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JOURNAL ARTICLE
Stacey E Rudd, Asif Noor, Katherine A Morgan, Paul S Donnelly
ConspectusMolecular imaging with antibodies radiolabeled with positron-emitting radionuclides combines the affinity and selectivity of antibodies with the sensitivity of Positron Emission Tomography (PET). PET imaging allows the visualization and quantification of the biodistribution of the injected radiolabeled antibody, which can be used to characterize specific biological interactions in individual patients. This characterization can provide information about the engagement of the antibody with a molecular target such as receptors present in elevated levels in tumors as well as providing insight into the distribution and clearance of the antibody...
April 26, 2024: Accounts of Chemical Research
#42
JOURNAL ARTICLE
Jingsong Lu, Yupei Wang, Xiaohan Gao, Ying Li, Neema Ufurahi-Pambe, Abdul Fahad, Zeping Jin, Zhijun He, Zhenhu Guo, Wensheng Xie, Shi Wang, Xiaodan Sun, Xiumei Wang, Jing Yu, Shenglei Che, Guifeng Zhang, Yen Wei, Lingyun Zhao
Enlightened by the great success of the drug repurposing strategy in the pharmaceutical industry, in the current study, material repurposing is proposed where the performance of carbonyl iron powder (CIP), a nutritional intervention agent of iron supplement approved by the US FDA for iron deficiency anemia in clinic, was explored in anti-cancer treatment. Besides the abnormal iron metabolic characteristics of tumors, serving as potential targets for CIP-based cancer therapy under the repurposing paradigm, the efficacy of CIP as a catalyst in the Fenton reaction, activator for dihydroartemisinin (DHA), thus increasing the chemo-sensitivity of tumors, as well as a potent agent for NIR-II photothermal therapy (PTT) was fully evaluated in an injectable alginate hydrogel form...
April 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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JOURNAL ARTICLE
Ciara Carroll, Mary Meehan, Roisin Connolly, Jayne Prendergast, Colette Magnone, Aine Meehan, Chantal Migone, Keith Ian Quintyne, Caroline Carpenter, Helen Byrne, Robert Cunney, Paul Mullane
An out-of-season increase in cases of invasive Group A streptococcus (iGAS) was observed in Ireland between October 2022 and August 2023. We describe the management of an iGAS outbreak involving three nursing home residents in Ireland in early 2023. A regional Department of Public Health was notified of an iGAS case in a nursing home resident in January 2023. When two further cases among residents were notified 7 days later, an outbreak was declared. Surveillance for GAS/iGAS infection in residents and staff was undertaken...
April 2024: Euro Surveillance
#44
JOURNAL ARTICLE
Zhenxiang Zheng, Ya Zeng, Kunjia Lai, Bin Liao, Pengfei Li, Chris Soon Heng Tan
The three-dimensional structure and the molecular interaction of proteins determine their roles in many cellular processes. Chemical protein painting with protein mass spectrometry can identify changes in structural conformations and molecular interactions of proteins including their binding sites. Nevertheless, most current protein painting techniques identify protein targets and binding sites of drugs in vitro using a cell lysate or purified protein. Here, we tested 11 membrane-permeable lysine-reactive chemical probes for intracellular covalent labeling of endogenous proteins, which reveals ortho -phthalaldehyde (OPA) as the most reactive probe in the intracellular environment...
April 24, 2024: Chemical Science
#45
JOURNAL ARTICLE
Samuel J Goodchild, Christopher A Ahern
Rapid and effectual inactivation in voltage-gated sodium channels is required for canonical action-potential firing. This "fast" inactivation arises from swift and reversible protein conformational changes that utilize transmembrane segments and the cytoplasmic linker between channel domains III and IV. Until recently, fast inactivation had been accepted to rely on a "ball and chain" mechanism whereby a hydrophobic triplet of DIII-IV amino acids (IFM) impairs conductance by binding to a site in central pore of the channel made available by channel opening...
April 24, 2024: Biophysical Journal
#46
JOURNAL ARTICLE
Yingchi Zhang, Tao Xu, Jie Xie, Hua Wu, Weihua Hu, Xuefeng Yuan
BACKGROUND: The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mitochondrial transfer has emerged as a promising therapy for cellular injury, with reported applications in central nerve injury. However, its potential therapeutic effect on peripheral nerve injury remains unclear. METHODS: We established a mouse sciatic nerve crush injury model...
