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Stem cella

Manuel J Steinbauer, John-Arvid Grytnes, Gerald Jurasinski, Aino Kulonen, Jonathan Lenoir, Harald Pauli, Christian Rixen, Manuela Winkler, Manfred Bardy-Durchhalter, Elena Barni, Anne D Bjorkman, Frank T Breiner, Sarah Burg, Patryk Czortek, Melissa A Dawes, Anna Delimat, Stefan Dullinger, Brigitta Erschbamer, Vivian A Felde, Olatz Fernández-Arberas, Kjetil F Fossheim, Daniel Gómez-García, Damien Georges, Erlend T Grindrud, Sylvia Haider, Siri V Haugum, Hanne Henriksen, María J Herreros, Bogdan Jaroszewicz, Francesca Jaroszynska, Robert Kanka, Jutta Kapfer, Kari Klanderud, Ingolf Kühn, Andrea Lamprecht, Magali Matteodo, Umberto Morra di Cella, Signe Normand, Arvid Odland, Siri L Olsen, Sara Palacio, Martina Petey, Veronika Piscová, Blazena Sedlakova, Klaus Steinbauer, Veronika Stöckli, Jens-Christian Svenning, Guido Teppa, Jean-Paul Theurillat, Pascal Vittoz, Sarah J Woodin, Niklaus E Zimmermann, Sonja Wipf
Globally accelerating trends in societal development and human environmental impacts since the mid-twentieth century 1-7 are known as the Great Acceleration and have been discussed as a key indicator of the onset of the Anthropocene epoch 6 . While reports on ecological responses (for example, changes in species range or local extinctions) to the Great Acceleration are multiplying 8, 9 , it is unknown whether such biotic responses are undergoing a similar acceleration over time. This knowledge gap stems from the limited availability of time series data on biodiversity changes across large temporal and geographical extents...
April 2018: Nature
David J Straus, Paul A Hamlin, Matthew J Matasar, Maria Lia Palomba, Pamela R Drullinsky, Andrew D Zelenetz, John F Gerecitano, Ariela Noy, Audrey M Hamilton, Rebecca Elstrom, Brett Wegner, Katy Wortman, David Cella
The standard treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) in frail elderly patients has not been established. A variation was made on rituximab (R), cyclophosphamide (C), etoposide (E), procarbazine and prednisone (P), substituting vorinostat (V) for procarbazine. Patients ≥aged 60 years with relapsed/refractory DLBCL, not candidates for autologous stem cell transplantation, were treated R-CVEP [R 375 mg/m(2) intravenously (IV), day 1; C 600 mg/m(2) IV days 1, 8: E 70 mg/m(2) IV day 1, 140 mg/m(2) days 2, 3 orally (PO); V (300 vs...
March 2015: British Journal of Haematology
Brittany R Tielbur, Donna E Rice Cella, Amanda Currie, Jonathan D Roach, Bryan Mattingly, Jack Boone, Christina Watwood, Ann McGauran, Howard S Kirshner, P David Charles
Disjointed patient care is a well-documented problem in health care systems, often stemming from poor communication between providers, services, and follow-up care resources. A multidisciplinary discharge huddle, augmented with cellular and tablet technology, was implemented on the Neurology Stroke Service to facilitate multidisciplinary communication, improve transition of patients, and increase referrals into affiliated follow-up care. After initiating the huddle, patient length of stay decreased by 1.4 days (25%), patient flow into continuum partners increased by 10%, and the number of patients going without services after their hospital stay decreased by more than 12%...
January 2015: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
Jill M Cyranowski, Nicholas Zill, Rita Bode, Zeeshan Butt, Morgen A R Kelly, Paul A Pilkonis, John M Salsman, David Cella
OBJECTIVE: The quality of our daily social interactions-including perceptions of support, feelings of loneliness, and distress stemming from negative social exchanges-influence physical health and well-being. Despite the importance of social relationships, brief yet precise unidimensional scales that assess key aspects of social relationship quality are lacking. As part of the National Institute of Health (NIH) Toolbox for the Assessment of Neurological and Behavioral Function, we developed brief self-report scales designed to assess aspects of social support, companionship, and social distress across age cohorts...
March 2013: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Elena De Momi, Chiara Caborni, Francesco Cardinale, Laura Castana, Giuseppe Casaceli, Massimo Cossu, Luca Antiga, Giancarlo Ferrigno
In StereoElectroEncephaloGraphy (SEEG) procedures, intracerebral electrodes are implanted in order to identify the epileptogenic zone in drug-resistant epileptic patients. This paper presents an automatic multitrajectory planner that computes the best trajectory in terms of distance from vessels and guiding screws angle, once the candidate entry and target regions are quickly and roughly defined. The planning process is designed also to spare some brain structures, such as cella media and trigone of the lateral ventricles and brain stem...
