Yadong Wang, Zhicheng Huang, Bowen Li, Jianchao Xue, Chao Guo, Zhongxing Bing, Zhibo Zheng, Yang Song, Yuan Xu, Guanghua Huang, Haochen Li, Xiaoqing Yu, Yankai Xia, Ruirui Li, Xiaoyan Si, Li Zhang, Ji Li, Lan Song, Yuanyuan Xiong, Dejian Gu, Mengmeng Song, Zhipeng Zhou, Rongrong Chen, Zhe Feng, Zhixin Bie, Xiaoguang Li, Huaxia Yang, Shanqing Li, Naixin Liang
The increase in the detection rate of synchronous multiple primary lung cancer (MPLC) has posed remarkable clinical challenges due to the limited understanding of its pathogenesis and molecular features. Here, comprehensive comparisons of genomic and immunologic features between MPLC and solitary lung cancer nodule (SN), as well as different lesions of the same patient, were performed. Compared with SN, MPLC displayed a lower rate of EGFR mutation but higher rates of BRAF, MAP2K1, and MTOR mutation, which function exactly in the upstream and downstream of the same signaling pathway...
April 26, 2024: Cancer Immunology, Immunotherapy: CII