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Camila Kruschewsky Falcao, Marina Campos Simoes Cabral, Jose Mauricio Mota, Samia Trigo Arbache, Aline Dantas Costa-Riquetto, David Queiroz Borges Muniz, Jade Cury-Martins, Madson Q Almeida, Priscilla Cukier Kaczemorska, Marcia Nery, Milena Gurgel Teles
CONTEXT: Lipodystrophy syndromes are rare disorders characterized by the selective loss of adipose tissue. We aimed to report the first case of acquired generalized lipodystrophy possibly associated with nivolumab. CASE DESCRIPTION: A woman was referred to our Endocrinology Department for uncontrolled diabetes mellitus. At 50 years of age, she was diagnosed with type 2 diabetes after a routine laboratory test and her diabetes was well controlled with low doses of metformin...
February 19, 2019: Journal of Clinical Endocrinology and Metabolism
Ivan Radovanovic, Amir R Dehdashti, Mazda K Turel, Joao Paulo Almeida, Bruno L Godoy, Francesco Doglietto, Allan D Vescan, Gelareh Zadeh, Fred Gentili
BACKGROUND: The role of expanded endonasal endoscopic surgery for primary and recurrent craniopharyngioma is not yet fully established. OBJECTIVE: To report and evaluate our experience with the endoscopic endonasal approach (EEA) for the resection of primary and recurrent craniopharyngiomas. METHODS: This is a retrospective cohort analysis of 43 consecutive EEA procedures in 40 patients operated from September 2006 to February 2012 for suprasellar craniopharyngiomas...
February 15, 2019: Operative Neurosurgery (Hagerstown, Md.)
Ray Rodgers, Jodie Avery, Vivienne Moore, Michael Davies, Ricardo Azziz, Elisabeth Stener-Victorin, Lisa Moran, Sarah Robertson, Nigel Stepto, Rob Norman, Helena J Teede
OBJECTIVE: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19-28% of women of reproductive age...
February 1, 2019: Endocrine Connections
F A Mishu, N Boral, N Ferdous, S Nahar, G S Sultana, M S Yesmin, N Z Khan
Zinc (Zn), Copper (Cu) and Magnesium (Mg) are essential trace elements for normal embryogenesis and fetal growth. Alteration of Zn, Cu and Mg concentrations in blood has been observed in normal pregnancy as well as in gestational diabetes mellitus (GDM). Aim of this study was to evaluate the serum Zn, Cu and Mg levels in Bangladeshi women with GDM in their second and third trimester of pregnancy. This descriptive cross sectional study was conducted at Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from July 2013 to June 2014...
January 2019: Mymensingh Medical Journal: MMJ
Alan J Garber, Martin J Abrahamson, Joshua I Barzilay, Lawrence Blonde, Zachary T Bloomgarden, Michael A Bush, Samuel Dagogo-Jack, Ralph A DeFronzo, Daniel Einhorn, Vivian A Fonseca, Jeffrey R Garber, W Timothy Garvey, George Grunberger, Yehuda Handelsman, Irl B Hirsch, Paul S Jellinger, Janet B McGill, Jeffrey I Mechanick, Paul D Rosenblit, Guillermo E Umpierrez
A1C = hemoglobin A1C; AACE = American Association of Clinical Endocrinologists; ACCORD = Action to Control Cardiovascular Risk in Diabetes; ACCORD BP = Action to Control Cardiovascular Risk in Diabetes Blood Pressure; ACE = American College of Endocrinology; ACEI = angiotensin-converting enzyme inhibitor; AGI = alpha-glucosidase inhibitor; apo B = apolipoprotein B; ARB = angiotensin II receptor blocker; ASCVD = atherosclerotic cardiovascular disease; BAS = bile acid sequestrant; BMI = body mass index; BP = blood pressure; CCB = calcium channel blocker; CGM = continuous glucose monitoring; CHD = coronary heart disease; CKD = chronic kidney disease; DKA = diabetic ketoacidosis; DPP4 = dipeptidyl peptidase 4; eGFR = estimated glomerular filtration rate; EPA = eicosapentaenoic acid; ER = extended release; FDA = Food and Drug Administration; GLP1 = glucagon-like peptide 1; HDL-C = high-density-lipoprotein cholesterol; HeFH = heterozygous familial hypercholesterolemia; LDL-C = low-density-lipoprotein cholesterol; LDL-P = low-density-lipoprotein particle; Look AHEAD = Look Action for Health in Diabetes; NPH = neutral protamine Hagedorn; OSA = obstructive sleep apnea; PCSK9 = proprotein convertase subtilisin-kexin type 9 serine protease; RCT = randomized controlled trial; SU = sulfonylurea; SGLT2 = sodium-glucose cotransporter 2; SMBG = self-monitoring of blood glucose; T2D = type 2 diabetes; TZD = thiazolidinedione...