April 25, 2024: Cell Communication and Signaling: CCS
#47
JOURNAL ARTICLE
Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck, Henry Fechner
BACKGROUND: The efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tumor cells. However, patients' tumors vary, and in the case of individual insensitivity to an OV, therapeutic efficacy is limited. Here, we present a protocol for rapid generation of tumor cell-specific adapted oncolytic coxsackievirus B3 (CVB3) with enhanced oncolytic potential and a satisfactory safety profile. This is achieved by combining directed viral evolution (DVE) with genetic modification of the viral genome and the use of a microRNA-dependent regulatory tool...
April 25, 2024: Biological Procedures Online
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JOURNAL ARTICLE
Sara Gordillo-Sampedro, Lina Antounians, Wei Wei, Marat Mufteev, Bas Lendemeijer, Steven A Kushner, Femke M S de Vrij, Augusto Zani, James Ellis
Astrocytes are in constant communication with neurons during the establishment and maturation of functional networks in the developing brain. Astrocytes release extracellular vesicles (EVs) containing microRNA (miRNA) cargo that regulates transcript stability in recipient cells. Astrocyte released factors are thought to be involved in neurodevelopmental disorders. Healthy astrocytes partially rescue Rett Syndrome (RTT) neuron function. EVs isolated from stem cell progeny also correct aspects of RTT. EVs cross the blood-brain barrier (BBB) and their cargo is found in peripheral blood which may allow non-invasive detection of EV cargo as biomarkers produced by healthy astrocytes...
April 23, 2024: Molecular and Cellular Neurosciences
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REVIEW
Yihao Zhang, Jiaxuan Li, Shipu Jiao, Yang Li, Yu Zhou, Xu Zhang, Bushra Maryam, Xianhua Liu
In recent years, numerous emerging contaminants have been identified in surface water, groundwater, and drinking water. Developing novel sensing methods for detecting diverse emerging pollutants in water is urgently needed, as even at low concentrations, these pollutants can pose a serious threat to human health and environmental safety. Traditional testing methods are based on laboratory equipment, which is highly sensitive but complex to operate, costly, and not suitable for on-site monitoring. Microfluidic sensors offer several benefits, including rapid evaluation, minimal sample usage, accurate liquid manipulation, compact size, automation, and in-situ detection capabilities...
April 23, 2024: Science of the Total Environment
#50
REVIEW
Arpana Parihar, Palak Sharma, Nishant Kumar Choudhary, Raju Khan, Ebrahim Mostafavi
To ensure environmental and health safety, relevant pollutants such as pesticides must be screened thoroughly to set their permissible limit. Various approaches have been used to identify pesticides such as capillary electrophoresis, gas and liquid-liquid chromatography, high-performance liquid chromatography, and enzyme-linked immune-absorbent tests. However, these techniques have some drawbacks, including time-consuming difficult steps, expensive bulky equipment, expert personnel, and a lack of selectivity...
April 23, 2024: Environmental Pollution
#51
REVIEW
Guozhi Ma, Xiaoyun Li, Jihai Cai, Xiaoying Wang
Concern about food safety triggers demand on rapid, accurate and on-site detection of foodborne pathogens. Among various fluorescent probes for detection, carbon dots (CDs) prepared by carbonization of carbon-rich raw materials show extraordinary performance for their excellent and tailorable photoluminescence property, as well as their facilely gained specificity by surface customization and modification. CDs-based fluorescent probes play a crucial role in many pathogenic bacteria sensing systems. In addition, microfluidic technology with characteristics of portability and functional integration is expected to combine with CDs-based fluorescent probes for point-of-care testing (POCT), which can further enhance the detection property of CDs-based fluorescent probes...
April 17, 2024: Food Chemistry
#52
JOURNAL ARTICLE
Jian Lu, Xiaofeng Yang, Jiaxuan Xiao, Yuhan Wang, Yue Yu, Yuan Wang, Zhen Zhang, Yanmin Zou, Yu Luan
Hydrogel biosensors present numerous advantages in food safety analysis owing to their remarkable biocompatibility, cargo-loading capabilities and optical properties. However, the current drawbacks (slow target responsiveness and poor mechanical strength) restricted their further utilization at on-site detection of targets. To address these challenges, a DNA-functionalized cryogel with hierarchical pore structures is constructed to improve the reaction rate and the robustness of hydrogel biosensor. During cryogel preparation, ice crystals serve as templates, shaping interconnected hierarchical microporous structures to enhance mass transfer for faster responses...
