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JOURNAL ARTICLE
Masanori Ozaki, Ken Kageyama, Kenjiro Kimura, Shinpei Eguchi, Akira Yamamoto, Ryota Tanaka, Takehito Nota, Hiroki Yonezawa, Hideyuki Nishiofuku, Yuki Sakai, Naoki Tani, Atsushi Jogo, Mizue Terai, Takami Sato, Takeaki Ishizawa, Yukio Miki
Liver metastases from pancreatic ductal adenocarcinoma (PDAC) are highly fatal. A rat-based patient-derived tumor xenograft (PDX) model is available for transcatheter therapy. This study aimed to create an immunodeficient rat model with liver xenografts of patient-derived primary PDAC and evaluate efficacy of hepatic arterial infusion chemotherapy with cisplatin in this model. Three patient-derived PDACs were transplanted into the livers of 21 rats each (totally, 63 rats), randomly assigned into hepatic arterial infusion, systemic venous infusion, and control groups (n = 7 each) four weeks post-implantation...
May 8, 2024: Scientific Reports
#2
JOURNAL ARTICLE
Yufeng Zhang, Haiyan Zhang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi
BACKGROUND AND AIMS: The prognosis of hepatocellular carcinoma (HCC) with macrovascular invasion(MaVI)is poor, and the treatment is limited. This study aims to explore the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC), combined with lenvatinib and programmed cell death-1(PD-1) inhibitor in the first-line treatment of HCC with MaVI. METHODS: From July 2020 to February 2022, we retrospectively analyzed consecutive patients with HCC with MaVI who received hepatic arterial infusion FOLFOX(oxaliplatin, 5-fluorouracil, and leucovorin)combined with lenvatinib and PD-1 inhibitor...
May 6, 2024: World Journal of Surgical Oncology
#3
JOURNAL ARTICLE
Mrittika Sen, Raksha Rao, Kaustubh Mulay, Vijay Anand P Reddy, Santosh G Honavar
OBJECTIVE: To study the long-term safety and efficacy of intravitreal topotecan (IVT) against vitreous seeds in eyes with retinoblastoma and risk factors for their recurrence. DESIGN: Retrospective, non-comparative, interventional study. SUBJECTS: 91 eyes of 90 patients with retinoblastoma treated between January 2013 to April 2019. INTERVENTION: Patients with recurrent or refractory vitreous seeds following completion of intravenous or intra-arterial chemotherapy were treated with IVT (30μg/0...
May 2, 2024: Ophthalmology
#4
JOURNAL ARTICLE
Long Li, Song Liu, Qingdong Wang, Yanhua Wang, Guangji Yu
OBJECTIVE: This study aimed to evaluate the efficacy and safety of sequential treatment of continuous transcatheter hepatic artery infusion chemotherapy (HAIC) with systemic capecitabine monotherapy and camrelizumab for treating unresectable hilar cholangiocarcinoma (HCCA). METHODS: This study retrospectively analyzed patients with unresectable HCCA admitted to Linyi Cancer Hospital in Shandong Province from October 2019 to December 2021. All enrolled patients were treated with HAIC (mFOLFOX7) + camrelizumab for 2-6 cycles and administered systemic therapy with capecitabine and camrelizumab...
April 1, 2024: Journal of Cancer Research and Therapeutics
#5
JOURNAL ARTICLE
Shumin Fu, Yongkang Xu, Ye Mao, Mengting He, Zhimeng Chen, Shenglan Huang, Dan Li, Yaqin Lv, Jianbing Wu
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) has demonstrated remarkable local therapeutic efficacy in treating patients with large unresectable hepatocellular carcinoma (HCC). Additionally, the combination of lenvatinib and programmed cell death protein-1 (PD-1) inhibitors has demonstrated promising antitumor effects in unresectable HCC. Therefore, we conducted a retrospective analysis to evaluate the efficacy and safety of combining HAIC with lenvatinib and PD-1 inhibitors as a first-line therapeutic approach in high-burden HCC patients...
May 2024: Cancer Medicine
#6
REVIEW
Ari D Kappel, Rohan Jha, Saibaba Guggilapu, William J Smith, Abdullah H Feroze, Adam A Dmytriw, Juan Vicenty-Padilla, Rodolfo E Alcedo Guardia, Florian A Gessler, Nirav J Patel, Rose Du, Alfred P See, Pier Paolo Peruzzi, Mohammad A Aziz-Sultan, Joshua D Bernstock
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selective intra-arterial cerebral infusion (SSIACI) with increasing precision. This treatment modality may offer the ability to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. However, challenges persist, including blood-brain barrier (BBB) penetration, hemodynamic complexities, and drug-tumor residence time...
April 22, 2024: Cancers
#7
JOURNAL ARTICLE
Aparna Ramasubramanian, Nisha S Rehman, Argudit Chauhan, Aurora Rodriguez, Amy Leverant, Nishant Tiwari
PURPOSE: To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma. METHODS: This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma. RESULTS: In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation...
