,5-methylenedioxybenzoyloxy (MDBz, 3 and 5 ) or hexanoyl (Hexa, 1 , 2 , 4 , and 6 ) group at the N-terminus. Interestingly, this is the first report on the isolation and characterization of CPABs from plants of the Simaroubaceae family...
May 24, 2024: Organic Letters