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Keywords Microbiome And Chronic Kidney ...

Microbiome And Chronic Kidney Disease

https://read.qxmd.com/read/38265670/the-tongue-microbiome-of-young-patients-with-chronic-kidney-disease-and-their-healthy-mothers
#21
JOURNAL ARTICLE
Karolin C Hoefer, Lutz T Weber, Anna Greta Barbe, Isabelle Graf, Stefanie Thom, Angela Nowag, Claus J Scholz, Hilmar Wisplinghoff, Michael J Noack, Nathalie Jazmati
OBJECTIVES: Oral microbiome plays a crucial role in the incidence and development of oral diseases. An altered intestinal microbiome has been reported in adults with chronic kidney disease (CKD). This study aimed to characterize the tongue microbiome of young patients with CKD compared to their healthy mothers to identify the influence of CKD-associated factors on resilient tongue ecosystem. MATERIAL AND METHODS: Thirty patients with CKD (mean age, 14.2 years; 16 males and 14 females) and generalized gingivitis were included in the study...
January 24, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38255253/exploring-the-relationship-between-gut-microbiome-composition-and-blood-indole-3-acetic-acid-in-hemodialysis-patients
#22
JOURNAL ARTICLE
Ping-Hsun Wu, Yu-Fang Tseng, Wangta Liu, Yun-Shiuan Chuang, Chi-Jung Tai, Chun-Wei Tung, Kean-Yee Lai, Mei-Chuan Kuo, Yi-Wen Chiu, Shang-Jyh Hwang, Wei-Chun Hung, Yi-Ting Lin
Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular and cognitive risk in HD patients. However, research on the microbiome-IAA association is limited. This study aimed to explore the gut microbiome's relationship with plasma IAA levels in 72 chronic HD patients aged over 18 (August 2016-January 2017). IAA levels were measured using tandem mass spectrometry, and gut microbiome analysis utilized 16s rRNA next-generation sequencing...
January 10, 2024: Biomedicines
https://read.qxmd.com/read/38244232/gut-flora-metagenomic-analysis-coupled-with-metabolic-and-deep-immune-profiling-in-chronic-kidney-disease
#23
JOURNAL ARTICLE
I-Wen Wu, Lun-Ching Chang, Yi-Lun Wu, Huang-Yu Yang, Yuh-Ching Twu, Po-Yu Tsai, Skyler Paulus, Rhian Resnick, Wen-Hung Chung, Chih-Wei Yang, Wen-Ping Hsieh, Shih-Chi Su
BACKGROUND AND HYPOTHESIS: Perturbation of gut microbiota has been linked to chronic kidney disease (CKD), which was correlated with a sophisticated milieu of metabolic and immune dysregulation. METHODS: To clarify the underlying host-microbe interaction in CKD, we performed multi-omics measurements, including systems-level gut microbiome, targeted serum metabolome, and deep immunotyping, in a cohort of patients and non-CKD controls. RESULTS: Our analyses on functional profiles of gut microbiome showed a decrease in the diversity and abundance of carbohydrate-active enzyme (CAZyme) genes but an increase in the abundance of antibiotic resistance, nitrogen cycling enzyme, and virulence factor genes in CKD...
January 19, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38237547/a-novel-enzyme-based-functional-correlation-algorithm-for-multi-omics-reveals-the-potential-mechanisms-of-traditional-chinese-medicines-taking-jian-pi-yi-shen-formula-as-an-example
#24
JOURNAL ARTICLE
Ying-Hao Yin, Chang-Hui Li, Hai-Piao Huang, Chi Zhang, Shang-Bin Zhang, Shun-Min Li, Jianping Chen
The integrated analysis of host metabolome and intestinal microbiome is an opportunity to explore the complex therapeutic mechanisms of traditional Chinese medicines. Currently, researchers mainly employ various statistical correlation analytical methods to investigate metabolome-microbiome correlations. However, these conventional correlation techniques often focus on statistical correlations and their biological meanings are always ignored, especially the functional relevance between them. Here, we developed a novel enzyme-based functional correlation (EBFC) algorithm to further improve the interpretability and the identified scope of microbe-metabolite correlations based on the conventional Spearman's analysis...
