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ceramide skin

Muresan Ximena Maria, Narzt Marie-Sophie, Brittany Woodby, Francesca Ferrara, Gruber Florian, Valacchi Giuseppe
BACKGROUND: The main functions of the skin are to protect against environmental insults and prevent water loss, which are performed by the complex lipid- and protein matrix present in the outermost layers of the epithelium. The lipidome of these outer layers is mainly composed of ceramides, fatty acids, and cholesterol, which regulates keratinocyte differentiation and skin barrier function. SR-B1 is a multifunctional scavenger receptor that is best known for facilitating uptake of cholesterol from HDL particles in the liver, but it is also expressed in the skin...
March 12, 2019: Archives of Biochemistry and Biophysics
Dharmendra Kumar Yadav, Surendra Kumar, Eun-Ha Choi, Sandeep Chaudhary, Mi-Hyun Kim
Lipid peroxidation by reactive oxygen species (ROS) during oxidative stress is non-enzymatic damage that affects the integrity of biological membrane, and alters the fluidity and permeability. We conducted molecular dynamic simulation studies to evaluate the structural properties of the bilayer after lipid peroxidation and to measure the permeability of distinct ROS. The oxidized membrane contains free fatty acid, ceramide, cholesterol, and 5α-hydroperoxycholesterol (5α-CH). The result of unconstrained molecular dynamic simulations revealed that lipid peroxidation causes area-per-lipid of the bilayer to increase and bilayer thickness to decrease...
March 14, 2019: Scientific Reports
Adrian Lowe, John Su, Mimi Tang, Caroline J Lodge, Melanie Matheson, Katrina J Allen, George Varigos, Arun Sasi, Noel Cranswick, Simone Hamilton, Colin F Robertson, Jennie Hui, Michael Abramson, Shaie O'Brien, Shyamali Dharmage
INTRODUCTION: The skin is an important barrier against environmental allergens, but infants have relatively impaired skin barrier function. There is evidence that impaired skin barrier function increases the risk of allergic sensitisation, atopic dermatitis (AD) and food allergy. We hypothesise that regular prophylactic use of emollients, particularly those that are designed to improve skin barrier structure and function, will help prevent these conditions. With the aim of determining if application of a ceramide-dominant emollient two times per day reduces the risk of AD and food allergy, we have commenced a multicentre phase III, outcome assessor blinded, randomised controlled trial of this emollient applied from birth to 6 months...
March 13, 2019: BMJ Open
Hiroyuki Kanoh, Asako Ishitsuka, Etsuko Fujine, Shuhei Matsuhaba, Mitsuhiro Nakamura, Hiroyasu Ito, Naoki Inagaki, Yoshiko Banno, Mariko Seishima
IFN- γ is detected in chronic lesions of atopic dermatitis (AD); however, its specific role remains to be elucidated. An impaired stratum corneum barrier function is a hallmark of AD, and it is associated with a reduction in ceramides with long-chain fatty acids (FAs) in the stratum corneum. FA elongases, ELOVL1 and ELOVL4, are essential for the synthesis of these ceramides, together with ceramide synthase 3 (CerS3). We have previously shown that IFN- γ , but not other cytokines, induced the downregulation of these enzymes in cultured keratinocytes...
2019: Journal of Immunology Research
Hye-Youn Kim, Hanyong Jin, Jeehyeon Bae, Hyung-Kyoon Choi
Melanoma is the most aggressive form of skin cancer, with metastatic melanoma being refractory to currently available conventional therapies. In this study, we evaluated the inhibitory effect of coronatine (COR) on the proliferation of metastatic melanoma cells. COR inhibited the proliferation of melanoma cells but negligibly affected the proliferation of normal melanocytes. Comparative metabolic and lipidomic profiling using gas chromatography-mass spectrometry and direct infusion-mass spectrometry was performed to investigate COR-induced metabolic changes...
February 28, 2019: Scientific Reports
Donald Y M Leung, Agustin Calatroni, Livia S Zaramela, Petra K LeBeau, Nathan Dyjack, Kanwaljit Brar, Gloria David, Keli Johnson, Susan Leung, Marco Ramirez-Gama, Bo Liang, Cydney Rios, Michael T Montgomery, Brittany N Richers, Clifton F Hall, Kathryn A Norquest, John Jung, Irina Bronova, Simion Kreimer, C Conover Talbot, Debra Crumrine, Robert N Cole, Peter Elias, Karsten Zengler, Max A Seibold, Evgeny Berdyshev, Elena Goleva
Skin barrier dysfunction has been reported in both atopic dermatitis (AD) and food allergy (FA). However, only one-third of patients with AD have FA. The purpose of this study was to use a minimally invasive skin tape strip sampling method and a multiomics approach to determine whether children with AD and FA (AD FA +) have stratum corneum (SC) abnormalities that distinguish them from AD without FA (AD FA -) and nonatopic (NA) controls. Transepidermal water loss was found to be increased in AD FA +. Filaggrin and the proportion of ω-hydroxy fatty acid sphingosine ceramide content in nonlesional skin of children with AD FA + were substantially lower than in AD FA - and NA skin...
