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Tyler Werbel, Philip R Cohen
Ranitidine is an H2 antihistamine used as an off-label therapy for recalcitrant verruca vulgaris. We describe a man who developed a sleep disturbance after initiating therapy with ranitidine and review similar adverse effects associated with other drugs in this class. The patient was a 40-year-old man with an eight-year history of a wart on his right plantar foot that was recalcitrant to several topical therapies. Adjunctive treatment with ranitidine 150 mg twice daily was initiated. He developed sleep disturbance with bizarre dreams and gastrointestinal symptoms...
April 3, 2018: Curēus
Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov
BACKGROUND: Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly genetically variable. Twelve major alleles confer partial or complete loss of OCT1 activity. The effects of these polymorphisms are highly substrate-specific and therefore difficult to predict. The renal transporter OCT2 has a common polymorphism, Ala270Ser, which was reported to affect OCT2 activity...
2017: PloS One
Konstantin I Galkin, Elena A Krivodaeva, Leonid V Romashov, Sergey S Zalesskiy, Vadim V Kachala, Julia V Burykina, Valentine P Ananikov
Spectral studies revealed the presence of a specific arrangement of 5-hydroxymethylfurfural (5-HMF) molecules in solution as a result of a hydrogen-bonding network, and this arrangement readily facilitates the aging of 5-HMF. Deterioration of the quality of this platform chemical limits its practical applications, especially in synthesis/pharma areas. The model drug Ranitidine (Zantac®) was synthesized with only 15 % yield starting from 5-HMF which was isolated and stored as an oil after a biomass conversion process...
July 11, 2016: Angewandte Chemie
Seema Khan, Theresa M Shalaby, Susan R Orenstein
BACKGROUND: Ranitidine is widely used for gastroesophageal reflux disease (GERD) in children, but optimal dosing is unclear. We compared effects of weight-based doses of oral ranitidine on gastric pH in children with clinical GERD. METHODS: Children ages 4-11 years with clinical GERD were enrolled in a multi-center prospective randomized study comparing a fixed dose of ranitidine (Zantac 75) with placebo after an overnight fast; gastric pH was measured for 6 h after the fixed dose (Phase 1)...
October 2004: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Caroline Peterson
OBJECTIVE: This case study reports on chiropractic care for pregnancy-related heartburn. The purpose of this article is to relate the benefit of chiropractic treatment for one individual, to contrast chiropractic management with the biomedical standard of care for pregnancy-related heartburn, and to point to potential epigenetic implications of the standard of care. CLINICAL FEATURES: A 32-year-old woman who was 24 weeks pregnant presented with persistent heartburn that she was treating with ranitidine (Zantac®) and calcium carbonate (Tums®) daily at the initiation of chiropractic care...
September 2012: Explore: the Journal of Science and Healing
Tae Young Han, Woo Sun Jang, Mi Yu, Hyun Kyung Lee, Sook-Ja Son, Seong Jun Seo
No abstract text is available yet for this article.
November 2011: International Journal of Dermatology
J Chrenova, M Durisova, C Mircioiu, L Dedik
The aim of study was to compare the bioavailability of ranitidine obtained from either Ranitidine (300 mg tablet; LPH® S.C. LaborMed Pharma S.A. Romania: the test formulation) and Zantac® (300 mg tablet; GlaxoSmithKline, Austria: the reference formulation). Twelve, Romanian, healthy volunteers were enrolled in the study. An open-label, two-period, crossover, randomized design was used. Plasma levels of ranitidine were determined using the validated, high-pressure liquid chromatography (HPLC) method. The physiologically motivated time-delayed model was used for the data evaluation and a paired Student's t-test and Schuirmann's two one-sided tests were carried out to compare parameters...
July 2010: Methods and Findings in Experimental and Clinical Pharmacology
H Gudjonsson, E Oddsson, M Sigurdardottir, B Thjodleifsson
OBJECTIVE: The study proposes to investigate the pharmacological efficacy of four commonly used acid inhibitory drugs. The effect on 24 hour gastric pH of seven days treatment was assessed for two omeprazole preparations, Losec(R) 20 mg (Hassle) and Lómex(R) 20 mg, (Omega Farma) and two H2 blockers, famotidine 40 mg (Famex(R), Omega Farma) and ranitidine 300 mg (Zantac(R), Glaxo). MATERIAL AND METHODS: Sixteen healthy volunteers participated in each experiment comparing blindly Losec(R) / Lómex(R) and Famex(R) / Zantac(R)...
June 1997: Læknablađiđ
Cindy K Barney, Vickie L Baer, Scott H Scoffield, Diane K Lambert, Mike Cook, Robert D Christensen
PURPOSE: Evidence is needed to guide NICU use of lansoprazole (Prevacid), ranitidine (Zantac), and metoclopramide (Reglan). As a step toward that goal, we conducted a historic cohort analysis of all patients who received any of these medications in 4 Intermountain Healthcare NICUs during the year 2006. SUBJECTS: Data were obtained from all patients admitted between January 1 and December 31, 2006, to any of 4 Intermountain Healthcare NICUs. DESIGN: This was a retrospective descriptive design...
June 2009: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Antonio Oliva, Sara Partemi, Vincenzo Arena, Fabio De Giorgio, Catia Colecchi, Nadia Fucci, Vincenzo L Pascali
INTRODUCTION: Ranitidine hydrochloride (Zantac), a histamine-2-receptor antagonist, is a widely used medication with an excellent safety record. Anaphylactic reaction to ranitidine is an extremely rare event and a related death has never been described in the literature. CASE PRESENTATION: We present the clinical history, histological and toxicological data of a 51-year-old man with negative anamnesis for allergic events, who died suddenly after the intravenous administration of one phial of Zantac 50 mg prescribed as a routine post-surgical prophylaxis for stress ulcer...