April 17, 2024: Talanta
#53
JOURNAL ARTICLE
Wenjie Chen, Guangrui Jin, Yijun Liu, Qiaohua Wei, Jing Tang
Atomically precise metal nanoclusters (NCs) present new opportunities for creating innovative solar-powered photoanodes due to their extraordinary physicochemical properties. Nevertheless, ultrasmall metal NCs tend to aggregate and lack active sites under light irradiation, which severely limits their widespread application. We have developed a strategy to design efficient ternary photoanodes by successively modifying AgAu NCs and CoNi-LDH on BiVO4 substrates using versatile impregnation and electrodeposition...
April 25, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Phan Ngoc Anh Thu, Nguyen Hoang Men, Cam-Duyen Thi Vo, Vo Van Toi, Phuoc Long Truong
The quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The available assays are suffering from limited capacities in simple, fast, low-cost, and on-site detection to increase prevention and proper treatment. Herein, we address these challenges by developing a simple, speedy, affordable, and ultrasensitive nanoplasmonic biosensor for colorimetric detection of cDNA from staphylococcal RNA relying on the distance-dependent optical features of silver nanostructures for the measurement of color variations and spectral shifts owing to the plasmon coupling generated by the cross-linking accumulation of AgNPs...
April 25, 2024: Analytical Methods: Advancing Methods and Applications
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JOURNAL ARTICLE
Christopher S Bibbs, R Bradley Sorensen, Ary Faraji, Gregory S White
The Salt Lake City Mosquito Abatement District (SLCMAD) detected a 20,000-fold resistance to Lysinibacillus sphaericus (Lsph) in Culex pipiens occurring in catch basins of Salt Lake City during 2016. In response, SLCMAD suspended use of Lsph and rotated use of spinosyn and s-methoprene products for the next three years. At the end of the third year, Lsph was evaluated again and efficacy similar to susceptible colony strains. During the second year of Lsph use, technicians observed lack of control of larvae at some urban sites...
April 25, 2024: Journal of the American Mosquito Control Association
#56
JOURNAL ARTICLE
Sen Tian, Xiang Li, Jian Liu, Xinyu Wang, Hui Chen, Zeyu Dai, Qian Chen, Hui Shi, Yonghua Li, Haidong Huang, Chong Bai
BACKGROUND: The diagnostic yield of radial endobronchial ultrasound (r-EBUS) for the diagnosis of peripheral pulmonary lesions (PPLs) varies between studies and is affected by multiple factors. We aimed to evaluate the efficacy and safety of r-EBUS, and to explore the factors influencing the diagnostic yield of r-EBUS in patients with PPLs. METHODS: The PubMed, Web of Science, and EMBASE databases were searched to identify relevant studies that used r-EBUS for diagnosing PPLs from the date of inception to Dec 2022...
April 30, 2024: Heliyon
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JOURNAL ARTICLE
Sri Harsha Boppana, L V Simhachalam Kutikuppala, Sushil Sharma, Madhavrao C, Gaurav Rangari, Arup Kumar Misra, Venkataramana Kandi, Snehasish Mishra, Puneet Kumar Singh, Ali A Rabaan, Ranjan K Mohapatra, Md Kudrat-E-Zahan
BACKGROUND AND AIM: The traditional drug delivery approach involves systemic administration of a drug that could be nonspecific in targeting, low on efficacy, and with severe side-effects. To address such challenges, the field of smart drug delivery has emerged aiming at designing and developing delivery systems that can target specific cells, tissues, and organs and have minimal off-target side-effects. METHODS: A literature search was done to collate papers and reports about the currently available various strategies for smart nano-inspired drug delivery...
