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https://read.qxmd.com/read/30771550/cannabis-for-refractory-epilepsy-in-children-a-review-focusing-on-cdkl5-deficiency-disorder
#1
REVIEW
Tristan Dale, Jenny Downs, Heather Olson, Ann Marie Bergin, Stephanie Smith, Helen Leonard
Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative treatments. Cannabis based products have attracted significant attention over recent years, primarily driven by reports of miraculous cures and a renewed public preference for 'natural' therapies, thus placing intense pressure on health professionals and the government for regulatory change...
February 5, 2019: Epilepsy Research
https://read.qxmd.com/read/30769936/disinfection-by-products-and-ecotoxic-risk-associated-with-hypochlorite-treatment-of-tramadol
#2
Valeria Romanucci, Antonietta Siciliano, Emilia Galdiero, Marco Guida, Giovanni Luongo, Renato Liguori, Giovanni Di Fabio, Lucio Previtera, Armando Zarrelli
In recent years, many studies have highlighted the consistent finding of tramadol (TRA) in the effluents from wastewater treatment plants (WTPs) and also in some rivers and lakes in both Europe and North America, suggesting that TRA is removed by no more than 36% by specific disinfection treatments. The extensive use of this drug has led to environmental pollution of both water and soil, up to its detection in growing plants. In order to expand the knowledge about TRA toxicity as well as the nature of its disinfection by-products (DBPs), a simulation of the waste treatment chlorination step has been reported herein...
February 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30769917/plant-natural-products-for-human-health
#3
EDITORIAL
Chun-Tao Che, Hongjie Zhang
The aim of this Special Issue on "Plant Natural Products for Human Health" is to compile a series of scientific reports to demonstrate the medicinal potential of plant natural products, such as in vitro and in vivo activities, clinical effects, mechanisms of action, structure-activity relationships, and pharmacokinetic properties. With the global trend growing in popularity for botanical dietary supplements and phytopharmaceuticals, it is hoped that this Special Issue would serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications...
February 15, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30769776/increased-phenolic-content-and-enhanced-antioxidant-activity-in-fermented-glutinous-rice-supplemented-with-fu-brick-tea
#4
Xiao Xu, Wenxiu Hu, Siduo Zhou, Chuanhai Tu, Xiudong Xia, Juanmei Zhang, Mingsheng Dong
Glutinous rice-based foods have a long history are consumed worldwide. They are also in great demand for the pursuit of novel sensory and natural health benefits. In this study, we developed a novel fermented glutinous rice product with the supplementation of Fu brick tea. Using in vitro antioxidant evaluation and phenolic compounds analysis, fermentation with Fu brick tea increased the total phenolic content and enhanced the antioxidant activity of glutinous rice, including scavenging of 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radical, 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical, and hydroxyl radical, ferric-reducing antioxidant power, and ferric ion reducing power and iron chelating capability...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30767730/recent-development-on-anti-obesity-compounds-and-their-mechanisms-of-action-a-review
#5
Yixing Qiu, Huanghe Yu, Rong Zeng, Shiyin Guo, Muhammad Daniyal, Zeyu Deng, Aibing Wang, Wei Wang
Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. In spite of the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of novel and known compounds have at least partially been revealed...
February 14, 2019: Current Medicinal Chemistry
https://read.qxmd.com/read/30767497/flexible-electronics-toward-wearable-sensing
#6
Wei Gao, Hiroki Ota, Daisuke Kiriya, Kuniharu Takei, Ali Javey
Wearable sensors play a crucial role in realizing personalized medicine, as they can continuously collect data from the human body to capture meaningful health status changes in time for preventive intervention. However, motion artifacts and mechanical mismatches between conventional rigid electronic materials and soft skin often lead to substantial sensor errors during epidermal measurement. Because of its unique properties such as high flexibility and conformability, flexible electronics enables a natural interaction between electronics and the human body...
