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intra-arterial chemotherapy

Amy Gerrish, Edward Stone, Samuel Clokie, John R Ainsworth, Helen Jenkinson, Maureen McCalla, Carol Hitchcott, Isabel Colmenero, Stephanie Allen, Manoj Parulekar, Trevor Cole
Retinoblastoma is the most common eye malignancy in childhood caused by mutations in the RB1 gene. Both alleles of the RB1 gene must be mutated for tumour development. The initial RB1 mutation may be constitutional germline or somatic (originating in one retinal cell only). Distinguishing between these alternative mechanisms is crucial, with wider implications for management of the patient and family members. Bilateral retinoblastoma is nearly always due to a constitutional mutation; however, approximately 15% of unilateral cases also carry a germline mutation, and identifying these cases is important...
February 11, 2019: British Journal of Ophthalmology
Duangnate Rojanaporn, Ekachat Chanthanaphak, Rawi Boonyaopas, Tharikarn Sujirakul, Suradej Hongeng, Sirintara Singhara Na Ayudhaya
PURPOSE: To study the safety and efficacy of intra-arterial chemotherapy (IAC) as a treatment for intraocular retinoblastoma in Thailand. DESIGN: Retrospective, interventional case series. METHODS: In this study, IAC was performed as primary or secondary treatment for patients with intraocular retinoblastoma using melphalan with or without additional topotecan or carboplatin. Survival rate, globe salvage rate, and treatment complications were recorded and analyzed...
February 4, 2019: Asia-Pacific Journal of Ophthalmology
Ka Wing Ma, Tan To Cheung, Brian Leung, Brian Wong Hoi She, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Chung Mau Lo
OBJECTIVE: To define the role of adjuvant chemotherapy in the management of resectable intrahepatic cholangiocarcinoma (ICC) by performing a meta-analysis. SUMMARY BACKGROUND DATA: Oncological benefit of adjuvant chemotherapy in resectable ICC remains controversial, high-level evidence in such context is lacking. METHOD: A comprehensive search using Pubmed, EMbase, and Web of Science was performed from inception to October 2018. Studies compared the survival of patients receiving adjuvant chemotherapy versus surgery alone were included...
February 2019: Medicine (Baltimore)
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
OBJECTIVE: We report a balloon-occluded arterial infusion therapy with an original four-lumen double-balloon catheter (4L-DB) which allows for the efficient injection of an anticancer agent at a high concentration to the target spot for patients with locally advanced uterine cervical cancer. METHODS: One hundred and forty-three patients with locally advanced cervical cancer treated with neoadjuvant intra-arterial chemotherapy (NAIAC) or a primary radical hysterectomy (PRH) were retrospectively assessed...
December 28, 2018: Oncotarget
Yuichiro Hayashi, Kohei Osawa, Rina Nakakaji, Shuhei Minamiyama, Nobuhide Ohashi, Takashi Ohya, Masaki Iida, Toshinori Iwai, Tomomichi Ozawa, Senri Oguri, Toshiyuki Koizumi, Makoto Hirota, Mitomu Kioi, Masaharu Hata, Kenji Mitsudo
BACKGROUND: The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra-arterial infusion chemotherapy concurrent with radiotherapy. METHODS: A total of 46 patients were reviewed retrospectively in this study. The treatment schedule comprised intra-arterial chemotherapy (total, 60 mg/m2 docetaxel and 150 mg/m2 cisplatin) and three-dimensional computed tomography based, daily conventional radiotherapy (total, 60 Gy/30 fr) for 6 weeks...
January 29, 2019: Head & Neck
Girolamo Ranieri, Mariarita Laforgia, Patrizia Nardulli, Simona Ferraiuolo, Pasquale Molinari, Ilaria Marech, Cosmo Damiano Gadaleta
Liver metastases (LM) are often consequences of colo-rectal cancer (CRC)and the majority of patients have unresectable LM. Oxaliplatin-based intravenous chemotherapy represents the gold standard treatment for CRC. Intravenous oxaliplatin has several side effects i.e., nephrologic, hematologic and neurological toxicity. Moreover, hepatic arterial infusion (HAI) of antitumor drugs deeply modifies the treatment of LMCRC due to the knowledge that LM are perfused by the hepatic artery network, whereas healthy tissue is perfused by the portal vein...
