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JOURNAL ARTICLE
Muluneh M Fashe, Tien V Le, Megan N Gower, Ian R Mulrenin, Karen F Dorman, Spenser Smith, John K Fallon, Julie B Dumond, Kim A Boggess, Craig R Lee
In preeclampsia models, nicotinamide (NAM) has protective effects in preeclampsia and is being evaluated as a therapeutic nutraceutical in clinical studies. NAM undergoes extensive hepatic metabolism by NAM N-methyltransferase to methylnicotinamide (MNA), which is subsequently metabolized to methyl-2-pyridone-5-carboxamide (M2PY) by aldehyde oxidase. However, the pharmacokinetics (PK) of NAM and its major metabolites has never been studied in pregnant individuals. Blood samples were collected before and 1, 2, 4, 8, and 24 hr after single 1g oral NAM dose in healthy pregnant (gestational age 24-33 weeks) and nonpregnant female volunteers (n=6/group)...
December 13, 2023: Clinical Pharmacology and Therapeutics
#2
JOURNAL ARTICLE
Noelle L Van Rysselberghe, Ryan Seltzer, Taylor A Lawson, Justin Kuether, Parker White, Phillip Grisdela, Hayley Daniell, Arya Amirhekmat, Nelson Merchan, Thomas Seaver, Aneesh Samineni, Augustine Saiz, Daniel Ngo, Clark Dorman, Eden Epner, Reese Svetgoff, Megan Terle, Mark Lee, Sean Campbell, Gregory Dikos, Stephen Warner, Timothy Achor, Michael J Weaver, Paul Tornetta, John Scolaro, John J Wixted, Timothy Weber, Michael J Bellino, L Henry Goodnough, Michael J Gardner, Julius A Bishop
OBJECTIVE: To compare clinical and radiographic outcomes following retrograde intramedullary nailing vs locked plating of "extreme distal" periprosthetic femur fractures, defined as those which contact or extend distal to the anterior flange.METHODS. DESIGN: Retrospective review. SETTING: Eight academic level I trauma centers. PATIENT SELECTION CRITERIA: adult patients with periprosthetic distal femur fractures at or distal to the anterior flange (OTA/AO 33B-C[VB1]) treated with rIMNs or LPs...
November 21, 2023: Journal of Orthopaedic Trauma
#3
Nicholas C Curtis, Seungmin Shin, Andrew P Hederman, Ruth I Connor, Wendy F Wieland-Alter, Steven Ionov, Jennifer Boylston, Josh Rose, Mrunal Sakharkar, Dana B Dorman, John A Dessaint, Lorraine L Gwilt, Andrew R Crowley, Jared Feldman, Blake M Hauser, Aaron G Schmidt, Alix Ashare, Laura M Walker, Peter F Wright, Margaret E Ackerman, Jiwon Lee
While our understanding of SARS-CoV-2 pathogenesis and antibody responses following infection and vaccination has improved tremendously since the outbreak in 2019, the sequence identities and relative abundances of the individual constituent antibody molecules in circulation remain understudied. Using Ig-Seq, we proteomically profiled the serological repertoire specific to the whole ectodomain of SARS-CoV-2 prefusion-stabilized spike (S) as well as to the receptor binding domain (RBD) over a 6-month period in four subjects following SARS-CoV-2 infection before SARS-CoV-2 vaccines were available...
September 11, 2023: bioRxiv
#4
JOURNAL ARTICLE
Rebecca M Pollak, Jacob C Tilmon, Melissa M Murphy, Michael J Gambello, Rossana Sanchez Russo, John P Dormans, Jennifer G Mulle
3q29 deletion syndrome (3q29del) is a rare genomic disorder caused by a 1.6 Mb deletion (hg19, chr3:195725000-197350000). 3q29del is associated with neurodevelopmental and psychiatric phenotypes, including an astonishing >40-fold increased risk for schizophrenia, but medical phenotypes are less well-described. We used the online 3q29 registry of 206 individuals (3q29deletion.org) to recruit 57 individuals with 3q29del (56.14% male) and requested information about musculoskeletal phenotypes with a custom questionnaire...
