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Melatonin and muscle

Gaia Favero, Francesca Bonomini, Caterina Franco, Rita Rezzani
Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis is consistent with mitochondrial dysfunction and oxidative stress, we evaluated the pathophysiological correlation among these factors studying some proteins involved in the mitochondrial homeostasis. We focused our attention on the roles of peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α), mitofusin2 (Mfn2), and coenzyme Q10 (CoQ10) in reserpine-induced myalgic (RIM) rats that manifest fibromyalgia-like chronic pain symptoms...
February 11, 2019: International Journal of Molecular Sciences
Keisuke Obara, Lin Ao, Tsukasa Ogawa, Takumi Ikarashi, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio Tanaka
The present study aimed to investigate the potential inhibitory effects of 21 clinically available hypnotics on acetylcholine (ACh)-induced contractions in rat urinary bladder smooth muscle (UBSM) in order to predict whether these hypnotics could induce voiding impairment. ACh-induced contraction in rat UBSM was inhibited only by diphenhydramine (a histamine H1 receptor antagonist) at a concentration that was clinically relevant. ACh-induced contraction was also significantly inhibited by flurazepam (a benzodiazepine hypnotic) and suvorexant (an orexin receptor antagonist), albeit at concentrations that substantially exceeded clinically achievable blood levels...
2019: Biological & Pharmaceutical Bulletin
Hung-Yuan Li, Yann-Lii Leu, Ya-Chieh Wu, Shu-Huei Wang
Chronic inflammation and proliferation play important roles in atherosclerosis progression. This study aimed to identify the mechanisms responsible for the anti-inflammatory and antiproliferative effects of melatonin on tumor necrosis factor-α (TNF-α)- and platelet-derived growth factor-BB (PDGF-BB)-treated rat aortic smooth muscle cells (RASMCs). Melatonin reduced TNF-α-induced RASMC inflammation by decreasing vascular cell adhesion molecule-1 (VCAM-1) expression and nuclear factor-kappa B (NF-κB) P65 activity by inhibiting P38 mitogen-activated protein kinase phosphorylation (P < 0...
January 20, 2019: Journal of Agricultural and Food Chemistry
Bohan Rong, Ruonan Feng, Chenlong Liu, Qiong Wu, Chao Sun
Adipocyte-derived exosomes (Exos) serve as bioinformation-containing messengers in cell-to-cell communications, and numerous reports demonstrate that resistin, an adipokine, is strongly associated with hepatic steatosis and other fatty liver diseases, suggesting that adipose dysfunction-generated altered pattern of exosomal cytokines may contribute to shaping the physiological activities in liver. Admittedly, melatonin-mediated positive effects on various tissues/organs have been respectively reported, but regulatory mechanisms of melatonin on the crosstalk between adipose tissue and liver have been investigated rarely...
January 19, 2019: Journal of Pineal Research
Samuel Gbadebo Olukole, Damilare Olaniyi Lanipekun, Eunice Olufunke Ola-Davies, Bankole Olusiji Oke
This study investigated the role of melatonin (MLT) on adrenal gland toxicity induced by bisphenol A (BPA). Adult male rats were divided into four groups of seven animals each: Group I (control) received oral 0.2 ml canola oil; group II received intra-peritoneal 10 mg/kg BW/day MLT; and group III received oral BPA (10 mg/kg BW/day). Group IV rats were treated with same dose of BPA as group III with a concomitant intra-peritoneal 10 mg/kg BW/day MLT. All treatments lasted for 14 days. BPA significantly increased (P < 0...
January 6, 2019: Environmental Science and Pollution Research International
Deniz Tuna Edizer, Zehra Dönmez, Mehmet Gül, Özgür Yiğit, Birgül Yiğitcan, Turgut Adatepe, Nurten Uzun
OBJECTIVES: To investigate the effects of topical and systemic administrations of melatonin and dexamethasone on facial nerve regeneration. MATERIALS AND METHODS: In total, 50 male albino Wistar rats underwent facial nerve axotomy and neurorrhaphy. The animals were divided into 5 groups: control, topical melatonin, systemic melatonin, topical dexamethasone, and systemic dexamethasone. Nerve conduction studies were performed preoperatively and at 3, 6, 9, and 12 weeks after drug administrations...
