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Grace risk score

Sumayya Shahzad, Somaiya Mateen, Asif Hasan, Shagufta Moin
BACKGROUND: Etiopathogenesis of myocardial infarction (MI) is contributed by oxidative injury and inflammatory response. The interplay of these processes determines outcomes in MI patients. However, studies showing the relationship of oxidative stress and inflammatory cytokines with prognosis and severity of MI are lacking. OBJECTIVE: The present study was designed to assess the degree of oxidative stress and inflammation in correlation with GRACE (Global Registry of Acute Coronary Events) risk score in patients of MI...
February 10, 2019: Immunobiology
Lisa Van de Wijer, Deborah N Mchaile, Quirijn de Mast, Blandina T Mmbaga, Nanda N J Rommelse, Ashanti Duinmaijer, André J A M van der Ven, Arnt F A Schellekens, Grace D Kinabo
BACKGROUND: Efavirenz is commonly prescribed for children with HIV infection, yet little is known about risks of neuropsychiatric side-effects. We aimed to compare competence (social involvement, activities, and school performance) and psychopathology (internalising and externalising problems), cognitive performance (intelligence and working memory), and adherence in Tanzanian children on an efavirenz-based versus a non-efavirenz-based regimen. METHODS: In this multicentre, cross-sectional, observational study, we included consecutive children (aged 6-12 years) with HIV infection, on combination antiretroviral therapy (cART) for at least 6 months, and with viral loads of less than 1000 copies per mL from HIV care clinics of three primary health facilities and three referral hospitals in Moshi, Kilimanjaro, Tanzania...
February 12, 2019: Lancet HIV
Abhinav Sharma, Jie-Lena Sun, Yuliya Lokhnygina, Matthew T Roe, Tariq Ahmad, Nihar R Desai, Michael A Blazing
Risk prediction following acute coronary syndrome (ACS) remains challenging. Data-driven machine-learning algorithms can potentially identify patients at high risk of clinical events. The Improved Reduction of Outcomes: Vytorin Efficacy International Trial randomized 18,144 post-ACS patients to ezetimibe + simvastatin or placebo + simvastatin. We performed hierarchical cluster analysis to identify patients at high risk of adverse events. Associations between clusters and outcomes were assessed using Cox proportional hazards models...
January 25, 2019: American Journal of Cardiology
Patrick C Yong, Keith Sigel, Juan Pablo de-Torres, Grace Mhango, Minal Kale, Chung Yin Kong, Javier J Zulueta, David Wilson, Stacey-Ann Whittaker Brown, Christopher Slatore, Juan Wisnivesky
PURPOSE: Lung cancer risk models optimise screening by identifying subjects at highest risk, but none of them consider emphysema, a risk factor identifiable on baseline screen. Subjects with a negative baseline low-dose CT (LDCT) screen are at lower risk for subsequent diagnosis and may benefit from risk stratification prior to additional screening, thus we investigated the role of radiographic emphysema as an additional predictor of lung cancer diagnosis in participants with negative baseline LDCT screens of the National Lung Screening Trial...
February 5, 2019: Thorax
Gabriela Borrayo-Sánchez, Martín Rosas-Peralta, Erick Ramírez-Arias, Guillermo Saturno-Chiu, Joel Estrada-Gallegos, Rodolfo Parra-Michel, Hugo R Hernandez-García, Ernesto A Ayala-López, Rafael Barraza-Felix, Andrés García-Rincón, Débora Adalid-Arellano, Guillermo Careaga-Reyna, José L Lázaro-Castillo, Lidia E Betancourt-Hernández, Rocío Camacho-Casillas, Martha Hernández-Gonzalez, Germán Celis-Quintal, Beatriz Villegas-González, Marco Hernández-Carrillo, Zaria M Benitez Arechiga, Abelardo Flores-Morales, Ana C Sepúlveda-Vildosola
INTRODUCTION: Mexico is the country with the highest mortality due to acute myocardial infarction in adults older than 45 years old according to the OECD (28 vs. 7.5% of the average). The first real-world study, RENASCA IMSS, showed a high-risk population at 65%, but 50% without reperfusion strategies. The aim was to describe the clinical presentation, treatment, and outcomes of acute coronary syndromes at the IMSS. METHODS: RENASCA IMSS is a nation-wide, prospective, longitudinal-cohort study...
