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JOURNAL ARTICLE
Joseph W Galvin, Rachel J Milam, Brendan M Patterson, James V Nepola, Joseph A Buckwalter, Brian R Wolf, Felicity M Say, Katherine E Free, Elizabeth Yohannes
BACKGROUND: The incremental biological changes in the synovial microenvironment of the shoulder in acute and chronic instability that may contribute to joint degeneration are poorly understood. Proteomic analysis of synovial fluid in patients with shoulder instability may improve our understanding of proteins that are shed into shoulder synovial fluid after an injury. HYPOTHESIS: Injury-specific factors such as the direction of instability and the severity of glenoid and humeral bone loss are associated with the proteome of synovial fluid in patients with shoulder instability...
May 4, 2024: American Journal of Sports Medicine
#2
JOURNAL ARTICLE
Psychogios Marios-Nikos, Brehm Alex, Fiehler Jens, Fragata Isabel, Gralla Jan, Katan Mira, Leker Ronen, Machi Paolo, Ribo Marc, Saver Jeffrey L, Strbian Daniel, van Es Adriaan, Zimmer Claus, Rommers Nikki, Balmer Luzia, Fischer Urs
RATIONALE: Whether endovascular therapy (EVT) in addition to best medical treatment (BMT) in people with acute ischemic stroke (AIS) due to a medium distal vessel occlusion (MDVO) is beneficial remains unclear. AIM: To determine if people experiencing an AIS due to an isolated MDVO (defined as the co- or non-dominant M2 segment, the M3 or M4 segment of the middle cerebral artery, the A1, A2, or A3 segment of the anterior cerebral artery or the P1, P2 or P3 segment of the posterior cerebral artery) will have superior outcome if treated with EVT in addition to BMT compared to BMT alone...
May 3, 2024: European Stroke Journal
#3
JOURNAL ARTICLE
Shaokun Zhao, Feng Sang, Chen Liu, Fei Wang, Jiawen Liu, Chuansheng Chen, Jun Wang, Xin Li, Zhanjun Zhang
BACKGROUND: Episodic memory (EM) deteriorates as a result of normal aging as well as Alzheimer's disease. The neural underpinnings of such age-related memory impairments in older individuals are not well-understood. Although previous research has unveiled the association between gray matter volume (GMV) and EM in the elderly population, such findings exhibit variances across distinct age cohorts. Consequently, an investigation into the dynamic evolution of this relationship with advancing age is imperative...
May 3, 2024: Behavioral and Brain Functions: BBF
#4
JOURNAL ARTICLE
Ju-Young Lee, So-Yeon Yun, Yu-Jin Koo, Jung-Mi Song, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim
Two vestibular signals, rotational and inertial cues, converge for the perception of complex motion. However, how vestibular perception is built on neuronal behaviors and decision-making processes, especially during the simultaneous presentation of rotational and inertial cues, has yet to be elucidated in humans. In this study, we analyzed the perceptual responses of 20 participants after pairwise rotational experiments, comprised of four control and four test sessions. In both control and test sessions, participants underwent clockwise and counterclockwise rotations in head-down and head-up positions...
May 3, 2024: Cerebellum
#5
JOURNAL ARTICLE
Ralf Krug, Lea Droste, Carolina Schreiber, Elisabeth Reichardt, Gabriel Krastl, Britta Hahn, Sebastian Soliman
OBJECTIVES: To assess the long-term clinical performance of ceramic in-/onlays (CIOs) and cast gold partial crowns (CGPCs) in posterior teeth in terms of success, survival, complications (biological, technical) and quality. MATERIAL AND METHODS: In a retrospective study, a total of 325 patients were recorded after up to 24.8 years (mean 13.9 ± 3.8 years) having (pre-)molars restored with CIO (Empress I, Ivoclar Vivadent, n = 161) and CGPC (Degunorm, DeguDent, n = 164) by supervised undergraduate students...
May 3, 2024: Clinical Oral Investigations
#6
JOURNAL ARTICLE
Konstantina Kilteni, H Henrik Ehrsson
An organism's ability to accurately anticipate the sensations caused by its own actions is crucial for a wide range of behavioral, perceptual, and cognitive functions. Notably, the sensorimotor expectations produced when touching one's own body attenuate such sensations, making them feel weaker and less ticklish and rendering them easily distinguishable from potentially harmful touches of external origin. How the brain learns and keeps these action-related sensory expectations updated is unclear. Here we employ psychophysics and functional magnetic resonance imaging to pinpoint the behavioral and neural substrates of dynamic recalibration of expected temporal delays in self-touch...