April 25, 2024: Journal of Pediatric Ophthalmology and Strabismus
#8
JOURNAL ARTICLE
Mei Li, Jun Liao, Li Wang, Tianye Lv, Qianfu Sun, Yan Xu, Zhi Guo, Manman Quan, Hao Qin, Haoyang Yu, Kai Zhang, Wenge Xing, Haipeng Yu
OBJECTIVES: This study aimed to examine the effectiveness of the best response rate (BRR) as a surrogate for overall survival (OS), using the modified Response Evaluation Criteria in Solid Tumors (mRECIST), in patients with unresectable hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC) with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) combined with molecular targeting and immunotherapy. METHODS: This study enrolled 111 consecutive patients who had complete imaging data...
2024: Frontiers in Immunology
#9
JOURNAL ARTICLE
Christina Stathopoulos, Guillaume Saliou, Alexandre Moulin, Maja Beck-Popovic, Francis Munier
No abstract text is available yet for this article.
April 2024: Klinische Monatsblätter Für Augenheilkunde
#10
Yanjie Cao, Dedong Yu, Yun Wu, Wei Zhu
INTRODUCTION: Pancreatic cancer is a highly aggressive malignancy with limited response to chemotherapy. This research aims to compare the effectiveness and safety of regional intra-arterial chemotherapy (RIAC) with conventional systemic chemotherapy in treating advanced stages of pancreatic cancer. METHODS: A comprehensive literature review was conducted using databases such as PubMed, Embase, Web of Science, and the Cochrane Library. Studies assessing the comparative outcomes of RIAC and systemic chemotherapy were included...
2024: Frontiers in Oncology
#11
REVIEW
John Buscombe, Jaroslaw Cwikla, Ann-Marie Quigley, Shaunak Navalkissoor, Dominic Yu
Selective intra-arterial radiotherapy (SIRT) is a technique which has evolved over the past 30 years. In present this is primarily used to treat primary and secondary tumors in the liver. The technique normally depends on the delivery of a therapeutic radiopharmaceutical or radiolabeled particulate via a radiologically placed intra-arterial catheter in the hepatic artery. This is because most of these tumors have a single arterial blood supply but normal hepatocytes are supplied by both the hepatic artery and portal vein...
April 15, 2024: Seminars in Nuclear Medicine
#12
JOURNAL ARTICLE
Xiuqian Yi, Xintong Lin, Chun Fang, Qiang Liu, Haifeng Chen, Jiang Qian, Kang Xue
PURPOSE: To evaluate changes in retinal microvascular density and choroidal vascularity in patients with retinoblastoma (RB) after intra-arterial chemotherapy (IAC). DESIGN: Retrospective clinical cohort study. METHODS: This study included 12 unilateral RB eyes treated with IAC (RB tumour), 12 contralateral normal eyes (RB fellow), and 12 healthy controls. The macular retinal thickness and retinal microvascular structure, including foveal avascular zone (FAZ) area, the macular and peripapillary superficial vessel density (SVD) and deep vessel density (DVD), were measured by optical coherence tomography angiography (OCTA)...
April 12, 2024: American Journal of Ophthalmology
#13
REVIEW
Rachna Meel, Suyash Kulkarni, Lata Singh, Girish Chinnaswamy, Venkatraman Radhakrishnan, Renu Madan, Archana Sasi, Tanvir Kaur, R S Dhaliwal, Sameer Bakhshi
Retinoblastoma (RB) is the most common childhood intraocular malignancy. Delayed presentation due to a lack of awareness and advanced intraocular tumors are a common scenario in low-middle income countries (LMICs). Remarkable treatment advances have been made in the past few decades allowing globe salvage in advanced intraocular RB (IORB) including systemic chemotherapy with focal consolidation and targeted treatments like intraarterial chemotherapy and intravitreal chemotherapy. However, a lack of availability and affordability limits the use of such advances in LMICs...
April 13, 2024: Indian Journal of Pediatrics
#14
JOURNAL ARTICLE
Wills F Filipe, Florian E Buisman, Stijn Franssen, Myrtle F Krul, Dirk J Grünhagen, Roel J Bennink, Karen Bolhuis, Rutger C G Bruijnen, Tineke E Buffart, Mark C Burgmans, Otto M van Delden, Pascal G Doornebosch, Paul D Gobardhan, Laura Graven, Jan Willem B de Groot, Cecile Grootscholten, Jeroen Hagendoorn, Paul Harmsen, Marjolein Y V Homs, Elizabeth G Klompenhouwer, Niels F M Kok, Marnix G E H Lam, Olaf J L Loosveld, Mark A J Meier, J Sven D Mieog, Ad H J Oostdijk, Loubna Outmani, Gijs A Patijn, Stefan Pool, Daphne D D Rietbergen, Jeanine M L Roodhart, Frank M Speetjens, Rutger Jan Swijnenburg, Michelle W J Versleijen, Cornelis Verhoef, Koert F D Kuhlmann, Adriaan Moelker, Bas Groot Koerkamp
INTRODUCTION: This study investigates the incidence of extrahepatic perfusion and incomplete hepatic perfusion at intraoperative methylene blue testing and on postoperative nuclear imaging in patients undergoing hepatic arterial infusion pump (HAIP) chemotherapy. METHODS: The first 150 consecutive patients who underwent pump implantation in the Netherlands were included. All patients underwent surgical pump implantation with the catheter in the gastroduodenal artery...
