Shani Stern, Lei Zhang, Meiyan Wang, Rebecca Wright, Idan Rosh, Yara Hussein, Tchelet Stern, Ashwani Choudhary, Utkarsh Tripathi, Patrick Reed, Hagit Sadis, Ritu Nayak, Aviram Shemen, Karishma Agarwal, Diogo Cordeiro, David Peles, Yuqing Hang, Ana P D Mendes, Tithi D Baul, Julien G Roth, Shashank Coorapati, Marco P Boks, W Richard McCombie, Hilleke Hulshoff Pol, Kristen J Brennand, János M Réthelyi, René S Kahn, Maria C Marchetto, Fred H Gage
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in monozygotic twins, about half of twin pairs are discordant for schizophrenia. To address the question of how and when concordance in monozygotic twins occur, we have obtained fibroblasts from two pairs of schizophrenia discordant twins (one sibling with schizophrenia while the second one is unaffected by schizophrenia) and three pairs of healthy twins (both of the siblings are healthy)...
May 4, 2024: Molecular Psychiatry