Laura Rizzi, Marco Turati, Elena Bresciani, Filippo Maria Anghilieri, Ramona Meanti, Laura Molteni, Massimiliano Piatti, Nicolò Zanchi, Silvia Coco, Francesco Buonanotte, Luca Rigamonti, Giovanni Zatti, Vittorio Locatelli, Robert J Omeljaniuk, Marco Bigoni, Antonio Torsello
This study investigated modifications of microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and rupture of the anterior cruciate ligament (ACL). Twelve microRNAs (26a-5p, 27a-3p, let7a-5p, 140-5p, 146-5p, 155-5p, 16-5p,186-5p, 199a-3p, 210-3p, 205-5p, and 30b-5p) were measured by real-time quantitative polymerase chain reaction (RT-qPCR) in synovial fluids obtained from 30 patients with ACL tear and 18 patients with knee OA. These 12 miRNAs were chosen on the basis of their involvement in pathological processes of bone and cartilage...
November 12, 2022: Biomedicines