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Dennis W Ashley, Robert F Mullins, Christopher J Dente, Tracy J Johns, Laura E Garlow, Regina S Medeiros, Elizabeth V Atkins, Gina Solomon, Dena Abston, Colville H Ferdinand
BACKGROUND: Readiness Costs are real expenses incurred by trauma centers to maintain essential infrastructure to provide emergent services on a 24/7 basis. Although the components for readiness are well described in the American College of Surgeon's Resources for Optimal Care of the Injured Patient, the cost associated with each component is not well defined. We hypothesized that meeting the requirements of the 2014 Resources for Optimal Care of the Injured Patient would result in significant costs for trauma centers...
February 13, 2019: Journal of Trauma and Acute Care Surgery
L Gallo, M Megna, T Cirillo, P Caterino, G Lodi, R Mozzillo, V Dente, A Balato
BACKGROUND/OBJECTIVE: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. METHODS: A real-life 4 weeks prospective, open study on Cal/BD aerosol foam (not compared to vehicle or emollient cream) was performed in adult psoriasis patients attending three Dermatology units located in Campania region, Italy, between March and October 2018...
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Hualiang Lin, Yanfei Guo, Zengliang Ruan, Paul Kowal, Qian Di, Yang Zheng, Jianpeng Xiao, Emiel O Hoogendijk, Elsa Dent, Michael G Vaughn, Steven W Howard, Zheng Cao, Wenjun Ma, Zhengmin Min Qian, Fan Wu
Background: Air pollution has been associated with various health outcomes. Its effect on hand-grip strength, a measurement of the construct of muscle strength and health status, remains largely unknown. Methods: We used the survey data from 31,209 adults ≥ 50 years of age within Wave 1 of the Study on Global AGEing and Adult Health in six low- and middle-income countries. The outdoor concentration of fine particulate matter pollution (PM2.5) was estimated using satellite data...
February 7, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Laurence Booth, Jane L Roberts, Andrew Poklepovic, Paul Dent
We focused on defining the role of the E3 ligase NEDD4 in NSCLC cell afatinib resistance. Afatinib resistant H1975 clones over-expressed NEDD4 and c-MET compared to control clones and expressed less ERBB1, ERBB3, ERBB4 and PTEN than control clones. Knock down of NEDD4 enhanced the expression of PTEN, ERBB1/3/4 and c-MET. This was also associated with a ∼3-fold enhancement in both mTOR expression and mTOR phosphorylation and a ∼4-fold elevation in phospho-ULK-1 S757 levels. In the absence of NEDD4 or the autophagy regulatory protein Beclin1, neither the drug combination of [pemetrexed + sildenafil] nor the HDAC inhibitor sodium valproate was as capable of: reducing the expression of ERBB1/3/4; reducing phosphorylation of ULK-1 S757; or at enhancing the phosphorylation of ULK-1 S317 and ATG13 S318...
June 2018: Oncology Signaling
Marc W Beutel, Stephen R Dent, Remy L Newcombe, Gregory Möller
This study evaluated the ability of hydrous ferric oxide reactive filtration (HFO-RF) to remove mercury (Hg) from municipal secondary effluent at four study sites. Pilot HFO-RF systems (136 m3 /day) at two sites demonstrated total Hg concentration removal efficiencies of 96% (inflow/outflow mean total Hg: 43.6/1.6  ng/L) and 80% (4.2/0.8 ng/L). A lightly loaded medium-scale HFO-RF system (950 m3 /day) had a concentration removal efficiency of 53% (0.98/0.46 ng/L) and removed 0.52 mg/day of total Hg and 2...
February 2019: Water Environment Research: a Research Publication of the Water Environment Federation
Adama I Seye, Cyril Bauland, Heloïse Giraud, Valérie Mechin, Matthieu Reymond, Alain Charcosset, Laurence Moreau
Silage quality traits of maize hybrids between the Dent and Flint heterotic groups mostly involved QTL specific of each parental group, some of them showing unfavorable pleiotropic effects on yield. Maize (Zea mays L.) is commonly used as silage for cattle feeding in Northern Europe. In addition to biomass production, improving whole-plant digestibility is a major breeding objective. To identify loci involved in the general (GCA, parental values) and specific combining ability (SCA, cross-specific value) components of hybrid value, we analyzed an incomplete factorial design of 951 hybrids obtained by crossing inbred lines issued from two multiparental connected populations, each specific to one of the heterotic groups used for silage in Europe ("Dent" and "Flint")...
