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JOURNAL ARTICLE
J Galván Fraile, Franz Scherr, José J Ramasco, Anton Arkhipov, Wolfgang Maass, Claudio R Mirasso
In an ever-changing visual world, animals' survival depends on their ability to perceive and respond to rapidly changing motion cues. The primary visual cortex (V1) is at the forefront of this sensory processing, orchestrating neural responses to perturbations in visual flow. However, the underlying neural mechanisms that lead to distinct cortical responses to such perturbations remain enigmatic. In this study, our objective was to uncover the neural dynamics that govern V1 neurons' responses to visual flow perturbations using a biologically realistic computational model...
March 7, 2024: PLoS Computational Biology
#2
JOURNAL ARTICLE
Natalia Fernanda Pascual Gómez, María Del Pilar Sanz Martín, María Auxiliadora Semiglia Chong, Nelly Daniela Zurita Cruz, Rosa Méndez Hernández, Iñigo Guerra Molina, Iñigo García Sanz, Angels Figuerola Tejerina, Fernando Ramasco Rueda
The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures...
February 15, 2024: Journal of Personalized Medicine
#3
REVIEW
Fernando Ramasco, Jesús Nieves-Alonso, Esther García-Villabona, Carmen Vallejo, Eduardo Kattan, Rosa Méndez
Sepsis and septic shock are associated with high mortality, with diagnosis and treatment remaining a challenge for clinicians. Their management classically encompasses hemodynamic resuscitation, antibiotic treatment, life support, and focus control; however, there are aspects that have changed. This narrative review highlights current and avant-garde methods of handling patients experiencing septic shock based on the experience of its authors and the best available evidence in a context of uncertainty. Following the first recommendation of the Surviving Sepsis Campaign guidelines, it is recommended that specific sepsis care performance improvement programs are implemented in hospitals, i...
February 3, 2024: Journal of Personalized Medicine
#4
JOURNAL ARTICLE
Rosa Méndez, Angels Figuerola, Fernando Ramasco, Marta Chicot, Natalia F Pascual, Íñigo García, Andrés von Wernitz, Nelly D Zurita, Auxiliadora Semiglia, Alberto Pizarro, Carmen Saez, Diego Rodríguez
Sepsis is a time-dependent disease whose prognosis is influenced by early diagnosis and therapeutic measures. Mortality from sepsis remains high, and for this reason, the guidelines of the Surviving Sepsis Campaign recommend establishing specific care programs aimed at patients with sepsis. We present the results of the application of a hospital model to improve performance in sepsis care, called Princess Sepsis Code , with the aim of reducing mortality. A retrospective study was conducted using clinical, epidemiological, and outcome variables in patients diagnosed with sepsis from 2015 to 2022...
January 29, 2024: Journal of Personalized Medicine
#5
JOURNAL ARTICLE
G Tamayo Medel, F Ramasco Rueda, C Ferrando Ortolá, R González de Castro, R Ferrandis Comes, C Pastorini, R Méndez Hernández, J García Fernández
INTRODUCTION: It is essential to understand the strategic importance of intensive care resources in the sustainable organisation of healthcare systems. Our objective has been to identify the intensive and intermediate care beds managed by Anaesthesiology and Resuscitation Services (A-ICU and A-IMCU) in Spain, their human and technical resources, and the changes made to these resources during the COVID -19 pandemic. MATERIAL AND METHODS: Prospective observational study performed between December 2020 and July 2021 to register the number and characteristics of A-ICU and A-IMCU beds in hospitals listed in the catalogue published by the Spanish Ministry of Health...
January 25, 2024: Revista española de anestesiología y reanimación
#6
REVIEW
Fernando Ramasco, Rosa Méndez, Alejandro Suarez de la Rica, Rafael González de Castro, Emilio Maseda
The main recent change observed in the field of critical patient infection has been universal awareness of the need to make better use of antimicrobials, especially for the most serious cases, beyond the application of simple and effective formulas or rigid protocols. The increase in resistant microorganisms, the quantitative increase in major surgeries and interventional procedures in the highest risk patients, and the appearance of a significant number of new antibiotics in recent years (some very specifically directed against certain mechanisms of resistance and others with a broader spectrum of applications) have led us to shift our questions from "what to deal with" to "how to treat"...
January 18, 2024: Journal of Personalized Medicine
#7
REVIEW
F Ramasco, G Aguilar, C Aldecoa, J Bakker, P Carmona, D Dominguez, M Galiana, G Hernández, E Kattan, C Olea, G Ospina-Tascón, A Pérez, K Ramos, S Ramos, G Tamayo, G Tuero
Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK-2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation...
February 2024: Revista española de anestesiología y reanimación
#8
REVIEW
G Caldarelli, E Arcaute, M Barthelemy, M Batty, C Gershenson, D Helbing, S Mancuso, Y Moreno, J J Ramasco, C Rozenblat, A Sánchez, J L Fernández-Villacañas
We argue that theories and methods drawn from complexity science are urgently needed to guide the development and use of digital twins for cities. The theoretical framework from complexity science takes into account both the short-term and the long-term dynamics of cities and their interactions. This is the foundation for a new approach that treats cities not as large machines or logistic systems but as mutually interwoven self-organizing phenomena, which evolve, to an extent, like living systems.