January 11, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38229879/gut-immune-axis-and-cardiovascular-risk-in-chronic-kidney-disease
#25
REVIEW
Felix Behrens, Hendrik Bartolomaeus, Nicola Wilck, Johannes Holle
Patients with chronic kidney disease (CKD) suffer from marked cardiovascular morbidity and mortality, so lowering the cardiovascular risk is paramount to improve quality of life and survival in CKD. Manifold mechanisms are hold accountable for the development of cardiovascular disease (CVD), and recently inflammation arose as novel risk factor significantly contributing to progression of CVD. While the gut microbiome was identified as key regulator of immunity and inflammation in several disease, CKD-related microbiome-immune interaction gains increasing importance...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38220540/bladder-cancer-and-the-urinary-microbiome-new-insights-and-future-directions-a-review
#26
REVIEW
Angela E Russo, Areeba Memon, Shahid Ahmed
The presence of a microbiome in the urinary system has been established through recent advancements in technology and investigation of microbial communities in the human body. The study of the taxonomic and genomic ecology of microbial communities has been greatly improved by the use of metagenomics. The research in this area has expanded our understanding of microbial ecosystems and shows that the urinary tract contains over 100 species from over 50 genera, with Lactobacillus, Gardnerella, and Streptococcus being the most common...
January 9, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38138114/role-of-probiotics-in-preventing-carbapenem-resistant-enterobacteriaceae-colonization-in-the-intensive-care-unit-risk-factors-and-microbiome-analysis-study
#27
JOURNAL ARTICLE
Jung-Hwan Lee, Jongbeom Shin, Soo-Hyun Park, Boram Cha, Ji-Taek Hong, Don-Haeng Lee, Kye Sook Kwon
Older patients with multiple comorbidities often necessitate prolonged hospital stays and antibiotic treatment in the intensive care unit (ICU), leading to a rise in multidrug-resistant organisms like carbapenem-resistant Enterobacteriaceae (CRE). This study examined risk factors for carbapenem-resistant Enterobacteriaceae colonization in the ICU and assessed probiotics' preventive role. In this single-center, retrospective study, 9099 ICU patients were tested for stool CRE culture from March 2017 to April 2022...
December 12, 2023: Microorganisms
https://read.qxmd.com/read/38095826/duodenal-microbiome-in-chronic-kidney-disease
#28
JOURNAL ARTICLE
Masahiro Kondo, Takehiro Torisu, Tomohiro Nagasue, Hiroki Shibata, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuichi Matsuno, Tomohiko Moriyama, Takanari Kitazono
BACKGROUND: The intestinal microbiome is involved in the pathogenesis of chronic kidney disease (CKD). Despite its importance, the microbiome of the small intestinal mucosa has been little studied due to sampling difficulties, and previous studies have mainly focused on fecal sources for microbiome studies. We aimed to characterize the small intestinal microbiome of CKD patients by studying the microbiome collected from duodenal and fecal samples of CKD patients and healthy controls. METHODS: Overall, 28 stage 5 CKD patients and 21 healthy participants were enrolled...
December 14, 2023: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38088374/oh-my-gut-new-insights-on-the-role-of-the-gastrointestinal-tract-and-the-gut-microbiome-in-chronic-kidney-disease-mineral-and-bone-disorder
#29
REVIEW
Seyedeh Nooshan Mirmohammadali, Kathleen M Hill Gallant, Annabel Biruete
PURPOSE OF REVIEW: The aim of this review is to highlight recent evidence on the role of the gastrointestinal tract and gut microbiome on chronic kidney disease-mineral bone disorder (CKD-MBD) outcomes, including intestinal phosphorus absorption and sensing, and the effect of gut-oriented therapies. RECENT FINDINGS: Recent evidence has revealed a complex interplay among mineral metabolism and novel gut-related factors, including paracellular intestinal phosphate absorption, the gut microbiome, and the immune system, prompting a reevaluation of treatment approaches for CKD-MBD...
March 1, 2024: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/38039494/trimethylamine-n-oxide-and-kidney-diseases-what-do-we-know
#30
JOURNAL ARTICLE
Ozkan Gungor, Nuri Baris Hasbal, Demet Alaygut
In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body. When dysbiosis of intestinal microbial homeostasis occurs, pathogenic metabolites may increase and one of them is trimethyl amine-N-oxide (TMAO). TMAO is thought to have a role in the pathogenesis of insulin resistance, diabetes, hyperlipidemia, atherosclerotic heart diseases, and cerebrovascular events. TMAO level is also associated with renal inflammation, fibrosis, acute kidney injury, diabetic kidney disease, and chronic kidney disease...
