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https://read.qxmd.com/read/30746415/mibg-myocardial-scintigraphy-identifies-premotor-pd-dlb-during-a-negative-dat-scan-period-second-report
#1
Ryuji Sakakibara, Fuyuki Tateno, Yosuke Aiba, Tsuyoshi Ogata, Masahiko Kishi, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka, Katsuyoshi Matsuoka
Objectives: Neuroimaging markers for Parkinson's disease (PD)/dementia with Lewy bodies (DLB) include dopamine transporter (DAT) scanning and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. It is unknown which marker is useful to identify the premotor phase PD/DLB. We reported four patients who, during a negative DAT scan period, had a positive MIBG result that suggested premotor PD/DLB. Here we report 18 additional patients. Methods: This study was a prospective cohort study...
January 2019: Movement Disorders Clinical Practice
https://read.qxmd.com/read/30741651/-clinical-usefulness-of-the-non-invasive-functional-study-of-the-lower-urinary-tract-voiding-phase-as-a-predictor-of-resolution-after-the-first-endoscopic-treatment-of-vesico-ureteral-reflux-in-children-older-than-3-years
#2
José Antonio March-Villalba, Leopoldo Marzullo-Zucchet, David Hervás-Marín, Alba Polo Rodrigo, Agustín Serrano Durbá, Carlos Domínguez Hinarejos, Francisco Boronat Tormo, Francisco Boronat Tormo
OBJECTIVES: To determine the usefulnessof voiding diary (VD), uroflowmetry with electromyography(UF-EMG), bladder wall thickness (before micturition)(VWTUS) and residual urine (PVR) (ultrasound measure)in predicting the outcome of the first endoscopic treatment(1ENDT) of vesicoureteral reflux (VUR) in children> 3 years. METHODS: Cross-sectional ambispective study of 48children with vesicoureteral reflux. Those with previousendoscopic treatment, age or neurological abnormalities and a history of urethralor abdominal surgery were excluded...
January 2019: Archivos Españoles de Urología
https://read.qxmd.com/read/30697909/lumbosacral-radicular-pain-during-micturition-defecation-or-orgasm
#3
R Haddad, C Hentzen, F Le Breton, S Sheikh Ismael, G Amarenco
BACKGROUND: The objective of this study is to describe, in a cohort of patients followed for bladder, bowel or sexual dysfunctions, the occurrence of radicular pain during micturition, defecation and/or orgasm. METHODS: The study included all patients referred in our neuro-urology department and who suffered from radicular pain before, during or after micturition, defecation and/or orgasm. Data included demographic and medical variables, urodynamic and perineal electromyographic diagnosis...
January 30, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30687660/limbus-vertebral-fracture-presenting-as-cauda-equina-syndrome-masquerading-an-acute-disc-prolapse-a-rare-case-report-and-review-of-literature
#4
Nigil Sadanandan Palliyil, Ravi Ranjan Rai, Kedar Deogaonkar
Introduction: Limbus vertebral fracture is an uncommon injury described in adolescents. It refers to the separation of a bony fragment from the unfused ring apophysis of lumbar vertebral end plate. It usually presents with back pain with/without radiculopathy masquerading an acute disc prolapse. However, the presentation as acute cauda equina syndrome has seldom been reported. Case Report: A 15-year-old male presented to the casualty with a history of acute-onset low back pain and bilateral lower limb radicular pain with weakness, after lifting of a heavy Indian musical instrument (Dholak)...
July 2018: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/30686885/urodynamic-changes-after-valve-fulguration-alone-and-valve-fulguration-with-bladder-neck-incision
#5
Sanjeet Kumar Singh, Vijay Sharma, Anjana Singh
Aims: The aim of this study is to compare urodynamic changes after valve fulguration alone and valve fulguration with bladder neck incision (BNI). Settings and Design: A total of 81 patients with posterior urethral valve were treated at our center from July 2010 to July 2016. Patients were randomized into two groups using simple randomization. Forty patients underwent BNI in addition to valve fulguration (Group I), and the remaining 41 patients underwent conventional transurethral valve fulguration (Group II)...
