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cyanoacrylate vein ablation

Atilla Sarac
OBJECTIVES: This study aims to present the early results of a prospective study of the use of novel n-butyl-2 cyanoacrylate (VenaBlock)-based nontumescent endovenous ablation with a guiding light for the treatment of patients with varicose veins. METHODS: Five hundred and seventy-three patients with lower-limb venous insufficiency were treated within in the previous four years. The study enrolled adults aged 21-70 years with symptomatic moderate to severe varicosities (C2-C6 patients clinical, etiological, anatomical, and pathophysiological classification) and great saphenous vein reflux lasting longer than 0...
February 10, 2019: Vascular
Seung Joon Park, Su Bin Yim, Dae Won Cha, Sung Chul Kim, Jo Han Rhee
Cyanoacrylate ablation, along with mechanochemical ablation, is one of the best-known non-thermal ablation treatment methods for superficial venous reflux. Cyanoacrylate ablation is comparable to thermal ablation in terms of efficacy and safety, and offers the benefit of not requiring tumescent injections and the use of compression stockings. Here, we report about a patient who developed recurrent reflux in the residual stump after cyanoacrylate ablation. As a refluxing long residual stump can be a risk factor for late recurrence, improvements are needed to make the protocol more refined, including leaving the stump as short as possible...
2019: SAGE Open Medical Case Reports
Boonying Siribumrungwong, Kanoklada Srikuea, Saritphat Orrapin, Thoetphum Benyakorn, Kittipan Rerkasem, Ammarin Thakkinstian
INTRODUCTION: Endovenous ablations are the new standard procedures for treatment of great saphenous vein reflux including endovenous laser ablation (EVLA), radio frequency ablation (RFA), endovenous steam ablation (EVSA), mechanochemical ablation (MOCA), cyanoacrylate injection and ultrasound-guided foam sclerotherapy (UGFS). EVLA and RFA have demonstrated similar anatomical success for short-term outcome, but results are controversial for longer term (≥5 years). Additional evidences from randomised controlled trials have been published...
January 30, 2019: BMJ Open
Tjun Y Tang, Harsha P Rathnaweera, Jia W Kam, Tze T Chong, Edward C Choke, Yih K Tan
OBJECTIVES: The aim of this prospective single-centre study is to assess the effectiveness and patient experience of the VenaSeal™ Closure System, a novel non-thermal, non-tumescent catheter technique, which uses cyanoacrylate glue to occlude the refluxing truncal superficial veins to treat varicose veins and chronic venous insufficiency, in a multi-ethnic Asian population from Singapore. METHODS: Seventy-seven patients (93 legs; 103 procedures) underwent VenaSeal™ Closure System ablation...
January 28, 2019: Phlebology
Cengiz Ovalı, Mustafa Behçet Sevin
OBJECTIVE: In this study, the clinical results of radiofrequency ablation (RFA) and n-butyl-cyanoacrylate embolization (CAE) methods were compared in the treatment of incompetent great saphenous veins (GSVs). METHODS: We analyzed retrospectively 244 patients (128 patients in the RFA group, 116 patients in the CAE group) with incompetent GSVs who were treated with RFA and CAE according to the patients' choice between June 2013 and June 2016. All patients were thoroughly examined preoperatively and at 1, 3, 6, and 12 months after the operation, and the clinical results and the quality of life were evaluated...
January 14, 2019: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Imre Bihari
During the 20th century, continuous development of classic varicose vein surgery was carried out. From the beginning of the 21st century, however, new endovascular interventions were introduced. Compared to classic surgery, their main benefit is that no incision and dissection is necessary. Only catheters are used to scar the saphenous stems, which are introduced via punctures. Before and during the intervention, ultrasound is used. Laser surgery is the most popular option, and its outcomes have improved a lot with the introduction of laser crossectomy...
December 2018: Orvosi Hetilap
Nick Morrison, Raghu Kolluri, Michael Vasquez, Monte Madsen, Andrew Jones, Kathleen Gibson
OBJECTIVE: To evaluate the 36-month efficacy and safety of cyanoacrylate closure for the treatment of incompetent great saphenous veins in comparison with radiofrequency ablation. METHODS: In this multicenter, prospective, randomized controlled trial, 222 symptomatic subjects with incompetent great saphenous veins were assigned to either cyanoacrylate closure or radiofrequency ablation. The primary endpoint, complete closure of the target great saphenous vein, was determined using duplex ultrasound examination starting from three-month visit...
