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https://read.qxmd.com/read/30771787/natural-history-of-ventriculomegaly-in-adults-a-cluster-analysis
#1
Claudia L Craven, Roshini Ramkumar, Linda D'Antona, Simon D Thompson, Lewis Thorne, Laurence D Watkins, Ahmed K Toma
OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. The authors hypothesized that the various presentations can be subtyped and represent different stages of decompensation. A cluster analysis was performed on a cohort of patients with chronic ventriculomegaly with the aim of elucidating typical clinical characteristics and outcomes in chronic ventriculomegaly in adults...
February 8, 2019: Journal of Neurosurgery
https://read.qxmd.com/read/30771540/the-first-case-report-of-bilateral-spontaneous-otogenic-pneumocephalus
#2
Richard Voldřich, Martin Májovský, Martin Chovanec, David Netuka
BACKGROUND: Pneumocephalus is commonly associated with cranial trauma including surgical interventions. Spontaneous pneumocephalus on the other hand is a rare diagnosis. Reported cases were predominantly unilateral. We report unique case of a bilateral spontaneous pneumocephalus probably related to bilateral tegmen defect related to repeated Politzer maneuvers. CASE DESCRIPTION: A 78-year-old man suffered from vertigo, tinnitus, instability and mild expressive aphasia...
February 13, 2019: World Neurosurgery
https://read.qxmd.com/read/30771232/n-myc-and-stat-interactor-correlates-with-severity-and-prognosis-in-acute-on-chronic-liver-failure-of-hepatitis-b-virus
#3
Lifu Xiong, Yanan Du, Tianhui Zhou, Bingying Du, Phimphone Visalath, Lanyi Lin, Shisan Bao, Wei Cai
BACKGROUND AND AIM: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by acute deterioration of chronic liver disease with excessive inflammation. N-myc and STAT interactor (NMI), an inflammation-mediated protein, involves in various inflammatory related diseases, but the role of NMI in development and prognosis in HBV-ACLF remains to be elucidated. METHODS: Serum NMI from healthy controls (HCs, n=20), chronic hepatitis B (CHB, n=50) patients and HBV-ACLF patients (n=50) were determined using ELISA...
February 16, 2019: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/30770940/risk-factors-for-vancomycin-nephrotoxicity-and-time-course-of-renal-function-during-vancomycin-treatment
#4
Toshinori Hirai, Kazuhiko Hanada, Ayako Kanno, Megumi Akashi, Toshimasa Itoh
PURPOSE: Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over time. METHODS: We conducted a retrospective analysis of patients receiving intravenous VCM treatment between June 2015 and August 2017 at Tokyo Women's Medical University, Medical Center East...
February 15, 2019: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/30770790/autoantibody-against-%C3%AE-1-adrenoceptor-promotes-the-differentiation-of-natural-regulatory-t-cells-from-activated-cd4-t-cells-by-up-regulating-ampk-mediated-fatty-acid-oxidation
#5
Wenli Xu, Ye Wu, Li Wang, Yan Bai, Yunhui Du, Yang Li, Ning Cao, Yuhui Zhao, Youyi Zhang, Huirong Liu
Therapeutic adoptive transfer of natural regulatory T cells (nTreg, CD4+ CD25+ Foxp3+ T cells) or in vivo selective expansion of nTreg cells has been demonstrated to improve the cardiac function in various cardiovascular disease models. The differentiation of nTreg cells is mediated by catecholamines via β1 -adrenergic receptor (β1 -AR) activation. Autoantibody against β1 -adrenoceptor (β1 -AA) as a β1 -AR agonist is closely associated with the occurrence and deterioration of cardiac dysfunction. However, whether β1 -AA has any impact on nTreg cells has not been reported...
February 15, 2019: Cell Death & Disease
https://read.qxmd.com/read/30770633/the-renew-%C3%A2-anal-insert-for-passive-faecal-incontinence-a-retrospective-audit-of-our-use-of-a-novel-device
#6
Cosimo Alex Leo, Gregory P Thomas, Jonathan D Hogkinson, Jonathan P Segal, Yasuko Maeda, Jamie Murphy, Carolynne J Vaizey
INTRODUCTION: The Renew® Anal Insert is a recent treatment for patients who suffer from passive faecal incontinence (FI). The aim was to assess the effectiveness of the insert and patient satisfaction. METHOD: A retrospective audit of patients who were treated with the Renew® Anal Insert was undertaken. The St Mark's Incontinence Score was used to evaluate clinical outcome. Renew® size, the number of inserts used per day and per week had also been recorded. Subjective assessment of symptoms, how beneficial Renew® was and how satisfied patients were with the device were all recorded...
