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Advanced adenoma

Gregory Kaltsas, Dionysia Kolomodi, Harpal Randeva, Ashley Grossman
CONTEXT: Although the majority of sellar lesions are related to pituitary adenomas, the region gives rise to a variety of neoplasms that can be associated with substantial morbidity and/or mortality. EVIDENCE ACQUISITION: Information from reviews and guidelines of relevant societies dealing with such neoplasms, and articles that have provided new developments which made important contributions in their pathogenesis and treatment up to 2018, were obtained: public indexes such as PubMed/MEDLINE were used with the search items...
February 19, 2019: Journal of Clinical Endocrinology and Metabolism
Guy Launoy
While organized screening for colorectal cancer has been extended to the whole of France since 2008, there is no evidence to suggest that this screening based on use of the guaiac test had a significant impact on trends in its incidence and mortality in France in the last 10 years. Following the first prospective trials conducted in Normandy, FIT (Fecal Immunological Test) was proposed to the entire national territory from 2015. Three years after its generalization, it is of course impossible to measure the effects of this modification of strategy on the incidence or mortality from colorectal cancer...
February 14, 2019: Bulletin du Cancer
Yoon Suk Jung, Nam Hee Kim, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND & AIMS: Previous assessments of colorectal neoplasia (CRN) recurrence after polypectomy used self-report to determine smoking status. We evaluated the association between change in smoking status and metachronous CRN risk after polypectomy using cotinine level in urine to determine tobacco exposure. METHODS: We performed a retrospective study of participants in the Kangbuk Samsung Health Study, in Korea, who underwent a screening colonoscopy examination and measurement of cotinine in urine samples...
February 14, 2019: Clinical Gastroenterology and Hepatology
Shunsuke Yamamoto
No abstract text is available yet for this article.
February 12, 2019: Gastrointestinal Endoscopy
Rosalie C Oey, Laurelle van Tilburg, Nicole S Erler, Herold J Metselaar, Manon C W Spaander, Henk R van Buuren, Robert A de Man
Colorectal cancer screening with colonoscopy is commonly used in candidate patients for liver transplantation. We initiated this study to define the risk-benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre-liver transplantation screening between 2004-2017 was conducted. Endoscopic and pathological findings and clinical events potentially related to the colonoscopy in the 30 days after the procedure were registered and compared with a 30 days in-patient control time frame...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Mustafa Çalışkan, Muhammed Kızılgül, Selvihan Beysel, Bekir Uçan, Fatih Akcan, Mümtaz Takır, Mustafa Özbek, Erman Çakal
Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients. Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 were enrolled in the study...
February 11, 2019: Turkish Journal of Medical Sciences
Callum P Rakhit, Ricky M Trigg, John Le Quesne, Michael Kelly, Jacqueline A Shaw, Catrin Pritchard, L Miguel Martins
Lung cancer is the leading cause of cancer-related death. Two-thirds of cases are diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies for the early detection of lung cancer are urgently sought. Total circulating free DNA (cfDNA) and tumour-derived circulating tumour DNA (ctDNA) are emerging as important biomarkers within a 'liquid biopsy' for monitoring human disease progression and response to therapy. Owing to the late clinical diagnosis of lung adenocarcinoma, the potential for cfDNA and ctDNA as early detection biomarkers remains unexplored...
February 12, 2019: Disease Models & Mechanisms
Georgia Papachristopoulou, Apostolos Malachias, Marina Devetzi, Evdoxia Kamouza, Andreas Scorilas, Dimitris Xynopoulos, Maroulio Talieri
Background Kallikrein-related peptidases (KLKs) are a subgroup of serine proteases located on chromosome 19q13.3. Most KLKs have been extensively studied as potential biomarkers for several carcinomas and other diseases. KLK5 was originally identified from a keratinocyte library, and its enzyme was purified from the stratum corneum of human skin. KLK5 was shown to be differentially expressed in a variety of endocrine tumors, although it is not as yet examined widely in colorectal cancer (CRC). Methods In this study, we quantitatively assessed the mRNA expression status of KLK5 in 197 colorectal tissues from 133 patients (70 cancerous and their paired normal colonic mucosa for 64 of them, as well as 63 colorectal adenomas) by quantitative real-time PCR (qPCR) using TaqMan probes...
