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JOURNAL ARTICLE
Abrar Al-Amri, Zeinab Yavari, Mohammad Reza Nikoo, Maryam Karimi
Microplastics (MPs) have recently been documented as an emerging pollutant that poses a critical threat to environment. Wastewater treatment plants (WWTPs) are commonly regarded as significant contributors to the presence of MPs. This study aimed to assess the MPs load of three wastewater treatment facilities in Oman using various treatments, including MBR, SBR, and CAS. Wastewater samples from influent, effluent, and sludge were collected and analyzed to determine the concentration, morphology, size, color, and polymer type of the MPs...
May 4, 2024: Chemosphere
#22
JOURNAL ARTICLE
Nezar Abdennur, Sameer Abraham, Geoffrey Fudenberg, Ilya M Flyamer, Aleksandra A Galitsyna, Anton Goloborodko, Maxim Imakaev, Betul A Oksuz, Sergey V Venev, Yao Xiao
Chromosome conformation capture (3C) technologies reveal the incredible complexity of genome organization. Maps of increasing size, depth, and resolution are now used to probe genome architecture across cell states, types, and organisms. Larger datasets add challenges at each step of computational analysis, from storage and memory constraints to researchers' time; however, analysis tools that meet these increased resource demands have not kept pace. Furthermore, existing tools offer limited support for customizing analysis for specific use cases or new biology...
May 6, 2024: PLoS Computational Biology
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JOURNAL ARTICLE
Saumya Agrawal, Andrey Buyan, Jessica Severin, Masaru Koido, Tanvir Alam, Imad Abugessaisa, Howard Y Chang, Josée Dostie, Masayoshi Itoh, Juha Kere, Naoto Kondo, Yunjing Li, Vsevolod J Makeev, Mickaël Mendez, Yasushi Okazaki, Jordan A Ramilowski, Andrey I Sigorskikh, Lisa J Strug, Ken Yagi, Kayoko Yasuzawa, Chi Wai Yip, Chung Chau Hon, Michael M Hoffman, Chikashi Terao, Ivan V Kulakovskiy, Takeya Kasukawa, Jay W Shin, Piero Carninci, Michiel J L de Hoon
The human genome is pervasively transcribed and produces a wide variety of long non-coding RNAs (lncRNAs), constituting the majority of transcripts across human cell types. Some specific nuclear lncRNAs have been shown to be important regulatory components acting locally. As RNA-chromatin interaction and Hi-C chromatin conformation data showed that chromatin interactions of nuclear lncRNAs are determined by the local chromatin 3D conformation, we used Hi-C data to identify potential target genes of lncRNAs...
2024: PloS One
#24
JOURNAL ARTICLE
Allah Bachayo Rajar, Zainab Malik, Javed Ahmed Ujan, Khalid Hussian Rind, Raqeeb Ullah, Saira Naz, Mujeeb Ullah, Muhammad Zahid, Khalid Khan, Khayyam Khayyam, Salim S Al-Rejaie, Mohamed Mohany
Heavy metal bioaccumulation in organisms is primarily a result of dietary uptake. The current study examines the concentrations of heavy metals (Pb, Cd, Cr, and Cu) in fish feed, water, sediment, and three fish species (Catla catla, Labeo rohita, and Cyprinus carpio) from different feeding zones in a polyculture pond system. Furthermore, associated human health risks were also evaluated. The fish samples (n = 25 for each species) were collected from 10 different fish ponds in the Kohat district, Pakistan...
May 6, 2024: Biological Trace Element Research
#25
JOURNAL ARTICLE
Claiborne Lucas, Ricardo Torres-Guzman, Andrew J James, Scott Corlew, Amy Stone, Maria E Powell, Michael Golinko, Matthew E Pontell
BACKGROUND: Even after palatoplasty, the incidence of velopharyngeal dysfunction (VPD) can reach 30%; however, these estimates arise from high-income countries (HICs) where speech-language pathologists (SLP) are part of standardized cleft teams. The VPD burden in low- and middle-income countries (LMICs) is unknown. This study aims to develop a machine-learning model that can detect the presence of VPD using audio samples alone. METHODS: Case and control audio samples were obtained from institutional and publicly available sources...