February 15, 2019: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://read.qxmd.com/read/30770294/patient-reported-outcomes-following-enzalutamide-or-placebo-in-men-with-non-metastatic-castration-resistant-prostate-cancer-prosper-a-multicentre-randomised-double-blind-phase-3-trial
#7
Bertrand Tombal, Fred Saad, David Penson, Maha Hussain, Cora N Sternberg, Robert Morlock, Krishnan Ramaswamy, Cristina Ivanescu, Gerhardt Attard
BACKGROUND: In the PROSPER trial, enzalutamide significantly improved metastasis-free survival in patients with non-metastatic, castration-resistant prostate cancer. Here, we report the results of patient-reported outcomes of this study. METHODS: In the randomised, double-blind, placebo-controlled, phase 3 PROSPER trial, done at 254 study sites worldwide, patients aged 18 years or older with non-metastatic, castration-resistant prostate cancer and a prostate-specific antigen doubling time of up to 10 months were randomly assigned (2:1) via an interactive voice web recognition system to receive oral enzalutamide (160 mg per day) or placebo...
February 12, 2019: Lancet Oncology
https://read.qxmd.com/read/30770109/self-reported-functional-health-status-following-interrupted-aortic-arch-repair-a-congenital-heart-surgeons-society-study
#8
Anusha Jegatheeswaran, Marshall L Jacobs, Christopher A Caldarone, Paul M Kirshbom, William G Williams, Eugene H Blackstone, William M DeCampli, Kim F Duncan, Linda M Lambert, Henry L Walters, Christo I Tchervenkov, Brian W McCrindle
OBJECTIVES: Improved survival after congenital heart surgery has led to interest in functional health status. We sought to identify factors associated with self-reported functional health status in adolescents and young adults with repaired interrupted aortic arch. METHODS: Follow-up of survivors (aged 13-24 years) from a 1987 to 1997 inception cohort of neonates included completion of functional health status questionnaires (Child Health Questionnaire-CF87 [age <18 years, n = 51] or the Short Form [SF]-36 [age ≥18 years, n = 66]) and another about 22q11 deletion syndrome (22q11DS) features (n = 141)...
January 11, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30769220/acute-sensorineural-hearing-loss-in-patients-with-vestibular-schwannoma-early-after-cyberknife-radiosurgery
#9
Chien-Hao Wu, Chang-Mu Chen, Po-Wen Cheng, Yi-Ho Young
OBJECTIVE: This study reviewed our experience in treating patients with vestibular schwannoma (VS) who had acute sensorineural hearing loss (ASHL) early after radiosurgery. PATIENTS AND METHODS: Seventy VS patients underwent cyberknife radiosurgery. Of them, 6 patients had ASHL early (<6 m) after radiosurgery (Group A), accounting for 8.6% prevalence. The remaining 64 patients without ASHL were assigned to Group B. Another 10 VS patients with tiny tumor and serviceable hearing adopted observation policy (Group C)...
February 6, 2019: Journal of the Neurological Sciences
https://read.qxmd.com/read/30769058/efficacy-of-cutting-balloon-angioplasty-for-chronic-total-occlusion-of-femoropopliteal-arteries
#10
Yoshihisa Shimada, Naoto Kino, Daisuke Tonomura, Yuki Yamanaka, Satoshi Nishiura, Kentaro Yano, Kazato Ito, Masataka Yoshida, Takao Tsuchida, Hitoshi Fukumoto
BACKGROUND: Chronic total occlusion (CTO) of femoropopliteal artery (FP) continues to be a lesion subset where maintaining long-term patency after endovascular treatment is challenging. We evaluated the efficacy of cutting balloon angioplasty (CBA) for de novo FP-CTOs in patients with symptomatic lower limb ischemia. METHODS: Seventy-three limbs of 67 symptomatic patients with de novo FP-CTOs successfully recanalized using CBA alone were enrolled in this study. Primary patency was defined as the absence of recurrent symptoms and no deterioration of the ankle-brachial index (ABI) >0...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30768190/analysis-of-benefit-of-intensive-care-unit-transfer-for-deteriorating-ward-patients-a-patient-centered-approach-to-clinical-evaluation
#11
Richard Grieve, Stephen O'Neill, Anirban Basu, Luke Keele, Kathryn M Rowan, Steve Harris
Importance: It is unknown which deteriorating ward patients benefit from intensive care unit (ICU) transfer. Objectives: To use an instrumental variable (IV) method that assesses heterogeneity and to evaluate estimates of person-centered treatment effects of ICU transfer and 28-day hospital mortality by age and illness severity. Design, Setting, and Participants: An analysis of a prospective cohort study from November 1, 2010, to December 31, 2011...
February 1, 2019: JAMA network open
https://read.qxmd.com/read/30768187/which-deteriorating-ward-patients-benefit-from-transfer-to-the-intensive-care-unit-critically-engaging-methods-in-a-well-designed-natural-experiment
#12
Michael Baiocchi
No abstract text is available yet for this article.