September 10, 2023: American Journal of Medical Genetics. Part A
#5
JOURNAL ARTICLE
Toxicity and chemical composition of commercial road palliatives versus oil and gas produced waters.
James Farnan, John P Vanden Heuvel, Frank L Dorman, Nathaniel R Warner, William D Burgos
Across the United States, road palliatives are applied to roads for maintenance operations that improve road safety. In the winter, solid rock salts and brine solutions are used to reduce the accumulation of snow and ice, while in the summer, dust suppressants are used to minimize fugitive dust emissions. Many of these products are chloride-based salts that have been linked to freshwater salinization, toxicity to aquatic organisms, and damage to infrastructure. To minimize these impacts, organic products have been gaining attention, though their widespread adoption has been limited due to their higher cost...
July 13, 2023: Environmental Pollution
#6
Rebecca M Pollak, Jacob C Tilmon, Melissa M Murphy, Michael J Gambello, Rossana Sanchez Russo, John P Dormans, Jennifer G Mulle
3q29 deletion syndrome (3q29del) is a rare genomic disorder caused by a 1.6 Mb deletion (hg19, chr3:195725000â€"197350000). 3q29del is associated with neurodevelopmental and psychiatric phenotypes, including an astonishing >40-fold increased risk for schizophrenia, but medical phenotypes are less well-described. We used the online 3q29 registry ( 3q29deletion.org ) to recruit 57 individuals with 3q29del (56.14% male) and requested information about musculoskeletal phenotypes with a custom questionnaire...
April 3, 2023: medRxiv
#7
JOURNAL ARTICLE
Ekaterina V Kurbatova, Patrick Pj Phillips, Susan E Dorman, Erin E Sizemore, Kia E Bryant, Anne E Purfield, Jessica Ricaldi, Nicole E Brown, John L Johnson, Carole L Wallis, Joseph P Akol, Oksana Ocheretina, Nguyen Van Hung, Harriet Mayanja-Kizza, Madeleine Lourens, Rodney Dawson, Nguyen Viet Nhung, Samuel Pierre, Yeukai Musodza, Justin Shenje, Sharlaa Badal-Faesen, Stals Charles Vilbrun, Ziyaad Waja, Lakshmi Peddareddy, Nigel A Scott, Yan Yuan, Stefan V Goldberg, Susan Swindells, Richard E Chaisson, Payam Nahid
INTRODUCTION: We developed a standardized method, "Possible poor treatment response" (PPTR), to help ascertain efficacy endpoints in Study S31/A5349 (NCT02410772), an open-label trial comparing two 4-month rifapentine-based regimens with a standard 6-month regimen for the treatment of pulmonary TB. We describe the use of the PPTR process and evaluate whether the goals of minimizing bias in efficacy endpoint assessment and attainment of relevant data to determine outcome for all participants were achieved...
February 15, 2023: American Journal of Respiratory and Critical Care Medicine
#8
JOURNAL ARTICLE
Dahlia F Davidoff, Eugenie S Lim, Diana E Benn, Yuvanaa Subramaniam, Eleanor Dorman, John R Burgess, Scott A Akker, Roderick J Clifton-Bligh
Phaeochromocytoma and paraganglioma are highly heritable tumours; half of those associated with a germline mutation are caused by mutations in genes for Krebs's cycle enzymes, including succinate dehydrogenase (SDH). Inheritance of SDH alleles is assumed to be Mendelian (probability of 50% from each parent). The departure from transmission of parental alleles in a ratio of 1:1 is termed transmission ratio distortion (TRD). We sought to assess whether TRD occurs in the transmission of SDHB pathogenic variants (PVs)...
