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https://read.qxmd.com/read/30770573/pulmonary-arterial-hypertension-in-adults-with-systemic-right-ventricles-referred-for-cardiac-transplantation
#1
Yuli Y Kim, Katherine Awh, Michael Acker, Pavan Atluri, Christian Bermudez, Maria Crespo, Joshua M Diamond, David Drajpuch, Rhondalyn Forde-Mclean, Stephanie Fuller, Lee Goldberg, Jeremy Mazurek, Christopher Mascio, Jonathan N Menachem, Eduardo Rame, Emily Ruckdeschel, Lynda Tobin, Joyce Wald
BACKGROUND: Systemic right ventricular [RV] failure may progress necessitating referral for orthotropic heart transplantation [OHT]. Pulmonary hypertension [PH] frequently coexists in adult congenital heart disease and can complicate the assessment for OHT. METHODS: Single-center case series of six patients [median age 34.9 years (IQR, 31.9-42.4)] with systemic RV physiology with PH referred for OHT evaluation from 2008-2017. RESULTS: One-third (n=6) of 18 patients with systemic RV physiology referred for OHT evaluation had pulmonary arterial hypertension [PAH] defined as mean pulmonary artery pressure [mPAP] > 25 mmHg and pulmonary vascular resistance [PVR] > 3 Wood Units...
February 15, 2019: Clinical Transplantation
https://read.qxmd.com/read/30767482/-establishment-and-one-year-evaluation-of-an-internal-medicine-consultation-in-a-maternity
#2
Marie-Anne Bouldouyre, Hélène Dauphin, Nathalie Cherradou, Hélène Gros
OBJECTIVE: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year. METHODS: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b...
September 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://read.qxmd.com/read/30766754/prognostic-factors-of-refractory-nsclc-patients-receiving-anlotinib-hydrochloride-as-the-third-or-further-line-treatment
#3
Jing Wang, Yizhuo Zhao, Qiming Wang, Li Zhang, Jianhua Shi, Zhehai Wang, Ying Cheng, Jianxing He, Yuankai Shi, Hao Yu, Yang Zhao, Weiqiang Chen, Yi Luo, Xiuwen Wang, Kejun Nan, Faguang Jin, Jian Dong, Baolan Li, Zhujun Liu, Baohui Han, Kai Li
Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy...
November 2018: Cancer Biology & Medicine
https://read.qxmd.com/read/30766431/identifying-treatment-related-problems-and-associated-factors-among-hospitalized-post-stroke-patients-through-medication-management-review-a-multi-center-study
#4
Iman A Basheti, Shahnaz Mohammed Ayasrah, Muayyad Ahmad
Background: Stroke is a major cause of disability and one of the leading causes of death among the elderly. Treatment related problems can lead to undesirable consequences. The Medication Management Review (MMR) service is aimed at identifying, resolving and preventing TRPs, subsiding the undesirable outcomes associated with TRPs. Objectives: To explore the types, frequencies and severity of TRPs amongst post-stroke patients recruited through hospitals via conducting the MMR service by clinical pharmacists in Jordan...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30763511/cardiovascular-phenotype-of-elevated-blood-pressure-differs-markedly-between-young-males-and-females-the-enigma-study
#5
Chiara Nardin, Kaisa M. Maki-Petaja, Karen L. Miles, Yasmin, Barry J. McDonnell, John R. Cockcroft, Ian B. Wilkinson, Carmel M. McEniery
Blood pressure (BP) in young adults predicts BP in later life. We aimed to identify metabolic, hemodynamic, and autonomic characteristics associated with raised BP in young adults and whether these differ between males and females. Three thousand one hundred forty-five healthy subjects, aged 18 to 40 years, were grouped according to sex and BP category following the recent reclassification of BP as part of American Heart Association/American College of Cardiology 2017 guidelines. All individuals undertook a lifestyle and medical history questionnaire and detailed metabolic, hemodynamic, and autonomic assessments...
December 2018: Hypertension
https://read.qxmd.com/read/30762831/effect-of-home-medication-titration-on-blood-pressure-control-in-patients-with-hypertension-a-meta-analysis-of-randomized-controlled-trials
#6
Ting-Yu Chen, Chi-Wen Kao, Shu-Meng Cheng, Yue-Cune Chang
BACKGROUND: Medication titration has been used in home blood pressure (BP) control, with the expectation of enabling patients with hypertension to better manage their BP. OBJECTIVE: The study goal was to estimate the effects of medication titration intervention in lowering the systolic blood pressure and diastolic blood pressure of patients with hypertension. METHODS: The meta-analysis included randomized controlled trials on adults diagnosed with hypertension and BP≧130/80 mm Hg, having a medication-titration intervention, and using a home BP measurement...
