Cristina Lopez, Nikolai Schleussner, Stephan H Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L Sczakiel, Helene Kretzmer, Umut H Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M Muller, Julian Seufert, Steve Hoffmann, Jan O Korbel, Robert B Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert
Histone methylation-modifiers, like EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole genome and transcriptome data of 186 mature B-cell lymphomas sequenced in the ICGC MMML-Seq project. Besides confirming common alterations of KMT2D (47% of cases), EZH2 (17%), SETD1B (5%), PRDM9 (4%), KMT2C (4%), and SETD2 (4%) also identified by prior exome or RNAseq studies, we here unravel KDM4C in chromosome 9p24, encoding a histone demethylase, to be recurrently altered...
April 28, 2022: Haematologica