February 1, 2023: Endocrine-related Cancer
#9
JOURNAL ARTICLE
Douglas Lawton, Anders S Huseth, George G Kennedy, Amy C Morey, William D Hutchison, Dominic D Reisig, Seth J Dorman, DeShae Dillard, Robert C Venette, Russell L Groves, John J Adamczyk, Izailda Barbosa Dos Santos, Tracey Baute, Sebe Brown, Eric Burkness, Ashley Dean, Galen P Dively, Hélène B Doughty, Shelby J Fleischer, Jessica Green, Jeremy K Greene, Krista Hamilton, Erin Hodgson, Thomas Hunt, David Kerns, Billy Rogers Leonard, Sean Malone, Fred Musser, David Owens, John C Palumbo, Silvana Paula-Moraes, Julie A Peterson, Ricardo Ramirez, Silvia I Rondon, Tracy L Schilder, Abby Seaman, Lori Spears, Scott D Stewart, Sally Taylor, Tyler Towles, Celeste Welty, Joanne Whalen, Robert Wright, Marion Zuefle
Overwintering success is an important determinant of arthropod populations that must be considered as climate change continues to influence the spatiotemporal population dynamics of agricultural pests. Using a long-term monitoring database and biologically relevant overwintering zones, we modeled the annual and seasonal population dynamics of a common pest, Helicoverpa zea (Boddie), based on three overwintering suitability zones throughout North America using four decades of soil temperatures: the southern range (able to persist through winter), transitional zone (uncertain overwintering survivorship), and northern limits (unable to survive winter)...
September 13, 2022: Proceedings of the National Academy of Sciences of the United States of America
#10
JOURNAL ARTICLE
Anowar H Khan, Sophia P Zhou, Margaret Moe, Braulio A Ortega Quesada, Khashayar R Bajgiran, Haley R Lassiter, James A Dorman, Elizabeth C Martin, John A Pojman, Adam T Melvin
Culturing cancer cells in a three-dimensional (3D) environment better recapitulates in vivo conditions by mimicking cell-to-cell interactions and mass transfer limitations of metabolites, oxygen, and drugs. Recent drug studies have suggested that a high rate of preclinical and clinical failures results from mass transfer limitations associated with drug entry into solid tumors that 2D model systems cannot predict. Droplet microfluidic devices offer a promising alternative to grow 3D spheroids from a small number of cells to reduce intratumor heterogeneity, which is lacking in other approaches...
August 24, 2022: ACS Biomaterials Science & Engineering
#11
JOURNAL ARTICLE
Charles J Marsh, Yanina V Sica, Connor J Burgin, Wendy A Dorman, Robert C Anderson, Isabel Del Toro Mijares, Jessica G Vigneron, Vijay Barve, Victoria L Dombrowik, Michelle Duong, Robert Guralnick, Julie A Hart, J Krish Maypole, Kira McCall, Ajay Ranipeta, Anna Schuerkmann, Michael A Torselli, Thomas Lacher, Russell A Mittermeier, Anthony B Rylands, Wes Sechrest, Don E Wilson, Agustín M Abba, Luis F Aguirre, Joaquín Arroyo-Cabrales, Diego Astúa, Andrew M Baker, Gill Braulik, Janet K Braun, Jorge Brito, Peter E Busher, Santiago F Burneo, M Alejandra Camacho, Paolo Cavallini, Elisandra de Almeida Chiquito, Joseph A Cook, Tamás Cserkész, Gábor Csorba, Erika Cuéllar Soto, Valeria da Cunha Tavares, Tim R B Davenport, Thomas Deméré, Christiane Denys, Christopher R Dickman, Mark D B Eldridge, Eduardo Fernandez-Duque, Charles M Francis, Greta Frankham, William