November 7, 2018: Phlebology
Eivind Inderhaug, Carl-Henrik Schelp, Inge Glambek, Ivar S Kristiansen
Objective: The aim of this work was to estimate cost-effectiveness of five common procedures for varicose vein surgery ( high ligation and stripping, radiofrequency ablation, endovenous laser ablation, steam vein sclerosis and cyanoacrylate glue ) in a Norwegian setting from both a societal and a healthcare payer perspective. Design: Cost-effectiveness analysis using decision tree modelling. Methods: A structured literature search was conducted to estimate the clinical effectiveness and the rate of complications in the five methods...
2018: SAGE Open Medicine
K T Weiß, F Zeman, S Schreml
Manjit S. Gohel et al. (N Engl J Med 2018; 378: 2105-2114) aimed to compare early endovenous ablation vs. deferred endovenous ablation of superficial venous reflux regarding time to healing of venous leg ulcers, rate of healing at 24 weeks, recurrence rate, ulcer-free time, and health-related quality of life. SETTING AND DESIGN: This multicentre, parallel-group (ratio 1:1), randomized controlled trial was conducted in a vascular surgery department setting at 20 participating centres across the United Kingdom...
September 20, 2018: British Journal of Dermatology
Kathleen Gibson, Renee Minjarez, Krissa Gunderson, Brian Ferris
Purpose Studies examining cyanoacrylate closure of saphenous veins with the VenaSeal™ System have not allowed concomitant procedures for tributaries at the time of the index procedure. Outside of clinical trials, however, concomitant procedures are frequently performed in conjunction with endovenous ablation. We report on the frequency of need for saphenous tributary treatment three months after cyanoacrylate closure of the treatment of great saphenous vein, small saphenous vein, and/or accessory saphenous vein...
September 18, 2018: Phlebology
Insoo Park, Min Ho Jeong, Chan Jin Park, Woo Il Park, Dong Wook Park, Jin Hyun Joh
BACKGROUND: Cyanoacrylate closure for the treatment of incompetent saphenous veins does not cause thermal damage and demonstrates satisfactory outcomes with rapid recovery. However, the characteristics of phlebitis-like abnormal reaction (PLAR), the most common adverse event after cyanoacrylate closure, have not been clarified. Moreover, it differs from typical phlebitis after thermal ablation. The objective of our study is to investigate the clinical features of PLAR after cyanoacrylate closure and to report its management...
September 11, 2018: Annals of Vascular Surgery
Gary K Yang, Marina Parapini, Joel Gagnon, Jerry C Chen
Objective To review clinical outcomes of varicose vein patients treated with cyanoacrylate embolization and radiofrequency ablation at our institution. Methods A retrospective review of patients who underwent cyanoacrylate embolization and radiofrequency ablation during a three-year period. Patient records were reviewed to assess demographics, location and severity of disease, treatment details and outcome at short- and mid-term follow-ups. Outcome parameters included treatment success and complications. Results Between January 2014 and December 2016, 335 patients with 476 veins were treated with either cyanoacrylate embolization (n = 148) or radiofrequency ablation (n = 328) at the Vancouver General Hospital Vascular Surgery Vein Clinic...
August 16, 2018: Phlebology
David Epstein, Sarah Onida, Roshan Bootun, Marta Ortega-Ortega, Alun H Davies
OBJECTIVES: To analyze the cost-effectiveness of current technologies (conservative care [CONS], high-ligation surgery [HL/S], ultrasound-guided foam sclerotherapy [UGFS], endovenous laser ablation [EVLA], and radiofrequency ablation [RFA]) and emerging technologies (mechanochemical ablation [MOCA] and cyanoacrylate glue occlusion [CAE]) for treatment of varicose veins over 5 years. METHODS: A Markov decision model was constructed. Effectiveness was measured by re-intervention on the truncal vein, re-treatment of residual varicosities, and quality-adjusted life-years (QALYs) over 5 years...
August 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Amjad Belramman, Roshan Bootun, Tjun Yip Tang, Tristan R A Lane, Alun H Davies
BACKGROUND: Thermal ablation techniques have become the first-line treatment of truncal veins in the management of chronic venous disease (CVD). Despite excellent outcomes, these methods are often associated with pain; generally due to their use of heat and the necessity of fluid infiltration around the vein. More recently, novel non-thermal techniques, such as mechanochemical ablation (MOCA) and cyanoacrylate adhesive (CAE) have been developed to overcome these unwelcome effects. So far, the novel techniques have been found to have similar efficacy to thermal methods, yet no direct comparisons between the non-thermal treatment techniques have been conducted to date, giving rise to this study...
