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Near infrared fluorescence

Tom Stennett, Philipp Bissinger, Stefanie Griesbeck, Stefan Ullrich, Ivo Krummenacher, Michael Auth, Andreas Sperlich, Matthias Stolte, Krzysztof Radacki, Chang-Jiang Yao, Frank Würthner, Andreas Steffen, Todd Marder, Holger Braunschweig
In this work, two new quadrupolar A-π-D-π-A chromophores have been prepared featuring a strongly electron-donating diborene core and strongly electron-accepting dimesitylboryl (BMes2) and bis(2,4,6-tris(trifluoromethyl)phenyl)boryl (BFMes2) end groups. Analysis of the compounds by NMR spectroscopy, X-ray crystallography, cyclic voltammetry and UV-vis-NIR absorption and emission spectroscopy indicated that the compounds possess extended conjugated π-systems spanning their B4C8 cores. The combination of exceptionally potent π-donor (diborene) and π-acceptor (diarylboryl) groups, both based on trigonal boron, leads to very small HOMO-LUMO gaps, resulting in strong absorption in the near-IR region with maxima in THF at 840 and 1092 nm, respectively, and very high extinction coefficients of ca...
February 19, 2019: Angewandte Chemie
Renhui Zhan, Xiaofeng Li, Wenfei Guo, Xiaojun Liu, Zhi-Xian Liu, Kehua Xu, Bo Tang
A growing body of evidence indicates that micropeptides encoded by long noncoding RNAs (lncRNAs) act independently or as regulators of larger proteins in fundamental biological processes, especially in the maintenance of cellular homeostasis. However, due to their small size and low intracellular expression, visual monitoring of micropeptides in living cells is still a challenge. In this work, we have designed and synthesized an aptamer-based near-infrared fluorescence nanoprobe for fluorescence imaging of phospholamban (PLN), which is an intracellular micropeptide that affects calcium homeostasis, and is closely associated with human heart failure in clinic...
February 19, 2019: ACS Sensors
Xue Shen, Tingting Li, Zhongyuan Chen, Xiaoxue Xie, Hanxi Zhang, Yi Feng, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
A promising approach towards cancer therapy is expected to integrate imaging and therapeutic agents into a versatile nanocarrier for achieving improved antitumor efficacy and reducing the side effects of conventional chemotherapy. Herein, we designed a poly(D,L-lactic-co-glycolic acid) (PLGA)-based theranostic nanoplatform using the double emulsion solvent evaporation method (W/O/W), which is associated with bovine serum albumin (BSA) modifications, to co-deliver indocyanine green (ICG), a widely used near-infrared (NIR) dye, and doxorubicin (Dox), a chemotherapeutic drug, for dual-modality imaging-guided chemo-photothermal combination cancer therapy...
February 18, 2019: Molecular Pharmaceutics
Xuan Zhang, Li Zhang, Wei-Wei Ma, Yong Zhou, Zhen-Ni Lu, Suying Xu
A benzothiazole-based near-infrared (NIR) ratiometric fluorescent probe ( HBT-Cys ) was developed for discriminating cysteine (Cys) from homocysteine (Hcy) and glutathione (GSH). The probe was designed by masking phenol group in the conjugated benzothiazole derivative with methacrylate group that could be selectively removed by Cys, and therefore an intramolecular charge transfer (ICT) fluorescence was switched on in the NIR region. In the absence of Cys, the probe exhibited a strong blue fluorescence emission at 431 nm, whereas a NIR fluorescence emission at 710 nm was significantly enhanced accompanied by a decrease of emission at 431 nm in the presence of Cys, allowing a ratiometric fluorescence detection of Cys...
2019: Frontiers in Chemistry
Jiacheng Lin, Xiaodong Zeng, Yuling Xiao, Lin Tang, Jinxia Nong, Yufang Liu, Hui Zhou, Bingbing Ding, Fuchun Xu, Hanxing Tong, Zixin Deng, Xuechuan Hong
Near-infrared II fluorescence imaging holds great promise for in vivo imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which largely hinders their biomedical application in vivo . In this study, the first NIR-II organic aggregation-induced emission (AIE) fluorophore ( HLZ-BTED ), encapsulated as nanoparticles ( HLZ-BTED dots) for in vivo biomedical imaging, was designed and synthesized...
January 28, 2019: Chemical Science
Shuwen Zhao, Ying Tao, Yunxiang Chen, Yijie Zhou, Rong Li, Lingling Xie, Aibin Huang, Ping Jin, Shidong Ji
Vanadium dioxide is one kind of desirable infrared modulators for sensors because of its remarkable temperature-responsive infrared modulation ability via autogeneic metal-insulator transition. However, the detriments of poor chemical stability and narrow scope of extensive-researched application (e.g. smart windows) restrict its mass production. Here, we propose a VO2@MgF2@PDA inorganic-organic hybrid coated architecture for great enhancing the optical durability more than 13 times in contrast to the pristine VO2, meanwhile the transmittance difference between room and high temperature changed within 20% (decreasing from 25% to 20...
