keyword
https://read.qxmd.com/read/38493716/kaempferol-inhibits-colorectal-cancer-metastasis-through-circ_0000345-mediated-jmjd2c-%C3%AE-catenin-signalling-pathway
#1
JOURNAL ARTICLE
Yunzhou Pu, Yicun Han, Yiran Ouyang, Haoze Li, Ling Li, Xinnan Wu, Liu Yang, Jingdong Gao, Lei Zhang, Jing Zhou, Qing Ji, Qing Song
BACKGROUND: Recurrence and metastasis are the main causes of disease deterioration in colorectal cancer (CRC) patients, yet efficient therapeutic strategies are lacking. Natural compounds for efficient antitumour therapeutics are becoming increasingly prominent. Kaempferol, one of the main components of flavonoids in plants, displays a variety of pharmacological activities. Our preliminary experiments suggested that kaempferol could inhibit CRC metastasis and is significantly associated with the β-catenin signalling pathway...
January 4, 2024: Phytomedicine
https://read.qxmd.com/read/38402304/hyperglycemia-and-micrornas-in-prostate-cancer
#2
JOURNAL ARTICLE
Valentina Russo, Lara Tamburrino, Simone Morselli, Cristina Sani, Elisabetta Baldi, Arcangelo Sebastianelli, Maria Rosaria Raspollini, Alessandra Mongia, Valentina Carradori, Eleonora Lallo, Armelle Munnia, Simonetta Bisanzi, Sara Marchiani, Carmen Visioli, Stefano Rapi, Sergio Serni, Marco Zappa, Francesca Carozzi, Marco Peluso
BACKGROUND: Hyperglycemia can promote the development of prostate cancer (PCa). Differential expression levels of miRNAs between PCa patients and controls were also reported. Therefore, we examined the relationship between hyperglycemia and miRNA levels in PCa. METHODS: Relative expression of urinary miR-574-3p, miR-375, miR-205-5p, miR-200b-3p, miR-187-3p, miR-182-5p, and miR-100-5p were investigated in 105 PCa patients and 138 noncancer controls by Real-Time quantitative PCR...
February 24, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38398215/identification-of-tissue-mirna-signatures-for-pancreatic-ductal-adenocarcinoma
#3
JOURNAL ARTICLE
Carlo Caputo, Michela Falco, Anna Grimaldi, Angela Lombardi, Chiara Carmen Miceli, Mariateresa Cocule, Marco Montella, Luca Pompella, Giuseppe Tirino, Severo Campione, Chiara Tammaro, Antonio Cossu, Grazia Fenu Pintori, Margherita Maioli, Donatella Coradduzza, Giovanni Savarese, Antonio Fico, Alessandro Ottaiano, Giovanni Conzo, Madhura S Tathode, Fortunato Ciardiello, Michele Caraglia, Ferdinando De Vita, Gabriella Misso
Pancreatic ductal adenocarcinoma (PDAC), a neoplasm of the gastrointestinal tract, is the most common pancreatic malignancy (90%) and the fourth highest cause of cancer mortality worldwide. Surgery intervention is currently the only strategy able to offer an advantage in terms of overall survival, but prognosis remains poor even for operated patients. Therefore, the development of robust biomarkers for early diagnosis and prognostic stratification in clinical practice is urgently needed. In this work, we investigated deregulated microRNAs (miRNAs) in tissues from PDAC patients with high (G3) or low (G2) histological grade and with (N+) or without (N-) lymph node metastases...