April 2024: Health Science Reports
#58
Iosif Lazaridis, Nick Patterson, David Anthony, Leonid Vyazov, Romain Fournier, Harald Ringbauer, Iñigo Olalde, Alexander A Khokhlov, Egor P Kitov, Natalia I Shishlina, Sorin C Ailincăi, Danila S Agapov, Sergey A Agapov, Elena Batieva, Baitanayev Bauyrzhan, Zsolt Bereczki, Alexandra Buzhilova, Piya Changmai, Andrey A Chizhevsky, Ion Ciobanu, Mihai Constantinescu, Marietta Csányi, János Dani, Peter K Dashkovskiy, Sándor Évinger, Anatoly Faifert, Pavel N Flegontov, Alin Frînculeasa, Mădălina N Frînculeasa, Tamás Hajdu, Tom Higham, Paweł Jarosz, Pavol Jelínek, Valeri I Khartanovich, Eduard N Kirginekov, Viktória Kiss, Alexandera Kitova, Alexeiy V Kiyashko, Jovan Koledin, Arkady Korolev, Pavel Kosintsev, Gabriella Kulcsár, Pavel Kuznetsov, Rabadan Magomedov, Mamedov Aslan Malikovich, Eszter Melis, Vyacheslav Moiseyev, Erika Molnár, Janet Monge, Octav Negrea, Nadezhda A Nikolaeva, Mario Novak, Maria Ochir-Goryaeva, György Pálfi, Sergiu Popovici, Marina P Rykun, Tatyana M Savenkova, Vladimir P Semibratov, Nikolai N Seregin, Alena Šefčáková, Mussayeva Raikhan Serikovna, Irina Shingiray, Vladimir N Shirokov, Angela Simalcsik, Kendra Sirak, Konstantin N Solodovnikov, Judit Tárnoki, Alexey A Tishkin, Viktov Trifonov, Sergey Vasilyev, Ali Akbari, Esther S Brielle, Kim Callan, Francesca Candilio, Olivia Cheronet, Elizabeth Curtis, Olga Flegontova, Lora Iliev, Aisling Kearns, Denise Keating, Ann Marie Lawson, Matthew Mah, Adam Micco, Megan Michel, Jonas Oppenheimer, Lijun Qiu, J Noah Workman, Fatma Zalzala, Anna Szécsényi-Nagy, Pier Francesco Palamara, Swapan Mallick, Nadin Rohland, Ron Pinhasi, David Reich
The Yamnaya archaeological complex appeared around 3300BCE across the steppes north of the Black and Caspian Seas, and by 3000BCE reached its maximal extent from Hungary in the west to Kazakhstan in the east. To localize the ancestral and geographical origins of the Yamnaya among the diverse Eneolithic people that preceded them, we studied ancient DNA data from 428 individuals of which 299 are reported for the first time, demonstrating three previously unknown Eneolithic genetic clines. First, a "Caucasus-Lower Volga" (CLV) Cline suffused with Caucasus hunter-gatherer (CHG) ancestry extended between a Caucasus Neolithic southern end in Neolithic Armenia, and a steppe northern end in Berezhnovka in the Lower Volga...
April 18, 2024: bioRxiv
#59
JOURNAL ARTICLE
Qinqin Li, Daocheng Gong, Zijian Chen, Jiangyong Li, Gengchen Wu, Shuo Deng, Hao Wang, Lingyan He, Boguang Wang
Formaldehyde (HCHO) is one of the key indicators of severe photochemical pollution and strong atmospheric oxidation capacity in southern China. However, current information on the origins of regional HCHO and the impacts of polluted air masses remains scarce and unclear. In this study, an intensive observation of HCHO was conducted at a mountainous background site in southern China during typical photochemical pollution episodes. The concentrations of HCHO reached up to 6.14 ppbv and averaged at 2.68 ± 1...
April 22, 2024: Science of the Total Environment
#60
JOURNAL ARTICLE
Yunjun Yang, Jialin Li, Zhijian Xiao, Yang Yun, Mingshan Zhu, Jingling Yang
Ground-level ozone has long posed a substantial menace to human well-being and the ecological milieu. The widely reported manganese-based catalysts for ozone decomposition still facing the persisting issues encompass inefficiency and instability. To surmount these challenges, we developed a mesoporous silica thin films with perpendicular nanochannels (SBA(⊥)) confined Mn3 O4 catalyst (Mn3 O4 @SBA(⊥)). Under a weight hourly space velocity (WHSV) of 500,000 mL g-1 h-1 , the Mn3 O4 @SBA(⊥) catalyst exhibited 100% ozone decomposition efficiency in 5 h and stability across a wide humidity range, which exceed the performance of bulk Mn3 O4 and Mn3 O4 confine in commonly reported SBA-15...
April 22, 2024: Chemosphere
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