February 18, 2019: ACS Applied Materials & Interfaces
Xiong-Jie Zhao, Yu-Ting Li, Yu-Ren Jiang, Bing-Qing Yang, Ce Liu, Zhi-Hong Liu
Hydrogen sulfide (H2 S) has been considered to be involved in cytoprotective processes and redox signaling. It is very meaningful to track and analyze it in mitochondria. Herein, we report a novel "turn-on" mitochondria-targeting near-infrared fluorescent probe (Mito-NIR-SH) for detection of H2 S in living cells, which was designed and synthesized by introducing 2,4-dinitrophenyl as fluorescence quenching group and H2 S response moiety into Changsha near-infrared fluorophore (CS-OH). The structure of the fluorophore and the probe were characterized by 1 H NMR, 13 C NMR and mass spectrometry...
May 15, 2019: Talanta
Melanie A McWade, Giju Thomas, John Q Nguyen, Melinda E Sanders, Carmen C Solórzano, Anita Mahadevan-Jansen
BACKGROUND: Misidentifying parathyroid glands (PGs) during thyroidectomies or parathyroidectomies, could significantly increase post-operative morbidity. Imaging systems based on near-infrared autofluorescence (NIRAF) detection can localize PGs with high accuracy. These devices however depict NIRAF images on remote display monitors, where images lack spatial context and comparability with actual surgical field-of-view (FOV). In this study, we designed an Overlay Tissue Imaging System (OTIS) that detects tissue NIRAF and back-projects the collected signal as a visible image directly onto the surgical FOV instead of a display monitor, and tested its ability for enhancing parathyroid visualization...
February 12, 2019: Journal of the American College of Surgeons
Sangmin Lee, Hannah E Salapa, Michael C Levin
Antibodies, including antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1, have been shown to contribute to the pathogenesis of multiple sclerosis, thus it is important to assess their biological activity using animal models of disease. Near-infrared optical imaging of fluorescently labeled antibodies and matrix metalloproteinase activity were measured and quantified in an animal model of multiple sclerosis, experimental autoimmune encephalomyelitis. We successfully labeled, imaged and quantified the fluorescence signal of antibodies that localized to the central nervous system of mice with experimental autoimmune encephalomyelitis...
2019: PloS One
Kosaku Amano, Yasuo Aihara, Shunsuke Tsuzuki, Yoshikazu Okada, Takakazu Kawamata
BACKGROUND: For the precise removal of pituitary tumors, preserving the surrounding normal structures, we need real-time intraoperative information on tumor location, margins, and surrounding structures. The aim of this study was to evaluate the benefits of a new intraoperative real-time imaging modality using indocyanine green (ICG) fluorescence through an endoscopic system during transsphenoidal surgery (TSS) for pituitary tumors. METHODS: Between August 2013 and October 2014, 20 patients with pituitary and parasellar region tumors underwent TSS using the ICG fluorescence endoscopic system...
February 14, 2019: Acta Neurochirurgica
M Bedyńska, G Szewczyk, T Klepacka, K Sachadel, T Maciejewski, D Szukiewicz, A Fijałkowska
PURPOSE: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery. METHODS: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018...
February 14, 2019: Archives of Gynecology and Obstetrics
David Buhrke, Neslihan N Tavraz, Daria M Shcherbakova, Luisa Sauthof, Marcus Moldenhauer, Francisco Vélazquez Escobar, Vladislav V Verkhusha, Peter Hildebrandt, Thomas Friedrich
Phytochromes are red/far-red light sensing photoreceptors employing linear tetrapyrroles as chromophores, which are covalently bound to a cysteine (Cys) residue in the chromophore-binding domain (CBD, composed of a PAS and a GAF domain). Recently, near-infrared (NIR) fluorescent proteins (FPs) engineered from bacterial phytochromes binding biliverdin IXα (BV), such as the iRFP series, have become invaluable probes for multicolor fluorescence microscopy and in vivo imaging. However, all current NIR FPs suffer from relatively low brightness...
February 12, 2019: Scientific Reports
Yue Wang, Li Liu, Xian-Li Zhou, Ming-Yu Wu
As the members of reactive sulfur species, SO₂ and biothiols play a significant role in physiological and pathological processes and directly influence numerous diseases. Furthermore, SO₂ and biothiols can provide a reductive environment for lysosomes to carry out their optimal functionality. To this end, the development of single fluorescent probes for imaging SO₂ and biothiols from different emission channels is highly desirable for understanding their physiological nature. Here, a lysosome-targeted fluorescent probe ( BPO-DNSP ) with a dual reaction site for SO₂ and biothiols was presented...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xinqi Zhou, Yuan Fang, Lauren Lesiak, Cliff Stains
Chemotherapeutic agents generally suffer from off-target cytotoxicity in noncancerous cell types, leading to undesired side effects. As a result, significant effort has been put into identifying compounds that are selective for cancerous versus noncancerous cell types. Our lab has recently developed a series of near-infrared (NIR) fluorophores containing a phosphinate functionality at the bridging position of the xanthene scaffold, termed Nebraska Red (NR) fluorophores. Herein, we report the selective cytotoxicity of one NR derivative, NR744, against HeLa (cervical cancer) cells versus NIH-3T3 (noncancerous fibroblast) cells...
