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https://read.qxmd.com/read/30742736/a-cohort-study-of-local-excision-followed-by-adjuvant-therapy-incorporating-a-contact-x-ray-brachytherapy-boost-instead-of-radical-resection-in-180-patients-with-rectal-cancer
#1
F M Smith, D M Pritchard, H Wong, K Whitmarsh, M J Hershman, A Sun Myint
AIM: Recent data have suggested near-equivalent oncological results when treating early rectal cancer by local excision followed by radio +/- chemotherapy rather than salvage radical surgery. The aim of this retrospective study was to assess the use of contact x-ray brachytherapy within this paradigm. METHODS: All patients had undergone local excision and were referred to our radiotherapy centre for treatment with contact x-ray brachytherapy. Postoperative (chemo) radiotherapy was also given in their local hospital in most cases...
February 11, 2019: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://read.qxmd.com/read/30715597/screening-for-clinical-insomnia-in-cancer-patients-with-the-edmonton-symptom-assessment-system-revised-a-specific-sleep-item-is-needed
#2
Josée Savard, Hans Ivers
OBJECTIVE: We previously investigated the capacity of the original version of the Edmonton Symptom Assessment System-Revised (ESAS-r) and the Canadian Problem Checklist (CPP) to screen for clinical levels of insomnia in cancer patients. The original ESAS-r includes an item assessing drowsiness and an "other symptom" item, both of which are rated on a scale from 0 to 10, while the CPC has a sleep item, a box which is checked when this problem is present. Because none of these items showed an optimal screening capacity, we concluded that it would be best to add a specific 0-10 sleep item to the ESAS-r...
February 4, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30658887/combination-of-novel-systemic-agents-and-radiotherapy-for-solid-tumors-part-ii-an-airo-italian-association-of-radiotherapy-and-clinical-oncology-overview-focused-on-treatment-toxicity
#3
REVIEW
Stefano Arcangeli, Barbara Alicia Jereczek-Fossa, Filippo Alongi, Cynthia Aristei, Carlotta Becherini, Liliana Belgioia, Michela Buglione, Luciana Caravatta, Rolando Maria D'Angelillo, Andrea Riccardo Filippi, Michele Fiore, Domenico Genovesi, Carlo Greco, Lorenzo Livi, Stefano Maria Magrini, Giulia Marvaso, Rosario Mazzola, Icro Meattini, Anna Merlotti, Isabella Palumbo, Stefano Pergolizzi, Sara Ramella, Umberto Ricardi, Elvio Russi, Marco Trovò, Alessandro Sindoni, Vincenzo Valentini, Renzo Corvò
Clinical development and use of novel systemic agents in combination with radiotherapy (RT) is at nowadays most advanced in the field of treatment of solid tumors. Although for many of these substances preclinical studies provide sufficient evidences on their principal capability to enhance radiation effects, the majority of them have not been investigated in even phase I clinical trials for safety in the context of RT. In clinical practice, unexpected acute and late side effects may emerge especially in combination with RT...
November 30, 2018: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/30634350/ten-year-outcomes-of-renal-tumor-radio-frequency-ablation
#4
Brett A Johnson, Igor Sorokin, Jeffrey A Cadeddu
PURPOSE: We reviewed long-term oncologic outcomes in patients with renal tumors treated with radio frequency ablation more than 10 years ago. MATERIALS AND METHODS: We retrospectively reviewed the records of patients with renal tumors who underwent radio frequency ablation from November 2000 to August 2007. Demographic, clinical and radiological data were assessed to determine evidence of disease recurrence. Patients with familial renal cell carcinoma syndromes were excluded from study...
February 2019: Journal of Urology
https://read.qxmd.com/read/30613312/cancer-stem-cell-impact-on-clinical-oncology
#5
REVIEW
Mariel E Toledo-Guzmán, Gabriele D Bigoni-Ordóñez, Miguel Ibáñez Hernández, Elizabeth Ortiz-Sánchez
Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo- and radio-resistance. Several mechanisms have been studied to explain chemo- and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes...