March 2019: Medical Care
https://read.qxmd.com/read/30760426/shortening-hospital-stay-is-feasible-and-safe-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-treated-with-balloon-pulmonary-angioplasty
#7
Mai Kimura, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Hidenori Moriyama, Sarasa Isobe, Toshimitsu Tsugu, Yuji Itabashi, Mitsushige Murata, Shinsuke Yuasa, Keiichi Fukuda
BACKGROUND: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications. METHODS: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66...
February 2019: Canadian Journal of Cardiology
https://read.qxmd.com/read/30758485/assessment-of-anastomotic-biliary-complications-in-adult-patients-undergoing-high-acuity-liver-transplant
#8
Fady M Kaldas, Islam M Korayem, Tara A Russell, Vatche G Agopian, Antony Aziz, Joseph DiNorcia, Douglas G Farmer, Hasan Yersiz, Jonathan R Hiatt, Ronald W Busuttil
Importance: Anastomotic biliary complications (ABCs) constitute the most common technical complications in liver transplant (LT). Given the ever-increasing acuity of LT, identification of factors contributing to ABCs is essential to minimize morbidity and optimize outcomes. A detailed analysis in a patient population undergoing high-acuity LT is lacking. Objective: To evaluate the rate of, risk factors for, and outcomes of ABCs and acuity level in LT recipients...
February 13, 2019: JAMA Surgery
https://read.qxmd.com/read/30756435/the-incidence-prevalence-and-clinical-features-of-mecp2-duplication-syndrome-in-australian-children
#9
Peter Giudice-Nairn, Jenny Downs, Kingsley Wong, Dylan Wilson, Daniel Ta, Michael Gattas, David Amor, Elizabeth Thompson, Cathy Kirrali-Borri, Carolyn Ellaway, Helen Leonard
AIM: The aim of this study was to assess the incidence and prevalence of MECP2 duplication syndrome in Australian children and further define its phenotype. METHODS: The Australian Paediatric Surveillance Unit was used to identify children with MECP2 duplication syndrome between June 2014 and November 2017. Reporting clinicians were invited to complete a questionnaire. Clinician data (n = 20) were supplemented with information from the International Rett Syndrome Phenotype Database and from caregivers (n = 7)...
February 12, 2019: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/30756370/effects-of-nutritional-nursing-intervention-based-on-glycemic-load-for-patient-with-gestational-diabetes-mellitus
#10
Shaofang Lv, Shanlan Yu, Rongxiang Chi, Dongmei Wang
OBJECTIVES: To determine the effects of nutritional nursing intervention based on glycemic load (GL) for patients with gestational diabetes mellitus. MATERIAL AND METHODS: One hundred thirty-four patients diagnosed with gestational diabetes mellitus at our hospital were selected from March 2015 to March 2017 and randomly divided into the observation (n = 67) and control groups (n = 67). All of the patients in the observation and control groups received conventional nutritional nursing...
2019: Ginekologia Polska
https://read.qxmd.com/read/30755578/transcatheter-aortic-valve-implantation-tavi-first-case-in-bangladesh
#11
S Nahar, A M Momenuzzaman, J Kabir, F Begum, K N Khan, M I Ahmed, T Ahmad, S S Shakil
We came across an 81 years old male with symptomatic severe aortic stenosis. He was hypertensive and had history of CABG 9 years back. Due to his advanced age and co morbidities, he was at high surgical risk. He underwent transcatheter aortic valve implantation in our centre (United Hospital Ltd) in July 2017 and no complications occurred during or in the peri-procedural period. He had good functional and haemodynamic results at 3 months follow-up.