May 3, 2024: Communications Biology
#7
JOURNAL ARTICLE
Takuya Yoshimoto, Mitsuhiro Nito, Wataru Hashizume, Kazuto Shimada, Tomomi Sato, Masaomi Shindo, Akira Naito
The anterior (DA) and posterior parts of the deltoid (DP) show alternating contraction during shoulder flexion and extension movements. It is expected that an inhibitory spinal reflex between the DA and DP exists. In this study, spinal reflexes between the DA and DP were examined in healthy human subjects using post-stimulus time histogram (PSTH) and electromyogram averaging (EMG-A). Electrical conditioning stimulation was delivered to the axillary nerve branch that innervates the DA (DA nerve) and DP (DP nerve) with the intensity below the motor threshold...
May 3, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#8
JOURNAL ARTICLE
Zairan Wang, Zijun Zhao, Zihan Song, Jiayi Xu, Yizheng Wang, Zongmao Zhao, Yongning Li
Mapping the localization of the functional brain regions in trigeminal neuralgia (TN) patients is still lacking. The study aimed to explore the functional brain alterations and influencing factors in TN patients using functional brain imaging techniques. All participants underwent functional brain imaging to collect resting-state brain activity. The significant differences in regional homogeneity (ReHo) and amplitude of low frequency (ALFF) between the TN and control groups were calculated. After familywise error (FWE) correction, the differential brain regions in ReHo values between the two groups were mainly located in bilateral middle frontal gyrus, bilateral inferior cerebellum, right superior orbital frontal gyrus, right postcentral gyrus, left inferior temporal gyrus, left middle temporal gyrus, and left gyrus rectus...
May 3, 2024: Scientific Reports
#9
JOURNAL ARTICLE
Wei Shang, Shuangyi Xie, Wenbo Feng, Zhuangzhuang Li, Jingyan Jia, Xiaoxiao Cao, Yanting Shen, Jing Li, Haibo Shi, Yiran Gu, Shi-Jun Weng, Longnian Lin, Yi-Hsuan Pan, Xiao-Bing Yuan
The neural basis of fear of heights remains largely unknown. In this study, we investigated the fear response to heights in male mice and observed characteristic aversive behaviors resembling human height vertigo. We identified visual input as a critical factor in mouse reactions to heights, while peripheral vestibular input was found to be nonessential for fear of heights. Unexpectedly, we found that fear of heights in naïve mice does not rely on image-forming visual processing by the primary visual cortex...
May 3, 2024: Nature Communications
#10
JOURNAL ARTICLE
Michele Matarazzo, Alexandra Pérez-Soriano, Nasim Vafai, Elham Shahinfard, Kevin Ju-Chieh Cheng, Jessamyn McKenzie, Nicole Neilson, Qing Miao, Paul Schaffer, Hitoshi Shinotoh, Jeffrey H Kordower, Vesna Sossi, A Jon Stoessl
Parkinson's disease (PD) is associated with aggregation of misfolded α-synuclein and other proteins, including tau. We designed a cross-sectional study to quantify the brain binding of [11 C]PBB3 (a ligand known to bind to misfolded tau and possibly α-synuclein) as a proxy of misfolded protein aggregation in Parkinson's disease (PD) subjects with and without cognitive impairment and healthy controls (HC). In this cross-sectional study, nineteen cognitively normal PD subjects (CN-PD), thirteen cognitively impaired PD subjects (CI-PD) and ten HC underwent [11 C]PBB3 PET...
May 3, 2024: NPJ Parkinson's Disease
#11
JOURNAL ARTICLE
Reprint of: Prelude to molecularization: The double gradient model of Sulo Toivonen and Lauri Saxén.
Scott F Gilbert
The present molecular investigations of Organizer phenomena show a remarkable connection to the earlier classical embryological studies that used transplantation as a method for making mechanistic models of induction. One of the most prominent of these connections is the dual gradient model for anterior-posterior and dorsal-ventral polarity. This paper will discuss some of the history of how transplantation experiments provided data that could be interpreted in terms of two gradients of biologically active materials...
May 2, 2024: Cells & development
#12
JOURNAL ARTICLE
Stability of proximal mandibular anatomical structures following bilateral sagittal split osteotomy.
M B Holte, T W Nielsen, P M Cattaneo, E M Pinholt
The aim of this study was to investigate the stability of the proximal mandibular reference structures that have been proposed in the literature for superimposition. Forty proximal mandibular segments of 20 patients who underwent bilateral sagittal split osteotomy (BSSO) for advancement were reconstructed from a pair of pre- and postoperative (2 years) cone beam computed tomography scans, and spatially divided into the mandibular condyle, the coronoid process, and 20 mandibular ramus regions. To assess the stability of the anatomical regions, the volumetric and surface discrepancy between the superimposed pre- and postoperative regions were calculated...