L Franklin, Thales Freitas, J Anthony Friend, Elizabeth L Gadsby, Guilherme S T Garbino, Philippe Gaubert, Norberto Giannini, Thomas Giarla, Jason S Gilchrist, Jaime Gongora, Steven M Goodman, Sharon Gursky-Doyen, Klaus Hackländer, Mark S Hafner, Melissa Hawkins, Kristofer M Helgen, Steven Heritage, Arlo Hinckley, Stefan Hintsche, Mary Holden, Kay E Holekamp, Rodney L Honeycutt, Brent A Huffman, Tatyana Humle, Rainer Hutterer, Carlos Ibáñez Ulargui, Stephen M Jackson, Jan Janecka, Mary Janecka, Paula Jenkins, Rimvydas Juškaitis, Javier Juste, Roland Kays, C William Kilpatrick, Tigga Kingston, John L Koprowski, Boris Kryštufek, Tyrone Lavery, Thomas E Lee, Yuri L R Leite, Roberto Leonan M Novaes, Burton K Lim, Andrey Lissovsky, Raquel López-Antoñanzas, Adrià López-Baucells, Colin D MacLeod, Fiona G Maisels, Michael A Mares, Helene Marsh, Stefano Mattioli, Erik Meijaard, Ara Monadjem, F Blake Morton, Grace Musser, Tilo Nadler, Ryan W Norris, Agustina Ojeda, Nicté Ordóñez-Garza, Ulyses F J Pardiñas, Bruce D Patterson, Ana Pavan, Michael Pennay, Calebe Pereira, Joyce Prado, Helder L Queiroz, Matthew Richardson, Erin P Riley, Stephen J Rossiter, Daniel I Rubenstein, Dennisse Ruelas, Jorge Salazar-Bravo, Stéphanie Schai-Braun, Cody J Schank, Christoph Schwitzer, Lori K Sheeran, Myron Shekelle, Georgy Shenbrot, Pipat Soisook, Sergio Solari, Richard Southgate, Mariella Superina, Andrew B Taber, Maurício Talebi, Peter Taylor, Thong Vu Dinh, Nelson Ting, Diego G Tirira, Susan Tsang, Samuel T Turvey, Raul Valdez, Victor Van Cakenberghe, Geraldine Veron, Janette Wallis, Rod Wells, Danielle Whittaker, Elizabeth A Williamson, George Wittemyer, John Woinarski, Dietmar Zinner, Nathan S Upham, Walter Jetz
Aim: Comprehensive, global information on species' occurrences is an essential biodiversity variable and central to a range of applications in ecology, evolution, biogeography and conservation. Expert range maps often represent a species' only available distributional information and play an increasing role in conservation assessments and macroecology. We provide global range maps for the native ranges of all extant mammal species harmonised to the taxonomy of the Mammal Diversity Database (MDD) mobilised from two sources, the Handbook of the Mammals of the World (HMW) and the Illustrated Checklist of the Mammals of the World (CMW)...
May 2022: Journal of Biogeography
#12
JOURNAL ARTICLE
Paul Elliott, David Haw, Haowei Wang, Oliver Eales, Caroline E Walters, Kylie E C Ainslie, Christina Atchison, Claudio Fronterre, Peter J Diggle, Andrew J Page, Alexander J Trotter, Sophie J Prosolek, Deborah Ashby, Christl A Donnelly, Wendy Barclay, Graham Taylor, Graham Cooke, Helen Ward, Ara Darzi, Steven Riley
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were rising during early summer 2021 in many countries as a result of the Delta variant. We assessed reverse transcription polymerase chain reaction swab positivity in the Real-time Assessment of Community Transmission–1 (REACT-1) study in England. During June and July 2021, we observed sustained exponential growth with an average doubling time of 25 days, driven by complete replacement of the Alpha variant by Delta and by high prevalence at younger, less-vaccinated ages...