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30755546/prevalence-and-predictors-of-depression-among-patients-with-type-2-diabetes-a-multicenter-cross-sectional-study-from-bangladesh
#12
A B Kamrul-Hasan, M Palash-Molla, M Mainul-Ahsan, A J Gaffar, M Asaduzzaman, M Saifuddin, M S Rahman, F Akter, H Rahman, S K Talukder, M Islam, P K Chanda, N I Siddiqui, S Selim
Depression is a common comorbidity of type 2 diabetes mellitus (T2DM) which adversely affects diabetes management and outcome. Identifying and treating comorbid depression may improve diabetes care. This cross-sectional study was conducted in several tertiary hospitals throughout Bangladesh from July 2017 to April 2018. Nine hundred (900) adult patients with T2DM aging ≥25 years having diabetes for at least 6 months and equal numbers of non-diabetic otherwise healthy controls were recruited from the outpatient departments of these centers...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30755026/sex-related-differences-in-patients-undergoing-thoracic-aortic-surgery-evidence-from-the-canadian-thoracic-aortic-collaborative
#13
Jennifer Chung, Louis-Mathieu Stevens, Maral Ouzounian, Ismail El-Hamamsy, Ismail Bouhout, François Dagenais, Andréanne Cartier, Mark Peterson, Munir Boodhwani, Ming Hao Guo, John Bozinovski, Michael H Yamashita, Carly Lodewyks, Rony Atoui, Bindu Bittira, Darrin Payne, Christopher Tarola, Michael W A Chu
BACKGROUND: Contemporary outcomes following surgical management of thoracic aortic disease have improved; however, the impact of sex-related differences is poorly understood. METHODS: A total of 1653 patients (498 (30.1%) female) underwent thoracic aortic surgery with hypothermic circulatory arrest between 2002 and 2017 in ten institutions of the Canadian Thoracic Aortic Collaborative. Outcomes of interest were in-hospital death, stroke and a modified Society of Thoracic Surgeons-defined composite (STS-COMP) for mortality or major morbidity (stroke, renal failure, deep sternal wound infection, reoperation, prolonged ventilation)...
February 13, 2019: Circulation
https://read.qxmd.com/read/30753683/use-of-combined-hormonal-contraceptives-among-women-with-systemic-lupus-erythematosus-with-and-without-medical-contraindications-to-oestrogen
#14
Arielle Mendel, Sasha Bernatsky, Christian A Pineau, Yvan St-Pierre, John G Hanly, Murray B Urowitz, Ann E Clarke, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Daniel J Wallace, Joan T Merrill, Jill Buyon, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Michelle Petri, Mary Anne Dooley, Paul Fortin, Dafna D Gladman, Kristján Steinsson, Rosalind Ramsey-Goldman, Munther A Khamashta, Cynthia Aranow, Meggan Mackay, Graciela Alarcón, Susan Manzi, Ola Nived, Andreas Jönsen, Asad A Zoma, Ronald F van Vollenhoven, Manuel Ramos-Casals, Giuillermo Ruiz-Irastorza, Sam Lim, Kenneth C Kalunian, Murat Inanc, Diane L Kamen, Christine A Peschken, Søren Jacobsen, Anca Askanase, Jorge Sanchez-Guerrero, Ian N Bruce, Nathalie Costedoat-Chalumeau, Evelyne Vinet
Objectives: To assess the prevalence of combined hormonal contraceptives (CHCs) in reproductive-age women with SLE with and without possible contraindications and to determine factors associated with their use in the presence of possible contraindications. Methods: This observational cohort study included premenopausal women ages 18-45 years enrolled in the SLICC Registry ⩽15 months after SLE onset, with annual assessments spanning 2000-2017. World Health Organization Category 3 or 4 contraindications to CHCs (e...
February 8, 2019: Rheumatology
https://read.qxmd.com/read/30745150/twin-pregnancy-outcomes-after-metabolic-and-bariatric-surgery
#15
Amihai Rottenstreich, Gabriel Levin, Misgav Rottenstreich, Yossef Ezra, Ram Elazary, Uriel Elchalal
BACKGROUND: The effect of bariatric surgery (BS) on twin pregnancy outcomes is unclear. OBJECTIVES: We examined associations of BS with maternal and perinatal outcomes among women with twin gestation. SETTING: A university hospital. METHODS: A retrospective case-control study of twin deliveries during 2006 through 2017. The study group comprised all women with twin pregnancy who had undergone BS and delivered during the study period...
January 25, 2019: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://read.qxmd.com/read/30743321/diastolic-dysfunction-and-acute-kidney-injury-in-elderly-patients-with-femoral-neck-fracture
#16
Woori Cho, Tae Yeon Hwang, Yoon Kyung Choi, Ji Hyun Yang, Myung-Gyu Kim, Sang-Kyung Jo, Won Yong Cho, Se Won Oh
Background: Femoral neck fracture is common in the elderly population. Acute kidney injury (AKI) is an important risk factor for mortality in patients who have had such fracture. We evaluated the incidence of AKI in patients who had femoral neck fracture and identified risk factors for AKI and mortality. Methods: This was an observational cohort study including 285 patients who were ≥ 65 years of age and who underwent femoral neck fracture surgery between 2013 and 2017...
