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Taiichi Hikichi, Mitsuko Agarie
Purpose: To investigate macular vascular alterations by using optical coherence tomography angiography (OCTA) in patients with a history of long-term anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (nAMD). Methods: Japanese patients with nAMD with a history of long-term anti-VEGF monotherapy at study entry were studied retrospectively. OCTA images were obtained, and the vessel densities (mm-1) of the superficial capillary plexus, deep capillary plexus (DCP), choriocapillaris (CC), and the plexus foveal avascular zone area (mm2) were calculated...
March 1, 2019: Investigative Ophthalmology & Visual Science
Massimo Lorusso, Virginia Milano, Eleni Nikolopoulou, Luisa Micelli Ferrari, Maria Vittoria Cicinelli, Giuseppe Querques, Tommaso Micelli Ferrari
BACKGROUND AND OBJECTIVE: To quantify and compare the vessel density (VD) in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP), as well as the size of the foveal avascular zone (FAZ) in patients with proliferative diabetic retinopathy (PDR) before and after panretinal photocoagulation (PRP). PATIENTS AND METHODS: This prospective clinical study was conducted in the Department of Ophthalmology, Miulli Hospital Acquaviva delle Fonti, Italy...
March 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Brooke Hildebrand Clubbs, Alan R Barnette, Natallia Gray, Lauren Weiner, April Bond, Jane Harden, Roberta Pineda
BACKGROUND: Volunteers can provide staff-directed sensory inputs to infants hospitalized in the NICU, but research on volunteer programs is limited. PURPOSE: To evaluate the feasibility of a developmental care partner (DCP) program in a level III NICU and determine its relationship with provider burnout and infant infection rates. METHODS: DCPs were trained to provide sensory input to infants, based on the behavioral cues observed by the occupational therapists and nursing staff, in medically stable infants...
March 19, 2019: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Qingjiao Gong, Yun Liu, Zhi Dang
A novel core-shell structured Fe3 O4 @GO@MIL-100(Fe) magnetic catalyst was successfully synthesized and used as heterogeneous photo-Fenton catalyst for 2,4-dichlorophenl (2,4-DCP) degradation. The catalyst was fully characterized by X-ray diffraction pattern (XRD), Raman spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunner-Emmet-Teller (BET) and magnetic hysteresis loops measurements. The effects of initial pH, H2 O2 concentration, catalyst load and irradiation intensity on 2,4-DCP degradation were also investigated...
March 6, 2019: Journal of Hazardous Materials
Tudor C Tepelus, Sheena Song, Enrico Borrelli, Muneeswar G Nittala, Elmira Baghdasaryan, SriniVas R Sadda, Vikas Chopra
PRéCIS:: By using OCT-A, we observed a reduction of the superficial macular, peripapillary, and optic nerve, as well as the choriocapillaris in eyes with low tension glaucoma, compared with normal controls. PURPOSE: To investigate macular and optic disc vascular parameters in patients with low tension glaucoma (LTG) using optical coherence tomography angiography (OCTA). METHODS: In this cross-sectional study, images were prospectively acquired from both eyes of 26 patients with clinically-diagnosed LTG and 22 age-matched volunteers with normal healthy eyes using the Zeiss swept-source (SS) OCTA (Plex Elite 9000, Carl Zeiss Meditec)...
March 18, 2019: Journal of Glaucoma
José Ignacio Fernández-Vigo, Bachar Kudsieh, Ana Macarro-Merino, Pedro Arriola-Villalobos, José María Martínez-de-la-Casa, Julián García Feijóo, José Ángel Fernández-Vigo
PURPOSE: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). METHODS: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris...
March 12, 2019: European Journal of Ophthalmology
Min Wu, Zhaobo Liu, Aiying Zhang, Ning Li
BACKGROUND: Hepatocellular carcinoma is a serious health problem worldwide, especially in Asian countries, such as China. However, there are difficulties in diagnosing and treating hepatocellular carcinoma. The alteration of fucosylated proteins was closely associated with carcinogenesis. This study is designed to evaluate the early diagnostic value of associated detection of fucosylated alpha-fetoprotein (fuc-AFP), fucosylated des-γ-carboxy prothrombin (fuc-DCP), and fucosylated glypican 3 (fuc-GPC3) in hepatocellular carcinoma...