February 7, 2019: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Maria Grazia Dente, Flavia Riccardo, Francesco Bolici, Nello Augusto Colella, Verica Jovanovic, Mitra Drakulovic, Milena Vasic, Habiba Mamlouk, Latifa Maazaoui, Mondher Bejaoui, Khatuna Zakhashvili, Irine Kalandadze, Paata Imnadze, Silvia Declich
BACKGROUND: In the Mediterranean and Black Sea Region, arbovirus infections are emerging infectious diseases. Their surveillance can benefit from one health inter-sectoral collaboration; however, no standardized methodology exists to study One Health surveillance. METHODS: We designed a situation analysis study to document how integration of laboratory/clinical human, animal and entomological surveillance of arboviruses was being implemented in the Region. We applied a framework designed to assess three levels of integration: policy/institutional, data collection/data analysis and dissemination...
February 5, 2019: Zoonoses and Public Health
Qinbang Zhou, Renwen Chen, Bin Huang, Chuan Liu, Jie Yu, Xiaoqing Yu
Automobile surface defects like scratches or dents occur during the process of manufacturing and cross-border transportation. This will affect consumers' first impression and the service life of the car itself. In most worldwide automobile industries, the inspection process is mainly performed by human vision, which is unstable and insufficient. The combination of artificial intelligence and the automobile industry shows promise nowadays. However, it is a challenge to inspect such defects in a computer system because of imbalanced illumination, specular highlight reflection, various reflection modes and limited defect features...
February 4, 2019: Sensors
Evangelia Koutelou, Li Wang, Andria Schibler, Hsueh-Ping Chao, Xianghong Kuang, Kevin Lin, Yue Lu, Jianjun Shen, Collene R Jeter, Andrew Salinger, Marenda Wilson, Yi Chun Chen, Boyko S Atanassov, Dean G Tang, Sharon Yr Dent
Usp22, a component of the SAGA complex, is over expressed in highly aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We determined that loss of Usp22 in mice results in embryonic lethality due to defects in extra-embryonic placental tissues and failure to establish proper vascular interactions with the maternal circulatory system. These phenotypes arise from abnormal gene expression patterns that reflect defective kinase signaling, including TGFβ and several receptor tyrosine kinase (RTK) pathways...
February 4, 2019: Development
Majid Nikpay, Kaitlyn Beehler, Armand Valsesia, Jorg Hager, Mary-Ellen Harper, Robert Dent, Ruth McPherson
Aims: To identify genetic variants that have a regulatory impact on circulating miRNAs and to connect genetic risk to blood traits/biomarkers through the circulating miRNAs. Methods and results: Leveraging miRNA-Seq data and the 1000 Genomes imputed genotypes, we carried out genome wide association analysis for SNPs that regulate the expression of circulating miRNAs in a sample of 710 unrelated subjects of European ancestry. Wherever possible, we used data from the Framingham and the Geuvadis studies to replicate our findings...
January 31, 2019: Cardiovascular Research
Erin B Taylor, Victoria L Wolf, Elena Dent, Michael J Ryan
Patients with autoimmune rheumatic diseases including rheumatoid arthritis and systemic lupus erythematosus have an increased prevalence of hypertension. There is now a large body of evidence showing that the immune system is a key mediator in both human primary hypertension and in experimental models. Many of the proposed immunological mechanisms leading to primary hypertension are paralleled in autoimmune rheumatic disorders. Therefore, examining the link between autoimmunity and hypertension can be informative for understanding primary hypertension...
February 3, 2019: British Journal of Pharmacology
Armand Valsesia, Qiao-Ping Wang, Nele Gheldof, Jérôme Carayol, Hélène Ruffieux, Teleri Clark, Victoria Shenton, Lisa J Oyston, Gregory Lefebvre, Sylviane Metairon, Christian Chabert, Ondine Walter, Polina Mironova, Paulina Lau, Patrick Descombes, Nathalie Viguerie, Dominique Langin, Mary-Ellen Harper, Arne Astrup, Wim H Saris, Robert Dent, Greg G Neely, Jörg Hager
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-caloric diet intervention cohorts of obese participants. Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort (n = 1166) and replicated in the DiOGenes cohort (n = 789)...
February 1, 2019: Nature Communications
Katelynn Edgehouse, Maria Escamilla, Louisa Wang, RhayAuna Dent, Kevin Pachuta, Lee Kendall, Peiran Wei, Alp Sehirliolgu, Emily Pentzer
Pickering emulsions are emulsions stabilized by particles instead of small molecules or polymers, and commonly consist of oil droplets dispersed into a continuous water phase with particles lying at the fluid-fluid interface. New particle surfactants are important for tuning the composition and properties of assemblies and enabling advanced applications, such as energy harvesting and management. Although most particle surfactants are spherical, graphene oxide (GO) nanosheets and clay platelets have garnered recent attention as 2D (i...
