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Electrochemical cancer

Amrita Soni, Chandra Mouli Pandey, Manoj Kumar Pandey, Gajjala Sumana
In this work, polyaniline nanospindles have been synthesized using iron oxide as sacrificial template. These nanospindles were utilized for the fabrication of PANI-MoS2 nanoflower architectures via hydrothermal route. The electrostatic interaction between PANI and MoS2 improves the conductivity and provides more direct paths for charge transportation. SEM, TEM, XRD, Raman Spectroscopy techniques were employed to explore the crystal structure, and morphological properties of the PANI-MoS2 nanocomposite. Furthermore, an electrochemical biosensing platform based on PANI-MoS2 nanocomposite was fabricated for the specific detection of chronic myelogenous leukemia (CML) by using electrochemical impedance spectroscopy technique...
May 9, 2019: Analytica Chimica Acta
Ramón Lorenzo-Gómez, Noelia Fernández-Alonso, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, María Jesús Lobo-Castañón
Cancer diagnosis based on serum biomarkers requires receptors of extreme sensitivity and selectivity. Tunability of aptamer selection makes them ideal for that challenge. However, aptamer characterization is a time-consuming task, not always thoroughly addressed, leading to suboptimal aptamer performance. In this work, we report on the affinity characterization and potential usage of two aptamers against a candidate cancer biomarker, the neutrophil gelatinase-associated lipocalin (NGAL). Electrochemical sandwich assays on Au electrodes and SPR experiments showed a restricted capture ability of one of the aptamers (LCN2-4) and a small detectability of the other (LCN2-2)...
May 15, 2019: Talanta
Zahra Taleat, Anna Larsson, Andrew G Ewing
Electrochemical measurements of exocytosis combined with intracellular vesicle impact electrochemical cytometry have been used to evaluate the effect of an anticancer drug, tamoxifen, on catecholamine release at the single cell level. Tamoxifen has been used for over 40 years to treat estrogen receptor positive breast cancers during both early stages of the disease and in the adjuvant setting. Tamoxifen causes memory and cognitive dysfunction, but the reasons for the cognitive impairment and memory problems induced by this anti-cancer drug are not well known...
February 14, 2019: ACS Chemical Neuroscience
Jiafu Chang, Xin Wang, Jiao Wang, Haiyin Li, Feng Li
Simultaneous detection of multiple tumor biomarkers is in great demand for early and accurate cancer diagnosis. Homogeneous electrochemical biosensor has been proved to possess high sensitivity, but achieving simultaneous detection of multiple tumor biomarkers is still a challenge. Herein, we develop a novel homogeneous electrochemical biosensor for simultaneous detection of multiple tumor biomarkers based on the functionalized metal-organic frameworks (MOFs). The functionalized MOFs were prepared by using porous UIO-66-NH2 as nanocontainer to load electroactive dyes, and dsDNA as gatekeeper to cap MOFs...
February 13, 2019: Analytical Chemistry
Roya Khodaei, Anita Ahmady, Seyyed Mehdi Khoshfetrat, Soheila Kashanian, Seyed Mohammad Tavangar, Kobra Omidfar
Silencing of tumor suppressor genes (E-cadherin) by promoter DNA methylation may lead to the development of invasive phenotypes in epithelial tissues. The authors describe an electrochemical nanobiosensor for early detection and screening of circulating methylated DNA as a biomarker for cancers. First, the antibody against 5-methylcytosine was physically immobilized onto modified with reduced graphene oxide and polyvinylalcohol. In the next step, methylated target DNA in samples was hybridized with ssDNA probe conjugated to Fe3 O4 -citric acid nanocomposites and placed on the modified electrode...
February 11, 2019: Mikrochimica Acta
Ruchita Shandilya, Arpit Bhargava, Neha Bunkar, Rajnarayan Tiwari, Irina Yu Goryacheva, Pradyumna Kumar Mishra
Early cancer diagnosis is of prime importance as it paves the way for effective treatment and possible patient survival. The recent advancements in the field of biosensorics have facilitated the development of functionalized nanobiosensors which have the potential to provide a cost-effective, reliable and rapid diagnostic strategy for cancers. These nanoscaled sensing systems utilize electrochemical, optical, mass and calorimetric sensing mechanisms to specifically identify the disease-specific biomarkers. Because of clinical translational utility, the present review aims to describe the recent developments and status of the nanobiosensors as a point-of-care approach for cancer diagnosis...
January 22, 2019: Biosensors & Bioelectronics
Ya Cao, Yuhao Dai, Hong Chen, Yingying Tang, Xu Chen, Ying Wang, Jing Zhao, Xiaoli Zhu
In this work, DNA-templated silver nanoclusters (DNA-AgNCs) with unique fluorescent and electrochemical properties are prepared as dual signal probes for both qualitative imaging and quantitative detection of cancer cells in an integrated system. ITO electrode that has good light transmittance and electric conductivity is employed as a substrate for dual analysis of cancer cells. ITO electrode is firstly modified by AS1141 aptamer, which could selectively bind to nucleolin overexpressed on the surface of a model breast cancer cell, MCF-7 cell line...