January 24, 2019: Cancers
Esmihan Almontaser, Carmel Ritchie, John Madison, Pascal Jabbour
Retinoblastoma (RB) is a rare cancer of the eye, most commonly seen in children. Intra-arterial chemotherapy for RB is a relatively new treatment modality that has gained increasing popularity worldwide. The principal underlying the intra-arterial approach is delivery of chemotherapeutic agents directly to the site of the tumor. This avoids system toxicities normally associated with higher dose of these drugs. The purpose of this continuing education article was to review the features of RB and its treatment, with a focus on the perioperative management of children undergoing intra-arterial chemotherapy at our institution...
January 16, 2019: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Elena Stenzel, Sophia Göricke, Petra Temming, Eva Biewald, Stefan Zülow, Juliane Göbel, Isabel Wanke, Lale Umutlu, Christoph Kleinschnitz, Norbert Bornfeld, Michael Forsting, Alexander Radbruch, Christoph Mönninghoff
PURPOSE: In the last 10 years, intra-arterial chemotherapy (IAC) has been increasingly used in the clinical management of retinoblastoma. It is reported to provide tumor control even in advanced stage disease that might have previously required enucleation. In our clinical experience, there are three conditions that may impair the use of IAC: (1) significant collaterals to meningeal arteries, (2) technical failure of ophthalmic artery catheterization, or (3) retina blood supply from collaterals different to the ophthalmic artery...
January 14, 2019: Neuroradiology
Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D'Angelo, Elisa Tirtei, Fraia Melchionda, Simona Vetrella, Francesco De Leonardis, Carmelita D'Ippolito, Annalisa Tondo, Antonella Nonnis, Giovanni Erminio, Anna Rita Gigliotti, Katia Mazzocco, Riccardo Haupt
BACKGROUND: Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome. METHODS: Of 3355 subjects aged 0-18 years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8...
January 11, 2019: Italian Journal of Pediatrics
Sarah Walcott-Sapp, Scott Naugler, Jeong Youn Lim, Jesse Wagner, Susan L Orloff, Khashayar Farsad, Kenneth J Kolbeck, John Kaufman, Erin Maynard, C Kristian Enestvedt, Skye C Mayo, Kevin G Billingsley
Background: Hepatocellular carcinoma (HCC) with portal vein invasion (PVI) has a poor prognosis with limited treatment options. Intra-arterial brachytherapy (IAB) and transarterial chemoembolization (TACE) yield local control but risk accelerating liver dysfunction. The outcomes, survival, and safety of selective liver-directed treatment are reported. Methods: Thirty-seven consecutive patients with HCC and PVI treated between 2009 and 2015 were reviewed from a prospectively collected database...
December 2018: Journal of Gastrointestinal Oncology
Hiroshi Doi, Masayuki Fujiwara, Kazuhiro Kitajima, Masao Tanooka, Tomonori Terada, Kazuma Noguchi, Reiichi Ishikura, Norihiko Kamikonya, Koichiro Yamakado
Concomitant intra-arterial infusion chemoradiotherapy (IA-CRT) has been used to treat locally advanced maxillary sinus squamous cell carcinoma (MSSCC) with positive outcomes. However, an optimal predictive prognostic factor for MSSCC treated with IA-CRT remains elusive. The aim of the present study was to assess the feasibility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), including volumetric parameters, to predict the prognosis of MSSCC treated with IA-CRT. Twenty-four patients with newly diagnosed MSSCC receiving FDG-PET imaging before IA-CRT treatment were analyzed in this retrospective study...
November 2018: Nagoya Journal of Medical Science
Natasa Mihailovic, Sandra Elges, Barbara Glitz, Ralph-Laurent Merté, Maged Alnawaiseh, Boris Buerke, Thomas Allkemper, Nicole Eter, Ulrike H Grenzebach
Adenoid cystic carcinoma of the lacrimal gland (ACC) is a rare malignant orbital tumour with a poor overall prognosis. Current therapeutic approaches like radical and local surgery, adjuvant radiation and neoadjuvant intra-arterial chemotherapy are controversial. We present three cases of patients with ACC with different therapy concepts and discuss these with current recommendations from the literature.
December 19, 2018: Klinische Monatsblätter Für Augenheilkunde
Bin Huang, Hua Wang, Hao Lin, Zhijun Yao, Jiabo Zheng, Wenzhe Fan, Shaopeng Qiu, Lingwu Chen, Junxing Chen
OBJECTIVE: Comparing intra-arterial chemotherapy combined with intravesical chemotherapy against intravesical chemotherapy alone in the treatment of T1-staged Grade 3 (T1G3) bladder cancer after transurethral resection of bladder tumor (TURBT). MATERIALS AND METHODS: From January 2007 to December 2012, 203 patients diagnosed with NMIBC were randomly assigned into either intra-arterial chemotherapy combined with intravesical chemotherapy group (Group A, n = 68) or intravesical chemotherapy alone group (Group B, n = 135) after TURBT...