February 1, 2019: Archives of Medical Research
Oren Zusman, Owen Bebb, Marlous Hall, Tatendashe Bernadette Dondo, Adam Timmis, Francois Schiele, Keith Aa Fox, Ran Kornowski, Chris P Gale, Zaza Iakobishvili
OBJECTIVE: To compare temporal changes in European Society of Cardiology (ESC) acute myocardial infarction (AMI) quality indicator (QI) attainment in the UK and Israel. METHODS: Data cross-walking using information from the Myocardial Ischaemia National Audit Project and the Acute Coronary Syndrome in Israel Survey for matching 2-month periods in 2006, 2010 and 2013 was used to compare country-specific attainment of 14 ESC AMI QIs. RESULTS: Patients in the UK (n=17 068) compared with Israel (n=5647) were older, more likely to be women, and had less diabetes, dyslipidaemia and heart failure...
January 30, 2019: Heart: Official Journal of the British Cardiac Society
Grace E Martin, Amanda Pugh, Susan G Williams, Dennis Hanseman, Vanessa Nomellini, Amy T Makley, Timothy A Pritts, Michael D Goodman
BACKGROUND: Deep vein thrombosis (DVT) remains a significant cause of morbidity after injury. Lower extremity duplex ultrasound screening (LEDUS) is designed to identify early, asymptomatic DVTs in moderate and high risk patients. We sought to describe when thrombus is detected and identify which trauma patients benefit from LEDUS. MATERIALS AND METHODS: A retrospective review was conducted on trauma patients who were moderate or high risk for venous thromboembolism based on risk assessment profile (RAP) scoring...
March 2019: Journal of Surgical Research
E G Kaboré, N V Yameogo, A Seghda, L Kagambèga, J Kologo, G Millogo, A Tall/Thiam, A K Samadoulougou, P Zabsonré
OBJECTIVES: The aims of this study was to assess evolution profile of acute coronary syndrome (ACS) based on risk level by GRACE, TIMI and SRI scores in the cardiology department, Yalgado Ouedraogo university hospital. PATIENTS AND METHODS: This was a prospective study of 111 consecutive patients admitted for ACS (mean age 57.61 years, 77.5% male) between January 1st and 2010 to May 31st 2015 in the department of cardiology. For each patient, risk scores were calculated and they were divided into risk group...
January 22, 2019: Annales de Cardiologie et D'angéiologie
Rebecca Hoban, Michael E Schoeny, Anita Esquerra-Zwiers, Tanyaporn K Kaenkumchorn, Gina Casini, Grace Tobin, Alan H Siegel, Kousiki Patra, Matthew Hamilton, Jennifer Wicks, Paula Meier, Aloka L Patel
Mother's own milk (MOM) reduces the risk of morbidities in very low birth weight (VLBW) infants. When MOM is unavailable, donor breastmilk (DM) is used, with unclear impact on short- and long-term growth. This retrospective analysis compared anthropometric data at six time points from birth to 20⁻24 months corrected age in VLBW infants who received MOM supplements of preterm formula ( n = 160) versus fortified DM ( n = 161) during neonatal intensive care unit (NICU) hospitalization. The cohort was 46% female; mean birth weight and gestational age (GA) were 998 g and 27...
January 22, 2019: Nutrients
Klara Komici, Dino Franco Vitale, Angela Mancini, Leonardo Bencivenga, Maddalena Conte, Sandra Provenzano, Fabrizio Vincenzo Grieco, Lucia Visaggi, Ilaria Ronga, Antonio Cittadini, Graziamaria Corbi, Bruno Trimarco, Carmine Morisco, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
BACKGROUND: Malnutrition is a frequent condition in the elderly, and is associated with prolonged hospitalization and increased mortality. However, the impacts of malnutrition among elderly patients with acute myocardial infarction have not been clarified yet. METHODS AND RESULTS: We enrolled 174 patients aged 65 years and over, admitted with the diagnosis of acute myocardial infarction (AMI), who underwent evaluation of nutritional status by Mini Nutritional Assessment (MNA) and evaluation of mortality risk by GRACE Score 2...