January 2019: Journal of Indian Association of Pediatric Surgeons
https://read.qxmd.com/read/30684702/spontaneous-hemorrhage-followed-by-paraparesis-in-a-patient-with-a-spinal-meningioma
#6
Joseph K Kim, Evan Lieberman, Evan G Stein, Simone A Betchen
BACKGROUND: Although rare, spinal meningiomas may cause motor and sensory deficits or difficulty with bladder or bowel function due to spinal cord compression. While hemorrhage of intracranial meningiomas is well documented, there are very few cases of hemorrhage or hematoma associated with spinal meningiomas in the literature. Spinal meningiomas have been reported to be associated with subdural, epidural, intratumoral, and subarachnoid hemorrhage and usually in the setting of inciting event such as lumbar puncture or anti-coagulation therapy...
January 23, 2019: World Neurosurgery
https://read.qxmd.com/read/30680636/functional-outcome-of-surgically-treated-u-shaped-sacral-fractures-experience-from-41-cases
#7
Li He, Chengla Yi, David J Hak, Zhiyong Hou
PURPOSE: To delineate the changes in functional outcomes of surgically treated U-shaped sacral fractures. METHODS: Forty-one patients with U-shaped sacral fractures were followed for a mean of 4.1 years after surgery. Impairment of lower extremities was assessed via a modified Gibbons score. Urinary function was assessed with a structured interview and residual urine volume. Sexual and bowel functions, as well as patient-reported health, were evaluated using a structured interview, and pain was evaluated with the visual analog scale...
January 24, 2019: European Spine Journal
https://read.qxmd.com/read/30667299/epidural-spinal-cord-stimulation-facilitates-immediate-restoration-of-dormant-motor-and-autonomic-supraspinal-pathways-after-chronic-neurologically-complete-spinal-cord-injury
#8
David Darrow, David Young Balser, Theoden Netoff, Andrei V Krassioukov, Aaron A Phillips, Ann M Parr, Uzma Samadani
Epidural Spinal Cord Stimulation (eSCS) in combination with extensive rehabilitation has been reported to restore volitional movement in a select group of subjects after motor-complete spinal cord injury (SCI). Numerous questions about the generalizability of these findings to patients with longer term SCI have arisen, especially regarding the possibility of restoring autonomic function. To better understand the effect of eSCS on volitional movement and autonomic function, two female participants five and ten years after injury at ages 48 and 52 respectively with minimal spinal cord preservation on MRI were implanted with an eSCS system at the vertebral T12 level...
January 22, 2019: Journal of Neurotrauma
https://read.qxmd.com/read/30663167/long-term-neuroimaging-and-neurological-outcome-of-fetal-spina-bifida-aperta-after-postnatal-surgical-repair
#9
Filomena Giulia Sileo, Petra Pateisky, Joana Curado, Kathryn Evans, Samantha Hettige, Basky Thilaganathan
BACKGROUND: Parents faced with the choice between postnatal management versus prenatal surgery for spina bifida need to have up-to-date information on outcomes. The aim of this study is to report the long-term physical and neurological outcomes prenatally diagnosed spina bifida managed by a multidisciplinary team from a large tertiary centre. METHODS: A retrospective cohort study of all cases fetal spina bifida managed in a tertiary unit between October 1999 and January 2018...
January 20, 2019: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/30655633/multidisciplinary-approach-to-prostatitis
#10
Vittorio Magri, Matteo Boltri, Tommaso Cai, Roberto Colombo, Salvatore Cuzzocrea, Pieter De Visschere, Rosanna Giuberti, Clara Maria Granatieri, Maria Agnese Latino, Gaetano Larganà, Christian Leli, Giorgio Maierna, Valentina Marchese, Elisabetta Massa, Alberto Matteelli, Emanuele Montanari, Giuseppe Morgia, Kurt G Naber, Vaia Papadouli, Gianpaolo Perletti, Nektaria Rekleiti, Giorgio I Russo, Alessandra Sensini, Konstantinos Stamatiou, Alberto Trinchieri, Florian M E Wagenlehner
The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They established the segmented culture technique for localizing the infections in the males to the urethra, the bladder, or the prostate and to differentiate the main categories of prostatitis. Such categories with slight modifications are still used according to the NIH classification: acute bacterial prostatitis, chronic bacterial prostatitis, Chronic Pelvic Pain Syndrome (CPPS) and asymptomatic prostatitis...