January 2019: Endocrine Practice
Tricia S Tang, Rowshanak Afshar, Thomas Elliott, Jason Kong, Sabrina Gill
BACKGROUND: The objective of this randomized controlled trial is to examine the effects of a 12-month telephone-based peer-led diabetes self-management support (DSMS) intervention on long-term diabetes-related health outcomes. METHODS: In total, 197 participants with type 2 diabetes were recruited from specialty care settings (diabetes and endocrinology clinics). They were randomly assigned to 1) a 12-month Peer-Led, Empowerment-based Approach to Self-management Efforts in Diabetes (PLEASED) program where they received 12 weekly contacts from their peer supporter (PS) in the first 3 months, followed by 18 biweekly telephone support contacts over the last 9 months, or 2) usual care...
February 7, 2019: Contemporary Clinical Trials
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
February 6, 2019: Lancet Diabetes & Endocrinology
Jorge Sapunar, Alex Escalona, A Verónica Araya, Carmen Gloria Aylwin, María Juliana Bastías, Camilo Boza, Carlos Cárcamo, Attila Csendes A, Patricio Davidof F, Ricardo Funke, Patricia Gómez, María Isabel González, Rodolfo Lahsen, Enrique Lanzarini, Alberto Maíz, Verónica Mujica, Rodrigo Muñoz, Gustavo Pérez, Félix Raimann, Patricio Salman, Matías Sepúlveda, Néstor Soto, Rodrigo Villagrán
Diabetes Mellitus (DM) and obesity are a public health problem in Chile. Bariatric surgery is the most effective treatment alternative to achieve a significant and sustained weight reduction in patients with morbid obesity. The results of controlled clinical trials indicate that, compared to medical treatment, surgery for obese patients with DM2 allows a better control of blood glucose and cardiovascular risk factors, reduces the need for medications and increases the likelihood for remission. Consensus conferences and clinical practice guidelines support bariatric surgery as an option to treat DM2 in Class III Obesity (Body Mass Index (BMI) > 40) regardless of the glycemic control and the complexity of pharmacological treatment and in Class II Obesity (BMI 35-39,9) with inadequate glycemic control despite optimal pharmacological treatment and lifestyle...
December 2018: Revista Médica de Chile
Tracy L Setji, Courtney Page, Neha Pagidipati, Benjamin A Goldstein
OBJECTIVE: This study evaluated whether there is a difference in the proportion of patients with type 2 diabetes who achieve an A1c <7% within one year following treatment by an endocrinologists or PCP. RESEARCH DESIGN AND METHODS: We conducted a retrospective, propensity-matched study of patients with type 2 diabetes that are not optimally controlled seen within our health system from 2007-2016. We assessed differences in short term health outcomes for patients following an endocrinologist visit compared to a PCP visit...
January 18, 2019: Endocrine Practice
Juan Delgado, Alicia Armstrong, Ricardo Correa, Richard Comi
OBJECTIVES: To our knowledge, no prior research has explored the prevalence of wearing CGM's and/or insulin pumps among in-training fellows and their perception of doing so as part of their education. Our objectives therefore are: to estimate the frequency with which wearing a CGM and/or insulin pump is used as a learning opportunity and to explore the main motivators and perception on its value. METHODS: A multiple-choice survey that addressed fellow's level of training, type of fellowship training program, and use of CGM and/or insulin pump among fellows was sent to all ACGME endocrinology, diabetes and metabolism program coordinators or programs directors...
January 18, 2019: Endocrine Practice
Neslihan Gokcen, Seher Cetinkaya Altuntas, Ilke Coskun Benlidayi, Murat Sert, Ersin Nazlican, Tunay Sarpel
OBJECTIVES: The objectives of the study were to analyze the clinical characteristic of diabetic cheiroarthropathy (DCA) in patients with type 1 diabetes mellitus (DM), type 2 DM, and prediabetes and to evaluate the frequency of DCA among groups. METHOD: The cross-sectional study was conducted at the Division of Endocrinology and Metabolism outpatient clinic over a 14-month period. A total of 239 patients (160 female, 79 male), who had type 1 DM, type 2 DM, and prediabetes, were enrolled...
February 2, 2019: Clinical Rheumatology
Asher Fawwad, Denira Govender, Mohammad Yakoob Ahmedani, Abdul Basit, Julie Ann Lane, Steven John Mack, Mark Alvin Atkinson, Clive Henry Wasserfall, Graham David Ogle, Janelle Annette Noble
Published information on diabetes in Pakistani youth is limited. We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age. The study was conducted at Baqai Institute of Diabetology and Endocrinology in Karachi from June 2013-December 2015. One hundred subjects aged <22 years at diagnosis were enrolled. Demographic characteristics, clinical information, biochemical parameters (blood glucose, HbA1c, C-peptide, glutamic acid decarboxylase 65 (GAD65) and islet antigen 2 (IA-2) autoantibodies) were measured...
