Zhida Chen, Zhe Wang, Yepeng Hu, Huangbo Lin, Li Yin, Jing Kong, Yikai Zhang, Bibi Hu, Tiekun Li, Xianan Zheng, Qiongying Yang, Shu Ye, Shengyao Wang, Qiao Zhou, Chao Zheng
ELABELA (ELA), a recently discovered peptide, is highly expressed in adult kidneys and the endothelium system. It has been identified as a novel endogenous ligand for the apelin receptor (APJ). This study aims to investigate the role of ELA in diabetic glomerular endothelial pyroptosis and its underlying mechanism. Initially, a significant decrease in ELA mRNA levels was observed in the renal cortex of db/db mice and high glucose-treated glomerular endothelial cells (GECs). It was also found that ELA deficiency in ELA+/- mice significantly accelerated diabetic glomerular injury, as shown by exacerbated glomerular morphological damage, increased serum creatine and blood urea nitrogen, and elevated 24-h urinary albumin excretion...
August 4, 2023: Inflammation