February 20, 2019: Science Translational Medicine
Xu Feng, Matthew C Fox, Jason S Reichenberg, Fabiana C P S Lopes, Katherine R Sebastian, Mia K Markey, James W Tunnell
Achieving adequate margins during tumor margin resection is critical to minimize the recurrence rate and maximize positive patient outcomes during skin cancer surgery. Although Mohs micrographic surgery is by far the most effective method to treat nonmelanoma skin cancer, it can be limited by its inherent required infrastructure, including time-consuming and expensive on-site histopathology. Previous studies have demonstrated that Raman spectroscopy can accurately detect basal cell carcinoma (BCC) from surrounding normal tissue; however, the biophysical basis of the detection remained unclear...
January 1, 2019: Biomedical Optics Express
Alisha Bhanot, Alyson Huntley, Matthew J Ridd
Atopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Medline (Ovid) was searched from inception (1946) to June 2018. All types of studies, with the exception of reviews, were included. Eligibility was assessed using a two-stage screening process against inclusion and exclusion criteria...
February 15, 2019: Dermatology and Therapy
Hiroshi Takahashi, Ryota Watanabe, Kenichi Nishimura, Taro Moriwaki
A recent study has shown that the addition of ceramide to adhesive materials of medical sheets or tapes improves or maintains skin barrier functions despite the irritation and damage caused by the repeated removal of the sheet or tape. This fact may imply that ceramide molecules are released from the adhesive material and penetrate the skin. In this study, we investigated whether ceramide molecules are released from a UV-curable acrylic adhesive resin (acResin® ) sheet containing ceramide molecules attached to a cultured skin sample by estimating the local ceramide concentration from the data obtained by synchrotron Fourier transform infrared micro-spectroscopy analysis...
February 13, 2019: Journal of Oleo Science
Minjeong Kim, Haengdueng Jeong, Buhyun Lee, Yejin Cho, Won Kee Yoon, Ahreum Cho, Guideock Kwon, Ki Taek Nam, Hunjoo Ha, Kyung-Min Lim
Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in DM skin disorders, we quantitated 49 lipids (34 ceramides, 14 free fatty acids (FFAs), and cholesterol) in the skin epidermis, liver, and kidneys of db/db mice, a Type 2 DM model, using UPLC-MS/MS. The expression of genes involved in lipid synthesis was also evaluated. With the full establishment of hyperglycemia at the age of 20 weeks, remarkable lipid enrichment was noted in the skin of the db/db mice, especially at the epidermis and subcutaneous fat bed...
February 8, 2019: Biomolecules & Therapeutics
Ji Yeon Noh, Jung U Shin, Ji Hye Kim, Seo Hyeong Kim, Bo-Mi Kim, Young Hwan Kim, Semin Park, Tae-Gyun Kim, Kyong-Oh Shin, Kyungho Park, Kwang Hoon Lee
Adipokines modulate immune responses and lipid metabolism in allergic disease; however, little is known about its role in the skin barrier and atopic dermatitis (AD). We identified zinc-alpha-2 glycoprotein (ZAG), an adipokine that regulates lipid mobilization, as a biomarker for AD. ZAG levels were consistently decreased in sera, T cells, and skin in human AD patients compared with healthy controls. ZAG was primarily detected in the stratum corneum along with filaggrin (FLG) and loricrin (LOR). Knockdown of ZAG with shRNA resulted in decreased FLG and increased thymic stromal lymphopoietin (TSLP)...
February 6, 2019: Journal of Investigative Dermatology
Arnout Mieremet, Rianne van Dijk, Gert Gooris, Joke A Bouwstra, Abdoelwaheb El Ghalbzouri
Human skin equivalents (HSEs) are three dimensional models resembling native human skin (NHS) in many aspects. Despite the manifold similarities to NHS, a restriction in its applications is the altered in vitro lipid barrier formation, which compromises the barrier functionality. This could be induced by suboptimal cell culturing conditions, which amongst others is the diminished activation of the vitamin D receptor (VDR) signalling pathway. The active metabolite of this signalling pathway is 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 )...
January 31, 2019: Journal of Steroid Biochemistry and Molecular Biology
Xue-Min Zhu, Yu Li, Fei Xu, Wei Gu, Guo-Jun Yan, Jie Dong, Jun Chen
The measurement of skin electrical resistance (SER) has drawn a great deal of attention for the rapid screening of transdermal penetration enhancers (PEs). However, the mechanisms underlying the SER measurement are still unclear. This study was to investigate the effects and mechanisms of seven oxygen-containing terpenes on the SER kinetics. Stratum corneum (SC) lipids were proved to play a key role in SER measurement. Then, the factors affecting the SER measurement were optimized. By the determination of SER kinetics, cyclic terpenes (1,8-cineole, terpinen-4-ol, menthol and α-terpineol) were demonstrated to possess higher enhancement ratio (ER) values compared with linear terpenes (linalool, geraniol and citral)...
