Yan Lin, Hyeim Jung, Christina A Bulman, James Ng, Robin Vinck, Cillian O'Beirne, Matthew S Moser, Nancy Tricoche, Ricardo Peguero, Robert W Li, Joseph F Urban, Patrice Le Pape, Fabrice Pagniez, Marco Moretto, Tobias Weil, Sara Lustigman, Kevin Cariou, Makedonka Mitreva, Judy A Sakanari, Gilles Gasser
UNLABELLED: Drug resistance observed with many anti-infectives clearly highlights the need for new broad-spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic parasitic pathogens including fungal infections. Since these diseases target the most vulnerable communities who are disadvantaged by health and socio-economic factors, new agents should be, if possible, easy-to-prepare to allow for commercialization based on their low cost. In this study, we show that simple modification of one of the most well-known antifungal drugs, fluconazole, with organometallic moieties not only improves the activity of the parent drug but also broadens the scope of application of the new derivatives...
June 30, 2023: bioRxiv