December 12, 2018: Journal of International Advanced Otology
Wen-Lai Guo, Zhi-Ping Qi, Li Yu, Tian-Wen Sun, Wen-Rui Qu, Qian-Qian Liu, Zhe Zhu, Rui Li
After nerve-root avulsion injury of the brachial plexus, oxidative damage, inflammatory reaction, and glial scar formation can affect nerve regeneration and functional recovery. Melatonin (MT) has been shown to have good anti-inflammatory, antioxidant, and neuroprotective effects. Chondroitin sulfate ABC (ChABC) has been shown to metabolize chondroitin sulfate proteoglycans and can reduce colloidal scar formation. However, the effect of any of these drugs alone in the recovery of nerve function after injury is not completely satisfactory...
February 2019: Neural Regeneration Research
Cristian Augusto Ostjen, Carlos Gustavo Sakuno Rosa, Renata Minuzzo Hartmann, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Norma Possa Marroni
In recent decades, the number of people who practice sports has grown exponentially, increasing the number of muscular injuries. Trauma injury occurs when the muscle is exposed to a sudden compression force. Melatonin (MLT) has often been cited in the literature as a potent antioxidant and anti-inflammatory agent. This study was designed to evaluate MLT action on muscle tissue in Wistar rats in an experimental model of muscle trauma. Twenty-eight Wistar rats were used, divided into four groups: CO (Control), CO + MLT (Control + Melatonin), T (Trauma) and T + MLT (Trauma + Melatonin)...
December 3, 2018: Experimental and Molecular Pathology
Yasemin Behram Kandemir, Ünal Guntekin, Veysel Tosun, Necmettin Korucuk, Mehmet Nuri Bozdemir
The aim of the present study is to investigate if the melatonin has any protective effect on diabetic cardiomyopathy and antioxidant enzymes via phosphorylation of vascular endothelial growth factor-A (VEGF-A). A total of 40 male Wistar rats were enrolled in the study. Rats were divided into four groups: group 1 (control, n=10), group 2 (DM, n=10), group 3 (melatonin, n=10), and group 4 (melatonin+DM, n=10). Melatonin was injected intraperitoneally at a dose of 50 mg/kg/day for 56 days to group 3 and group 4...
November 30, 2018: Cellular and Molecular Biology
Silvia Bona, Graziella Rodrigues, Andrea J Moreira, Fábio C Di Naso, Alexandre S Dias, Thêmis R Da Silveira, Claudio A Marroni, Norma P Marroni
Background and Aim: Liver diseases are a major public health problem, accounting for a significant number of hospital visits and admissions and an increasing mortality rate. Melatonin (MLT) is a powerful antioxidant molecule that has been shown to be beneficial under various conditions. The objective was to evaluate the effect of MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl4 ) in rats. Methods: Twenty male Wistar rats (230-250 g) were divided into four groups...
August 2018: JGH open: an open access journal of gastroenterology and hepatology
Dušan T Sokolović, Ljubiša Lilić, Vesko Milenković, Rade Stefanović, Tatjana Popović Ilić, Branimir Mekić, Igor Ilić, Nikola M Stojanović, Ivan R Ilić
Animal models demonstrating skeletal muscle (SM) disorders are rarely investigated, although these disorders accompany liver disorders and can occur during prolonged exercise/training. In cases of SM disorders exogenous antioxidants, such as melatonin, could help by generally improving tissues antioxidant capacities. We aimed to analyze the potential of melatonin in preventing biochemical and structural changes in rat biceps muscle (BM) occurring after an acute exposure to carbon tetrachloride (CCl4 ). Biceps muscles obtained from male Wistar rats belonging to different experimental groups were biochemically (determination of tissue MDA, total antioxidant capacity, GSH, CAT, SOD and GPx activities) and pathologically analyzed...
November 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Jennifer E Hewitt, Amelia K Pollard, Leila Lesanpezeshki, Colleen S Deane, Christopher J Gaffney, Timothy Etheridge, Nathaniel J Szewczyk, Siva A Vanapalli
Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying mechanisms and treatments of muscular dystrophies, analogous strength-based measurements in this disease model are lacking. Here we describe the first demonstration of the direct measurement of muscular strength in dystrophin-deficient C. elegans mutants using a micropillar-based force measurement system called NemaFlex...
November 5, 2018: Disease Models & Mechanisms
Zhaoxia Xu, Ying Wu, Yanyan Zhang, Huirong Zhang, Lijun Shi
The pineal hormone melatonin is a neuroendocrine hormone with high membrane permeability that is involved in regulation of circadian rhythm of several biological functions. Large-conductance Ca2+ -activated K+ (BKCa ) channels are abundantly expressed in vascular smooth muscle cells and play an important role in vascular tone regulation. We investigated the mechanisms through which myocyte BKCa channels mediate effects of melatonin on cerebral arteries (CAs). Arterial contractility measurements showed that melatonin alone did not change vascular tone in CAs; however, it induced concentration-dependent vasodilation of phenylephrine-induced contraction in CAs...