February 15, 2019: Accounts of Chemical Research
https://read.qxmd.com/read/30764815/comparison-of-individual-group-and-environmental-sampling-strategies-to-conduct-influenza-surveillance-in-pigs
#7
Jorge Garrido-Mantilla, Julio Alvarez, Marie Culhane, Jayaveeramuthu Nirmala, Jean Paul Cano, Montserrat Torremorell
BACKGROUND: Influenza A virus (IAV) is an important pathogen in pigs that affects productivity and has important public health implications because of its zoonotic nature. Surveillance is central to the control of influenza, however, detection of IAV infections can be challenging in endemically infected herds with low prevalence of infection. METHODS: In groups of suckling (18-21 days of age) and growing (35-45 days of age) pigs, we compared various sampling approaches to detect, isolate and sequence IAV using individual (nasal swabs, nasal wipes and oropharyngeal swabs), group (oral fluids, surface wipes and sow udder skin wipes) and environmental (airborne particles deposited on surfaces and air samples) sampling approaches...
February 14, 2019: BMC Veterinary Research
https://read.qxmd.com/read/30763762/discovery-of-ndm-1-inhibitors-from-natural-products
#8
Cheng Shi, Jiaxing Chen, Bin Xiao, Xinyue Kang, Xingzhen Lao, Heng Zheng
OBJECTIVES: Human health is seriously threatened by metallo-beta-lactamase(MBL)-mediated bacterial resistance. Among them, the New Delhi metallo-beta-lactamase-1(NDM-1) has received great attention due to its extensive substrate specificity and high lateral gene transfer. Currently there is no inhibitor of NDM-1 available in clinical therapy, thus making an argent need for the research and development of novel NDM-1 inhibitors. METHODS: A natural compound library was screened to determine potential inhibitors of NDM-1 based on the crystal structure of NDM-1...
February 11, 2019: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/30761172/identification-of-three-iso-flavonoid-glucosyltransferases-from-pueraria-lobata
#9
Xin Wang, Changfu Li, Zilin Zhou, Yansheng Zhang
(Iso)flavonoids are one of the largest groups of natural phenolic products conferring great value to the health of plants and humans. Pueraria lobata , a legume, has long been used in Chinese traditional medicine. (Iso)flavonoids mainly present as glycosyl-conjugates and accumulate in P. lobata roots. However, the molecular mechanism underlying the glycosylation processes in (iso)flavonoid biosynthesis are not fully understood. In the current study, three novel UDP-glycosyltransferases (PlUGT4, PlUGT15, and PlUGT57) were identified in P...
2019: Frontiers in Plant Science
https://read.qxmd.com/read/30759801/engineering-of-fatty-acid-synthases-fass-to-boost-the-production-of-medium-chain-fatty-acids-mcfas-in-mucor-circinelloides
#10
Syed Ammar Hussain, Ahsan Hameed, Md Ahsanul Kabir Khan, Yao Zhang, Huaiyuan Zhang, Victoriano Garre, Yuanda Song
Increasing energy demands and health-related concerns worldwide have motivated researchers to adopt diverse strategies to improve medium-chain fatty acid (MCFA) biosynthesis for use in the functional food and aviation industries. The abundance of naturally produced MCFAs from botanical sources (i.e., coconut fruit/seeds and palm tree) has been observed to be insufficient compared with the various microorganisms used to cope with industrial demands. Mucor circinelloides is one of many promising microorganisms; it exhibits diverse biotechnological importance ranging from the production of functional lipids to applications in the manufacture of bio-fuel...