April 2013: IEEE Transactions on Bio-medical Engineering
Karel Otero, Masahiro Shinohara, Haibo Zhao, Marina Cella, Susan Gilfillan, Angela Colucci, Roberta Faccio, F Patrick Ross, Steve L Teitelbaum, Hiroshi Takayanagi, Marco Colonna
TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits intracellular signals through the adaptor DAP12. Individuals with genetic mutations inactivating TREM2 or DAP12 develop the Nasu-Hakola disease (NHD) with cystic-like lesions of the bone and brain demyelination that lead to fractures and presenile dementia. The mechanisms of this disease are poorly understood. In this study, we report that TREM2-deficient mice have an osteopenic phenotype reminiscent of NHD. In vitro, lack of TREM2 impairs proliferation and β-catenin activation in osteoclast precursors (OcP) in response to M-CSF...
March 15, 2012: Journal of Immunology: Official Journal of the American Association of Immunologists
Luigi Cella, Aldo Oppici, Mariacristina Arbasi, Mauro Moretto, Massimo Piepoli, Daniele Vallisa, Adriano Zangrandi, Camilla Di Nunzio, Luigi Cavanna
PURPOSE: Bisphosphonate - related osteonecrosis of the JAW (BRONJ) is a well known side effect of bisphosphonate therapies in oncologic and non oncologic patients. Since to date no definitive consensus has been reached on the treatment of BRONJ, novel strategies for the prevention, risk reduction and treatment need to be developed. We report a 75 year old woman with stage 3 BRONJ secondary to alendronate and pamidronate treatment of osteoporosis. The patient was unresponsive to recommended treatment of the disease, and her BRONJ was worsening...
2011: Head & Face Medicine
Maria Teresa Sartori, Simone Cesaro, Mattia Peruzzo, Chiara Messina, Graziella Saggiorato, Elisabetta Calore, Marta Pillon, Stefania Varotto, Luca Spiezia, Giuseppe Cella
BACKGROUND: Veno-occlusive disease (VOD) is a major complication following hematopoietic stem cell transplantation (HSCT). Its diagnosis is based on clinical criteria, which have a limited sensitivity. Increased plasminogen activator inhibitor-1 (PAI-1) levels have been suggested as a marker of VOD. We aimed to prospectively evaluate how the fibrinolytic parameters behaved to discriminate VOD from other liver disorders occurring after HSCT in a pediatric population. PROCEDURES: A total of 195 HSCT were performed on 161 children and VOD complicated 11 cases (6...
May 2012: Pediatric Blood & Cancer
Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli
Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome...
2009: Mediterranean Journal of Hematology and Infectious Diseases
John R Wingard, I-Chan Huang, Kathleen A Sobocinski, Michael A Andrykowski, David Cella, J Douglas Rizzo, Marianne Brady, Mary M Horowitz, Michelle M Bishop
Hematopoietic cell transplantation (HCT) is an intensive treatment for hematologic malignancies that has the potential to cure disease or prolong life, but also to impair quality of life for survivors. Earlier studies have suggested that various factors are associated with physical and mental health after HCT. In this study, we evaluated demographic and clinical factors before and after HCT and selected psychosocial factors after HCT, exploring their association with self-reported physical and mental health...
December 2010: Biology of Blood and Marrow Transplantation
Lucrecia Cella Pizarro, Alejandro J Bisigato
BACKGROUND AND AIMS: The growth-differentiation balance hypothesis (GDBH) states that there is a physiological trade-off between growth and secondary metabolism and predicts a parabolic effect of resource availability (such as water or nutrients) on secondary metabolite production. To test this hypothesis, the response of six Patagonian Monte species (Jarava speciosa, Grindelia chiloensis, Prosopis alpataco, Bougainvillea spinosa, Chuquiraga erinacea and Larrea divaricata) were investigated in terms of total biomass and resource allocation patterns in response to a water gradient...
August 2010: Annals of Botany
Yaming Wang, Marina Cella, Susan Gilfillan, Marco Colonna
Polyinosinic:polycytidylic acid (poly I:C), a synthetic analog of double-stranded viral RNA, serves as a potent adjuvant for vaccination against soluble proteins, pathogens, and tumors. Poly I:C is sensed by both TLR3 in the endosomes and melanoma differentiation-associated protein 5 (MDA5) in the cytoplasm. Although it is known that TLR3 is required for cross-priming of CD8 T cells specific for viral Ags, the role of MDA5 in inducing CD8 T cell responses is still unclear. In this study, we demonstrate that in mice lacking MDA5, the majority of CD8 T cells do not survive after primary immunization with poly I:C and Ag, impairing memory response to subsequent Ag challenge...
March 15, 2010: Journal of Immunology: Official Journal of the American Association of Immunologists
Yu Cheng Tang, Marilyn Thoman, Phyllis-Jean Linton, Albert Deisseroth
Multiple investigators have reported the presence of defects in the immune response of the elderly [Castle In: Clin Infect Dis 31:578, 2000; Ortqvist et al. In: Eur Respir J 30:414-422, 2007; Saurwein-Teissl et al. In: J Immunol 168:5893, 2002; Haynes et al. In: Proc Natl Acad Sci USA 100:15053-15058, 2003]. These defects reduce the magnitude of the immune response to infection and to vaccination. In individuals greater than 55 years of age, the probability of developing a fully protective neutralizing antibody response to the yearly multivalent particle inactivated influenza vaccine is less than 20% [Jefferson et al...