February 18, 2024: Cancers
https://read.qxmd.com/read/38376578/circ-luc7l-absence-attenuates-diabetic-nephropathy-progression-by-reducing-mesangial-cell-excessive-proliferation-inflammation-and-extracellular-matrix-accumulation-via-mediating-the-mir-205-5p-tgfbr1-pathway
#4
JOURNAL ARTICLE
Zhan Fang, Dan Wang, Fang Sun, Jing Chang, Dong Yuan, Shuhua Lin, Jian Teng
Diabetic nephropathy (DN) threatens the survival quality of patients, with complex pathogenesis. Circular RNA (circRNA) dysregulation occurs in DN development. This work aimed to investigate the role of circ-Luc7l in DN cell models and related molecular mechanisms. The expression of circ-Luc7l, microRNA (miR)-205-5p, and transforming growth factor-beta receptor 1 (Tgfbr1) was examined by real-time quantitative PCR (RT-qPCR). Cell viability and proliferation were detected by Cell Counting Kit-8 (CCK-8) assay and EdU assay...
February 20, 2024: Biochemical Genetics
https://read.qxmd.com/read/38327836/value-of-negatively-correlated-mir-205-5p-hmgb3-and-mir-96-5p-foxo1-on-the-diagnosis-of-breast-cancer-and-benign-breast-diseases
#5
JOURNAL ARTICLE
Jiaying Li, Shuang Peng, Xuan Zou, Xiangnan Geng, Tongshan Wang, Wei Zhu, Tiansong Xia
BACKGROUND: MicroRNA (miRNA) and mRNA levels in matching specimens were used to identify miRNA-mRNA interactions. We aimed to integrate transcriptome, immunophenotype, methylation, mutation, and survival data analyses to examine the profiles of miRNAs and target mRNAs and their associations with breast cancer (BC) diagnosis. METHODS: Based on the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA), differentially expressed miRNAs and targeted mRNAs were screened from experimentally verified miRNA-target interaction databases using Pearson's correlation analysis...
July 2023: Cancer Pathog Ther
https://read.qxmd.com/read/38325349/mir-205-5p-mediated-magi1-inhibition-attenuates-the-injury-induced-by-diabetic-nephropathy
#6
JOURNAL ARTICLE
Yuanbing Xiang, Min Sun, Yuxi Wu, Yao Hu
INTRODUCTION: Membrane-associated guanylate kinase with an inverted domain structure-1 (MAGI1) is dysregulated in diabetes; however, its role in diabetic nephropathy (DN) remains unclear. In this study, we determined the function and associated mechanisms of MAGI1 in DN. METHODS: Serum samples from 28 patients with DN and 28 normal volunteers were collected. High-glucose (HG)-treated human renal mesangial cells (HRMCs) and streptozotocin-treated rats were used as cell and animal models of DN, respectively...
February 7, 2024: Pharmacology
https://read.qxmd.com/read/38279415/prostatitis-no-1-traditional-chinese-medicine-significantly-exhibited-anti-inflammation-role-on-prostatitis-through-mir-205-5p-yes1
#7
JOURNAL ARTICLE
Jia Liu, Yongchao Fan, Ruiyu Song, Zhaohui Tian, Baofei Yan, Yuting Ma, Qingqi Zeng
Prostatitis is one common male disease with a high prevalence. Traditional Chinese medicine (TCM) has been used as an alternative method for the treatment. However, the molecular mechanism of Prostatitis No.1 Traditional Chinese Medicine (P1TCM) on prostatitis is still unclear. For this purpose, the rat models were constructed and treated with PITCM of control, model, low (10 g/kg/d), medium (20 g/kg/d), and high (40 g/kg/d), as well as the transfections of medium dosage+NC mimic, and medium dosage+miR-205-5p mimic, medium dosage+NC mimic+pc-NC, medium dosage+miR-205-5p mimic+pc-NC, and medium dosage+miR-205-5p mimic+pc-v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES1)...