February 13, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
Monika Migdalska-Sęk, Karolina H Czarnecka, Michał Kusiński, Dorota Pastuszak-Lewandoska, Ewa Nawrot, Krzysztof Kuzdak, Ewa Brzeziańska-Lasota
BACKGROUND: Loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumor etiopathogenesis occurring in several chromosomal critical areas, including 3p12-25.3, 7q21-31, 10q22-24, and 15q11-13, with loci of tumor suppressor genes. OBJECTIVE: We evaluated the usefulness of LOH/MSI as a diagnostic/prognostic biomarker in lesions derived from thyroid follicular cells: follicular thyroid carcinoma (FTC); follicular adenoma (FA), papillary thyroid carcinoma (PTC), and nodular goiter (NG)...
February 11, 2019: Molecular Diagnosis & Therapy
P J Pickhardt, B D Pooler, K A Matkowskyj, D H Kim, W M Grady, R B Halberg
OBJECTIVE: Sessile serrated adenomas/polyps (SSA/Ps) are now recognized as potential cancer precursors, but little is known about their natural history. We assessed the in vivo growth rates of histologically proven SSA/Ps at longitudinal CT colonography (CTC) and compared results with non-advanced tubular adenomas (TAs). METHODS: We identified a cohort of 53 patients (mean age, 54.8 ± 5.5 years; M:F, 26:27) from one center with a total of 58 SSA/Ps followed longitudinally at CTC (mean follow-up interval, 5...
February 11, 2019: European Radiology
Shengbing Zhao, Shuling Wang, Peng Pan, Tian Xia, Xin Chang, Xia Yang, Liliangzi Guo, Qianqian Meng, Fan Yang, Wei Qian, Zhichao Xu, Yuanqiong Wang, Zhijie Wang, Lun Gu, Rundong Wang, Fangzhou Jia, Jun Yao, Zhaoshen Li, Yu Bai
BACKGROUND & AIMS: We performed a systematic review and meta-analysis to comprehensively estimate the adenoma miss rate (AMR) and advanced AMR (AAMR) and explore associated factors. METHODS: We searched the PubMed, Web of Science, and Ovid EMBASE databases for studies published through April 2018 on tandem colonoscopies, with AMR and AAMR as the primary outcomes. We performed meta-regression analyses to identify risk factors and factors associated with outcome...
February 6, 2019: Gastroenterology
Min Cheol Kim, Jung Gil Park, Byung Ik Jang, Heon Ju Lee, Won Kee Lee
Nonalcoholic fatty liver disease (NAFLD) is associated with risks for developing colorectal adenoma. This study aimed to evaluate the association between advanced fibrosis in NAFLD and the risk for colorectal adenoma.We retrospectively analyzed the data of 6332 adults who underwent abdominal ultrasound and 1st-time colonoscopy on the same day in a health screening program at a single center. We evaluated the presence of advanced fibrosis in NAFLD using various noninvasive score, which also analyzed the detection rate of colorectal adenoma according to the presence of advanced fibrosis in NAFLD...
February 2019: Medicine (Baltimore)
Si Yi Yuan, Wei Wu, Jing Fu, Yi Xuan Lang, Ji Chi Li, Ye Guo, Ya Nan Wang, Jia Ming Qian, Jing Nan Li
OBJECTIVES: To investigate the performance of the quantitative immunochemical fecal occult blood test (qFIT), and determine the association between the fecal hemoglobin (Hb) level and the location, size of adenomas and the grades of colorectal cancer (CRC). METHODS: A total of 692 participants were included in the study. The fecal Hb level was measured using an OC-SENSA MICRO qFIT. The colonoscopy results, including the location, size, and histological features of the adenomas, as well as the relationship between the Hb level and different characteristics were analyzed...
February 3, 2019: Journal of Digestive Diseases
Ajay P Abad
PURPOSE OF REVIEW: Sellar and parasellar lesions are numerous and varying in terms of their patholphysiology and physical and radiographic characteristics but often incite pain syndromes that are similar in semiology. The goal of this review was to familiarize the reader with a variety of sellar and parasellar lesions grouped together based on common clinical symptomatology, with a focus on important imaging characteristics that are often distinguishing features diagnostically. RECENT FINDINGS: In most cases, tissue acquisition via surgical resection or stereotactic biopsy are the mainstay for definitive diagnosis of sellar and parasellar lesions...