2008: Journal of Medical Case Reports
Osamu Okamoto, Sakuhei Fujiwara
An 80-year-old male who developed a generalized papular erythema-type drug eruption after being treated with ranitidine hydrochloride is herein reported. The duration from the intake of the medicine to the onset of the eruption was 3 days, and the eruption remained unchanged for a week after withdrawal of the medicine and even after the eruption itself was treated. A diagnosis of drug eruption by ranitidine hydrochloride was confirmed based on a strongly-positive reaction of a drug-induced lymphocyte stimulation test (DLST)...
January 2007: Journal of Dermatology
Christos Kosmas, Nicolas Tsavaris
BACKGROUND: Many investigations have focused on optimal doses/schedules since regulatory agency approval of paclitaxel (Taxol). Paclitaxel is generally administered at doses of 175-225 mg/m2 over 3 hours or 135-175 mg/m2 over 24 hours, every 3 weeks. The purpose of this study was to simplify administration and render it suitable and practical in the outpatient setting. Using this rationale, the duration of administration was decreased to one hour, with a minimized premedication regimen...
November 2006: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Vanessa Z Ameen, Bonnie F Pobiner, Gregory C Giguere, Eric G Carter
BACKGROUND: The histamine H(2) receptor antagonist ranitidine is US FDA-approved for the treatment of gastroesophageal reflux disease and healing of erosive esophagitis in children >or=1 month of age. A low-dose strength of ranitidine is now available in a citrus-flavored 25 mg effervescent tablet (dissolved in 5 mL of water); this formulation was developed to facilitate use in infants and smaller children. Ranitidine syrup is available in a peppermint-flavored 15 mg/mL formulation...
2006: Paediatric Drugs
Lina Paulionis, Sheri-Lynn Kane, Kelly A Meckling
BACKGROUND: Ageing can be associated with poor dietary intake, reduced nutrient absorption, and less efficient utilization of nutrients. Loss of memory and related cognitive function are also common among older persons. This study aimed to measure the prevalence of inadequate vitamin status among long-term care patients and determine if an association exists between vitamin status and each of three variables; cognitive function, vitamin supplementation, and medications which alter gastric acid levels...
December 13, 2005: BMC Geriatrics
Keith A Swanson
No abstract text is available yet for this article.
July 2005: Journal of the American Pharmacists Association: JAPhA
Maryam Banikazemi, Thomas Ullman, Robert J Desnick
Gastrointestinal symptoms are often an early and prominent manifestation of Fabry disease, an X-linked inborn error of metabolism caused by the deficient activity of the lysosomal enzyme, alpha-galactosidase A. This enzyme deficiency results in the progressive accumulation of globotriaosylceramide and other glycosphingolipids in tissue lysosomes throughout the body. In classically affected patients, glycosphingolipid accumulation in the vascular endothelium eventually culminates in life-threatening renal, cardiac, and cerebrovascular disease...
August 2005: Molecular Genetics and Metabolism
M A Skinner, D L Keen, N A Parlane, K L Hamel, G F Yates, B M Buddle
Possums are a wildlife vector of bovine tuberculosis in New Zealand. Vaccination of possums with BCG is being considered as a measure to control the spread of bovine tuberculosis to cattle and deer. Delivery via oral bait is feasible but BCG is degraded in the stomach. The aim was to determine whether ranitidine (Zantac) would reduce gastric acidity and enhance the efficacy of intragastrically administered BCG. A dose of 75 mg reduced gastric acidity for at least 4 h. Thus, possums were vaccinated intragastrically with BCG after receiving 75 mg ranitidine or ranitidine or BCG alone, as controls, before challenge with virulent Mycobacterium bovis...
June 2005: Research in Veterinary Science
G A Pipkin, J G Mills, L Kler, J S Dixon, J R Wood
Ranitidine bismuth citrate (Pylorid, Tritec) is a novel drug which heals peptic ulcers and when co-prescribed with either clarithromycin or amoxycillin eradicatesHelicobacter pylori. In controlled clinical studies it was well-tolerated when given alone or when co-prescribed with either antibiotic. Data from 20 clinical studies are reported in this analysis of safety with almost 5000 patients having received ranitidine bismuth citrate (200, 400, or 800 mg twice daily). The incidence of adverse events reported with this new drug, either alone or with an antibiotic, was not different from or lower than in patients given placebo and was independent of the dose of ranitidine bismuth citrate tested...
November 1996: Pharmacoepidemiology and Drug Safety
Chantal Incledon, Chantal Paquet, Andrea Johnston, Rick Jairam, Lenny Dass, Herman Lam
PURPOSE: To present a selective analytical Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) method developed and validated for the quantitation of tablet film coatings containing titanium. METHODS: Tablet samples were decomposed by either digestion or dry ashing. The amount of film tablet coating was calculated based on titanium content of the sample. RESULTS: The reported ICP-AES method was accurate, precise, sensitive and linear for determination of titanium concentrations from 2...
March 10, 2003: Journal of Pharmaceutical and Biomedical Analysis
Iu V Vasil'ev
There are the results of the examination and treatment of 68 patients with duodenal ulcers, 52 of them having the Helicobacter pylori (HP) semination of the mucous coat of stomach revealed by the histologic method and/or fast urease test before the treatment. The healing of the duodenal bulb ulcer was recorded in 82.7% of cases in this group of patients after the four-week treatment (ranitidine, 150 mg b.i.d. for four weeks in combination with amoxicillin, 500 mg q.i.d., and metronidazole, 500 mg b.i.d. for the initial ten-day period); the healing of ulcers was recorded in 81...
2002: Experimental & Clinical Gastroenterology
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