Ilya A Pletenev, Maria Bazarevich, Diana R Zagirova, Anna D Kononkova, Alexander V Cherkasov, Olga I Efimova, Eugenia A Tiukacheva, Kirill V Morozov, Kirill A Ulianov, Dmitriy Komkov, Anna V Tvorogova, Vera E Golimbet, Nikolay V Kondratyev, Sergey V Razin, Philipp Khaitovich, Sergey V Ulianov, Ekaterina E Khrameeva
Chromatin architecture regulates gene expression and shapes cellular identity, particularly in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and maintenance of neuronal cell type by reorganizing chromatin into repressive domains that limit the expression of fate-determining genes and sustain distinct gene expression patterns in neurons. Here, we map the 3D genome architecture in neuronal and non-neuronal cells isolated from the Wernicke's area of four human brains and comprehensively analyze neuron-specific aspects of chromatin organization...
April 22, 2024: Nucleic Acids Research