Marzieh Tavakol, Samaneh Delavari, Fereshte Salami, Sarina Ansari, Seyed Erfan Rasouli, Zahra Chavoshzadeh, Roya Sherkat, Hamid Ahanchian, Soheila Aleyasin, Hossein Esmaeilzadeh, Nasrin Moazzen, Alireza Shafiei, Farhad Abolnezhadian, Sara Iranparast, Sareh Sadat Ebrahimi, Tannaz Moeini Shad, Salar Pashangzadeh, Farzad Nazari, Arezou Rezaei, Ali Saeedi-Boroujeni, Mohammad Nabavi, Saba Arshi, Morteza Fallahpour, Mohammad Hassan Bemanian, Samin Sharafian, Sima Shokri, Sarvin Eshaghi, Shiva Nazari, Bibi Shahin Shamsian, Mehrdad Dargahi Mal-Amir, Roya Khazaei, Pooya Ashkevari, Armin Khavandegar, Sabahat Haghi, Marzie Esmaeili, Hassan Abolhassani, Nima Rezaei
Genetic defects in the development, maturation, and/or function of the immune cells can lead to Inborn errors of immunity (IEI) which may predispose patients to malignancies. The overall risk for cancer in children with IEI ranges from 4 to 25% and the type of malignancy is highly dependent on the specific mutant gene underlying IEI. We investigated 3056 IEI patients registered in the Iranian national registry between the years 1999 and 2020 in this retrospective cohort study. The frequency of malignancy and its association with the type of IEI in these patients were evaluated...
December 12, 2022: Allergy, Asthma, and Clinical Immunology