October 26, 2018: European Journal of Pharmacology
Hongxuan Li, Jingyuan Li, Xiuxin Jiang, Shangming Liu, Yan Liu, Weiqian Chen, Jianmin Yang, Cheng Zhang, Wencheng Zhang
OBJECTIVE: Melatonin, an endogenous neurohormone secreted predominately by the pineal gland, has a variety of physiological functions. However, its protective role in atherosclerosis is not clear. In this study, we sought to investigate the potential effects of melatonin in modulating atherosclerotic plaque stability in apolipoprotein E knockout (ApoE) mice. METHOD AND RESULTS: Smooth muscle cells were treated with melatonin, which significantly increased mRNA and protein levels of a key intracellular enzyme essential for collagen maturation and secretion, prolyl-4-hydroxylase α1 (P4Hα1)...
October 17, 2018: Journal of Hypertension
Rodrigo Martins Dos Santos, Fernando Marani, Fernando Yamamoto Chiba, Maria Sara de Lima Coutinho Mattera, Thais Verônica Saori Tsosura, Gestter Willian Lattari Tessarin, Renato Felipe Pereira, Bianca Elvira Belardi, Beatriz Costa E Silva Pinheiro, Doris Hissako Sumida
AIM: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). MAIN METHODS: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM)...
October 12, 2018: Life Sciences
Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang, Russel J Reiter, Pallab Bhattacharya, Yongchun Cui, Hongwei Yang, He Ma, Jiemin Yao, Sean E Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental, Hany Aly, Mark D Johnson, E Antonio Chiocca, Xin Wang
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS), in brain injury, liver damage, and bone health...
October 11, 2018: Free Radical Biology & Medicine
Andre Felipe Fajardo, Curtis Sobchak, Yulia Shifrin, Jingyi Pan, Tanja Gonska, Jaques Belik
BACKGROUND: When compared with infant formula, human milk enhances gastric emptying in preterm infants. Hydrogen peroxide (H2 O2 ) is present in large quantities in human milk that has an antimicrobial role for the mother and infant. In vitro adult rat studies suggest that H2 O2 facilitates gastric motor contraction. Hypothesizing that H2 O2 enhances gastric motility, we investigated its effects on the newborn rat stomach tissue. METHODS: Rat newborn and adult gastric fundic segments, or their smooth muscle cells, were used to evaluate the muscle response to H2 O2 exposure...
August 24, 2018: Pediatric Research
Yves Dauvilliers, Carlos H Schenck, Ronald B Postuma, Alex Iranzo, Pierre-Herve Luppi, Giuseppe Plazzi, Jacques Montplaisir, Bradley Boeve
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is characterized by loss of muscle atonia during REM sleep (known as REM sleep without atonia, or RSWA) and abnormal behaviours occurring during REM sleep, often as dream enactments that can cause injury. RBD is categorized as either idiopathic RBD or symptomatic (also known as secondary) RBD; the latter is associated with antidepressant use or with neurological diseases, especially α-synucleinopathies (such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy) but also narcolepsy type 1...
August 30, 2018: Nature Reviews. Disease Primers
Natalia Kurhaluk, Arkadiusz Szarmach, Olga V Zaitseva, Alina Sliuta, Svitlana Kyriienko, Pawel J Winklewski
Lipopolysaccharide (LPS) administration in an in vivo experimental mice model causes oxidative damage in the liver, muscle, and kidney. We aimed to determine specific mechanisms underlying melatonin's antioxidant protective role. Assays were carried out in quadruplicate in the control, melatonin (10 mg/kg, 10 days), acute LPS administration (once 150 μg), and LPS + melatonin groups. LPS stimulated lipid peroxidation processes (dienes and malondialdehyde) and antioxidant enzyme concentrations (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) were assessed in all investigated tissues...
November 2018: Canadian Journal of Physiology and Pharmacology
Marcus J Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C Kisanga, Denise Owen, Paul White, David Cottrell
BACKGROUND: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in the bladder. There is limited evidence supporting use of melatonin to alleviate urinary frequency at night in the treatment of nocturia. The aim of this study was to evaluate the effect of melatonin on the mean number of nocturia episodes per night in patients with MS...
August 6, 2018: BMC Neurology
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