Gloria Bonuccelli, Aristotelis Tsirigos, Diana Whitaker-Menezes, Stephanos Pavlides, Richard G Pestell, Barbara Chiavarina, Philippe G Frank, Neal Flomenberg, Anthony Howell, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Previously, we proposed a new model for understanding the "Warburg effect" in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and the resulting energy-rich metabolites are then transferred to epithelial cancer cells, where they enter the TCA cycle, resulting in high ATP production via oxidative phosphorylation. We have termed this new paradigm "The Reverse Warburg Effect." Here, we directly evaluate whether the end-products of aerobic glycolysis (3-hydroxy-butyrate and L-lactate) can stimulate tumor growth and metastasis, using MDA-MB-231 breast cancer xenografts as a model system...
September 1, 2010: Cell Cycle