May 2023: Nature computational science
#9
RANDOMIZED CONTROLLED TRIAL
Carlos Ferrando, Albert Carramiñana, Patricia Piñeiro, Lucia Mirabella, Savino Spadaro, Julián Librero, Fernando Ramasco, Gaetano Scaramuzzo, Oriol Cervantes, Ignacio Garutti, Ana Parera, Marta Argilaga, Gracia Herranz, Carmen Unzueta, Marc Vives, Kevin Regi, Marta Costa-Reverte, María Sonsoles Leal, Jesús Nieves-Alonso, Esther García, Aurelio Rodríguez-Pérez, Roberto Fariña, Sergio Cabrera, Elisabeth Guerra, Lucia Gallego-Ligorit, Alba Herrero-Izquierdo, J Vallés-Torres, Silvia Ramos, Daniel López-Herrera, Manuel De La Matta, Sertcakacilar Gokhan, Evrim Kucur, Ana Mugarra, Marina Soro, Laura García, José Alfonso Sastre, Pilar Aguirre, Claudia Jimena Salazar, María Carolina Ramos, Diego Rolando Morocho, Ramón Trespalacios, Félix Ezequiel-Fernández, Angella Lamanna, Leonarda Pia Cantatore, Donato Laforgia, Soledad Bellas, Carlos López, Ricard Navarro-Ripoll, Samira Martínez, Jordi Vallverdú, Adriana Jacas, María José Yepes-Temiño, Francisco Javier Belda, Gerardo Tusman, Fernando Suárez-Sipmann, Jesús Villar
BACKGROUND: It is uncertain whether individualisation of the perioperative open-lung approach (OLA) to ventilation reduces postoperative pulmonary complications in patients undergoing lung resection. We compared a perioperative individualised OLA (iOLA) ventilation strategy with standard lung-protective ventilation in patients undergoing thoracic surgery with one-lung ventilation. METHODS: This multicentre, randomised controlled trial enrolled patients scheduled for open or video-assisted thoracic surgery using one-lung ventilation in 25 participating hospitals in Spain, Italy, Turkey, Egypt, and Ecuador...
March 2024: Lancet Respiratory Medicine
#10
JOURNAL ARTICLE
A Pérez Lucendo, P Piñeiro Otero, P Matía Almudévar, S Alcántara Carmona, E López López, F Ramasco Rueda
This group is a product of the collaboration agreement signed by SOMIAMA (Sociedad de Medicina Intensiva de Madrid) and SAR MADRID (Sociedad de Anestesiología, Reanimación y Terapéutica del Dolor de Madrid) under which the organisations agreed to create joint working groups to improve critical patient care. Pain, discomfort, agitation, and delirium cause suffering, delay discharge, and can lead to serious complications in patients admitted to medical and surgical critical care units and post-anaesthesia care units...
September 22, 2023: Revista española de anestesiología y reanimación
#11
JOURNAL ARTICLE
Fernando Ramasco Rueda, Antonio Planas Roca, Rosa Méndez Hernández, Angels Figuerola Tejerina, Eduardo Tamayo Gómez, Carlos Garcia Bernedo, Emilio Maseda Garrido, Natalia F Pascual Gómez, Olga de la Varga-Martínez
The need for postoperative organic support is associated with patient outcomes. Biomarkers may be useful for detecting patients at risk. MR-ProADM is a novel biomarker with an interesting profile that can be used in this context. The main objective of this study was to verify whether there was an association between the preoperative serum levels of MR-ProADM and the need for organic support after elective abdominal cancer surgery, and to determine the preoperative MR-ProADM value that predicts the need for postoperative organic support...
July 18, 2023: Journal of Personalized Medicine
#12
JOURNAL ARTICLE
J Ripollés-Melchor, M J Colomina, C Aldecoa, J Alonso-Cabello, J M Alonso-Íñigo, H Aya, M Basora, F Clau-Terre, E Del Cojo-Peces, F Cota-Delgado, R Ferrandis-Comes, P Galán-Menéndez, D García-López, I Garruti, I J López, J L Jover-Pinillos, J V Llau-Pitarch, J V Lorente, J Mesquida, I Mojarro, M I Monge-García, S C Montesinos-Fadrique, J L Muñoz-Rodes, M de Nadal, F Ramasco, J L Tomé-Roca, A Pérez, R Uña-Orejón, G Yanes, A Zorrilla-Vaca, D Escarraman, J García-Fernández
BACKGROUND: Research in fluid therapy and perioperative hemodynamic monitoring is difficult and expensive. The objectives of this study were to summarize these topics and to prioritize these topics in order of research importance. METHODS: Electronic structured Delphi questionnaire over three rounds among 30 experts in fluid therapy and hemodynamic monitoring identified through the Fluid Therapy and Hemodynamic Monitoring Subcommittee of the Hemostasis, Transfusion Medicine and Fluid Therapy Section of the Spanish Society of Anesthesiology and Critical Care...