December 17, 2021: Science
#13
JOURNAL ARTICLE
Andrew D Gewitz, Belén P Solans, William R Mac Kenzie, Chad Heilig, William C Whitworth, John L Johnson, Pheona Nsubuga, Susan Dorman, Marc Weiner, Radojka M Savic
The identification of sensitive, specific, and reliable biomarkers that can be quantified in the early phases of tuberculosis treatment and predictive of long-term outcome is key for the development of an effective short-course treatment regimen. Time to positivity (TTP), a biomarker of treatment outcome against Mycobacterium tuberculosis, measures longitudinal bacterial growth in mycobacterial growth indicator tube broth culture and may be predictive of standard time to stable culture conversion (TSCC). In two randomized phase 2b trials investigating dose-ranging rifapentine (Studies 29 and 29X), 662 participants had sputum collected over 6 months where TTP, TSCC, and time to culture conversion were quantified...
September 17, 2021: Antimicrobial Agents and Chemotherapy
#14
RANDOMIZED CONTROLLED TRIAL
Susan E Dorman, Payam Nahid, Ekaterina V Kurbatova, Patrick P J Phillips, Kia Bryant, Kelly E Dooley, Melissa Engle, Stefan V Goldberg, Ha T T Phan, James Hakim, John L Johnson, Madeleine Lourens, Neil A Martinson, Grace Muzanyi, Kim Narunsky, Sandy Nerette, Nhung V Nguyen, Thuong H Pham, Samuel Pierre, Anne E Purfield, Wadzanai Samaneka, Radojka M Savic, Ian Sanne, Nigel A Scott, Justin Shenje, Erin Sizemore, Andrew Vernon, Ziyaad Waja, Marc Weiner, Susan Swindells, Richard E Chaisson
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis. METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmonary tuberculosis from 13 countries, we compared two 4-month rifapentine-based regimens with a standard 6-month regimen consisting of rifampin, isoniazid, pyrazinamide, and ethambutol (control) using a noninferiority margin of 6...
May 6, 2021: New England Journal of Medicine
#15
JOURNAL ARTICLE
Cory J Evans, John M Olson, Bama Charan Mondal, Pratyush Kandimalla, Ariano Abbasi, Mai M Abdusamad, Osvaldo Acosta, Julia A Ainsworth, Haris M Akram, Ralph B Albert, Elitzander Alegria-Leal, Kai Y Alexander, Angelica C Ayala, Nataliya S Balashova, Rebecca M Barber, Harmanjit Bassi, Sean P Bennion, Miriam Beyder, Kush V Bhatt, Chinmay Bhoot, Aaron W Bradshaw, Tierney G Brannigan, Boyu Cao, Yancey Y Cashell, Timothy Chai, Alex W Chan, Carissa Chan, Inho Chang, Jonathan Chang, Michael T Chang, Patrick W Chang, Stephen Chang, Neel Chari, Alexander J Chassiakos, Iris E Chen, Vivian K Chen, Zheying Chen, Marsha R Cheng, Mimi Chiang, Vivian Chiu, Sharon Choi, Jun Ho Chung, Liset Contreras, Edgar Corona, Courtney J Cruz, Renae L Cruz, Jefferson M Dang, Suhas P Dasari, Justin R O De La Fuente, Oscar M A Del Rio, Emily R Dennis, Petros S Dertsakyan, Ipsita Dey, Rachel S Distler, Zhiqiao Dong, Leah C Dorman, Mark A Douglass, Allysen B Ehresman, Ivy H Fu, Andrea Fua, Sean M Full, Arash Ghaffari-Rafi, Asmar Abdul Ghani, Bosco Giap, Sonia Gill, Zafar S Gill, Nicholas J Gills, Sindhuja