May 2, 2024: International Journal of Oral and Maxillofacial Surgery
#13
JOURNAL ARTICLE
Nafisseh S Warner, Andrew C Hanson, Phillip J Schulte, Firat Kara, Robert I Reid, Christopher G Schwarz, Eduardo E Benarroch, Jonathan Graff-Radford, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, David O Warner, Michelle M Mielke, Kejal Kantarci
OBJECTIVE: To evaluate the associations between prescription opioid exposures in community-dwelling older adults and gray and white matter structure by magnetic resonance imaging. METHODS: Secondary analysis was conducted of a prospective, longitudinal population-based cohort study employing cross-sectional imaging of older adult (≥65 years) enrollees between November 1, 2004, and December 31, 2017. Gray matter outcomes included cortical thickness in 41 structures and subcortical volumes in 6 structures...
May 2024: Mayo Clinic Proceedings
#14
JOURNAL ARTICLE
Rota Clelia, Martinelli Federico, Cheli Andrea, Pederzini Luigi Adriano, Celli Andrea
In the forearm, post-traumatic heterotopic ossification usually forms as a proximal radioulnar synostosis. It can occur after soft tissue injury involving the interosseous membrane or after surgery involving the radio and ulna, like distal biceps tendon repair. It can also be induced by radial head dislocation or fracture. Screening radiography can be used to select the appropriate time for excision. The synostosis can be resected when the ectopic bone margin and trabeculation appear mature on x-rays. An interval of 6-12 months from the injury is generally recommended based on ectopic bone maturity...
May 1, 2024: Journal of ISAKOS
#15
JOURNAL ARTICLE
Gülin Acar, Taha Özer
This study aimed to investigate the impact of implant placement levels within the bone on stress distribution in the context of the All-on-Four concept. In this Finite Element Analysis(FEA), two 4.1 mm x 10 mm implants were axially placed in the anterior region of the jawbone, while two 4.1 mm x 14 mm implants were tilted at 30 degrees in the posterior region following the all-on-four concept. In the EC scenario, all implants were inserted at the equicrestal level. In other scenarios, implants were positioned at 1 mm and 2 mm subcrestal levels (SC1, SC2)...
May 1, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
#16
JOURNAL ARTICLE
Xin Hu, Keyu Pan, Min Zhao, Jiali Lv, Jing Wang, Xiaofeng Zhang, Yuxi Liu, Yulu Song, Aaron T Gudmundson, Richard A E Edden, Fuxin Ren, Tao Zhang, Fei Gao
During aging, the brain is subject to greater oxidative stress (OS), which is thought to play a critical role in cognitive impairment. Glutathione (GSH), as a major antioxidant in the brain, can be used to combat OS. However, how brain GSH levels vary with age and their associations with cognitive function is unclear. In this study, we combined point-resolved spectroscopy and edited spectroscopy sequences to investigate extended and closed forms GSH levels in the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and occipital cortex (OC) of 276 healthy participants (extended form, 166 females, age range 20-70 years) and 15 healthy participants (closed form, 7 females, age range 26-56 years), and examined their relationships with age and cognitive function...
May 1, 2024: NeuroImage
#17
JOURNAL ARTICLE
Makoto Inoue, Yuji Itoh, Hiroko Bissen-Miyajima, Takashi Koto
PURPOSE: To compare the quality of images of gratings placed in a model eye viewed through an extended depth of focus (EDoF) intraocular lens (IOL) to that of diffractive bifocal IOL or monofocal IOL. DESIGN: Experimental laboratory investigation. METHODS: Non-diffractive wavefront shaping EDoF (CNAET0, Alcon laboratories), echelette-designed EDoF (ZXR00V, Johnson & Johnson Vision), diffractive bifocal IOL with low power addition (SV25T, Alcon Laboratories), or monofocal IOL (CNA0T0, Alcon laboratories) was placed in a fluid-filled model eye...