December 31, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/38256008/role-of-exosomal-mir-205-5p-cargo-in-angiogenesis-and-cell-migration
#8
JOURNAL ARTICLE
Miriam Martínez-Santos, María Ybarra, María Oltra, María Muriach, Francisco J Romero, Maria E Pires, Javier Sancho-Pelluz, Jorge M Barcia
Exosomes or small extracellular vesicles (sEVs) represent a pivotal component in intercellular communication, carrying a diverse array of biomolecules. Several factors can affect sEVs release dynamics, as occurs in hyperglycemia or inflammation. In fact, sEVs release has been associated with the promotion of physio-pathological processes. Among the sEVs cargo, microRNAs play an essential role in cell-to-cell regulation. More concretely, miR-205-5p is related to angiogenesis and cell proliferation. The aim of this study is to understand the specific role of sEVs containing miR-205-5p under high glucose conditions...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38203361/the-discovery-and-characterization-of-conserved-and-novel-mirnas-in-the-different-developmental-stages-and-organs-of-pikeperch-sander-lucioperca
#9
JOURNAL ARTICLE
Marieke Verleih, Tina Visnovska, Julien A Nguinkal, Alexander Rebl, Tom Goldammer, Rune Andreassen
Micro RNAs (miRNAs) are short non-coding RNAs that act as post-transcriptional gene expression regulators. Genes regulated in vertebrates include those affecting growth and development or stress and immune response. Pikeperch ( Sander lucioperca ) is a species that is increasingly being considered for farming in recirculation aquaculture systems. We characterized the pikeperch miRNA repertoire to increase the knowledge of the genomic mechanisms affecting performance and health traits by applying small RNA sequencing to different developmental stages and organs...
December 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38105269/overexpression-of-microrna-205-5p-promotes-cholangiocarcinoma-growth-by-reducing-expression-of-homeodomain-interacting-protein-kinase-3
#10
JOURNAL ARTICLE
Aye Myat Mon, Kitti Intuyod, Sirinapha Klungsaeng, Apinya Jusakul, Thatsanapong Pongking, Worachart Lert-Itthiporn, Vor Luvira, Chawalit Pairojkul, Tullayakorn Plengsuriyakarn, Kesara Na-Bangchang, Somchai Pinlaor, Porntip Pinlaor
The microRNA miR-205-5p has diverse effects in different malignancies, including cholangiocarcinoma (CCA), but its effects on CCA progression is unclear. Here we investigated the role and function of miR-205-5p in CCA. Three CCA cell lines and human serum samples were found to have much higher expression levels of miR-205-5p than seen in typical cholangiocyte cell lines and healthy controls. Inhibition of miR-205-5p suppressed CCA cell motility, invasion and proliferation of KKU-213B whereby overexpression of miR-205-5p promoted cell proliferation and motility of KKU-100 cells...
December 17, 2023: Scientific Reports
https://read.qxmd.com/read/38087801/tumor-related-exosomal-circ_0001715-promotes-lung-adenocarcinoma-cell-proliferation-and-metastasis-via-enhancing-m2-macrophage-polarization-by-regulating-triggering-receptor-expressed-on-myeloid-cells-2
#11
JOURNAL ARTICLE
Mengjun Chen, Chengzhang Cao, Jun Ma
BACKGROUND: Circular RNAs (circRNAs) have been shown to mediate tumor-associated macrophages (TAMs) to regulate the development of many cancers, including lung adenocarcinoma (LUAD). However, whether circ_0001715 regulates LUAD progression by mediating TAMs polarization remains uncertain. METHODS: Monocytes (THP-1) were treated with PMA to induce M0 macrophages. M0 macrophages were incubated with LUAD cells-derived exosomes and then cocultured with LUAD cells. The levels of circ_0001715, M2 macrophage markers, microRNA (miR)-205-5p, and triggering receptor expressed on myeloid cells-2 (TREM2) were examined using quantitative real-time PCR...
December 12, 2023: Thoracic Cancer
https://read.qxmd.com/read/38050438/lncrna-linc01703-promotes-the-proliferation-migration-and-invasion-of-colorectal-cancer-by-activating-pi3k-akt-pathway
#12
JOURNAL ARTICLE
Yuanhui Xu, Keliang Jia, Xianhai Zhao, Yuantao Li, Zhen Zhang
The role of LINC01703 in cancers, especially in colorectal cancer (CRC), is still largely unclear. Bioinformatics prediction, real-time quantitative polymerase chain reaction (RT-qPCR), 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, colony formation assay, Transwell assays, in vivo animal experiments, IF, luciferase reporter assay, and Western blot were carried out for the exploration of the potential involvement and underlying molecular mechanisms of LINC01703 in CRC cells. The results showed that LINC01703 appeared upregulated in CRC and was linked to poor prognosis...