June 4, 2023: Revista española de anestesiología y reanimación
#13
JOURNAL ARTICLE
Johann H Martínez, José J Ramasco, Massimiliano Zanin
Entropy and time asymmetry are two intertwined aspects of a system's dynamics, with the production of entropy marking a clear direction in the temporal dimension. In the last few years, metrics to quantify both properties in time series have been designed around the same concept, i.e., the use of ordinal patterns. In spite of this, the relationship between these two families of metrics is yet not well understood. In this contribution, we study this problem by constructing an entropy-time asymmetry plane and evaluating it on a large set of synthetic and real-world time series...
March 2023: Chaos
#14
JOURNAL ARTICLE
Mattia Mazzoli, Riccardo Gallotti, Filippo Privitera, Pere Colet, José J Ramasco
Proximity social interactions are crucial for infectious diseases transmission. Crowded agglomerations pose serious risk of triggering superspreading events. Locations like transportation hubs (airports and stations) are designed to optimize logistic efficiency, not to reduce crowding, and are characterized by a constant in and out flow of people. Here, we analyze the paradigmatic example of London Heathrow, one of the busiest European airports. Thanks to a dataset of anonymized individuals' trajectories, we can model the spreading of different diseases to localize the contagion hotspots and to propose a spatial immunization policy targeting them to reduce disease spreading risk...
March 20, 2023: Nature Communications
#15
JOURNAL ARTICLE
David Abella, Maxi San Miguel, José J Ramasco
We study the non-Markovian effects associated with aging for binary-state dynamics in complex networks. Aging is considered as the property of the agents to be less prone to change their state the longer they have been in the current state, which gives rise to heterogeneous activity patterns. In particular, we analyze aging in the Threshold model, which has been proposed to explain the process of adoption of new technologies. Our analytical approximations give a good description of extensive Monte Carlo simulations in Erdős-Rényi, random-regular and Barabási-Albert networks...
February 2023: Physical Review. E
#16
REVIEW
Rosa Méndez Hernández, Fernando Ramasco Rueda
A biomarker is a molecule that can be measured in a biological sample in an objective, systematic, and precise way, whose levels indicate whether a process is normal or pathological. Knowing the most important biomarkers and their characteristics is the key to precision medicine in intensive and perioperative care. Biomarkers can be used to diagnose, in assessment of disease severity, to stratify risk, to predict and guide clinical decisions, and to guide treatments and response to them. In this review, we will analyze what characteristics a biomarker should have and how to ensure its usefulness, and we will review the biomarkers that in our opinion can make their knowledge more useful to the reader in their clinical practice, with a future perspective...
February 15, 2023: Journal of Personalized Medicine
#17
JOURNAL ARTICLE
Alex Giménez-Romero, Javier Galván, Marina Montesinos, Joan Bauzà, Martin Godefroid, Alberto Fereres, José J Ramasco, Manuel A Matías, Eduardo Moralejo
The vector-borne bacterium Xylella fastidiosa is responsible for Pierce's disease (PD), a lethal grapevine disease that originated in the Americas. The international plant trade is expanding the geographic range of this pathogen, posing a new threat to viticulture worldwide. To assess the potential incidence of PD, we have built a dynamic epidemiological model based on the response of 36 grapevine varieties to the pathogen in inoculation assays and on the vectors' distribution when this information is available...
December 20, 2022: Communications Biology
#18
JOURNAL ARTICLE
Ana Pérez-Manrique, Juan Fernández-Gracia, Antoni Gomila, José J Ramasco
Networks in biology have provided a powerful tool to describe and study very complex biological processes and systems such as animal societies. Social network analysis allows us to assess different processes occurring in animal groups. In the current study, we use this approach to investigate how conflict dynamics and post-conflict interactions shape the social networks of groups of captive bottlenose dolphins. We first examined temporal changes and aggression-affiliation motifs in the observed dolphins' network structure...
November 16, 2022: Scientific Reports
#19
JOURNAL ARTICLE
David Abella, Maxi San Miguel, José J Ramasco
The Schelling model has become a paradigm in social sciences to explain the emergence of residential spatial segregation, even in the presence of high tolerance to mixed neighborhoods by the side of citizens. In particular, we consider a noisy constrained version of the Schelling model, in which agents maximize its satisfaction, related to the composition of the local neighborhood, by infinite-range movements towards satisfying vacancies. We add to it an aging effect by making the probability of agents to move inversely proportional to the time they have been satisfied in their present location...
November 12, 2022: Scientific Reports
#20
JOURNAL ARTICLE
Elsa Arcaute, José J Ramasco
Cities are characterized by the presence of a dense population with a high potential for interactions between individuals of diverse backgrounds. They appear in parallel to the Neolithic revolution a few millennia ago. The advantages brought in terms of agglomeration for economy, innovation, social and cultural advancements have kept them as a major landmark in recent human history. There are many different aspects to study in urban systems from a scientific point of view, one can concentrate in demography and population evolution, mobility, economic output, land use and urban planning, home accessibility and real estate market, energy and water consumption, waste processing, health, education, integration of minorities, just to name a few...
2022: PloS One
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