December 1, 2023: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://read.qxmd.com/read/38022571/intestinal-homeostasis-in-the-gut-lung-kidney-axis-a-prospective-therapeutic-target-in-immune-related-chronic-kidney-diseases
#31
REVIEW
Xinyin Liu, Xiaoran Wang, Peipei Zhang, Yiwen Fang, Yanyan Liu, Yueyue Ding, Wen Zhang
In recent years, the role of intestinal homeostasis in health has received increasing interest, significantly improving our understanding of the complex pathophysiological interactions of the gut with other organs. Microbiota dysbiosis, impaired intestinal barrier, and aberrant intestinal immunity appear to contribute to the pathogenesis of immune-related chronic kidney diseases (CKD). Meanwhile, the relationship between the pathological changes in the respiratory tract (e.g., infection, fibrosis, granuloma) and immune-related CKD cannot be ignored...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38020091/altered-gut-microbiome-plays-an-important-role-in-aki-to-ckd-transition-in-aged-mice
#32
JOURNAL ARTICLE
Myung-Gyu Kim, Won Yong Cho, Suk Min Chung, Young Eun Choi, Yina Fang, Myeong Soo Park, Sang Jun Park, Yoon Sook Ko, Hee Young Lee, Jihyun Yang, Se Won Oh, Sang-Kyung Jo
INTRODUCTION: This study investigated the role of renal-intestinal crosstalk in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) in elderly individuals. METHODS: Using young and aged mice, we induced bilateral ischemia-reperfusion injury (IRI) and compared intestinal and kidney inflammation over 28 days. To determine the role of the microbiome in gut-kidney crosstalk, we analyzed the microbiome of fecal samples of the young vs...
2023: Frontiers in Medicine
https://read.qxmd.com/read/38002033/an-overview-of-chronic-kidney-disease-pathophysiology-the-impact-of-gut-dysbiosis-and-oral-disease
#33
REVIEW
Serena Altamura, Davide Pietropaoli, Francesca Lombardi, Rita Del Pinto, Claudio Ferri
Chronic kidney disease (CKD) is a severe condition and a significant public health issue worldwide, carrying the burden of an increased risk of cardiovascular events and mortality. The traditional factors that promote the onset and progression of CKD are cardiometabolic risk factors like hypertension and diabetes, but non-traditional contributors are escalating. Moreover, gut dysbiosis, inflammation, and an impaired immune response are emerging as crucial mechanisms in the disease pathology. The gut microbiome and kidney disease exert a reciprocal influence commonly referred to as "the gut-kidney axis" through the induction of metabolic, immunological, and endocrine alterations...
November 12, 2023: Biomedicines
https://read.qxmd.com/read/37970557/dietary-phosphate-disturbs-of-gut-microbiome-in-mice
#34
JOURNAL ARTICLE
Naoko Oda, Kohei Sugihara, Takashi Uebanso, Hirokazu Ohminami, Kohta Ohnishi, Masashi Masuda, Hisami Yamanaka-Okumura, Yutaka Taketani
Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. Recent reports have demonstrated that gut microbiome disturbance is associated with both the etiology and progression of chronic kidney disease. However, the relationship between dietary phosphate and gut microbiome remains unknown. Here, we examined the effects of excessive intake of phosphate on gut microbiome...
November 2023: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/37960279/renoprotective-effects-of-solid-state-cultivated-antrodia-cinnamomea-in-juvenile-rats-with-chronic-kidney-disease
#35
JOURNAL ARTICLE
You-Lin Tain, Guo-Ping Chang-Chien, Sufan Lin, Chih-Yao Hou, Chien-Ning Hsu
Antrodia cinnamomea (AC), a medicinal mushroom, has multiple beneficial actions, such as acting as a prebiotic. The incidence of chronic kidney disease (CKD) in children has steadily increased year by year, and CKD is related to gut microbiota dysbiosis. Herein, we investigated the renoprotection of solid-state cultivated AC in adenine-induced CKD juvenile rats. CKD was induced in 3-week-old male rats by feeding with adenine (0.5%) for three weeks. Treated groups received oral administration of AC extracts at either a low (10 mg/kg/day) or high dose (100 mg/kg/day) for six weeks...