December 4, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38006958/exosomal-derived-mir-1246-from-hydroquinone-transformed-cells-drives-s-phase-accumulation-arrest-by-targeting-cyclin-g2-in-tk6-cells
#13
JOURNAL ARTICLE
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
BACKGROUND: Hydroquinone (HQ), a major metabolite of benzene and known hematotoxic carcinogen. MicroRNA 1246 (miR-1246), an oncogene, regulates target genes in carcinogenesis including leukemia. This study investigates the impact of exosomal derived miR-1246 from HQ-transformed (HQ19) cells on cell-to-cell communication in recipient TK6 cells. METHODS: RNA sequencing was used to identify differentially expressed exosomal miRNAs in HQ19 cells and its phosphate buffered solution control cells (PBS19), which were then confirmed using qRT-PCR...
November 23, 2023: Chemico-biological Interactions
https://read.qxmd.com/read/38003618/knockdown-of-simulated-solar-radiation-sensitive-mir-205-5p-does-not-induce-progression-of-cutaneous-squamous-cell-carcinoma-in-vitro
#14
JOURNAL ARTICLE
Marc Bender, I-Peng Chen, Stefan Henning, Sarah Degenhardt, Mouna Mhamdi-Ghodbani, Christin Starzonek, Beate Volkmer, Rüdiger Greinert
Solar radiation is the main risk factor for cSCC development, yet it is unclear whether the progression of cSCC is promoted by solar radiation in the same way as initial tumorigenesis. Additionally, the role of miRNAs, which exert crucial functions in various tumors, needs to be further elucidated in the context of cSCC progression and connection to solar radiation. Thus, we chronically irradiated five cSCC cell lines (Met-1, Met-4, SCC-12, SCC-13, SCL-II) with a custom-built irradiation device mimicking the solar spectrum (UVB, UVA, visible light (VIS), and near-infrared (IRA))...
November 17, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37994026/circ_0006944-aggravates-lps-induced-hk2-cell-injury-via-modulating-mir-205-5p-ubl4a-pathway
#15
JOURNAL ARTICLE
Fan Zhou, Dong Liu, Junwei Ye, Bingqi Li
Circular RNAs (circRNAs) has been manifested to be involved in the development of human diseases, including sepsis-associated acute kidney injury (SA-AKI). However, the function and mechanism of circ_0006944 in SA-AKI has not been validated. Lipopolysaccharide (LPS) was utilised to induce AKI cell model. Levels of genes and proteins were monitored by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. Cell counting kit 8 assay, EdU assay and flow cytometry were exploited to estimate cell proliferation and apoptosis...
December 2023: Autoimmunity
https://read.qxmd.com/read/37950093/integrating-a-microrna-signature-as-a-liquid-biopsy-based-tool-for-the-early-diagnosis-and-prediction-of-potential-therapeutic-targets-in-pancreatic-cancer
#16
JOURNAL ARTICLE
Wenjie Shi, Thomas Wartmann, Sara Accuffi, Sara Al-Madhi, Aristotelis Perrakis, Christoph Kahlert, Alexander Link, Marino Venerito, Verena Keitel-Anselmino, Christiane Bruns, Roland S Croner, Yue Zhao, Ulf D Kahlert
INTRODUCTION: Pancreatic cancer is a highly aggressive cancer, and early diagnosis significantly improves patient prognosis due to the early implementation of curative-intent surgery. Our study aimed to implement machine-learning algorithms to aid in early pancreatic cancer diagnosis based on minimally invasive liquid biopsies. MATERIALS AND METHODS: The analysis data were derived from nine public pancreatic cancer miRNA datasets and two sequencing datasets from 26 pancreatic cancer patients treated in our medical center, featuring small RNAseq data for patient-matched tumor and non-tumor samples and serum...