January 18, 2019: Archivio Italiano di Urologia, Andrologia
https://read.qxmd.com/read/30639501/glioblastoma-multiforme-of-the-conus-medullaris-management-strategies-and-complications
#11
REVIEW
Amir Goodarzi, Bart Thaci, Atrin Toussi, Tejas Karnati, Kee Kim, Ruben Fragoso
Primary spinal glioblastoma multiforme (GBM) of the conus medullaris is a rare and devastating pathology. Presenting symptoms commonly include progressive neurologic deficits in the lower extremities, bowel and bladder dysfunction, and low back pain. Histologically, these tumors have high-grade features similar to their intracranial counterparts, however, recent advancements in the field of molecular oncology are beginning to elucidate a unique molecular blueprint for these spinal gliomas. Given the lack of standardized treatment strategies, we present our institutional experience in treating a small series of patients suffering from conus medullaris GBM and review the literature on relevant molecular markers, management strategies, and complication avoidance for this malignant pathology...
January 10, 2019: World Neurosurgery
https://read.qxmd.com/read/30639497/myelopathy-due-to-intracranial-dural-arteriovenous-fistula-with-perimedullary-venous-drainage-clinical-and-medico-legal-aspects-in-a-case-of-diagnostic-pitfall
#12
Gabriele Rocca, Fiorella Caputo, Claudio Terranova, Stefano Alice, Francesco Ventura
BACKGROUND: An intracranial dural arteriovenous fistula (DAVF) consists of a meshwork of arteriovenous shunts. Drainage of the fistula may be into a dural sinus or directly into cortical veins. Rarely, DAVFs drain exclusively into perimedullary veins. Prompt diagnosis is important as the clinical course is potentially life-threatening. CASE DESCRIPTION: A 67-year-old man presented with difficulties in walking and bladder retention. Magnetic resonance imaging (MRI) revealed central myelopathy, edema from C6 to T8, and dilated posterior medullary veins...
January 10, 2019: World Neurosurgery
https://read.qxmd.com/read/30628980/risk-factors-for-rapidly-progressive-neurological-deterioration-in-cervical-spondylotic-myelopathy
#13
Eiji Takasawa, Yasunori Sorimachi, Yoichi Iizuka, Daisuke Tsunoda, Tokue Mieda, Haku Iizuka, Hirotaka Chikuda
STUDY DESIGN: A retrospective single-center study. OBJECTIVE: This study sought to clarify the risk factors and to evaluate the surgical outcome in patients with rapidly progressive cervical spondylotic myelopathy (rp-CSM). SUMMARY OF BACKGROUND DATA: CSM is a degenerative spine disease presenting a slow development of myelopathy. However, some patients show rapidly progressive neurological deterioration (especially gait disturbances) without any trauma...
January 4, 2019: Spine
https://read.qxmd.com/read/30622896/acute-transverse-myelitis-a-rare-clinical-manifestation-of-lyme-neuroborreliosis
#14
Igor Dumic, Danilo Vitorovic, Scott Spritzer, Erik Sviggum, Janki Patel, Poornima Ramanan
Acute transverse myelitis (ATM) is a rare, potentially devastating neurological syndrome that has variety of causes, infectious being one of them. Lyme disease (LD) is the most common vector borne zoonosis in the United States (U.S.). While neurologic complications of LD are common, acute transverse myelitis is an exceedingly rare complication. We present a case of a previously healthy 25-year-old man who presented with secondary erythema migrans, aseptic meningitis and clinical features of transverse myelitis including bilateral lower extremity motor and sensory deficits manifesting as weakness and numbness, urinary retention and constipation...
2019: IDCases
https://read.qxmd.com/read/30620687/spinal-cord-involvement-in-lewy-body-related-%C3%AE-synucleinopathies
#15
Raffaele Nardone, Yvonne Höller, Francesco Brigo, Viviana Versace, Luca Sebastianelli, Cristina Florea, Kerstin Schwenker, Stefan Golaszewski, Leopold Saltuari, Eugen Trinka
CONTEXT: Lewy body (LB)-related α-synucleinopathy (LBAS) is the neuropathological hallmark of several neurodegenerative diseases such as Parkinson disease (PD), but it is also found in neurologically asymptomatic subjects. An abnormal accumulation of α-synuclein has been reported also in the spinal cord, but extent and significance of the spinal cord involvement are still poorly defined. OBJECTIVE: We aimed to review the studies addressing the spinal cord involvement of LBAS in healthy subjects and in patients with PD or other neurodegenerative diseases...