February 12, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30759597/assessment-of-the-geographical-detector-method-for-investigating-heavy-metal-source-apportionment-in-an-urban-watershed-of-eastern-china
#11
Lili Luo, Kun Mei, Liyin Qu, Chi Zhang, Han Chen, Siyu Wang, Di Di, Hong Huang, Zhenfeng Wang, Fang Xia, Randy A Dahlgren, Minghua Zhang
Assessing heavy metal pollution in river sediments and identifying the key factors contributing to metal pollution are critical components for devising river environmental protection and remediation strategies to protect human and ecological health. This is especially important in urban areas where metals from a wide range of sources contribute to sediment pollution. In this study, the metal enrichment factor (EF) was used to measure the watershed distribution of Cu, Zn, Pb and Cd in sediments in the Wen-Rui Tang urban river system in Wenzhou, Eastern China...
February 25, 2019: Science of the Total Environment
https://read.qxmd.com/read/30758279/the-impact-of-organic-vs-inorganic-selenium-on-dairy-goat-productivity-and-expression-of-selected-genes-in-milk-somatic-cells
#12
Daria Reczyńska, Bożena Witek, Justyna Jarczak, Michał Czopowicz, Marcin Mickiewicz, Jarosław Kaba, Lech Zwierzchowski, Emilia Bagnicka
The aim of this study was to determine the effect of diet supplemented with selenized yeast (Se-yeast) on milk yield and milk composition of goats and expression of casein and mammary-gland-immune system genes in milk somatic cells (MSC). Twenty-four dairy goats in their second to fourth lactations were divided into control and experimental groups, balanced according to lactation number and breed (Polish White or Fawn Improved). Morning milk and blood samples were collected four times during lactation (on the 21st, 70th, 120th, 180th day after kidding)...
February 13, 2019: Journal of Dairy Research
https://read.qxmd.com/read/30755770/nutraceuticals-inspiring-the-current-therapy-for-lifestyle-diseases
#13
REVIEW
Silpi Chanda, Raj Kumar Tiwari, Arun Kumar, Kuldeep Singh
Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value. Such a product is designed to improve the physical health, fight against day-to-day challenges such as stress, increase longevity, etc. Nowadays, emphasis is given to those herbs which are used as food and medicine due to its greater acceptance. Due to dynamic action, the popularity of nutraceuticals among people as well as healthcare providers has been increased over medicines and health supplements...
2019: Advances in Pharmacological Sciences
https://read.qxmd.com/read/30744641/a-bibliometric-analysis-of-health-related-literature-on-natural-disasters-from-1900-to-2017
#14
Waleed M Sweileh
BACKGROUND: Worldwide, natural disasters have caused a large number of deaths and considerable morbidity. Nevertheless, limited information is available on how the health-related literature on natural disasters has evolved. The current study aims to assess the growth and pattern of health-related literature on natural disasters. METHOD: A bibliometric method was implemented using Scopus database for the period from 1900 to 2017. Keywords used in the search strategy were obtained from the classifications of natural disasters presented by the Centre for Research on the Epidemiology of Disasters...
February 11, 2019: Health Research Policy and Systems
https://read.qxmd.com/read/30744001/impact-of-biogenic-amines-on-food-quality-and-safety
#15
REVIEW
Claudia Ruiz-Capillas, Ana M Herrero
Today, food safety and quality are some of the main concerns of consumer and health agencies around the world. Our current lifestyle and market globalization have led to an increase in the number of people affected by food poisoning. Foodborne illness and food poisoning have different origins (bacteria, virus, parasites, mold, contaminants, etc.), and some cases of food poisoning can be traced back to chemical and natural toxins. One of the toxins targeted by the Food and Drug Administration (FDA) and European Food Safety Authority (EFSA) is the biogenic amine histamine...
February 8, 2019: Foods (Basel, Switzerland)
https://read.qxmd.com/read/30743235/biomass-burning-contribution-to-pm-10-concentration-in-rome-italy-seasonal-daily-and-two-hourly-variations
#16
C Perrino, L Tofful, S Dalla Torre, T Sargolini, S Canepari
The possibility of a relevant contribution of biomass burning for domestic heating to PM10 in the urban area of Rome was explored. The concentration of levoglucosan was determined for 31 months in Rome and in a nearby peri-urban area. During the cold season it reached several hundreds of ng/m3 at both sites, with a clear inverse relationship with air temperature. During the summer it remained well below 100 ng/m3 . Although at the peri-urban station the concentration was about 50% higher than at the urban site, the two seasonal patterns show a very good agreement (R2  = 0...