February 2, 2019: Current Pain and Headache Reports
Keisuke Okamura, Tetsu Okuda, Yusuke Fukuda, Yosuke Takamiya, Kazuyuki Shirai, Shigerou Miyajima, Tatsu Ishii, Hidenori Urata
BACKGROUND Before partial adrenalectomy for primary aldosteronism due to a primary adrenal adenoma, the aldosterone-producing tumor can be localized by segmental adrenal vein sampling (S-AVS). Cardiologists, who regularly perform percutaneous coronary intervention (PCI), or coronary angioplasty with stent, may not be familiar with the technique of S-AVS. A case of the use of S-AVS is reported in a patient who presented with primary aldosteronism and a right adrenal adenoma. CASE REPORT A 44-year-old man with a history of hypertension presented with a man in the posterior part of the right adrenal gland...
February 2, 2019: American Journal of Case Reports
Argha Chatterjee, Camila Lopes Vendrami, Paul Nikolaidis, Pardeep K Mittal, Andrew J Bandy, Christine O Menias, Nancy A Hammond, Vahid Yaghmai, Guang-Yu Yang, Frank H Miller
Intraluminal pathologic conditions of the bile ducts and gallbladder are common, most frequently consisting of calculi and adenocarcinoma. In recent years, intraductal papillary neoplasm of the bile ducts (IPN-B), which is analogous to intraductal papillary mucinous neoplasm of the pancreas, has been recognized as a distinct pathologic entity and a precursor lesion to adenocarcinoma of the bile ducts. Intraductal tubulopapillary neoplasm (ITPN) of the bile duct was subsequently described as a distinct pathologic entity...
February 1, 2019: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Marta Herreros-Villanueva, Saray Duran-Sanchon, Ana Carmen Martín, Rosa Pérez-Palacios, Elena Vila-Navarro, María Marcuello, Mireia Diaz-Centeno, Joaquín Cubiella, Maria Soledad Diez, Luis Bujanda, Angel Lanas, Rodrigo Jover, Vicent Hernández, Enrique Quintero, Juan José Lozano, Marta García-Cougil, Ibon Martínez-Arranz, Antoni Castells, Meritxell Gironella, Rocio Arroyo
OBJECTIVES: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising diagnostic biomarkers for colorectal cancer (CRC) screening. In this study, we investigated the performance of a specific signature of miRNA in plasma samples to design a robust predictive model that can distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases...
January 2019: Clinical and Translational Gastroenterology
Naa Naamuah Tagoe, Vera Adobea Essuman, Patrick Bankah, Thomas Dakurah, Vincent Kwaku Hewlett, Josephine Akpalu, Thomas Akuetteh Ndanu
Background: Craniotomy and transphenoidal microsurgery are surgical options for treatment of pituitary adenoma at Korle Bu Teaching Hospital(KBTH). Despite major advances and reported success rates of transphenoidal resection globally, paucity of local data regarding visual outcome of either procedure exists. We evaluated the visual outcome of patient with pituitary adenoma following surgery in a tertiary hospital in Ghana. Methods: This is a prospective study of 18 of 45 consecutive new patients with pituitary adenoma seen from November 2010 to July 2013 at Korle-Bu Teaching Hospital(KBTH), Accra, Ghana...
January 2019: Ethiopian Journal of Health Sciences
David Karsenti, Gaelle Tharsis, Pascal Burtin, Franck Venezia, Gilles Tordjman, Agnès Gillet, Joelle Samama, Karine Nahon-Uzan, Philippe Cattan, Maryan Cavicchi
BACKGROUND: Colonoscopy is considered a valid primary screening tool for colorectal cancer (CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate (ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years...
January 28, 2019: World Journal of Gastroenterology: WJG
Kristin Ranheim Randel, Edoardo Botteri, Katrine Maria Kauczynska Romstad, Svein Oskar Frigstad, Michael Bretthauer, Geir Hoff, Thomas de Lange, Øyvind Holme
BACKGROUND & AIMS: The fecal immunochemical test (FIT) is the tool most frequently used for colorectal cancer (CRC) screening worldwide. It is unclear how the use of aspirin and oral anticoagulants in the screening population affect the diagnostic performance of FIT. METHODS: We performed a cross-sectional study in an ongoing CRC screening trial in Norway. Participants 50-74 years old with a positive result from a FIT (>15μg hemoglobin/g feces) and subsequent colonoscopy (reference standard) were included...
January 25, 2019: Gastroenterology
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