February 11, 2019: Kidney Research and Clinical Practice
https://read.qxmd.com/read/30742582/heart-failure-guidelines-what-you-need-to-know-about-the-2017-focused-update
#17
REVIEW
Lee Rodney Haselhuhn, Daniel J Brotman, Ilan Shor Wittstein
The 2017 focused update of the 2013 ACC/AHA guideline on heart failure contains new and important recommendations on prevention, novel biomarker uses, heart failure with preserved ejection fraction (HFpEF), and comorbidities such as hypertension, iron deficiency, and sleep-disordered breathing. Potential implications for management of acute decompensated heart failure will also be explored.
February 2019: Cleveland Clinic Journal of Medicine
https://read.qxmd.com/read/30741822/age-related-comorbidities-and-mortality-in-people-living-with-hiv-in-rural-tanzania-data-from-a-prospective-cohort-study
#18
Sascha Albrecht, Fabian C Franzeck, Herry Mapesi, Christoph Hatz, Aneth V Kalinjuma, Tracy R Glass, Dorcas Mnzava, Emili Letang, Daniel H Paris, Manuel Battegay, Maja Weisser
OBJECTIVE: Causes of morbidity and mortality of people living with HIV are changing with access to antiretroviral therapy and increased life expectancy. Age-related data on comorbidities and their impact on mortality in sub-Saharan Africa are scarce. DESIGN: This prospective analysis evaluated comorbidities, assessed by means of International Classification of Diseases and Related Health problems 10th revision codes and clinical variables, derived from data collected from the Kilombero & Ulanga antiretroviral cohort of people living with HIV in rural Tanzania...
February 7, 2019: AIDS
https://read.qxmd.com/read/30741067/endovascular-therapy-for-erectile-dysfunction-who-benefits-most-insights-from-a-single-center-experience
#19
Nicolas Diehm, Stefanie Marggi, Yasushi Ueki, Dagmar Schumacher, Hak Hong Keo, Christian Regli, Dai Do Do, Tilmann Moeltgen, Philipp Grimsehl, Stephen Wyler, Heinz Schoenhofen, Lorenz Räber, Martin Schumacher
PURPOSE: To report the 1-year outcomes of a single-center, all-comers registry aimed to assess effectiveness and safety of endovascular revascularization for atherosclerotic erectile dysfunction (ED) in an unselected patient cohort. MATERIALS AND METHODS: Between April 2016 and October 2017, 50 consecutive patients (mean age 59.6±10.3 years) underwent endovascular revascularization for ED owing to >50% stenosis in 82 erection-related arteries. Patients were treated by means of standard balloon angioplasty (16%), drug-coated balloon angioplasty (27%), or drug-eluting stent (55%) implantation...
February 11, 2019: Journal of Endovascular Therapy
https://read.qxmd.com/read/30738780/addition-of-radium-223-to-abiraterone-acetate-and-prednisone-or-prednisolone-in-patients-with-castration-resistant-prostate-cancer-and-bone-metastases-era-223-a-randomised-double-blind-placebo-controlled-phase-3-trial
#20
Matthew Smith, Chris Parker, Fred Saad, Kurt Miller, Bertrand Tombal, Quan Sing Ng, Martin Boegemann, Vsevolod Matveev, Josep Maria Piulats, Luis Eduardo Zucca, Oleg Karyakin, Go Kimura, Nobuaki Matsubara, William Carlos Nahas, Franco Nolè, Eli Rosenbaum, Axel Heidenreich, Yoshiyuki Kakehi, Amily Zhang, Heiko Krissel, Michael Teufel, Junwu Shen, Volker Wagner, Celestia Higano
BACKGROUND: Abiraterone acetate plus prednisone or prednisolone improves progression-free survival and overall survival in patients with metastatic castration-resistant prostate cancer. Radium-223 improves overall survival and delays the onset of symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases. We assessed concurrent treatment with abiraterone acetate plus prednisone or prednisolone and radium-223 in such patients. METHODS: We did a randomised, double-blind, placebo-controlled, phase 3 trial at 165 oncology and urology centres in 19 countries...
February 6, 2019: Lancet Oncology
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