August 7, 2018: Trials
Erdinc Eroglu, Alptekin Yasim
OBJECTIVE: To compare early and two year results for N-butyl cyanoacrylate (NBCA), radiofrequency ablation (RFA), and endovenous laser ablation (EVLA) in the treatment of varicose veins. METHODS: This was a randomised clinical trial. Five hundred and twenty five patients were blindly randomised into NBCA, RFA, and EVLT groups (175 patients to each group; block randomisation using sealed envelopes). Four hundred and fifty six patients were monitored for 2 years (ultrasound at 2 days, and 6, 12, and 24 months)...
October 2018: European Journal of Vascular and Endovascular Surgery
Kathleen Gibson, Nick Morrison, Raghu Kolluri, Michael Vasquez, Robert Weiss, Daniel Cher, Monte Madsen, Andrew Jones
OBJECTIVE: We previously reported 3-month and 12-month occlusion rates after treatment of clinically symptomatic saphenous vein reflux with either cyanoacrylate closure (CAC) using the VenaSeal Closure System (Medtronic, Dublin, Ireland) or radiofrequency ablation (RFA) in a randomized, multicenter, clinical trial, VenaSeal Sapheon Closure System vs Radiofrequency Ablation for Incompetent Great Saphenous Veins (VeClose). Herein we report the 24-month follow-up results of the VeClose trial...
September 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Daniele Bissacco, Silvia Stegher, Fabio Massimo Calliari, Marco Piercarlo Viani
BACKGROUND: To review published evidence regarding an n-butyl-cyanoacrylate (NBCA) injection device for great (GSV) and small (SSV) saphenous vein incompetence in terms of occlusion rate, postoperative complications and quality of life improvement. MATERIAL AND METHODS: International bibliographic databases (PubMed, EMBASE, Scopus) were searched to identify possible target articles. The only inclusion criterion was the use of the Variclose® system (Biolas, Ankara, Turkey) for superficial vein insufficiency...
April 19, 2018: Minimally Invasive Therapy & Allied Technologies: MITAT
Turhan Yavuz, Altay Nihat Acar, Huseyin Aydın, Evren Ekingen
Objective This study aims to present the early results of a retrospective study of the use of novel n-butyl-2-cyanoacrylate (VenaBlock)-based nontumescent endovenous ablation with a guiding light for the treatment of patients with varicose veins. Methods Patients with lower limb venous insufficiency were treated with n-butyl-2-cyanoacrylate (VenaBlock Venous Closure System) between April 2016 and July 2016. The study enrolled adults aged 21-70 years with symptomatic moderate to severe varicosities (C2-C4b) and great saphenous vein reflux lasting longer than 0...
October 2018: Vascular
Cornelis G Vos, Çağdaş Ünlü, Jan Bosma, Clarissa J van Vlijmen, A Jorianne de Nie, Michiel A Schreve
BACKGROUND: Endothermal treatment of the great saphenous vein (GSV) has become the first-line treatment for superficial venous reflux. Nonthermal ablation has potential benefits for acceptability by patients and decreased risk of nerve injury. We performed a systematic review and meta-analysis to evaluate the efficacy of mechanochemical endovenous ablation (MOCA) and cyanoacrylate vein ablation (CAVA) for GSV incompetence. METHODS: MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, and Cochrane databases were searched for papers published between January 1966 and December 2016...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Mehmet Senel Bademci, Kaptanıderya Tayfur, Gökhan Ocakoglu, Serkan Yazman, Muhammet Akyüz, Haydar Yasa
Background We have made a retrospective evaluation of the results of the cyanoacrylate ablation technique which has recently started to be used in the treatment of giant saphenous vein insufficiency today and in which tumescent anesthesia is not required. Methods Giant saphenous vein was treated in 50 patients between September 2015 and September 2016 by using endovenous cyanoacrylate ablation. In the procedure, tumescent anesthesia and varsity socks were not used. Control duplex ultrasound evaluation was performed in the post-procedural 1st, 6th and 12th months...
April 2018: Vascular
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