January 22, 2019: Nutrients
Jian-Jun Wang, Yan Fan, Yan Zhu, Jian-Dong Zhang, Su-Mei Zhang, Zhao-Fei Wan, Hong-Ling Su, Na Jiang
BACKGROUND: The Global Registry of Acute Coronary Events (GRACE) score is recommended by current ST-elevation myocardial infarction (STEMI) guidelines. But it has inherent defects. The present study aimed to investigate the more compatible risk stratification for Chinese patients with STEMI and to determine whether the addition of biomarkers to the Korea Acute Myocardial Infarction Registry (KAMIR) score could enhance its predictive value for long-term outcomes. METHODS: A total of 1093 consecutive STEMI patients were included and followed up 48...
January 5, 2019: Chinese Medical Journal
Samet Yılmaz, Mehmet Koray Adalı, Oğuz Kılıç, Ayşen Til, Yalın Tolga Yaylalı, Dursun Dursunoğlu, Havane Asuman Kaftan
OBJECTIVE: Acute coronary syndrome (ACS) has become more frequent in the elderly population due to increased life expectancy. The aim of this trial was to determine clinical and laboratory factors related to in-hospital mortality in patients over 80 years of age who presented with ACS. METHODS: A total 171 patients (86 men, median age 83 years) who were over 80 years of age and were hospitalized due to a diagnosis of ACS were enrolled in this study. The patients' demographic data, clinical features, and laboratory values were screened retrospectively from hospital records...
January 2019: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Héctor González-Pacheco, Rafael Bojalil, Luis M Amezcua-Guerra, Julio Sandoval, Guering Eid-Lidt, Alexandra Arias-Mendoza, Francisco Azar-Manzur, Amada Álvarez-Sangabriel, Alfredo Altamirano-Castillo, José L Briseño-Cruz, Jorge Carrillo-Vega, Armando Vazquez-Rangel, Antonio Abbate, Jose Gomez-Arroyo, Carlos Martínez-Sánchez
BACKGROUND: Accurate assessment of inflammatory status of patients during acute coronary syndrome (ACS) has become of great importance in their risk classification and in the research of new anti-inflammatory therapies. METHOD: The study cohort included 7396 patients with ACS. We sought to derive and internally validate an inflammation-based score that included high-sensitivity C-reactive protein, white blood cell count, and serum albumin level at admission to evaluate the predictive role of systemic inflammation in the clinical outcome of these patients...
December 29, 2018: Journal of Cardiology
Rhona Martin-Smith, Duncan S Buchan, Julien S Baker, Mhairi J Macdonald, Nicholas F Sculthorpe, Chris Easton, Allan Knox, Fergal M Grace
BACKGROUND: This study examined the impact of a 4-week school-based sprint interval training program on cardiorespiratory fitness (CRF), daily physical activity (PA) behavior, and cardiometabolic risk (CMR) outcomes in adolescents. METHODS: A total of 56 adolescents (22 females) were allocated to either an intervention (n = 22; 17.0 [0.3] y) or control group (n = 30; 16.8 [0.5] y). Intervention group performed 5 to 6, 30 second "all out" running sprints, interspersed with 30-second rest intervals, 3 times per week, for 4 consecutive weeks, whereas control group performed their normal physical education lessons...
December 30, 2018: Pediatric Exercise Science
Sharadindu Shekhar Roy, S T M Abu Azam, Md Khalequzzaman, Mohammad Ullah, Mohammad Arifur Rahman
AIMS: We aimed to compare the GRACE and TIMI risk scores in patients with non- ST elevation acute coronary syndrome for their accuracy in predicting the angiographic severity of coronary artery disease. METHOD: The cross-sectional study done in the Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh from April, 2015-April, 2016. The patients admitted with non-ST elevation acute coronary syndrome were evaluated to calculate the GRACE and TIMI risk score...
December 2018: Indian Heart Journal
Gassan Moady, Zaza Iakobishvili, Roy Beigel, Nir Shlomo, Shlomi Matetzky, Doron Zahger, Shaul Atar
BACKGROUND: The GRACE risk score is currently recommended as the major score for risk prediction on admission in patients with acute coronary syndrome (ACS). Anemia in patients with ACS adversely affects their clinical outcomes, yet hemoglobin level on admission is not included as a parameter in the GRACE score. We hypothesized that hemoglobin level on admission would improve the predictive value of the GRACE score. METHODS: We retrospectively studied one-year mortality in consecutive ACS patients included in the ACSIS (acute coronary syndrome Israeli Survey) registry between the years 2008 and 2013...