December 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30612162/-18-f-dopa-pet-ct-in-brain-tumors-impact-on-multidisciplinary-brain-tumor-board-decisions
#6
Olivier Humbert, Véronique Bourg, Lydiane Mondot, Jocelyn Gal, Pierre-Yves Bondiau, Denys Fontaine, Esma Saada-Bouzid, Marie Paquet, David Chardin, Fabien Almairac, Fanny Vandenbos, Jacques Darcourt
PURPOSE: This study aimed to assess the therapeutic impact and diagnostic accuracy of 18 F-DOPA PET/CT in patients with glioblastoma or brain metastases. METHODS: Patients with histologically proven glioblastoma or brain metastases were prospectively included in this monocentric clinical trial (IMOTEP). Patients were included either due to a clinical suspicion of relapse or to assess residual tumor infiltration after treatment. Multimodality brain MRI and 18 F-DOPA PET were performed...
March 2019: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30607587/patient-preferences-regarding-intraoperative-versus-external-beam-radiotherapy-for-early-breast-cancer-and-the-impact-of-socio-demographic-factors
#7
Saskia Spaich, Sophie Krickeberg, Svetlana Hetjens, Frederik Wenz, Axel Gerhardt, Marc Sütterlin
PURPOSE: Patient comfort and preference have steadily gained attention in radio-oncologic treatment of breast cancer. Therefore, the purpose of this investigation was to further explore patient preferences in choosing between intraoperative radiotherapy (IORT) and external beam radiotherapy (EBRT). METHODS: We prospectively analysed data of 101 women, who were candidates for breast-conserving surgery with adjuvant radiotherapy. A two-part video was shown to patients: an educational section about EBRT/IORT, followed by a preference elicitation section focusing on additional accepted risk (AAR) of recurrence after either treatment...
January 4, 2019: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30595340/-locoregional-control-and-patterns-of-locoregional-failure-in-women-with-breast-cancer-treated-by-highly-conformal-electron-beam-irradiation
#8
G Loganadane, Z Xi, N Fournier-Bidoz, H P Xu, N Grellier Adedjouma, L Bazire, A Fourquet, Y M Kirova
PURPOSE: The purpose of this study was to evaluate locoregional control and describe the patterns of locoregional failure in women with breast cancer irradiated by a previously described post-mastectomy highly conformal electron beam radiotherapy technique. MATERIAL AND METHODS: We included all women irradiated by post-mastectomy highly conformal electron beam radiotherapy technique for non-metastatic breast cancer between 2007 and 2011 in our department. All cases of bilateral breast cancer were excluded...
December 27, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://read.qxmd.com/read/30595157/cancer-du-rein-et-radioth%C3%A3-rapie-radior%C3%A3-sistance-et-au-del%C3%A3
#9
Benoîte Mery, Chloé Rancoule, Elise Rowinski, Claire Bosacki, Alexis Vallard, Jean-Baptiste Guy, Nicolas Magné
RADIORESISTANCE AND BEYOND: Metastatic renal cancer has a poor prognosis because of the limited impact of usual treatment modalities, and notably radiotherapy. Renal cell carcinoma is traditionally considered to be radioresistant, and conventional radiotherapy fraction sizes of 1.8 to 2 Gy are thought to have little role in its management. Technological advances in radiation oncology have led to stereotactic approaches that overcome radio resistance mechanisms of renal cancer cells and could be successful. The technical ability of applying high dose per fraction, leads to a distinct biological response which is different from the one observed with conventional irradiation through high responses rates...
December 2018: Bulletin du Cancer
https://read.qxmd.com/read/30591391/photobiomodulation-with-low-level-laser-therapy-reduces-oral-mucositis-caused-by-head-and-neck-radio-chemotherapy-prospective-randomized-controlled-trial
#10
F Marín-Conde, L Castellanos-Cosano, J Pachón-Ibañez, M A Serrera-Figallo, J L Gutiérrez-Pérez, D Torres-Lagares
The objective of this study was to assess the effectiveness of photobiomodulation with low-level laser therapy (LLLT) as a preventive and therapeutic procedure for the treatment of oral and oropharyngeal mucositis caused by radio-chemotherapy in patients diagnosed with oral squamous cell carcinoma (SCC). An experimental, prospective, double-blind, randomized controlled study was conducted involving patients diagnosed with oral SCC undergoing oncological treatment. The variables analyzed included grade, appearance, and remission of mucositis...