May 6, 2024: Journal of Craniofacial Surgery
#26
REVIEW
Anita van Zwieten, Siah Kim, Amanda Dominello, Chandana Guha, Jonathan C Craig, Germaine Wong
Children and adolescents in families of lower socioeconomic position (SEP) experience an inequitable burden of reduced access to healthcare and poorer health. For children living with chronic kidney disease (CKD), disadvantaged SEP may exacerbate their considerable disease burden. Across the life-course, CKD may also compromise the SEP of families and young people, leading to accumulating health and socioeconomic disadvantage. This narrative review summarizes the current evidence on relationships of SEP with kidney care and health among children and adolescents with CKD from a life-course approach, including impacts of family SEP on kidney care and health, and bidirectional impacts of CKD on SEP...
May 2024: KI Reports
#27
JOURNAL ARTICLE
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Exposure to gestational diabetes mellitus (GDM) during pregnancy has significant consequences for the unborn baby and newborn infant. However, whether and how GDM exposure induces the development of neonatal brain hypoxia/ischemia-sensitive phenotype and the underlying molecular mechanisms remain unclear. In this study, we used a late GDM rat model induced by administration of streptozotocin (STZ) on gestational day 12 and investigated its effects of GDM on neonatal brain development. The pregnant rats exhibited increased blood glucose levels in a dose-dependent manner after STZ administration...
January 2024: Reproductive Toxicology
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JOURNAL ARTICLE
Tianxiang Gao, Kai Liu, Qi Liu, Danyang Wang
Echeneis naucrates, as known as live sharksucker, is famous for the behavior of attaching to hosts using a highly modified dorsal fin with oval-shaped sucking disc. Here, we generated an improved high-quality chromosome-level genome assembly of E. naucrates using Illumina short reads, PacBio long reads and Hi-C data. Our assembled genome spans 572.85 Mb with a contig N50 of 23.19 Mb and is positioned to 24 pseudo-chromosomes. Additionally, at least one telomere was identified for 23 out of 24 chromosomes...
May 4, 2024: Scientific Data
#29
REVIEW
Jia-Wei Liu, Kexin Guo, Rui Zhang, Rongrong Wang, Dong-Lai Ma, Xue Zhang
BACKGROUND: Ichthyosis is a common keratotic skin disease with high clinical, etiological and genetic heterogeneity. There are four types of non-syndromic hereditary ichthyoses, among which autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of recessive Mendelian disorders. ARCI present with different phenotypes and ABCA12 pathogenic variants have been shown to cause complex ARCI phenotypes, including harlequin ichthyosis (HI), lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE)...
May 2024: Molecular Genetics & Genomic Medicine
#30
JOURNAL ARTICLE
Magriet van Niekerk, Shahida Moosa, Ronald van Toorn, Regan Solomons
Next generation sequencing (NGS)-based tests have become routine first-line investigative modalities in paediatric neurology clinics in many high-income countries (HICs). Studies from these countries show that these tests are both cost-effective and reliable in diagnosing many complex childhood neurological diseases. However, NGS-based testing in low-and middle-income countries (LMICs) is limited due to affordability constraints. The primary objective of this study was to evaluate the diagnostic yield and impact of targeted gene panel sequencing in a selected paediatric cohort attending a tertiary paediatric neurology clinic in the Western Cape Province of South Africa...
May 3, 2024: European Journal of Human Genetics: EJHG
#31
JOURNAL ARTICLE
Connor S Wagner, Michaela K Hitchner, Natalie M Plana, Carrie Z Morales, Lauren K Salinero, Carlos E Barrero, Matthew E Pontell, Scott P Bartlett, Jesse A Taylor, Jordan W Swanson
OBJECTIVE: Recent investigations focused on health equity have enumerated widespread disparities in cleft and craniofacial care. This review introduces a structured framework to aggregate findings and direct future research. DESIGN: Systematic review was performed to identify studies assessing health disparities based on race/ethnicity, payor type, income, geography, and education in cleft and craniofacial surgery in high-income countries (HICs) and low/middle-income countries (LMICs)...