January 31, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Masashi Morifuji
Excessive exposure to ultraviolet (UV) radiation can chemically alter biological molecules and is one of the major environmental health risks with potential to damage the structure and function of the skin. Numerous dietary supplements are known to optimize the skin's defenses against radiation exposure. Several studies in which the beneficial roles of functional food components, that can protect against UV-induced skin damage, have been demonstrated. Supplemental dietary sphingomyelin maintains covalently bound ω-hydroxy ceramides to avert skin barrier defects after UVB irradiation...
February 2019: Experimental Dermatology
Ronald B. Vender, Anneke Andriessen, Benjamin Barankin, Anatoli Freiman, Dimitrios Kyritsis, Loukia-Maria Mistos, Jennifer Salsberg, Laetitia Amar
Introduction: The skin of subjects with dry, flaking, and/or scaling conditions is characterized by decreased water and skin lipids content among other findings. It is well understood that daily use of gentle cleansers and moisturizers may help to restore and maintain an optimal skin barrier function. A cohort study of patients with dry skin was developed to evaluate efficacy of daily use of a ceramide containing cleanser and cream that also has salicylic acid. Methods: Thirty-five adults with mild-to-moderate dry skin conditions were recruited from four dermatology centers in Canada...
January 1, 2019: Journal of Drugs in Dermatology: JDD
Melanie Köllmer, Parinaz Mossahebi, Elena Sacharow, Sascha Gorissen, Nicole Gräfe, Dirk-Heinrich Evers, Michael E Herbig
The Skin Parallel Artificial Membrane Permeability Assay (PAMPA) is a 96-well plate-based skin model with an artificial membrane containing free fatty acid, cholesterol, and synthetic ceramide analogs to mimic the stratum corneum (SC) barrier. The current study evaluates the compatibility of lipophilic solvents/penetration enhancer, topical emulsions containing different emulsifier systems, and organic acceptor media additives with the artificial membrane of the assay. Additionally, different assay setups (standard setup: donor in bottom plate versus modified setup: donor in top plate) were compared...
January 24, 2019: AAPS PharmSciTech
Takahito Chiba, Takeshi Nakahara, Futoshi Kohda, Toshio Ichiki, Motomu Manabe, Masutaka Furue
Epidermal ceramides are indispensable lipids that maintain the functions of the stratum corneum. Esterified omega-hydroxyacyl-sphingosine (EOS) ceramide with a linoleate moiety is one of the most important ceramide species for forming cornified lipid envelopes. This linoleate moiety is eventually metabolized to trihydroxy-linoleic acid (triol, 9,10,13-trihydroxy-11E-octadecenoic acid). Thus, we assumed that a decrease of triols might reflect skin barrier dysfunction. Against this background, the purposes of this study were to measure the triols by a simple tape-stripping method and to determine the correlation between the amount of triols and transepidermal water loss (TEWL) as an indicator of barrier dysfunction in atopic dermatitis patients...
2019: PloS One
Taraneh Yazdanparast, Saman Ahmad Nasrollahi, Leila Izadi Firouzabadi, Alireza Firooz
Background: Contact dermatitis is a common skin condition observed by dermatologists, presenting a burden on healthcare systems. Recently, there has been a trend in producing skin-identical topical preparations for the repair of skin. However, there is a limited number of experimental studies to assess the safety and efficacy of this products. Objective: This study assessed the clinical efficacy and safety of a skin-identical ceramide complex cream (Dermalex Repair Contact Eczema; Omega Pharma, Nazareth, Belgium) in the treatment of contact dermatitis...
November 2018: Journal of Clinical and Aesthetic Dermatology
Ilona Jurek, Ilona Góral, Zofia Mierzyńska, Barbara Moniuszko-Szajwaj, Kamil Wojciechowski
The effect of a saponin-rich extract from rhizomes of Soapwort (Saponaria officinalis L) and four synthetic surfactants: sodium lauryl sulphate (SLS), sodium laureth sulphate (SLES), ammonium lauryl sulphate (ALS) and cocamidopropyl betaine (CAPB) on two model lipid monolayers is analyzed using surface pressure, surface dilatational rheology and fluorescence microscopy. The following monolayers were employed: dipalmitoylphosphatidylcholine/cholesterol mixture in a molar ratio of 7:3 (DPPC/CHOL) and Ceramide [AP]/stearic acid/cholesterol in a molar ratio of 14:14:10 (CER/SA/CHOL)...
December 20, 2018: Biochimica et Biophysica Acta. Biomembranes
Nana Watanabe, Takuya Suzuki, Yuya Yamazaki, Kozue Sugiyama, Seiji Koike, Megumi Nishimukai
Plasmalogen (Pls) is a glycerophospholipid derived from alkyl phospholipid (Alk) with antioxidant functions in vivo. The present study investigated the effects of ether phospholipids, such as Pls and Alk, on intercellular lipid barriers in the skin of NC/Nga mice, a model of atopic dermatitis (AD). NC/Nga mice fed Alk showed increased plasma levels of Alk and Pls. The AD-related changes in ceramide composition in the skin were abrogated by oral administration of Alk. Moreover, Alk suppressed skin inflammation in AD mice...
December 20, 2018: Bioscience, Biotechnology, and Biochemistry
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