January 8, 2019: Journal of Spinal Cord Medicine
https://read.qxmd.com/read/30618512/urological-problems-in-patients-with-menkes-disease
#16
Mi Young Kim, Ji Hyun Kim, Myung Hyun Cho, Young Hun Choi, Seong Heon Kim, Young Jae Im, Kwanjin Park, Hee Gyung Kang, Jong-Hee Chae, Hae Il Cheong
Background: Menkes disease (MD) is a rare X-linked hereditary multisystemic disorder that is caused by dysfunction of copper metabolism. Patients with MD typically present with progressive neurodegeneration, some connective tissue abnormalities, and characteristic "kinky" hair. In addition, various types of urological complications are frequent in MD because of underlying connective tissue abnormalities. In this study, we studied the clinical features and outcomes of MD, focusing on urological complications...
January 7, 2019: Journal of Korean Medical Science
https://read.qxmd.com/read/30614917/facial-palsy-induced-by-checkpoint-blockade-a-single-center-retrospective-study
#17
Carlen Yuen, Pankti Reid, Zuoli Zhang, Betty Soliven, Jason J Luke, Kourosh Rezania
The augmented immune response caused by immune checkpoint inhibitors leads to the emergence of a class of side effects called immune-related adverse events (irAEs). Facial palsy (FP) is rarely reported as an irAE. In this retrospective study, we reviewed the records of 353 patients treated with immunotherapy in our center from 2015-2018. We identified 4 male patients and 1 female patient with FP. Four had metastatic melanoma and were treated with ipilimumab either as monotherapy or in combination with nivolumab or pembrolizumab...
January 4, 2019: Journal of Immunotherapy
https://read.qxmd.com/read/30614062/neurological-lower-urinary-tract-dysfunction-essential-terminology
#18
Jerzy B Gajewski, Marcus J Drake
AIMS: To introduce basic concepts and definitions in the International Continence Society (ICS) Standardisation of Terminology in adult Neurogenic Lower Urinary Tract Dysfunction (NLUTD). METHODS: Fundamental terminology in the ICS Standardisation of Terminology of Adult NLUTD was identified and summarized. RESULTS: NLUTD is often associated with impairment of cognitive, motor, sensory, and/or autonomic functions. Lesions are categorized into suprapontine, pontine/suprasacral spinal, sacral spinal, cauda equina/peripheral nerve, or mixed lesions...
August 2018: Neurourology and Urodynamics
https://read.qxmd.com/read/30606645/-robotic-assisted-laparoscopic-implantation-of-artificial-urinary-sphincter-ams-800-%C3%A2-in-woman-single-center-experience
#19
P Callerot, M-A Perrouin-Verbe, M Thoulouzan, A Valeri, G Fournier
INTRODUCTION: Artificial urinary sphincter (AUS) is the treatment of last resort of stress urinary incontinence (UI) due to intrinsic sphincter deficiency (IS). The implantation procedure has been described by open surgery and laparoscopy with a significative rate of complication by Lucas et al. (2012) and Costa et al. (2001). We report our experience of implantation of SUA by robotic-assisted laparoscopy (R-SUA) in 17 patients among 3 revisions. MATERIAL AND METHODS: Between 2012 and 2017, 17 patients have been consecutively included...
December 31, 2018: Progrès en Urologie
https://read.qxmd.com/read/30599498/urethral-pressure-measurement-as-a-tool-for-the-urodynamic-diagnosis-of-detrusor-sphincter-dyssynergia
#20
Lauren E Corona, Anne P Cameron, J Quentin Clemens, Yongmei Qin, John T Stoffel
PURPOSE: To describe a technique for urodynamic diagnosis of detrusor sphincter dyssynergia (DSD) using urethral pressure measurements and examine potential associations between urethral pressure and bladder physiology among patients with DSD. METHODS: Multiple sclerosis (MS) and spinal cord injured (SCI) patients with known DSD diagnosed on videourodynamics (via electromyography or voiding cystourethrography) were retrospectively identified. Data from SCI and MS patients with detrusor overactivity (DO) without DSD were abstracted as control group...
December 2018: International Neurourology Journal
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