Godavarthi, Talin Golnazarian, Raghav Goyal, Ricardo Gray, Alexander M Grunfeld, Kelly M Gu, Natalia C Gutierrez, An N Ha, Iman Hamid, Ashley Hanson, Celesti Hao, Chongbin He, Mengshi He, Joshua P Hedtke, Ysrael K Hernandez, Hnin Hlaing, Faith A Hobby, Karen Hoi, Ashley C Hope, Sahra M Hosseinian, Alice Hsu, Jennifer Hsueh, Eileen Hu, Spencer S Hu, Stephanie Huang, Wilson Huang, Melanie Huynh, Carmen Javier, Na Eun Jeon, Sunjong Ji, Jasmin Johal, Amala John, Lauren Johnson, Saurin Kadakia, Namrata Kakade, Sarah Kamel, Ravinder Kaur, Jagteshwar S Khatra, Jeffrey A Kho, Caleb Kim, Emily Jin-Kyung Kim, Hee Jong Kim, Hyun Wook Kim, Jin Hee Kim, Seong Ah Kim, Woo Kyeom Kim, Brian Kit, Cindy La, Jonathan Lai, Vivian Lam, Nguyen Khoi Le, Chi Ju Lee, Dana Lee, Dong Yeon Lee, James Lee, Jason Lee, Jessica Lee, Ju-Yeon Lee, Sharon Lee, Terrence C Lee, Victoria Lee, Amber J Li, Jialing Li, Alexandra M Libro, Irvin C Lien, Mia Lim, Jeffrey M Lin, Connie Y Liu, Steven C Liu, Irene Louie, Shijia W Lu, William Y Luo, Tiffany Luu, Josef T Madrigal, Yishan Mai, Darron I Miya, Mina Mohammadi, Sayonika Mohanta, Tebogo Mokwena, Tonatiuh Montoya, Dallas L Mould, Mark R Murata, Janani Muthaiya, Seethim Naicker, Mallory R Neebe, Amy Ngo, Duy Q Ngo, Jamie A Ngo, Anh T Nguyen, Huy C X Nguyen, Rina H Nguyen, Thao T T Nguyen, Vincent T Nguyen, Kevin Nishida, Seo-Kyung Oh, Kristen M Omi, Mary C Onglatco, Guadalupe Ortega Almazan, Jahzeel Paguntalan, Maharshi Panchal, Stephanie Pang, Harin B Parikh, Purvi D Patel, Trisha H Patel, Julia E Petersen, Steven Pham, Tien M Phan-Everson, Megha Pokhriyal, Davis W Popovich, Adam T Quaal, Karl Querubin, Anabel Resendiz, Nadezhda Riabkova, Fred Rong, Sarah Salarkia, Nateli Sama, Elaine Sang, David A Sanville, Emily R Schoen, Zhouyang Shen, Ken Siangchin, Gabrielle Sibal, Garuem Sin, Jasmine Sjarif, Christopher J Smith, Annisa N Soeboer, Cristian Sosa, Derek Spitters, Bryan Stender, Chloe C Su, Jenny Summapund, Beatrice J Sun, Christine Sutanto, Jaime S Tan, Nguon L Tan, Parich Tangmatitam, Cindy K Trac, Conny Tran, Daniel Tran, Duy Tran, Vina Tran, Patrick A Truong, Brandon L Tsai, Pei-Hua Tsai, C Kimberly Tsui, Jackson K Uriu, Sanan Venkatesh, Maique Vo, Nhat-Thi Vo, Phuong Vo, Timothy C Voros, Yuan Wan, Eric Wang, Jeffrey Wang, Michael K Wang, Yuxuan Wang, Siman Wei, Matthew N Wilson, Daniel Wong, Elliott Wu, Hanning Xing, Jason P Xu, Sahar Yaftaly, Kimberly Yan, Evan Yang, Rebecca Yang, Tony Yao, Patricia Yeo, Vivian Yip, Puja Yogi, Gloria Chin Young, Maggie M Yung, Alexander Zai, Christine Zhang, Xiao X Zhang, Zijun Zhao, Raymond Zhou, Ziqi Zhou, Mona Abutouk, Brian Aguirre, Chon Ao, Alexis Baranoff, Angad Beniwal, Zijie Cai, Ryan Chan, Kenneth Chang Chien, Umar Chaudhary, Patrick Chin, Praptee Chowdhury, Jamlah Dalie, Eric Y Du, Alec Estrada, Erwin Feng, Monica Ghaly, Rose Graf, Eduardo Hernandez, Kevin Herrera, Vivien W Ho, Kaitlyn Honeychurch, Yurianna Hou, Jo M Huang, Momoko Ishii, Nicholas James, Gah-Eun Jang, Daphne Jin, Jesse