December 24, 2018: International Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/30476004/long-term-endocrine-and-metabolic-consequences-of-cancer-treatment-a-systematic-review
#11
Judith Gebauer, Claire Higham, Thorsten Langer, Christian Denzer, Georg Brabant
The number of patients surviving five or more years after initial cancer diagnosis has significantly increased over the last decades due to considerable improvements in the treatment of many cancer entities. A negative consequence of this is the emergence of long-term sequelae and endocrine disorders account for a high proportion of these. These late effects can occur decades after cancer treatment and affect up to 50% of childhood cancer survivors. Multiple predisposing factors for endocrine late effects have been identified; including radiation, gender and age at the time of diagnosis...
November 23, 2018: Endocrine Reviews
https://read.qxmd.com/read/30443801/a-new-methodology-to-derive-3d-kinetic-parametric-fdg-pet-images-based-on-a-mathematical-approach-integrating-an-error-model-of-measurement
#12
Elyse Colard, Sarkis Delcourt, Laetitia Padovani, Sébastien Thureau, Arthur Dumouchel, Pierrick Gouel, Justine Lequesne, Bardia Farman Ara, Pierre Vera, David Taïeb, Isabelle Gardin, Dominique Barbolosi, Sébastien Hapdey
BACKGROUND: In FDG-PET, SUV images are hampered by large potential biases. Our aim was to develop an alternative method (ParaPET) to generate 3D kinetic parametric FDG-PET images easy to perform in clinical oncology. METHODS: The key points of our method are the use of a new error model of PET measurement extracted from a late dynamic PET acquisition of 15 min, centered over the lesion and an image-derived input function (IDIF). The 15-min acquisition is reconstructed to obtain five images of FDG mean activity concentration and images of its variance to model errors of PET measurement...
November 15, 2018: EJNMMI Research
https://read.qxmd.com/read/30405890/effect-of-therapies-mediated-modulation-of-telomere-and-or-telomerase-on-cancer-cells-radiosensitivity
#13
REVIEW
Ganiou Assani, Yudi Xiong, Fuxiang Zhou, Yunfeng Zhou
Cancer is one of the leading causes of death in the world. Many strategies of cancer treatment such as radiotherapy which plays a key role in cancer treatment are developed and used nowadays. However, the side effects post-cancer radiotherapy and cancer radioresistance are two major causes of the limitation of cancer radiotherapy effectiveness in the cancer patients. Moreover, reduction of the limitation of cancer radiotherapy effectiveness by reducing the side effects post-cancer radiotherapy and cancer radioresistance is the aim of several radiotherapy-oncologic teams...
October 9, 2018: Oncotarget
https://read.qxmd.com/read/30383900/quantitative-imaging-of-cancer-in-the-postgenomic-era-radio-geno-mics-deep-learning-and-habitats
#14
REVIEW
Sandy Napel, Wei Mu, Bruna V Jardim-Perassi, Hugo J W L Aerts, Robert J Gillies
Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. Herein, the authors propose that quantitative image analytics, known as "radiomics," can be used to quantify and characterize this heterogeneity. Virtually every patient with cancer is imaged radiologically...
November 1, 2018: Cancer
https://read.qxmd.com/read/30350489/optical-and-x-ray-technology-synergies-enabling-diagnostic-and-therapeutic-applications-in-medicine
#15
Brian W Pogue, Brian C Wilson
X-ray and optical technologies are the two central pillars for human imaging and therapy. The strengths of x-rays are deep tissue penetration, effective cytotoxicity, and the ability to image with robust projection and computed-tomography methods. The major limitations of x-ray use are the lack of molecular specificity and the carcinogenic risk. In comparison, optical interactions with tissue are strongly scatter dominated, leading to limited tissue penetration, making imaging and therapy largely restricted to superficial or endoscopically directed tissues...
