Yuhang Jiang, Cuifeng Li, Qian Wu, Peng An, Laiquan Huang, Jia Wang, Chen Chen, Xi Chen, Fan Zhang, Li Ma, Sanhong Liu, Hanqing He, Shuyun Xie, Yangbai Sun, Hanshao Liu, Yu Zhan, Yu Tao, Zhi Liu, Xiaohua Sun, Yiming Hu, Qi Wang, Deji Ye, Jie Zhang, Shanhua Zou, Ying Wang, Gang Wei, Yongzhong Liu, Yufang Shi, Y Eugene Chin, Yongqiang Hao, Fudi Wang, Xiaoren Zhang
Trace elements play important roles in human health, but little is known about their functions in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared to iron-normal controls. Mice with iron deficiency also exhibit attenuated T-dependent or T-independent antigen-specific antibody responses. We show that iron is essential for B cell proliferation; both iron deficiency and α-ketoglutarate inhibition could suppress cyclin E1 induction and S phase entry of B cells upon activation...
July 3, 2019: Nature Communications