November 10, 2023: British Journal of Cancer
https://read.qxmd.com/read/37894829/exosomal-mir-205-5p-improves-endometrial-receptivity-by-upregulating-e-cadherin-expression-through-zeb1-inhibition
#17
JOURNAL ARTICLE
Seong-Lan Yu, Da-Un Jeong, Eui-Jeong Noh, Hye Jin Jeon, Dong Chul Lee, Minho Kang, Tae-Hyun Kim, Sung Ki Lee, Ae Ra Han, Jaeku Kang, Seok-Rae Park
Endometrial receptivity is a complex process that prepares the uterine endometrium for embryo implantation; insufficient endometrial receptivity is one of the causes of implantation failure. Here, we analyzed the microRNA expression profiles of exosomes derived from both receptive (RL95-2) and non-receptive (AN3-CA) endometrial epithelial cell (EEC) lines to identify exosomal miRNAs closely linked to endometrial receptivity. Among the 466 differentially expressed miRNAs, miR-205-5p was the most highly expressed in exosomes secreted from receptive RL95-2 cells...
October 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37853466/circular-rna-fk501-binding-protein-51-boosts-bone-marrow-mesenchymal-stem-cell-proliferation-and-osteogenic-differentiation-via-modulating-microrna-205-5p-runt-associated-transcription-factor-2-axis
#18
JOURNAL ARTICLE
Yingchao Shen, Bo Jiang, Bin Luo, Xiaowei Jiang, Yang Zhang, Qiang Wang
OBJECTIVE: Osteogenesis is the key process of bone homeostasis differentiation. Numerous studies have manifested that circular RNA (circRNA) is a critical regulator of osteogenesis. The research was to explore circRNA-mediated mechanisms in osteogenesis. METHODS: Bone marrow mesenchymal stem cells (BMSCs) were cultured and induced to osteogenic differentiation (OD). Then, oe-circ-FKBP5, oe-NC, si-circ-FKBP5, si-NC, miR-205-5p mimic, mimic NC, miR-205-5p inhibitor, inhibitor NC, sh-RUNX2, or sh-NC were transfected into BMSCs...
October 18, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/37834189/loss-of-key-emt-regulating-mirnas-highlight-the-role-of-zeb1-in-egfr-tyrosine-kinase-inhibitor-resistant-nsclc
#19
JOURNAL ARTICLE
Linus Gohlke, Ahmad Alahdab, Angela Oberhofer, Karolina Worf, Stefan Holdenrieder, Martin Michaelis, Jindrich Cinatl, Christoph A Ritter
Despite recent advances in the treatment of non-small cell lung cancer (NSCLC), acquired drug resistance to targeted therapy remains a major obstacle. Epithelial-mesenchymal transition (EMT) has been identified as a key resistance mechanism in NSCLC. Here, we investigated the mechanistic role of key EMT-regulating small non-coding microRNAs (miRNAs) in sublines of the NSCLC cell line HCC4006 adapted to afatinib, erlotinib, gefitinib, or osimertinib. The most differentially expressed miRNAs derived from extracellular vesicles were associated with EMT, and their predicted target ZEB1 was significantly overexpressed in all resistant cell lines...
September 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37829327/retraction-notice-to-tnfaip8-promotes-cisplatin-chemoresistance-in-triple-negative-breast-cancer-by-repressing-p53-mediated-mir-205-5p-expression
#20
Hong-Yu Ma, Yang Li, Hui-Zi Yin, Hang Yin, Yuan-Yuan Qu, Qing-Yong Xu
[This retracts the article DOI: 10.1016/j.omtn.2020.09.025.].
December 12, 2023: Molecular Therapy. Nucleic Acids
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