January 30, 2019: Diabetes Research and Clinical Practice
Yoshikazu Ogawa, Kuniyasu Niizuma, Teiji Tominaga
BACKGROUND:  Intracranial chondromas are extremely rare and represent only 0.2% of all intracranial primary neoplasms. The histologic appearance lacks nuclear atypism and mitoses, and it usually shows low growth potential, although these benign features do not necessarily imply a good prognosis. CASE DESCRIPTION:  A 44-year-old man was referred to our institution with a subarachnoid hemorrhage (SAH). He had a history of SAH 5 years previously that was diagnosed as unknown etiology at another hospital...
February 1, 2019: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Guy I Sydney, Kalliopi J Ioakim, Stavroula A Paschou
An adrenal incidentaloma (AI) is an adrenal mass incidentally found via a radiological modality, independent of an endocrinological investigation. In this review, we aimed to investigate the possible reasons behind the increased frequency in AI detection, especially in ageing populations. The pathophysiological effects of insulin resistance (IR), hyperinsulinemia and various anabolic pathways are analyzed. In addition, we review data from studies indicating an increased incidence of adrenal adenomas and carcinomas in patients with type 2 diabetes mellitus (T2DM)...
March 2019: Maturitas
Nathanaëlle Montanier, Lise Bernard, Céline Lambert, Bruno Pereira, Françoise Desbiez, Daniel Terral, Armand Abergel, Jérôme Bohatier, Eugenio Rosset, Jeannot Schmidt, Valérie Sautou, Samy Hadjadj, Marie Batisse-Lignier, Igor Tauveron, Salwan Maqdasy, Béatrice Roche
INTRODUCTION: Insulin infusion is recommended during management of diabetic patients in critical care units to rapidly achieve glycaemic stability and reduce the mortality. The application of an easy-to-use standardized protocol, compatible with the workload is preferred. Glycaemic target must quickly be reached, therefore static algorithms should be replaced by dynamic ones. The dynamic algorithm seems closer to the physiological situation and appreciates insulin sensitivity. However, the protocol must meet both safety and efficiency requirements...
2019: PloS One
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
February 2019: Lancet Diabetes & Endocrinology
Brynn E Marks, Joseph I Wolfsdorf, Gretchen Waldman, Diane E Stafford, Katharine C Garvey
BACKGROUND: Recent data demonstrating a lack of improvement in average hemoglobin A1c levels despite the increased use of insulin pumps and continuous glucose monitors (CGMs) suggest that patients are not using these technologies optimally. Suboptimal provider understanding of these devices may be a contributing factor. METHODS: We sought to assess fellows' knowledge, attitudes, and practices regarding insulin pumps and CGMs using a mixed-methods survey. We polled 42 pediatric endocrinology fellows and 69 attending physicians in pediatric endocrinology using items on a five-point Likert scale...
January 25, 2019: Diabetes Technology & Therapeutics
Laila Azam, John Meurer, David Nelson, Onur Asan, Kathryn Flynn, Paul Knudson, Staci Young
OBJECTIVE: The aim of this study is to understand how the physician-patient relationship is related to referral practices for diabetes self-management education and physicians' perceptions of culturally competent health care delivery at a large health system affiliated with an academic medical center in a Midwestern city. METHODS: Sixteen physicians (6 family medicine, 6 internal medicine, 4 endocrinology) participated in semistructured interviews. Interviews were audio-recorded, transcribed, and coded...
December 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
Gerardo García-Maldonado, Rubén de Jesús Castro-García
The prescribing of Lithium is common in psychiatric clinical practice. The aim of this study was to identify the most common endocrine side effects associated with this drug and to clarify the pathophysiological basis. A systematic review was conducted in Psycinfo, Embase, PubMed, and Scopus. A computerised search for information was performed using a PICO (patient, intervention, comparative, outcomes) strategy. The main neuroendocrine alterations were reported in kidneys, thyroid and parathyroid glands, pancreas, and the communication pathways between the pituitary and adrenal glands...
January 2019: Revista Colombiana de Psiquiatría
Abul Kalam Azad, Sumudu Setunge, Shahjada Selim, Shahabul Huda Chowdhury, Mohammad Ferdousur Rahaman, Md Abdul Jalil Chowdhury, Barbora de Courten, Dragan Ilic, Md Nazmul Karim
BACKGROUND: Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients. METHODS: The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh...
January 2019: Diabetes & Metabolic Syndrome
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