January 18, 2019: Biosensors & Bioelectronics
Tongxu Gu, Yao Wang, Yunhao Lu, Liang Cheng, Liangzhu Feng, Hui Zhang, Xiang Li, Gaorong Han, Zhuang Liu
Electrochemical therapy (EChT), by inserting electrodes directly into tumors to kill cancer cells under direct current (DC), is clinically used in several countries. In EChT, the drastic pH variation nearby the inserted electrodes is the main cause of tumor damage. However, its limited effective area and complex electrode configuration have hindered the clinical application of EChT in treating diverse tumor types. Herein, a conceptually new electric cancer treatment approach is presented through an electro-driven catalytic reaction with platinum nanoparticles (PtNPs) under a square-wave alternating current (AC)...
February 8, 2019: Advanced Materials
Vivianne S Velozo-Sá, Luciano R Pereira, Aliny P Lima, Francyelli Mello-Andrade, Manuela R M Rezende, Rebeca M Goveia, Wanessa C Pires, Monize M Silva, Katia M Oliveira, Antonio G Ferreira, Javier Ellena, Victor M Deflon, Cesar Koppe Grisolia, Alzir A Batista, Elisângela P Silveira-Lacerda
In this paper, four new ruthenium complexes, [Ru(N-S)(dppm)2]PF6 (1), [Ru(N-S)(dppe)2]PF6 (2), [Ru(N-S)2(dppp)] (3) and [Ru(N-S)2(PPh3)2] (4) [dppm = 1,1-bis(diphenylphosphino)methane, dppe = 1,2-bis(diphenylphosphino)ethane, dppp = 1,3-bis(diphenylphosphino)propane, PPh3 = triphenylphosphine and N-S = 2-mercaptopyrimidine anion] were synthesized and characterized using spectroscopy techniques, molar conductance, elemental analysis, electrochemical techniques and X-ray diffraction. The DNA binding studies were investigated using voltammetry and spectroscopy techniques...
February 6, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Meysam Yousefi, Sadegh Dehghani, Rahim Nosrati, Hamed Zare, Mehdi Evazalipour, Jafar Mosafer, Bahram Soltani Tehrani, Alireza Pasdar, Ahad Mokhtarzadeh, Mohammad Ramezani
Mucin 1 protein (MUC1) is a membrane-associated glycoprotein overexpressed in the majority of human malignancies and considered as a predominant protein biomarker in cancers. Owing to the crucial role of MUC1 in cancer dissemination and metastasis, detection and quantification of this biomarker is of great importance in clinical diagnostics. Today, there exist a wide variety of strategies for the determination of various types of disease biomarkers, especially MUC1. In this regard, aptamers, as artificial single-stranded DNA or RNA oligonucleotides with catalytic and receptor properties, have drawn lots of attention for the development of biosensing platforms...
January 15, 2019: Biosensors & Bioelectronics
Kumuthini Rajendran, Thangavelu Kokulnathan, Shen-Ming Chen, Joseph Anthuvan Allen, Chinnuswamy Viswanathan, Helen Annal Therese
An electrochemical sensor is described for the determination of nilutamide (NLM) in biological fluids. A flexible mat of nitrogen-doped carbon nanofibers (NCNFs) was prepared by electrospinning. This was followed by carbonization and the growth of one-dimensional vanadium tetrasulfide (VS4 ) nanorods in the circumference of the NCNFs by a solvothermal route. The material was used to modify a glassy carbon electrode (GCE). Cyclic voltammetry and amperometry revealed an excellent electrocatalytic activity of the VS4 /NCNF mat towards NLM at a working potential of - 0...
February 1, 2019: Mikrochimica Acta
Tailin Liu, Bo Fu, Jincheng Chen, Kang Li
A nonenzymatic electrochemical sensor is described for the prostate cancer biomarker sarcosine (Sar). Riboflavin was employed to mimic the active center of the enzyme sarcosine oxidase for constructing the biomimetic sensor. The use of riboflavon (Rf) avoids the disadvantages of an enzymatic sensor, such as high cost and poor stability. A glassy carbon electrode (GCE) was modified with a graphene-chitosan (GR) composite and further modified with gold-platinum bimetallic nanoparticles in a polypyrrole (PPy) matrix in order to enhance the catalytic activity of the enzyme mimic...
February 1, 2019: Mikrochimica Acta
Dongmiao Qin, Xiaohua Jiang, Guichun Mo, Jinsu Feng, Chunhe Yu, Biyang Deng
A sensitive sandwich electrochemiluminescence immunosensor was established by employing graphene oxide-PEI-carbon quantum dots (CQDs)-Au nanohybrid as probe to measure carbohydrate antigen 15-3 (CA15-3), a breast cancer biomarker. In this work, the nanocomposites of Ag nanoparticles and polydopamine (AgNPs-PDA) were synthesized by redox reaction between dopamine and Ag+. The nanocomposite with high surface area can provide an efficient substrate for immobilizing initial antibody (Ab1). Carbon quantum dots (CQDs) are fixed on polyethylenimine-functionalized graphene oxide (PEI-GO) by amide bonds...