Juarez, Ayse Elif Kesaf, Sat Kartar Khalsa, Hannah Kim, Jenna Kovsky, Chak Lon Kuang, Shraddha Kumar, Gloria Lam, Ceejay Lee, Grace Lee, Li Li, Joshua Lin, Josephine Liu, Janice Ly, Austin Ma, Hannah Markovic, Cristian Medina, Jonelle Mungcal, Bilguudei Naranbaatar, Kayla Patel, Lauren Petersen, Amanda Phan, Malcolm Phung, Nadiyah Priasti, Nancy Ruano, Tanveer Salim, Kristen Schnell, Paras Shah, Jinhua Shen, Nathan Stutzman, Alisa Sukhina, Rayna Tian, Andrea Vega-Loza, Joyce Wang, Jun Wang, Rina Watanabe, Brandon Wei, Lillian Xie, Jessica Ye, Jeffrey Zhao, Jill Zimmerman, Colton Bracken, Jason Capili, Andrew Char, Michel Chen, Pingdi Huang, Sena Ji, Emily Kim, Kenneth Kim, Julie Ko, Sean Louise G Laput, Sam Law, Sang Kuk Lee, Olivia Lee, David Lim, Eric Lin, Kyle Marik, Josh Mytych, Andie O'Laughlin, Jensen Pak, Claire Park, Ruth Ryu, Ashwin Shinde, Manny Sosa, Nick Waite, Mane Williams, Richard Wong, Jocelyn Woo, Jonathan Woo, Vishaal Yepuri, Dorothy Yim, Dan Huynh, Dinali Wijiewarnasurya, Casey Shapiro, Marc Levis-Fitzgerald, Leslie Jaworski, David Lopatto, Ira E Clark, Tracy Johnson, Utpal Banerjee
Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify genes important for hematopoiesis in Drosophila. This screen disrupted the function of approximately 3500 genes and identified 137 candidate genes for which loss of function leads to observable changes in the hematopoietic development. Targeting RNAi to maturing, progenitor, and regulatory cell types identified key subsets that either limit or promote blood cell maturation...
January 18, 2021: G3: Genes—Genomes—Genetics
#16
JOURNAL ARTICLE
Marc Weiner, Jon Gelfond, Teresa L Johnson-Pais, Melissa Engle, John L Johnson, William C Whitworth, Erin Bliven-Sizemore, Pheona Nsubuga, Susan E Dorman, Rada Savic
BACKGROUND: Rifapentine exposure is associated with bactericidal activity against Mycobacterium tuberculosis, but high interindividual variation in plasma concentrations is encountered. OBJECTIVES: To investigate a genomic association with interindividual variation of rifapentine exposure, SNPs of six human genes involving rifamycin metabolism (AADAC, CES2), drug transport (SLCO1B1, SLCO1B3) and gene regulation (HNF4A, PXR) were evaluated. METHODS: We characterized these genes in 173 adult participants in treatment trials of the Tuberculosis Trials Consortium...
February 11, 2021: Journal of Antimicrobial Chemotherapy
#17
JOURNAL ARTICLE
Emmanouil Grigoriou, John P Dormans, Alexandre Arkader
OBJECTIVE: Aneurysmal bone cysts (ABC) are benign but locally aggressive lesions. Treating children with spinal ABC poses risks due to the proximity of the lesion to the spinal cord and the need to preserve spinal stability after surgery. This study reports the updated outcomes of a uniform aggressive initial surgical technique for the treatment of spinal ABC in children. METHODS: Twenty-nine cases of spinal ABC were collected from a tertiary pediatric tumor center over a 24-year period (January 1990-September 2014)...