October 2018: Journal of Biomedical Optics
https://read.qxmd.com/read/30324220/methotrexate-polyglutamate-levels-and-co-distributions-in-childhood-acute-lymphoblastic-leukemia-maintenance-therapy
#16
Jacob Nersting, Stine Nygaard Nielsen, Kathrine Grell, Maria Paerregaard, Jonas Abrahamsson, Bendik Lund, Olafur Gisli Jonsson, Kaie Pruunsild, Goda Vaitkeviciene, Jukka Kanerva, Kjeld Schmiegelow
PURPOSE: Methotrexate polyglutamates (MTXpg) facilitate incorporation of thioguanine nucleotides into DNA (DNA-TG, the primary cytotoxic thiopurine metabolite and outcome determinant in MTX/6-mercaptopurine treatment of childhood ALL). We hypothesized that mapping erythrocyte levels of MTXpg with 1-6 glutamates and their associations with DNA-TG formation would facilitate future guidelines for maintenance therapy dosing. METHODS AND RESULTS: Summed MTX with 1-6 glutamates resolved by LCMS [median (interquartile): 5...
October 15, 2018: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/30273007/prolonged-versus-short-duration-use-of-nasogastric-tubes-in-patients-with-head-and-neck-cancer-during-radiotherapy-alone-or-combined-chemoradiotherapy
#17
Vittoria Espeli, Stephanie Vergotte, Pierre-Yves Dietrich, Claude Pichard, Marco Siano
To compare safety and effectiveness of prolonged (>28 days) versus short duration (≤28 days) use of nasogastric tube for enteral nutrition and weight loss prevention during curative radiotherapy with or without concurrent chemotherapy or cetuximab for head and neck cancer patients. We performed a retrospective study and database review of all patients at our center, treated with radiotherapy for head and neck cancer receiving enteral nutrition by nasogastric tube. Type of treatment, weight and body mass index changes, and related complications (gastroesophageal reflux, pneumonia, ulcer, feeding tube obstruction, or dislocation) were documented...
October 1, 2018: Nutrition and Cancer
https://read.qxmd.com/read/30219733/a-smart-and-operator-independent-system-to-delineate-tumours-in-positron-emission-tomography-scans
#18
Albert Comelli, Alessandro Stefano, Giorgio Russo, Maria Gabriella Sabini, Massimo Ippolito, Samuel Bignardi, Giovanni Petrucci, Anthony Yezzi
Positron Emission Tomography (PET) imaging has an enormous potential to improve radiation therapy treatment planning offering complementary functional information with respect to other anatomical imaging approaches. The aim of this study is to develop an operator independent, reliable, and clinically feasible system for biological tumour volume delineation from PET images. Under this design hypothesis, we combine several known approaches in an original way to deploy a system with a high level of automation...
September 8, 2018: Computers in Biology and Medicine
https://read.qxmd.com/read/30213593/prognostic-role-of-resection-margin-in-open-oncologic-laryngeal-surgery-survival-analysis-of-a-cohort-of-139-patients-affected-by-squamous-cell-carcinoma
#19
Carmelo Saraniti, Riccardo Speciale, Salvatore Gallina, Pietro Salvago
INTRODUCTION: The treatment of laryngeal squamous cell carcinoma needs accurate risk stratification, in order to choose the most suitable therapy. The prognostic significance of resection margin is still highly debated, considering the contradictory results obtained in several studies regarding the survival rate of patients with a positive resection margin. OBJECTIVE: To evaluate the prognostic role of resection margin in terms of survival and risk of recurrence of primary tumour through survival analysis...
June 2, 2018: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/30182247/treatment-of-malnutrition-decreases-complication-rates-and-shortens-the-length-of-hospital-stays-in-a-radiation-oncology-department
#20
Johannes Kufeldt, Marén Viehrig, Daniela Schweikert, Andreas Fritsche, Michael Bamberg, Michael Adolph
PURPOSE: The nutritional status of inpatients influences the therapeutic outcome. Malnutrition is a common comorbidity in oncological patients. Both radio- and radiochemotherapy may contribute to the additional deterioration of the nutritional status. The aim of this study was to evaluate the impact of specialized treatment of malnutrition as a clinical routine. METHODS: The nutritional status of inpatients was assessed by the Nutritional risk screening (NRS-2002) on the day of admission to the University Department of Radiation Oncology...
November 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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