February 6, 2019: Chemosphere
https://read.qxmd.com/read/30739280/effect-of-incorporating-white-red-or-black-quinoa-flours-on-free-and-bound-polyphenol-content-antioxidant-activity-and-colour-of-bread
#17
Jaime Ballester-Sánchez, Jose Vicente Gil, Claudia Monika Haros, María Teresa Fernández-Espinar
Interest in quinoa as a functional food ingredient is currently emerging. The flours from white, red and black quinoa seeds were analysed in terms of total polyphenol content and antioxidant activity. They were incorporated at 25% on flour basis into the bread dough formula to evaluate their potential to improve the functional properties of wheat breads. The contribution of extractable polyphenols (soluble forms) and the largely unexplored hydrolysable polyphenols (bound forms that can be found in the residues of the former) were taken into account to reflect a realistic health-promoting potential of breads...
February 9, 2019: Plant Foods for Human Nutrition
https://read.qxmd.com/read/30738430/trans-vaccenic-acid-inhibits-proliferation-and-induces-apoptosis-of-human-nasopharyngeal-carcinoma-cells-via-a-mitochondrial-mediated-apoptosis-pathway
#18
Jian Song, Yujie Wang, Xiaoqin Fan, Hanwei Wu, Jinghong Han, Ming Yang, Lu Lu, Guohui Nie
BACKGROUND: Intake of trans fatty acids (TFAs) from partially hydrogenated vegetable oil is associated with a variety of adverse outcomes, but little is known about the health effects of ruminant trans fats. Trans-vaccenic acid (TVA) is a naturally occurring TFA found in the fat of ruminants and in human dairy products. The present study was conducted to investigate the anticancer activity and underlying mechanisms of TVA on human nasopharyngeal carcinoma (NPC) 5-8F and CNE-2 cells. METHODS: A CCK8 assay was used to determine the effect of TVA and the Mcl-1 inhibitor S63845 on the proliferation of NPC cells...
February 9, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/30736354/chronic-in-vivo-effects-of-repeated-exposure-to-low-oral-doses-of-tetrodotoxin-preliminary-evidence-of-nephrotoxicity-and-cardiotoxicity
#19
Andrea Boente-Juncal, Carmen Vale, Manuel Cifuentes, Paz Otero, Mercedes Camiña, Mercedes Rodriguez-Vieytes, Luis Miguel Botana
Tetrodotoxin (TTX) is one of the most potent naturally occurring neurotoxins. InitiallyTTX was associated with human food intoxications in Japan, but nowadays, concerns about thehuman health risks posed by TTX have increased in Europe after the identification of the toxin infish, marine gastropods, and bivalves captured in European waters. Even when TTX monitoring isnot currently performed in Europe, an acute oral no observable effect level (NOAEL) of 75 μg/kghas been recently established but, to date, no studies evaluating the chronic oral toxicity of TTXhave been released, even when EFSA has highlighted the need for them...
February 6, 2019: Toxins
https://read.qxmd.com/read/30735144/evaluating-the-quality-of-health-information-in-a-changing-digital-ecosystem
#20
Alla Keselman, Catherine Arnott Smith, Anita C Murcko, David R Kaufman
BACKGROUND: Critical evaluation of online health information has always been central to consumer health informatics. However, with the emergence of new Web media platforms and the ubiquity of social media, the issue has taken on a new dimension and urgency. At the same time, many established existing information quality evaluation guidelines address information characteristics other than the content (eg, authority and currency), target information creators rather than users as their main audience, or do not address information presented via novel Web technologies...
February 8, 2019: Journal of Medical Internet Research
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