December 24, 2018: Journal of Cardiology
Klaus F Kofoed, Henning Kelbæk, Peter Riis Hansen, Christian Torp-Pedersen, Dan Høfsten, Lene Kløvgaard, Lene Holmvang, Steffen Helqvist, Erik Jørgensen, Søren Galatius, Frants Pedersen, Lia Bang, Kari Saunamaki, Peter Clemmensen, Jesper J Linde, Merete Heitmann, Olav Wendelboe Nielsen, Ilan E Raymond, Ole Peter Kristiansen, Ida Hastrup Svendsen, Jan Bech, Maria Helena Dominguez Vall-Lamora, Charlotte Kragelund, Thomas Fritz Hansen, Jens Dahlgaard Hove, Tem Jørgensen, Gitte G Fornitz, Rolf Steffensen, Birgit Jurlander, Jawdat Abdulla, Stig Lyngbæk, Hanne Elming, Susette Krohn Therkelsen, Ulrik Abildgaard, Jan Skov Jensen, Gunnar Gislason, Lars V Køber, Thomas Engstrøm
BACKGROUND: The optimal timing of invasive coronary angiography (ICA) and revascularization in patients with non-ST-segment elevation acute coronary syndrome is not well defined. We tested the hypothesis that a strategy of very early ICA and possible revascularization within 12 hours of diagnosis is superior to an invasive strategy performed within 48 to 72 hours in terms of clinical outcomes. METHODS: Patients admitted with clinical suspicion of non-ST-segment elevation acute coronary syndrome in the Capital Region of Copenhagen, Denmark, were screened for inclusion in the VERDICT trial (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography) ( ClinicalTrials...
December 11, 2018: Circulation
Jocelyn M Biagini Myers, Eric Schauberger, Hua He, Lisa J Martin, John Kroner, Gregory M Hill, Patrick H Ryan, Grace K LeMasters, David I Bernstein, James E Lockey, S Hasan Arshad, Ramesh Kurukulaaratchy, Gurjit K Khurana Hershey
BACKGROUND: Asthma phenotypes are currently not amenable to primary prevention or early intervention because their natural history cannot be reliably predicted. Clinicians remain reliant on poorly predictive asthma outcome tools because of a lack of better alternatives. OBJECTIVE: We sought to develop a quantitative personalized tool to predict asthma development in young children. METHODS: Data from the Cincinnati Childhood Allergy and Air Pollution Study (n = 762) birth cohort were used to identify factors that predicted asthma development...
December 7, 2018: Journal of Allergy and Clinical Immunology
Grace Joshy, Emily Banks, Anthony Lowe, Rory Wolfe, Leonie Tickle, Bruce Armstrong, Mark Clements
OBJECTIVES: To develop and validate a prediction model for short-term mortality in Australian men aged ≥45years, using age and self-reported health variables, for use when implementing the Australian Clinical Practice Guidelines for Prostate-Specific Antigen (PSA) Testing and Early Management of Test-Detected Prostate Cancer. Implementation of one of the Guideline recommendations requires an estimate of 7-year mortality. DESIGN: Prospective cohort study using questionnaire data linked to mortality data...
December 14, 2018: BMJ Open
Emma Thomas, Mojtaba Lotfaliany, Sherry L Grace, Brian Oldenburg, C Barr Taylor, David L Hare, Wp Thanuja Rangani, Ds Anoja F Dheerasinghe, Dominique A Cadilhac, Adrienne O'Neil
BACKGROUND: Ageing populations and increasing survival following acute coronary syndrome has resulted in large numbers of people living with cardiovascular disease and at high risk of hospitalizations. Rising hospital admissions have a significant financial cost to the healthcare system. AIM: The purpose of this study was to determine whether cardiac rehabilitation is protective against long-term hospital readmission (frequency and length) following acute coronary syndrome...
December 14, 2018: European Journal of Cardiovascular Nursing
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