August 2020: International Journal of Spine Surgery
#18
JOURNAL ARTICLE
Qingyun Li, Xiyu Peng, Eric R Burrough, Orhan Sahin, Stacie A Gould, Nicholas K Gabler, Crystal L Loving, Karin S Dorman, John F Patience
Post-weaning diarrhea caused by enterotoxigenic E. coli (ETEC) causes significant economic losses for pig producers. This study was to test the hypotheses that an ETEC challenge disrupts intestinal microbial homeostasis and the inclusion of dietary soluble (10% sugar beet pulp) or insoluble fiber (15% corn distillers dried grains with solubles) with or without exogenous carbohydrases will protect or restore the gut microbial homeostasis in weaned pigs. Sixty crossbred piglets (6.9 ± 0.1 kg) were blocked by body weight and randomly assigned to one of six treatments ( n = 10), including a non-challenged control (NC), ETEC F18-challenged positive control (PC), ETEC-challenged soluble fiber without (SF-) or with carbohydrases (SF+), and ETEC-challenged insoluble fiber without (IF-) or with carbohydrases (IF+)...
2020: Frontiers in Microbiology
#19
Andrew S Levey, Kai-Uwe Eckardt, Nijsje M Dorman, Stacy L Christiansen, Ewout J Hoorn, Julie R Ingelfinger, Lesley A Inker, Adeera Levin, Rajnish Mehrotra, Paul M Palevsky, Mark A Perazella, Allison Tong, Susan J Allison, Detlef Bockenhauer, Josephine P Briggs, Jonathan S Bromberg, Andrew Davenport, Harold I Feldman, Denis Fouque, Ron T Gansevoort, John S Gill, Eddie L Greene, Brenda R Hemmelgarn, Matthias Kretzler, Mark Lambie, Pascale H Lane, Joseph Laycock, Shari E Leventhal, Michael Mittelman, Patricia Morrissey, Marlies Ostermann, Lesley Rees, Pierre Ronco, Franz Schaefer, Jennifer St Clair Russell, Caroline Vinck, Stephen B Walsh, Daniel E Weiner, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer
The worldwide burden of kidney disease is rising, but public awareness remains limited, underscoring the need for more effective communication by stakeholders in the kidney health community. Despite this need for clarity, the nomenclature for describing kidney function and disease lacks uniformity. In June 2019, Kidney Disease: Improving Global Outcomes (KDIGO) convened a Consensus Conference with the goal of standardizing and refining the nomenclature used in the English language to describe kidney function and disease, and of developing a glossary that could be used in scientific publications...
June 2020: Kidney International
#20
MULTICENTER STUDY
Debashis Sarker, Ruth Plummer, Tim Meyer, Mikael H Sodergren, Bristi Basu, Cheng Ean Chee, Kai-Wen Huang, Daniel H Palmer, Yuk Ting Ma, T R Jeff Evans, Duncan R C Spalding, Madhava Pai, Rohini Sharma, David J Pinato, James Spicer, Sarah Hunter, Vineet Kwatra, Joanna P Nicholls, David Collin, Robert Nutbrown, Helen Glenny, Sonia Fairbairn, Vikash Reebye, Jon Voutila, Stephanie Dorman, Pinelopi Andrikakou, Peter Lloyd, Steve Felstead, Jenni Vasara, Robert Habib, Chris Wood, Pal Saetrom, Hans E Huber, David C Blakey, John J Rossi, Nagy Habib
PURPOSE: Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA oligonucleotide drug that upregulates C/EBP-α. PATIENTS AND METHODS: We conducted a phase I, open-label, dose-escalation trial of MTL-CEBPA in adults with advanced hepatocellular carcinoma (HCC) with cirrhosis, or resulting from nonalcoholic steatohepatitis or with liver metastases...
August 1, 2020: Clinical Cancer Research
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