May 3, 2024: Cleft Palate-craniofacial Journal
#32
JOURNAL ARTICLE
Seong-Eun Park, Kanghyun Park, Eungyung Kim, Chae Yeon Kim, Sung-Min Hwang, Jae-Mok Lee, Jo-Young Suh, Youngkyun Lee, Myoung Ok Kim, Yong-Gun Kim
OBJECTIVE AND BACKGROUND: This research aimed to examine the role of C-X-C motif chemokine ligand 5 (CXCL5) and C-X-C motif chemokine ligand 8 (CXCL8; also known as IL-8) in neutrophilic inflammation triggered by peri-implantitis and to shed light on the underlying mechanisms that link them to the development of this condition. MATERIALS: This study included 40 patients who visited the Department of Periodontology at Kyungpook University Dental Hospital. They were divided into two groups based on their condition: healthy implant (HI) group (n = 20) and peri-implantitis (PI) group (n = 20)...
May 3, 2024: Journal of Periodontal Research
#33
REVIEW
Matthew T Hey, Madeleine Carroll, Lili B Steel, Mayte Bryce-Alberti, Radzi Hamzah, Rachel E Wittenberg, Anam Ehsan, Hodan Abdi, Latoya Stewart, Raina Parikh, Raisa Rauf, Jacqueline Cellini, Kiana Winslow, Isaac G Alty, Craig D McClain, Geoffrey A Anderson
OBJECTIVE: This study evaluated how surgical and anesthesiology departments adapted their resources in response to the coronavirus disease 2019 (COVID-19) pandemic. DESIGN: This scoping review used the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews protocol, with Covidence as a screening tool. An initial search of PubMed, Embase, Web of Science, Global Index Medicus, and Cochrane Systematic Reviews returned 6,131 results in October 2021...
April 2024: American Journal of Disaster Medicine
#34
JOURNAL ARTICLE
Chromosome-level genome assembly of the bethylid ectoparasitoid wasp Sclerodermus sp. 'alternatusi'.
Yi Wan, Hui-Jie Wu, Jia-Peng Yang, Jin-Li Zhang, Zhi-Cheng Shen, Hai-Jun Xu, Yu-Xuan Ye
The Bethylidae are the most diverse of Hymenoptera chrysidoid families. As external parasitoids, the bethylids have been widely adopted as biocontrol agents to control insect pests worldwide. Thus far, the genomic information of the family Bethylidae has not been reported yet. In this study, we crystallized into a high-quality chromosome-level genome of ant-like bethylid wasps Sclerodermus sp. 'alternatusi' (Hymenoptera: Bethylidae) using PacBio sequencing as well as Hi-C technology. The assembled S. alternatusi genome was 162...
May 2, 2024: Scientific Data
#35
JOURNAL ARTICLE
Rosalie V McDonough, Nathaniel B Rex, Johanna M Ospel, Nima Kashani, Leon A Rinkel, Arshia Sehgal, Joachim C Fladt, Ryan A McTaggart, Raul Nogueira, Bijoy Menon, Andrew M Demchuk, Alexandre Poppe, Michael D Hill, Mayank Goyal
BACKGROUND AND PURPOSE: Hemorrhagic transformation can occur as a complication of endovascular treatment for acute ischemic stroke. This study aimed to determine whether ischemia depth as measured by admission CTP metrics can predict the development of hemorrhagic transformation at 24 hours. MATERIALS AND METHODS: Patients with baseline CTP and 24-hour follow-up imaging from the ESCAPE-NA1 trial were included. RAPID software was used to generate CTP volume maps for relative CBF, CBV, and time-to-maximum at different thresholds...
May 2, 2024: AJNR. American Journal of Neuroradiology
#36
JOURNAL ARTICLE
Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Victor Bass, Jaanam Gopalakrishnan, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Lauren Reich, Chen Yao, Hong-Wei Sun, Stephen R Brooks, Kan Jiang, Vijayaraj Nagarajan, Yongbing Zhao, Seolkyoung Jung, Rachael Phillips, Yohei Mikami, Caleb A Lareau, Yuka Kanno, Dragana Jankovic, Martin J Aryee, Aleksandra Pękowska, Yasmine Belkaid, John O'Shea, Han-Yu Shih
Cytokine expression during T cell differentiation is a highly regulated process that involves long-range promoter-enhancer and CTCF-CTCF contacts at cytokine loci. Here, we investigated the impact of dynamic chromatin loop formation within the topologically associating domain (TAD) in regulating the expression of interferon gamma (IFN-γ) and interleukin-22 (IL-22); these cytokine loci are closely located in the genome and are associated with complex enhancer landscapes, which are selectively active in type 1 and type 3 lymphocytes...