March 10, 2019: International Journal of Biological Markers
Maiko Yoshida, Hiroyuki Ogino, Hiromitsu Iwata, Yukiko Hattori, Shingo Hashimoto, Koichiro Nakajima, Shigeru Sasaki, Masaki Hara, Yoshitaka Sekido, Jun-Etsu Mizoe, Yuta Shibamoto
Transient increases in α-fetoprotein (AFP) and protein induced by vitamin K antagonist II (PIVKA-II), so-called flares, are frequently observed after treatment of hepatocellular carcinoma (HCC). In the present study, changes in AFP and PIVKA-II levels after proton therapy (PT), and the relationship between the flare phenomenon and clinical response were investigated. In 82 patients with stage I/II HCC (59 with no recurrence and 23 with out-of-field recurrence within 1 year), serum AFP and PIVKA-II levels were measured at 1, 3, 6, 9 and 12 months post-PT...
March 2019: Oncology Letters
Alaa Mansour, Lina Abu Nada, Haider Al-Waeli, Mohamed Amine Mezour, Mohamed-Nur Abdallah, Joseph M Kinsella, Jacqueline Kort-Mascort, Janet E Henderson, Jose Luis Ramirez-Garcialuna, Simon D Tran, Osama A Elkashty, Aisha Mousa, Amir A El-Hadad, Doaa Taqi, Faez Al-Hamad, Omar Alageel, Mari T Kaartinen, Faleh Tamimi
Immunomodulation strategies are believed to improve the integration and clinical performance of synthetic bone substitutes. One potential approach is the modification of biomaterial surface chemistry to mimic bone extracellular matrix (ECM). In this sense, we hypothesized that coating synthetic dicalcium phosphate (DCP) bioceramics with bone ECM proteins would modulate the host immune reactions and improve their regenerative performance. To test this, we evaluated the in vitro proteomic surface interactions and the in vivo performance of ECM-coated bioceramic scaffolds...
March 7, 2019: Acta Biomaterialia
M Ouederni, H Sassi, F Nefaa, A Kharroubi, N Kellil, M Cheour
INTRODUCTION: The purpose of our study was to describe the microvascular abnormalities on OCT-angiography in eyes with branch retinal vein occlusion (BRVO), to measure the surface of the foveal avascular zone (FAZ) and the capillary density, and to establish anatomic-functional correlations. METHODS: We conducted an observational prospective study in the ophthalmology department of Habib Thameur Hospital in Tunis, which included 17 eyes of patients with unilateral BRVO...
March 7, 2019: Journal Français D'ophtalmologie
Ahmed M Hagag, Jie Wang, Kevin Lu, Gareth Harman, Richard G Weleber, David Huang, Paul Yang, Mark E Pennesi, Yali Jia
PURPOSE: Using projection-resolved optical coherence tomographic angiography (PR-OCTA) to characterize the microvascular changes in 3 distinct retinal plexuses in retinitis pigmentosa (RP) patients. DESIGN: Prospective cross-sectional study. METHODS: A commercial 70-kHz spectral-domain OCT system (RTVue-XR, Optovue) was used to acquire 6mm macular scans from RP patients and age-matched healthy participants at a tertiary academic center. Blood flow was detected using a commercial version of split-spectrum amplitude decorrelation algorithm (SSADA)...
March 5, 2019: American Journal of Ophthalmology
Kazuki Orita, Akio Sakamoto, Takeshi Okamoto, Shuichi Matsuda
BACKGROUND Hepatocellular carcinoma (HCC) is a common primary hepatic cancer. Regardless of its metastatic potential, metastasis to skeletal muscle is rare, especially to one solitary muscle. The diagnostic efficiency of Protein induced by Vitamin K absence/antagonist-II (PIVKA-II) has been illustrated sufficiently and it has been proven that PIVKA-II is a potent biomarker and independent of alpha-fetoprotein (AFP). The present report describes a case of solitary muscle metastasis with PIVKA-II elevation. CASE REPORT An 81-year-old man noticed a growing mass in the proximal posterior thigh, and it was found to be a solitary tumor in the biceps femoris muscle...
March 8, 2019: American Journal of Case Reports
Sanjoy Kumar Sheet, Bhaskar Sen, Snehadrinarayan Khatua
In this work, cationic organoiridium(III) complex based photoluminescent (PL) probes have been developed to selectively detect the chemical warfare nerve agent mimic, diethyl chlorophosphate(DCP) at nanomolar range by distinct bright green to orange-red luminescence color switching (on-off-on) in solution as well as in the vapor phase. Interference of other chemical warfare agents (CWAs) and their mimics was not observed either by PL spectroscopy or with the naked-eye in solution and gas phase. The detection was attained via a simultaneous nucleophilic attack of two -OH groups of the 4,7-dihydroxy-1,10-phenanthroline ligand with DCP by forming bulkier phosphotriester...