December 11, 2018: Journal of Cancer Research and Clinical Oncology
Bruno Bartolini, Francesco Puccinelli, Steven D Hajdu, Christina Stathopoulos, Maja Beck-Popovic, Francis L Munier, Guillaume Saliou
We report the intentional occlusion of the middle meningeal artery arising from the lacrimal artery, a novel technique to improve drug delivery in a 14-month-old boy with a history of right sporadic unilateral cavitary retinoblastoma group D. The patient was referred to our institution for intra-arterial chemotherapy after two systemic chemotherapy treatments. The digital subtraction angiography showed a large middle meningeal artery arising from the right lacrimal artery and decrease choroidal enhancement thus decreased flow to the tumor...
November 28, 2018: Interventional Neuroradiology
Kaname Sakuma, Toshiyuki Koizumi, Kenji Mitsudo, Jun Ueda, Yuichiro Hayashi, Toshinori Iwai, Makoto Hirota, Mitomu Kioi, Haruka Yoshii, Hisashi Kaizu, Masaharu Hata, Akira Tanaka, Iwai Tohnai
We herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2 ), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases...
February 5, 2018: Oral Radiology
Yasushi Fukuoka, Toshihiro Tanaka, Hideyuki Nishiofuku, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Hiroshi Sakaguchi, Kimihiko Kichikawa
PURPOSE: To develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer. MATERIALS AND METHODS: The design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port...
November 2, 2018: Cardiovascular and Interventional Radiology
Karl R Aigner, Emir Selak, Kornelia Aigner
PURPOSE: Head and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The evaluation of a technique for short-term intra-arterial infusion chemotherapy is described herein. METHODS: In a retrospective study, we reviewed the medical records of 97 patients with head and neck cancers who received short-term intra-arterial infusion chemotherapy (62 patients previously untreated, 35 patients with prior radiotherapy)...
October 31, 2018: Journal of Cancer Research and Clinical Oncology
Masanari Umemura, Md Rafikul Islam, Hidenobu Fukumura, Itaru Sato, Yusuke Kawabata, Kousuke Matsuo, Rina Nakakaji, Akane Nagasako, Makoto Ohtake, Takayuki Fujita, Utako Yokoyama, Tomohiro Nakayama, Haruki Eguchi, Yoshihiro Ishikawa
We previously identified a novel nanomagnetic particle, N,N'-bis(salicylidene)ethylenediamineiron [Fe(Salen)]. Fe(Salen) exhibits not only anti-tumor effects but also magnetic properties. We found that Fe(Salen) can be used for magnet-guided drug delivery and visualization of accumulated drug by magnetic resonance imaging (MRI) because of its magnetism. In addition, Fe(Salen) can generate heat by itself when exposed to an alternating current magnetic field (AMF), resulting in a hyperthermia effect. Here, we partly elucidated the anti-tumor mechanism of Fe(Salen) and performed an intravenous repeated dose toxicity study to decide the therapeutic amount...
October 29, 2018: Cancer Science
Christina Eder-Czembirek, Sascha Rechinger, Gabriela Kornek, Edgar Selzer, Rudolf Seemann
OBJECTIVES: This retrospective study performed a comprehensive analysis of the usage of intra-arterial chemotherapy (iaCh) for locally recurrent UICC stage IV oral squamous cell carcinoma (OSCC) over two decades at the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Vienna to assess the utility of its future use. METHODS: Between 1994 and 2014, iaCh was indicated in 48 OSCC cases. In these, the two most frequent iaCh schemes, cisplatin/5-fluorouracil (Cis/5-FU) and methotrexate/bleomycin (MTX/Bleo), were chosen for further analysis...
October 18, 2018: Clinics
Yuichiro Hayashi, Shuhei Minamiyama, Takashi Ohya, Masaki Iida, Toshinori Iwai, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Masaharu Hata, Masataka Taguri, Kenji Mitsudo
Background and objectives: The aim of present study was to compare the treatment results of daily cisplatin (CDDP), weekly docetaxel (DOC) intra-arterial infusion chemotherapy combined with radiotherapy (DIACRT) regimen and weekly CDDP intra-arterial infusion chemotherapy combined with radiotherapy (WIACRT) for patients with tongue cancer. Materials and Methods: Between January 2007 and December 2016, a total of 11 patients treated with WIACRT and 45 patients treated with DIACRT were enrolled in the present study...
July 30, 2018: Medicina
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