April 26, 2024: Immunity
#37
JOURNAL ARTICLE
Mehmet Zafer Sabuncuoglu, Isa Sozen, Ismail Zihni, Girayhan Celik, Ayfer Sen Acar, Fatmanur Dal, Demet Gunduz
Bile leakage is a common complication following liver surgeries, particularly in the cases of liver hydatid cyst operations. Currently, there is no adequate method which could be utilized to prevent this complication effectively. Our study aimed to assess the efficacy of the biliary lipid test (BLT) in reducing biliary complications after hydatid cyst surgery. We retrospectively included patients who underwent open liver hydatid cyst surgery between January 2011 and January 2024. The study encompassed 122 patients, with 41 males and 81 females, ranging in age from 18 to 79 years...
April 10, 2024: Biomol Biomed
#38
JOURNAL ARTICLE
Christine Marie Mills, Liza Boyar, Jessica A O'Flaherty, Heather H Keller
BACKGROUND: In high-income countries, between 65 and 70 percent of community-dwelling adults aged 65 and older are at high nutrition risk. Nutrition risk is the risk of poor dietary intake and nutritional status. Consequences of high nutrition risk include frailty, hospitalization, death, and reduced quality of life. Social factors (such as social support and commensality) are known to influence eating behavior in later life; however, to the authors' knowledge, no reviews have been conducted examining how these social factors are associated with nutrition risk specifically...
April 2, 2024: JMIR Research Protocols
#39
REVIEW
Raj Kalaria, Gladys Maestre, Simin Mahinrad, Daisy M Acosta, Rufus Olusola Akinyemi, Suvarna Alladi, Ricardo F Allegri, Faheem Arshad, David Oluwasayo Babalola, Olusegun Baiyewu, Thomas H Bak, Tarek Bellaj, David K Brodie-Mends, Maria C Carrillo, Kaputu-Kalala-Malu Celestin, Albertino Damasceno, Ranil Karunamuni de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope H Farombi, Robert P Friedland, Noe Garza, Antoine Gbessemehlan, Eliza Eleni-Zacharoula Georgiou, Ishtar Govia, Lea T Grinberg, Maëlenn Guerchet, Seid Ali Gugssa, Joy Louise Gumikiriza-Onoria, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Thomas Gregor Issac, Linus Jönsson, Wambui M Karanja, Joseph H Lee, Iracema Leroi, Gill Livingston, Facundo Francisco Manes, Lingani Mbakile-Mahlanza, Bruce L Miller, Christine Wayua Musyimi, Victoria N Mutiso, Noeline Nakasujja, David M Ndetei, Sam Nightingale, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius A Ogeng'o, Adesola Ogunniyi, Maira Okada de Oliveira, Njideka U Okubadejo, Martin Orrell, Stella-Maria Paddick, Margaret A Pericak-Vance, Zvezdan Pirtosek, Felix Claude Victor Potocnik, Rema Raman, Mie Rizig, Mónica Rosselli, Marufjon Salokhiddinov, Claudia L Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire E Sexton, Ingmar Skoog, Peter H St George-Hyslop, Claudia Kimie Suemoto, Prekshy Thapa, Chinedu Theresa Udeh-Momoh, Victor Valcour, Jeffery M Vance, Mathew Varghese, Jaime H Vera, Richard W Walker, Henrik Zetterberg, Yared Z Zewde, Ozama Ismail
Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high-income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC-focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations...
May 2, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#40
REVIEW
Joselyne Nzisabira, Sarah Nuss, Estephanía Candelo, Ernest Aben Oumo, Keshav V Shah, Eric K Kim, Joshua Wiedermann, Ornella Masimbi, Natnael Shimelash, Mary Jue Xu
BACKGROUND: Medical simulation is essential for surgical training yet is often too expensive and inaccessible in low- and middle-income countries (LMICs). Furthermore, in otolaryngology-head and neck surgery (OHNS), while simulation training is often focused on senior residents and specialists, there is a critical need to target general practitioners who carry a significant load of OHNS care in countries with limited OHNS providers. This scoping review aims to describe affordable, effective OHNS simulation models for early-stage trainees and non-OHNS specialists in resource-limited settings and discuss gaps in the literature...
May 1, 2024: BMC Medical Education
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