March 7, 2019: Inorganic Chemistry
Raimondo Forte, Hanan Haulani, Agnieszka Dyrda, Ignasi Jürgens
PURPOSE: To evaluate swept source optical coherence tomography angiography (SS-OCTA) in patients treated with hydroxychloroquine (HCQ) for more than 5 years and to compare results with the tests currently recommended for screening of HCQ retinopathy. METHODS: In this controlled pilot study, consecutive patients treated with HCQ for more than 5 years underwent SS-OCTA, SS-OCT B-scan and en-face C-scan, fundus autofluorescence (FAF), 10-2 automated visual field (AVF) testing and multifocal electroretinography (mfERG)...
March 6, 2019: British Journal of Ophthalmology
Francesco C Blumetti, Jenny Chia Ning Wu, Federica Barzi, Matthias W Axt, Mary-Clare Waugh, Paulo Selber
BACKGROUND: Outcomes after orthopaedic interventions in patients with dystonic cerebral palsy (DCP) are historically regarded as unpredictable. This study aims to evaluate the overall outcome of orthopaedic surgery in children with DCP. METHOD: Children with DCP who underwent lower limb orthopaedic surgery with a minimum follow-up of 12 months were included. Data collected included age at time of surgery, surgical procedures performed, Gross Motor Function Classification System (GMFCS) level, and Barry Albright Dystonia Scale (BADS) score...
April 2019: Journal of Pediatric Orthopedics
Sakineh Barshan, Saeed Khalaji, Mahdi Hedayati, Mojtaba Yari
1. The current experiment was performed to elucidate the effects of degelatinised bone meal (DBM) in combination with different particle sizes of limestone or oyster shell on broiler performance, bone characteristics and digestive and plasma alkaline phosphatase (ALP) activity. 2. Treatments were applied as a 3 × 3 factorial arrangement with three sources of P (DCP, bone meal and DBM) and three particle sizes (50, 100 and 200 µm) of limestone. Chickens were given either DCP or DBM with oyster shell (523 µm), resulting in a total of 11 treatments with five replicates of eight chicks...
March 6, 2019: British Poultry Science
Magdalena Niestrata-Ortiz, Piotr Fichna, Witold Stankiewicz, Marcin Stopa
PURPOSE: Evaluation of foveal avascular zone (FAZ) in children with diabetes (DM) using OCTA. METHODS: We examined 112 diabetic children without DR aged 6-18 years and 30 age-matched controls using Topcon OCT Angiography and measured FAZ in superficial (SCP) and deep capillary plexus (DCP). The study group was divided into three subgroups depending on DM duration group 1: < 5 years (n = 40), group 2: 5-10 years (n = 42), group 3: > 10 years (n = 30)...
March 1, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Adam Gyedu, Barclay Stewart, Cameron Gaskill, Emmanuella Lebasaana Salia, Raymond Wadie, Peter Donkor, Charles Mock
INTRODUCTION: The Lancet Commission on Global Surgery proposed 5000 operations/100,000 people annually as a benchmark for developing countries but did not define benchmarks for different age groups. We evaluated the operation rate for elderly patients (≥65 years) in Ghana and estimated the unmet surgical need for the elderly by comparison to a high-income country benchmark. METHODS: Data on operations performed for elderly patients over a 1-year period in 2014-5 were obtained from representative samples of 48/124 small district hospitals and 12/16 larger referral hospitals and scaled-up for nationwide estimates...
March 1, 2019: World Journal of Surgery
Weichuan Qiao, Yunhao Zhang, Zhenyu Xie, Yang Luo, Xuansong Zhang, Cunxing Sang, Shuguang Xie, Jun Huang
As a persistent organic pollutant listed in the Stockholm Convention, perfluorooctane sulfonate (PFOS) is extremely refractory to degradation under ambient conditions. Its potential ecotoxicity has aroused great concerns and research interests. However, little is known about the toxicity of PFOS on fungus. In this study, the white rot fungus Phanerochaete chrysosporium (P. chrysosporium) was adopted to assess the toxicity of PFOS in liquid culture. The addition of 100 mg/L PFOS potassium salt significantly decreased the fungal biomass by up to 76...
February 26, 2019: Ecotoxicology and Environmental Safety
Chun-Sik Bae, Chul-Ho Yun, Taeho Ahn
In this study, it was demonstrated that 1,3-dichloro-2-propanol (1,3-DCP) induced oxidative stress and cell death in HuH7, human hepatocytes. The protective effects of Erythronium japonicum ( E. japonicum ) and Corylopsis coreana Uyeki ( C. coreana Uyeki) extracts against 1,3-DCP-treated cells were also investigated. First, the activities of superoxide dismutase (SOD) and catalase (CAT) were diminished by the treatment of 1,3-DCP. Moreover, 1,3-DCP stimulated the expression and catalytic activity of cytochrome P450 2E1 (CYP2E1), an enzyme that generates reactive oxygen species in the liver...
February 2019: Food Science and Biotechnology
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