December 2009: Cancer Immunology, Immunotherapy: CII
Gale Harding, David Cella, Don Robinson, Parthiv J Mahadevia, Jason Clark, Dennis A Revicki
BACKGROUND: Renal cell carcinoma (RCC) has multiple symptoms stemming from disease and treatments. There are few validated scales for evaluating RCC symptoms. METHODS: A national cross-sectional study of adult RCC patients was conducted from October to December 2003 to define patient-reported RCC symptomology. Participants were asked open-ended questions regarding their signs and symptoms and completed an 86-item pilot questionnaire of physical and psychological symptoms...
2007: Health and Quality of Life Outcomes
Michelle M Bishop, Jennifer L Beaumont, Elizabeth A Hahn, David Cella, Michael A Andrykowski, Marianne J Brady, Mary M Horowitz, Kathleen A Sobocinski, J Douglas Rizzo, John R Wingard
PURPOSE: Little is known about the long-term effects of cancer and hematopoietic stem-cell transplantation (HCT) on spouses or partners. The purpose of this study was to examine the health-related quality of life and post-traumatic growth (PTG) of spouses/partners compared with survivors and controls and to identify factors associated with those outcomes. PATIENTS AND METHODS: HCT survivor/partner pairs (n = 177), coupled continuously since HCT, were drawn from 40 North American transplantation centers...
April 10, 2007: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Friederike H Kreisel, Amanda Blasius, Daniel Kreisel, Marco Colonna, Marina Cella
In this study, we sorted total bone marrow (BM) into six distinct subsets based on surface expression of CD31 and Ly6C and investigated the capacity of these subsets to acquire characteristics of plasmacytoid dendritic cells (PDCs) after in vitro culture with FMS-like tyrosine kinase 3 ligand (Flt3-L). Cultured CD31(high)/Ly6C(-) cells were the only subset that consistently developed immunophenotypic, functional, and morphologic characteristics of PDCs. Culture of this subset resulted in expression of CD11c, B220, and the PDC-specific marker 440C and secretion of interferon-alpha (IFN-alpha) when stimulated with CPG ODN 2216...
August 2006: Cellular Immunology
G Cella, M Marchetti, A Vignoli, M L Randi, G Saggiorato, L Pasetto, A Pagnan, T Barbui, A Falanga
Recombinant human G-CSF (rHuG-CSF) is used for hematopoietic progenitor cells (HPC) mobilization and collection. Activation of polymorphonuclear leukocytes (PMN) is present during rHuG-CSF treatment and is associated with endothelial cell dysfunction and hypercoagulation. We evaluated whether PMN activation by rHuG-CSF may alter the blood oxidative status and subsequently affect the vascular cell function. Fourteen healthy individuals received rHuG-CSF for HPC harvesting. Blood was drawn before starting rHuG-CSF (T0), on the last day of rHuG-CSF (T1) and 1 week after stopping rHuG-CSF (T2)...
August 2006: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Maria Teresa Sartori, Luca Spiezia, Simone Cesaro, Chiara Messina, Myriam Paris, Marta Pillon, Graziella Saggiorato, Antonio Pagnan, Antonio Girolami, Luigi Zanesco, Giuseppe Cella
Hepatic veno-occlusive disease (VOD) is a severe complication after hematopoietic stem cell transplantation (HSCT). Recent studies, mainly in adults receiving HSCT, have identified an increase in the plasminogen activator inhibitor-1 (PAI-1) as a possible marker of VOD. To confirm this finding, the fibrinolytic, coagulation and liver function parameters were assayed before and weekly for 1 month after 61 HSCT performed in 53 consecutive children. Non-VOD patients had a slight increase in t-PA antigen, fibrinogen and P-selectin levels, as well as a mildly longer aPTT and a drop in antithrombin after HSCT...
April 2005: Thrombosis and Haemostasis
Michael A Andrykowski, Michelle M Bishop, Elizabeth A Hahn, David F Cella, Jennifer L Beaumont, Marianne J Brady, Mary M Horowitz, Kathleen A Sobocinski, J Douglas Rizzo, John R Wingard
PURPOSE: To examine health-related quality of life (HRQOL) and growth, and spiritual well-being in adult survivors of hematopoietic stem-cell transplantation (HSCT) for a malignant disease. METHODS: HSCT survivors (n = 662) were recruited through the International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry and were drawn from 40 transplantation centers. HSCT survivors completed a telephone interview and a set of questionnaires a mean of 7...
January 20, 2005: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Stephanie J Lee, Steven Joffe, Haesook T Kim, Gerard Socie, Andrew L Gilman, John R Wingard, Mary M Horowitz, David Cella, Karen L Syrjala
Studies investigating quality of life (QOL) after hematopoietic stem cell transplantation demonstrate the spectrum of QOL outcomes awaiting survivors. Nevertheless, how transplantation physicians interpret and apply QOL information to clinical practice is poorly understood. We conducted a cross-sectional survey of transplantation physicians to address these issues and received 180 (24%) responses from physicians in 29 countries. Seventy-two percent reported that their patients are willing to accept poor QOL for a small chance of cure...
October 1, 2004: Blood
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