February 12, 2019: Chembiochem: a European Journal of Chemical Biology
Mayeul Collot, Pichandi Ashokkumar, Halina Anton, Emmanuel Boutant, Orestis Faklaris, Thierry Galli, Yves Mély, Lydia Danglot, Andrey S Klymchenko
The proper staining of the plasma membrane (PM) is critical in bioimaging as it delimits the cell. Herein, we developed MemBright, a family of six cyanine-based fluorescent turn-on PM probes that emit from orange to near infrared when reaching the PM, and enable homogeneous and selective PM staining with excellent contrast in mono- and two-photon microscopy. These probes are compatible with long-term live-cell imaging and immunostaining. Moreover, MemBright label neurons in a brighter manner than surrounding cells, allowing identification of neurons in acute brain tissue sections and neuromuscular junctions without any use of transfection or transgenic animals...
February 6, 2019: Cell Chemical Biology
Xiaodong Zeng, Ziyang Chen, Lin Tang, Han Yang, Nan Liu, Hui Zhou, Yang Li, Junzhu Wu, Zixin Deng, Yi Yu, Hai Deng, Xuechuan Hong, Yuling Xiao
A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.
February 11, 2019: Chemical Communications: Chem Comm
Shashank Shankar Chetty, Selvarasu Praneetha, Kavitha Govarthanan, Rama Shanker Verma, Arumugam Vadivel Murugan
Acute liver injury is a critical syndrome ascribed to prevalent death of hepatocyte and imperatively requires a liver transplantation. Such methodology is certainly hampered due to deficit of healthy donors. In this regard, stem cells-based regenerative therapies are attractive in repairing injured tissues and organs for medical applications. However, it is crucial to understand the migration, engraftment and regeneration capabilities of transplanted stem cells in the living animal models. For the first time, we demonstrate rapid labeling of umbilical cord-derived mesenchymal stem cells (MSCs) with near-infrared (NIR) fluorescent CuInS2-ZnS nanocrystals (CIZS-NCs) to develop an innovative nano-bioconjugates (MSCs-CIZS-NBCs) that exhibit 98% labeling efficiency...
February 11, 2019: ACS Applied Materials & Interfaces
M Carmen Ortega-Liebana, M Mar Encabo-Berzosa, Alvaro Casanova, M Desiree Pereboom, Octavio Alda, Jose Luis Hueso, Jesus Santamaria
This work describes the synthesis of nitrogen-doped carbon nanodots (CNDs) synthesized from ethylene diamine tetra acetic acid (EDTA) as a precursor and their application as luminescent agents with a dual-mode theranostic role as near-infrared (NIR) triggered imaging and photodynamic therapy agents. Interestingly, these fluorescent CNDs are more rapidly and selectively internalized in tumor cells and exhibit no cytotoxicity until remotely activated with a NIR illumination source. These CNDs are excellent candidates for photo-theranostic purposes, i...
February 11, 2019: Chemistry: a European Journal
Mohammad A Ghane, Dina W Yakout, Angela M Mabb
Postsynaptic trafficking of receptors to and from the cell surface is an important mechanism by which neurons modulate their responsiveness to different stimuli. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which are responsible for fast excitatory synaptic transmission in neurons, are trafficked to and from the postsynaptic surface to dynamically alter neuronal excitability. AMPA receptor trafficking is essential for synaptic plasticity and can be disrupted in neurological disease...
January 28, 2019: Journal of Visualized Experiments: JoVE
G Kate Park, Jeong Heon Lee, Andrew Levitz, Georges El Fakhri, Nathaniel S Hwang, Maged Henary, Hak Soo Choi
Longitudinal tracking of living cells is crucial to understanding the mechanism of action and toxicity of cell-based therapeutics. To quantify the presence of administered cells in the host tissue without sacrifice of animals, labeling of the target cells with a nontoxic and stable contrast agent is a prerequisite. However, such long-term live cell tracking is currently limited by the lack of fluorophores with steady optical and physicochemical properties in the near-infrared (NIR) window. Herein, for the first time, the design of fixable cell-tracking NIR fluorophores (CTNFs) with high optical properties, excellent cell permeation and retention, and high stability against chemical treatments is reported...
February 10, 2019: Advanced Materials
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