January 23, 2019: Journal of Colloid and Interface Science
William J Phillips, Christopher Johnson, Angeline Law, Michele Turek, Alex R Small, Susan Dent, Terrence D Ruddy, Rob S Beanlands, Benjamin J W Chow, Gary R Small
BACKGROUND: In breast cancer patients, coincidental detection of CAC at chest CT may be important in determining cardiovascular (CV) outcomes and facilitate CV disease primary prevention strategies. METHODS: 408 consecutive breast cancer patients referred to cardiac oncology clinic were included in the study. 256 patients without a prior history of coronary artery disease had undergone a chest CT. CT images were reviewed to detect CAC. Framingham risk score (FRS) was calculated and patient electronic medical records were interrogated to document the incidence of a composite clinical end point of all-cause mortality and cardiac events (coronary revascularization, heart failure hospitalization and de novo atrial fibrillation)...
January 23, 2019: International Journal of Cardiology
Amanda M Lauer, Micheal L Dent, Wei Sun, Matthew A Xu-Friedman
The effects of traumatic noise-exposure and deafening on auditory system function have received a great deal of attention. However, lower levels of noise as well as temporary conductive hearing loss also have consequences on auditory physiology and hearing. Here we review how abnormal acoustic experience at early ages affects the ascending and descending auditory pathways, as well as hearing behavior.
January 24, 2019: Neuroscience
John Bedson, Jonathon Hill, David White, Ying Chen, Simon Wathall, Stephen Dent, Kendra Cooke, Danielle van der Windt
BACKGROUND: Assessing daily change in pain and related symptoms help in diagnosis, prognosis, and monitoring response to treatment. However, such changes are infrequently assessed, and usually reviewed weeks or months after the start of treatment. We therefore developed a smartphone application (Keele Pain Recorder) to record information on the severity and impact of pain on daily life. Specifically, the study goal was to assess face, content and construct validity of data collection using the Pain Recorder in primary care patients receiving new analgesic prescriptions for musculoskeletal pain, as well as to assess its acceptability and clinical utility...
January 25, 2019: BMC Medical Informatics and Decision Making
Christina Boutsiouki, Roland Frankenberger, Susanne Lücker, Norbert Krämer
OBJECTIVE: To investigate secondary caries inhibition after dentine pre-treatment with 2% CHX, experimental addition of CHX in primer and adhesive of a 3-step adhesive system, and industrial addition od CHX in a 2-step adhesive system. MATERIALS AND METHOD: Sixty Class-V cavities were restored according to the adhesive protocol (n=12): 1) control group, Scotchbond Multi-Purpose, 3M (CTRL), 2) 2% CHX dentine pre-treatment (DENT), 3) 0.1% CHX in primer (PRIM), 4) 0...
January 21, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
Brian Dent, Vincent A Wavreille, Laura E Selmic
OBJECTIVE: To describe a novel surgical technique for ventral orbital reconstruction after ventral orbitectomy by using a temporalis fascia transposition flap. STUDY DESIGN: Case report. METHODS: A 7-year-old, spayed female Boston terrier was treated for multilobular osteochondrosarcoma arising from the cranial aspect of the left zygomatic arch, causing asymmetry of the face and mild exophthalmos of the left eye. A ventral orbitectomy with a wide surgical excision (including the cranial aspect of the zygomatic bone, the medial aspect of the lacrimal bone, and the dorsal aspect of the maxilla) was performed with preservation of the left eye...
January 24, 2019: Veterinary Surgery: VS
Kee Thai Yeo, Paula Embury, Timothy Anderson, Peter Mungai, Indu Malhotra, Christopher King, James Kazura, Arlene Dent
Infections during pregnancy can expose the fetus to microbial Ags, leading to inflammation that affects B cell development. Prenatal fetal immune priming may have an important role in infant acquisition of pathogen-specific immunity. We examined plasma proinflammatory biomarkers, the proportions of various B cell subsets, and fetal priming to tetanus vaccination in cord blood from human United States and Kenyan neonates. United States neonates had no identified prenatal infectious exposures, whereas Kenyan neonates examined had congenital CMV or mothers with prenatal HIV or Plasmodium falciparum or no identified infectious exposures...
January 23, 2019: Journal of Immunology: Official Journal of the American Association of Immunologists
Susan J Robertson, Mohammed F K Ibrahim, Carol Stober, John Hilton, Zuzana Kos, Sasha Mazzarello, Tim Ramsay, Dean Fergusson, Lisa Vandermeer, Ranjeeta Mallick, Angel Arnaout, Susan F Dent, Roanne Segal, Sandeep Sehdev, Stan Gertler, Brian Hutton, Mark Clemons
OBJECTIVE: The three Magee Equations provide an estimate of the Oncotype DX recurrence score using commonly available clinicopathologic information (tumour size, grade, oestrogen receptor, progesterone receptor, HER2, and Ki67). We assessed whether integration of Magee Equations into routine clinical practice affected the frequency of Oncotype DX requests. METHODS: Patients with newly diagnosed, node negative, hormone receptor positive, and HER2 negative invasive breast cancer were randomized to undergo a Magee calculation or not...
January 23, 2019: Journal of Evaluation in Clinical Practice
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