May 1, 2024: American Journal of Ophthalmology
#18
JOURNAL ARTICLE
Irmak Karaca, Albert Bromeo, Hashem Ghoraba, Xun Lyu, Zheng Xian Thng, Cigdem Yasar, Amir Akhavanrezayat, Negin Yavari, Gunay Uludag Kirimli, Ngoc Tuong Trong Than, YongUn Shin, Ankur Sudhir Gupta, Anadi Khatri, S Saeed Mohammadi, Jia-Horung Hung, Christopher Or, Diana V Do, Quan Dong Nguyen
PURPOSE: To ascertain whether the use of ultra-wide-field fluorescein angiography (UWFFA) at baseline visit alters the assessment of disease activity and localization, as well as the management of patients presenting to a tertiary uveitis clinic. DESIGN: Retrospective comparison of diagnostic approaches. METHODS: Baseline visits of 158 patients who presented to the Uveitis Clinic at the Byers Eye Institute at Stanford between 2017 and 2022 were evaluated by three uveitis-trained ophthalmologists (I...
May 1, 2024: American Journal of Ophthalmology
#19
JOURNAL ARTICLE
Ruth Chia, Anindita Ray, Zalak Shah, Jinhui Ding, Paola Ruffo, Masashi Fujita, Vilas Menon, Sara Saez-Atienzar, Paolo Reho, Karri Kaivola, Ronald L Walton, Regina H Reynolds, Ramita Karra, Shaimaa Sait, Fulya Akcimen, Monica Diez-Fairen, Ignacio Alvarez, Alessandra Fanciulli, Nadia Stefanova, Klaus Seppi, Susanne Duerr, Fabian Leys, Florian Krismer, Victoria Sidoroff, Alexander Zimprich, Walter Pirker, Olivier Rascol, Alexandra Foubert-Samier, Wassilios G Meissner, François Tison, Anne Pavy-Le Traon, Maria Teresa Pellecchia, Paolo Barone, Maria Claudia Russillo, Juan Marín-Lahoz, Jaime Kulisevsky, Soraya Torres, Pablo Mir, Maria Teresa Periñán, Christos Proukakis, Viorica Chelban, Lesley Wu, Yee Y Goh, Laura Parkkinen, Michele T Hu, Christopher Kobylecki, Jennifer A Saxon, Sara Rollinson, Emily Garland, Italo Biaggioni, Irene Litvan, Ileana Rubio, Roy N Alcalay, Kimberly T Kwei, Steven J Lubbe, Qinwen Mao, Margaret E Flanagan, Rudolph J Castellani, Vikram Khurana, Alain Ndayisaba, Andrea Calvo, Gabriele Mora, Antonio Canosa, Gianluca Floris, Ryan C Bohannan, Anni Moore, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Horacio Kaufmann, Changyoun Kim, Michiyo Iba, Eliezer Masliah, Ted M Dawson, Liana S Rosenthal, Alexander Pantelyat, Marilyn S Albert, Olga Pletnikova, Juan C Troncoso, Jon Infante, Carmen Lage, Pascual Sánchez-Juan, Geidy E Serrano, Thomas G Beach, Pau Pastor, Huw R Morris, Diego Albani, Jordi Clarimon, Gregor K Wenning, John A Hardy, Mina Ryten, Eric Topol, Ali Torkamani, Adriano Chiò, David A Bennett, Philip L De Jager, Philip A Low, Wolfgang Singer, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson, Bryan J Traynor, J Raphael Gibbs, Clifton L Dalgard, Owen A Ross, Henry Houlden, Sonja W Scholz
Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is poorly understood, and treatments are limited to supportive measures. Here, we performed a comprehensive analysis of whole genome sequence data from 888 European-ancestry MSA cases and 7,128 controls to systematically investigate the genetic underpinnings of this understudied neurodegenerative disease. We identified four significantly associated risk loci using a genome-wide association study approach...
April 24, 2024: Neuron
#20
JOURNAL ARTICLE
Feidi Wang, Huan Sun, Mingyue Chen, Ban Feng, Yu Lu, Mi Lyu, Dongqi Cui, Yifang Zhai, Ying Zhang, Yaomin Zhu, Changhe Wang, Haitao Wu, Xiancang Ma, Feng Zhu, Qiang Wang, Yan Li
Social memory has been developed in humans and other animals to recognize familiar conspecifics and is essential for their survival and reproduction. Here, we demonstrated that parvalbumin-positive neurons in the sensory thalamic reticular nucleus (sTRNPvalb ) are necessary and sufficient for mice to memorize conspecifics. sTRNPvalb neurons receiving glutamatergic projections from the posterior parietal cortex (PPC) transmit individual information by inhibiting the parafascicular thalamic nucleus (PF). Mice in which the PPCCaMKII →sTRNPvalb →PF circuit was inhibited exhibited a disrupted ability to discriminate familiar conspecifics from novel ones...
May 1, 2024: Neuron
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