March 20, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
#15
JOURNAL ARTICLE
Muhammad Umer Riaz Gondal, John Lemoine, Jared Segal, Zainab Kiyani, Muhammad Ibraiz Bilal, Fawwad Ansari, Brian McCauley
INTRODUCTION: Combination-based adjuvant chemotherapy utilising capecitabine and oxaliplatin is widely used in gastric cancer treatment. Rare but severe cardiac events such as prolonged QT, cardiac arrest and cardiogenic shock can result from their use. CASE DESCRIPTION: A 45-year-old female with gastric adenocarcinoma was started on capecitabine-oxaliplatin chemotherapy one week before presenting to the emergency department with weakness. Blood pressure was 78/56 mmHg, heart rate 140 bpm and oxygen saturation 85%...
2024: European Journal of Case Reports in Internal Medicine
#16
JOURNAL ARTICLE
Baogen Zhang, Biqing Huang, Fan Yang, Jiandong Yang, Man Kong, Jing Wang, Yaoxian Xiang, Kangjie Wang, Ruchen Peng, Kun Yang, Chao An, Dong Yan
OBJECTIVE: To compare the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) with transarterial chemoembolization (TACE) for the treatment of high-risk hepatocellular carcinoma (hHCC) patients. METHODS: Between January 2014 and August 2022, a total of 1765 consecutive patients with hHCC who underwent initial intra-arterial therapies were reviewed and divided into a TACE group (n, 507) and a HAIC group (n, 426). The study used propensity score matching (PSM) to reduce selectivity bias...
2024: Journal of Hepatocellular Carcinoma
#17
REVIEW
M Kodetová, K Švojgr, J Širc, J Vaněček, P Pochop
Retinoblastoma is the most common primary malignant intraocular tumor in children. Seeding, specifically the dispersion of the tumor into the adjacent compartments, represents a major parameter determining the degree of retinoblastoma according to the International Classification of Retinoblastoma. In this article we focused on vitreous seeding, one of the main limiting factors in the successful "eye preservation treatment" of retinoblastoma. This article presents an overview of the history of vitreous seeding of retinoblastoma, established treatment procedures and new-research modalities...
2024: Ceská a Slovenská Oftalmologie
#18
JOURNAL ARTICLE
Diamantis I Tsilimigras, Yutaka Endo, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W Bauer, Irinel Popescu, George A Poultsides, Shishir K Maithel, Hugo P Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, François Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M Pawlik
INTRODUCTION: Although up to 50-70% of patients with intrahepatic cholangiocarcinoma (ICC) recur following resection, data to predict post-recurrence survival (PRS) and guide treatment of recurrence are limited. METHODS: Patients who underwent resection of ICC between 2000 and 2020 were identified from an international, multi-institutional database. Data on primary disease as well as laboratory and radiologic data on recurrent disease were collected. Factors associated with PRS were examined and a novel scoring system to predict PRS (PRS score) was developed and internally validated...
March 23, 2024: Annals of Surgical Oncology
#19
REVIEW
Peter Kolyvas, Aazrin Mir, Thomas Stirrat, Brittany Brookner, Nathanael Pilar, Eric Monroe, Rakesh Ahuja
Retinoblastoma is the most common eye malignancy in children that if left untreated can invade intraocular structures, metastasize, and rarely lead to death. Traditionally treated with systemic chemotherapy, Intra-arterial chemotherapy is gaining popularity as it allows for the direct administration of chemotherapy through the ophthalmic artery, thus reducing systemic side effects. Intra-arterial chemotherapy procedures have evolved, with refinements to reduce risks and radiation exposure. Intra-arterial chemotherapy boasts an impressive technical success rate and one year ocular survival even amongst advanced cases...
April 2024: Cardiovascular and Interventional Radiology
#20
JOURNAL ARTICLE
Khashayar Farsad, Paula M Novelli, Christopher Laing, Ripal T Gandhi, Jacob Cynamon, Claudia S López, Erin S Stempinski, Robert Strasser, Ramtin Agah
Treatment of hypovascular tumors, such as pancreatic adenocarcinoma, is challenging due to inefficient drug delivery. This report examines the potential mechanism of localized drug delivery via trans-arterial micro perfusion (TAMP) using a proprietary adjustable double-balloon occlusion catheter in a porcine model. Adult Yorkshire swine (N=21) were used in IACUC-approved protocols. The RC-120 catheter was positioned into visceral, femoral, and pulmonary arteries with infusion of methylene blue dye, gemcitabine, or gold nanoparticles...
March 18, 2024: Journal of Vascular and Interventional Radiology: JVIR
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