Koustav Roy, Xuzhao Zhou, Rintaro Otani, Ping-Chuan Yuan, Shuji Ioka, Kaspar E Vogt, Tamae Kondo, Nouran H T Farag, Haruto Ijiri, Zhaofa Wu, Youhei Chitose, Mao Amezawa, David S Uygun, Yoan Cherasse, Hiroshi Nagase, Yulong Li, Masashi Yanagisawa, Manabu Abe, Radhika Basheer, Yi-Qun Wang, Tsuyoshi Saitoh, Michael Lazarus
Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential to alleviate symptoms, cure diseases, and improve quality of life while preventing uncontrolled drug effects. The development of in-vivo applications for optochemistry to render brain cells photoresponsive without relying on genetic engineering has been progressing slowly. The nucleus accumbens (NAc) is a region for the regulation of slow-wave sleep (SWS) through the integration of motivational stimuli...
April 30, 2024: Nature Communications