October 31, 2023: Nutrients
https://read.qxmd.com/read/37937647/remote-effects-of-kidney-drug-transporter-oat1-on-gut-microbiome-composition-and-urate-homeostasis
#36
JOURNAL ARTICLE
Vladimir S Ermakov, Jeffry C Granados, Sanjay K Nigam
The organic anion transporter OAT1 (SLC22A6, originally identified as NKT) is a multispecific transporter responsible for the elimination by the kidney of small organic anions that derive from the gut microbiome. Many are uremic toxins associated with chronic kidney disease (CKD). OAT1 is among a group of "drug" transporters that act as hubs in a large homeostatic network regulating interorgan and interorganismal communication via small molecules. The Remote Sensing and Signaling Theory predicts that genetic deletion of such a key hub in the network results in compensatory interorganismal communication (e...
November 8, 2023: JCI Insight
https://read.qxmd.com/read/37915930/the-dietary-source-of-trimethylamine-n-oxide-and-clinical-outcomes-an-unexpected-liaison
#37
REVIEW
Marie Evans, Lu Dai, Carla Maria Avesani, Karolina Kublickiene, Peter Stenvinkel
The profile of gut microbiota can vary according to host genetic and dietary characteristics, and be influenced by disease state and environmental stressors. The uremic dysbiosis results in a loss of biodiversity and overgrowth of microorganisms that may cause elevation of metabolic solutes such as trimethylamine N-oxide (TMAO), inducing pathogenic effects on its host. In patients with chronic kidney disease (CKD), TMAO levels are elevated because of a decreased clearance and an increased production from the uremic gut dysbiosis with a disrupted intestinal barrier and elevated enzymatic hepatic activity...
November 2023: Clinical Kidney Journal
https://read.qxmd.com/read/37881747/blood-gut-and-oral-microbiome-in-kidney-transplant-recipients
#38
JOURNAL ARTICLE
Susana Sampaio, Ricardo Araujo, Ana Merino-Riba, Benjamin Lelouvier, Florence Servant, Janete Quelhas-Santos, Manuel Pestana, Benedita Sampaio-Maia
BACKGROUND AND OBJECTIVE: Recent reports describe the existence of a blood microbiome profile not associated with an infection state. Given the high impact that the dysbiotic human microbiome appears to have in chronic kidney disease and, in particular, in the outcome of kidney transplant recipients (KTRs), we aimed to explore the variations and correlations of the gut, oral, and blood microbiome of recipients, 3 months after kidney transplantation. MATERIALS AND METHODS: We conducted a cross-sectional study where the microbiome of stool, saliva, and blood collected from recipients 3 months after kidney transplantation ( N = 6) was analyzed by polymerase chain reaction (PCR) amplification and sequencing of the V3-V4 hypervariable regions of the 16S rRNA gene using MiSeq Illumina® technology...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37871960/circulating-metabolomic-associations-with-neurocognitive-outcomes-in-pediatric-ckd
#39
JOURNAL ARTICLE
Arthur M Lee, Yunwen Xu, Stephen R Hooper, Alison G Abraham, Jian Hu, Rui Xiao, Matthew B Matheson, Celina Brunson, Eugene P Rhee, Josef Coresh, Ramachandran S Vasan, Sarah Schrauben, Paul L Kimmel, Bradley A Warady, Susan L Furth, Erum A Hartung, Michelle R Denburg
BACKGROUND: Children with CKD are at risk for impaired neurocognitive functioning. We investigated metabolomic associations with neurocognition in children with CKD. METHODS: We leveraged data from the Chronic Kidney Disease in Children (CKiD) study and the Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease (NiCK) study. CKiD is a multi-institutional cohort that enrolled children aged 6 months to 16 years with eGFR 30-90 ml/min per 1...
October 23, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/37858192/washed-microbiota-transplantation-improves-renal-function-in-patients-with-renal-dysfunction-a-retrospective-cohort-study
#40
JOURNAL ARTICLE
Hao-Jie Zhong, Xinqiang Xie, Wen-Jia Chen, Yu-Pei Zhuang, Xuan Hu, Ying-Li Cai, Hong-Lie Zeng, Chuanxing Xiao, Ying Li, Yu Ding, Liang Xue, Moutong Chen, Jumei Zhang, Qingping Wu, Xing-Xiang He
BACKGROUND: Changes in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting the gut microbiota present a potent approach for CKD treatment. This study aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT), a modified faecal microbiota transplantation method, on the renal activity of patients with renal dysfunction. METHODS: A comparative analysis of gut microbiota profiles was conducted in patients with renal dysfunction and healthy controls...
October 19, 2023: Journal of Translational Medicine
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