January 29, 2019: ACS Sensors
Faria Khan, Naeem Akhtar, Nasir Jalal, Irshad Hussain, Rafal Szmigielski, Muhammad Qasim Hayat, Hafiz B Ahmad, Waleed A El-Said, Minghui Yang, Hussnain Ahmed Janjua
This study reports on a simple approach for the fabrication of an electrode modified with biocompatible C-dot wrapped ZnO nanoparticles for selective photoelectrochemical monitoring of H2 O2 released from living cells. The biocompatibility of the ZnO nanoparticles was confirmed through in-vitro cellular testing using the MTT assay on Huh7 cell lines. The ZnO nanoparticles wrapped with dopamine-derived C-dots possess numerous catalytically active sites, excessive surface defects, good electrical conductivity, and efficient separation ability of photo-induced electrons and holes...
January 25, 2019: Mikrochimica Acta
Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, María Jesús Lobo-Castañón
Despite having been underappreciated in favor of their protein-coding counterparts for a long time, long noncoding RNAs (lncRNAs) have emerged as functional molecules, which defy the central dogma of molecular biology, with clear implications in cancer. Altered expression levels of some of these large transcripts in human body fluids have been related to different cancer conditions that turns them into potential noninvasive cancer biomarkers. In this review, a brief discussion about the importance and current challenges in the determination of lncRNAs associated to cancer is provided...
January 26, 2019: Analytical and Bioanalytical Chemistry
Leila Farzin, Sodeh Sadjadi, Mojtaba Shamsipur, Shahab Sheibani, Mohammad Hasan Mousazadeh
In this study, a high-performance biosensing nanoplatform based on amidoxime-modified polyacrylonitrile nanofibers decorated with Ag nanoparticles (AgNPs-PAN-oxime NFs) is described. The AgNPs-PAN-oxime NFs were prepared by the combination of electrospinning technique and chemical modification of nitrile group in the PAN. The proposed signal amplifiying nanoplatform was applied in the fabrication of an electrochemical aptasensor for the sensitive detection of CA 125 based on aptamer-cDNA duplex and target induced strand displacement recognition mechanism...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
Seyedeh Zeinab Mousavisani, Jahan-Bakhsh Raoof, Kwan Yee Cheung, Aura Rocío Hernández Camargo, Tautgirdas Ruzgas, Anthony P F Turner, Wing Cheung Mak
Skin cancer is the most frequent kind of cancer in white people in many parts of the world. UV-induced DNA damage and genetic mutation can subsequently lead to skin cancer. Therefore development of new biosensing strategies for detection of UV-induced DNA damage is of great importance. Here we demonstrate a novel combination of an ex-vivo skin biointerface and an electrochemical DNA sensor for the direct detection of UV induced DNA damage and investigation the protective effect of various UV blockers (Zinc-oxide (ZnO), titanium-dioxide (TiO2 ) nanoparticles (NPs) and sunscreens) against DNA damage...
December 18, 2018: Biosensors & Bioelectronics
Stéphane Sengmany, Mathilde Sitter, Eric Léonel, Erwan Le Gall, Gervaise Loirand, Thierry Martens, Didier Dubreuil, Florian Dilasser, Morgane Rousselle, Vincent Sauzeau, Jacques Lebreton, Muriel Pipelier, Rémy Le Guével
Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vitro antiproliferative activity of these products was evaluated against a representative panel of cancer cell lines (HuH7, CaCo-2, MDA-MB-231, HCT116, PC3, NCI-H727, HaCaT) and oncogenicity prevention of the more efficient derivatives was highlighted on human breast cancer cell line MDA-MB 468-Luc prior establishing their interaction with p44/42 and Akt-dependent signaling pathways...
December 23, 2018: Bioorganic & Medicinal Chemistry Letters
Ana Díaz-Fernández, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, Eloy Fernández Rodríguez, María Jesús Lobo-Castañón
The development of chemical sensors capable of detecting the specific glycosylation patterns of proteins offers a powerful mean for the early detection of cancer. Unfortunately, this strategy is scarcely explored because receptors recognizing the glycans linked to proteins are challenging to discover. In this work, we describe a simple method for directing the selection of aptamers toward the glycan structure of the glycoproteins, with prostate-specific antigen (PSA) as a model target. Using this strategy, we identified one aptamer (PSA-1) that binds the glycan moiety of PSA with reasonable affinity (a dissociation constant of 177 ± 65 nM)...
December 26, 2018: Biosensors & Bioelectronics
Cafer Saka
Prostate cancer is the second most common malignant type of cancer in men and fifth among fatal types of cancer. Because drugs used in prostate cancer, such as in many other drugs, are also present in low concentrations in body fluids, it is important to develop highly sensitive and sensitive methods that allow the correct amount of prostate cancer drugs to be determined at low concentrations in biological specimens. Electrochemical approaches for the quantitation of prostate cancer drugs have several advantages over other common techniques, including sensitive, selective, fast, broad linear concentration range...
January 12, 2019: Critical Reviews in Analytical Chemistry
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