February 1, 2019: JAMA network open
https://read.qxmd.com/read/30768141/the-first-reported-case-of-gluteal-implant-associated-anaplastic-large-cell-lymphoma-alcl
#13
Orr Shauly, Daniel J Gould, Imran Siddiqi, Ketan M Patel, Joseph Carey
Anaplastic large-cell lymphoma (ALCL) is a very rare but life-threatening complication that has largely been demonstrated to be associated with breast implants (BIA-ALCL). Patients are at risk of BIA-ALCL with the placement of breast implants for either cosmetic or reconstructive purposes, with the highest risks associated with textured breast implants. In the past decade, there have been an increasing number of publications focused on BIA-ALCL, but there has yet to be a reported case outside of the breast...
February 15, 2019: Aesthetic Surgery Journal
https://read.qxmd.com/read/30768059/factors-that-impact-kidney-function-during-open-and-endovascular-reconstruction-of-aortic-aneurysms
#14
Carlos A Hinojosa, Javier E Anaya-Ayala, Myriam Carrera-Ramirez, Paula Leal-Anaya, Ramón García-Alva, Rodrigo Lozano-Corona
Background: To analyze the factors that influence the deterioration of postoperative renal function in patients undergoing open or endovascular aortic reconstruction, and the impact on survival. Method: Retrospective review of patients who underwent invasive treatment was conducted. Demographics, laboratory data, clinical, intraoperative and postoperative variables were recorded; renal function was determined, Fisher's exact test was used to find associations and Kaplan Meier analysis to estimate survival...
2019: Cirugia y Cirujanos
https://read.qxmd.com/read/30767742/structure-and-function-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-in-atherosclerosis
#15
Lei Zhang, Zahid Hussain, Zhuanqin Ren
BACKGROUND: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH. OBJECTIVE: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH...
February 14, 2019: Current Drug Targets
https://read.qxmd.com/read/30767741/recent-advances-in-rational-diagnosis-and-treatment-of-normal-pressure-hydrocephalus-a-critical-appraisal-on-novel-diagnostic-therapy-monitoring-and-treatment-modalities
#16
Zahid Hussain, Lei Zhang, Zhuanqin Ren
BACKGROUND: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH. OBJECTIVE: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH...
February 14, 2019: Current Drug Targets
https://read.qxmd.com/read/30767436/polysomnographic-and-neuropsychological-characteristics-of-rapid-eye-movement-sleep-behavior-disorder-patients
#17
Xuan Zhang, Zhiyi Song, Jingyi Ye, Ying Fu, Jinying Wang, Lei Su, Xiaodong Zhu, Meiyun Zhang, Yan Cheng, Wei Wu, Rong Xue
OBJECTIVES: To compare the sleep characteristics and cognition between rapid eye movement sleep behavior disorder (RBD) patients and non-RBD (nRBD) healthy control subjects and to determine the correlation between sleep and cognition in RBD patients. METHODS: Polysomnography (PSG) was performed to confirm and exclude RBD. Fifteen iRBD patients, 12 PD with RBD patients, and 23 matched nRBD healthy control subjects were enrolled. Subjective sleep and neuropsychological evaluations were performed...
February 14, 2019: Brain and Behavior
https://read.qxmd.com/read/30767113/current-challenges-and-emergent-technologies-for-manufacturing-artificial-right-ventricle-to-pulmonary-artery-rv-pa-cardiac-conduits
#18
REVIEW
Iman Manavitehrani, Pegah Ebrahimi, Irene Yang, Sean Daly, Aaron Schindeler, Akshat Saxena, David G Little, David F Fletcher, Fariba Dehghani, David S Winlaw
Despite advances in modern surgery, congenital heart disease remains a medical challenge and major cause of infant mortality. Valved conduits are routinely used to surgically correct blood flow in hearts with congenital malformations by connecting the right ventricle to the pulmonary artery (RV-PA). This review explores the current range of RV-PA conduits and describes their strengths and disadvantages. Homografts and xenografts are currently the primary treatment modalities, however both graft types have limited biocompatibility and durability, and present a disease transmission risk...
February 14, 2019: Cardiovascular Engineering and Technology
https://read.qxmd.com/read/30766937/effective-treatment-of-refractory-sympathetic-ophthalmia-with-glaucoma-using-adalimumab
#19
Tomona Hiyama, Yosuke Harada, Yoshiaki Kiuchi
Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab. Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO...
June 2019: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/30766505/brief-metacognitive-therapy-for-emotional-distress-in-adult-cancer-survivors
#20
Peter L Fisher, Angela Byrne, Louise Fairburn, Helen Ullmer, Gareth Abbey, Peter Salmon
Background: Adult cancer survivors often experience substantial psychological morbidity following the completion of acute cancer treatment. Unfortunately, current psychological interventions are of limited efficacy. This study explored if metacognitive therapy (MCT); a brief transdiagnostic psychological intervention was potentially efficacious and could be delivered effectively to adult cancer survivors with psychological morbidity. Methods: An open trial with 3- and 6-month follow-up evaluated the treatment effects of MCT in 27 consecutively referred individuals to a clinical psychology health service specializing in psycho-oncology...
2019: Frontiers in Psychology
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