Phillip Aitken, Ioana Stanescu, Laura Boddington, Caroline Mahon, Andras Fogarasi, Yi-Hua Liao, Marta Ivars, Ester Moreno-Artero, Doris Trauner, Steven T DeRoos, Jasna Jancic, Milos Nikolic, Patrícia Balážová, Harper N Price, Kinga Hadzsiev, Kate Riney, Stacie Stapleton, Megha M Tollefson, Derek Bauer, Blanka Pinková, Hartley Atkinson
BACKGROUND: Facial angiofibromas (FA) are a major feature of tuberous sclerosis complex (TSC).Topical rapamycin can successfully treat FA. A new stabilised cream formulation which protects rapamycin from oxidation has been developed in 0.5% and 1% concentrations. OBJECTIVES: To assess the efficacy and safety of a novel stabilised topical rapamycin cream formulation. METHODS: This multicentre, double-blind, randomised, placebo-controlled, dose-response phase II/III study with a parallel design included participants aged 6 - 65 years with FA of mild or moderate severity using the investigator's global assessment (IGA) scale...
July 18, 2023: British Journal of Dermatology