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JOURNAL ARTICLE
David R McIlroy, Xiaoke Feng, Matthew Shotwell, Sophia Wallace, Rinaldo Bellomo, Amit X Garg, Kate Leslie, Philip Peyton, David Story, Paul S Myles
BACKGROUND: Acute kidney injury (AKI) is common after major abdominal surgery. Selection of candidate kidney protective strategies for testing in large trials should be based on robust preliminary evidence. METHODS: We conducted a secondary analysis of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) trial, in adult patients undergoing major abdominal surgery and randomly assigned to a restrictive or liberal perioperative fluid regimen...
February 21, 2024: Anesthesiology
#2
JOURNAL ARTICLE
Julia Paxino, Rebecca A Szabo, Stuart Marshall, David Story, Elizabeth Molloy
INTRODUCTION: Clinical debriefing (CD) improves teamwork and patient care. It is implemented across a range of clinical contexts, but delivery and structure are variable. Furthermore, terminology to describe CD is also inconsistent and often ambiguous. This variability and the lack of clear terminology obstructs understanding and normalisation in practice. This review seeks to examine the contextual factors relating to different CD approaches with the aim to differentiate them to align with the needs of different clinical contexts...
December 30, 2023: BMJ Quality & Safety
#3
JOURNAL ARTICLE
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C Marzin, Robert C J Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C Trolese, Takashi Saito, Takaomi C Saido, Katharine H Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A Galloway, Rochelle Y Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I Radulescu, Jia Hui Wong, Anna M Barron, Amy M Smith, Samuel J Barnes, David W Hampton, Paul van der Valk, Steven Jacobson, Owain W Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B Tournier, Philippe Millet, Paul M Matthews, Craig S Moore, Sandra Amor, David R Owen
Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative interpretation remains uncertain. We show that TSPO expression increases in activated microglia in mouse brain disease models but does not change in a non-human primate disease model or in common neurodegenerative and neuroinflammatory human diseases. We describe genetic divergence in the TSPO gene promoter, consistent with the hypothesis that the increase in TSPO expression in activated myeloid cells depends on the transcription factor AP1 and is unique to a subset of rodent species within the Muroidea superfamily...
August 28, 2023: Nature Communications
#4
JOURNAL ARTICLE
Camille Paynter, Cassie McDonald, David Story, Jill J Francis
PURPOSE: Methods for assessing acceptability of healthcare interventions have been inconsistent until the development of the theoretical framework of acceptability (TFA). Despite its rapid adoption in healthcare research, the TFA has rarely been used to assess acceptability of surgical interventions. We sought to explore the sufficiency of the TFA in this context and provide methodological guidance to support systematic use of this framework in research. METHOD: Acceptability was assessed in a consecutive sample of 15 patients at least 3 months post-joint replacement surgery via theory-informed semi-structured interviews...
June 24, 2023: British Journal of Health Psychology
#5
JOURNAL ARTICLE
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the underlying mechanism(s) are poorly understood. Here, using human-induced pluripotent stem cell-derived microglia-like cells (hiPSC-MG) harboring the most common ALS/FTD mutation ( C9orf72 , mC9-MG), gene-corrected isogenic controls (isoC9-MG), and C9orf72 knockout hiPSC-MG (C9KO-MG), we show that reduced C9ORF72 protein is associated with impaired phagocytosis and an exaggerated immune response upon stimulation with lipopolysaccharide...
April 21, 2023: Science Advances
#6
RANDOMIZED CONTROLLED TRIAL
Dharshi Karalapillai, Laurence Weinberg, Ary Serpa Neto, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Grace Liskaser, Ajay Balasubramaniam, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones
BACKGROUND: We recently reported the results for a large randomized controlled trial of low tidal volume ventilation (LTVV) versus conventional tidal volume (CTVV) during major surgery when positive end expiratory pressure (PEEP) was equal between groups. We found no difference in postoperative pulmonary complications (PPCs) in patients who received LTVV. However, in the subgroup of patients undergoing laparoscopic surgery, LTVV was associated with a numerically lower rate of PPCs after surgery...
March 7, 2023: BMC Anesthesiology
#7
JOURNAL ARTICLE
Cassie E McDonald, Camille Paynter, Jill J Francis, Daevyd Rodda, Supreet Bajwa, Dwane Jackson, David Story
INTRODUCTION: Arthroplasty is an effective, yet costly, surgical procedure for end-stage osteoarthritis. Shorter stays in hospital are being piloted in Australia. In some countries, short stay is established practice, associated with improving perioperative care and enhanced recovery after surgery practices. Exploring the acceptability to patients of a short stay care pathway in hospital postarthroplasty is important for informing health policy, adoption and potential scalability of this model of care...
August 2022: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
#8
RANDOMIZED CONTROLLED TRIAL
Ianthe Boden, Kate Sullivan, Claire Hackett, Brooke Winzer, Rita Hwang, David Story, Linda Denehy
BACKGROUND: Postoperative pneumonia and delayed physical recovery are significant problems after emergency laparotomy. No randomized controlled trial has assessed the feasibility, safety, or effectiveness of intensive postoperative physical therapy in this high-risk acute population. METHODS: The internal pilot phase of the Incidence of Complications after Emergency Abdominal Surgery: Get Exercising (ICEAGE) trial was a prospective, randomized controlled trial that evaluated the feasibility, safety, and clinical trial processes of providing intensive physical therapy immediately following emergency laparotomy...
June 1, 2022: Journal of Trauma and Acute Care Surgery
#9
JOURNAL ARTICLE
Dharshi Karalapillai, Laurence Weinberg, Ary Serpa Neto, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Sree Appu, Anthony Wilson, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones
BACKGROUND: Low tidal volume (VT ) ventilation and its associated increase in arterial carbon dioxide (PaCO2 ) may affect postoperative neurologic function. We aimed to test the hypothesis that intraoperative low VT ventilation affect the incidence of postoperative ICD-10 coded delirium and/or the need for antipsychotic medications. METHODS: This is a post-hoc analysis of a large randomized controlled trial evaluating low vs. conventional VT ventilation during major non-cardiothoracic, non-intracranial surgery...
May 16, 2022: BMC Anesthesiology
#10
JOURNAL ARTICLE
The-Phung To, Sabine Braat, Andrew Lim, Jo-Anne Brien, Melodie Heland, Andrew Hardidge, David Story
BACKGROUND: Managing medications inappropriately when patients have oral intake restrictions can cause patient harm. This study evaluated the impact of a medication policy separating fasting from nil by mouth with respect to giving oral medications in patients fasting before a diagnostic or interventional procedure. METHODS: The policy stipulated that 'fasting' means oral medications should be given with a sip of water up to 1 hour before a procedure, unless there is a clinical reason to withhold, while 'nil by mouth' means nothing to be given orally, including medications...
May 2022: BMJ Open Quality
#11
JOURNAL ARTICLE
Scott McAlister, Forbes McGain, Matilde Petersen, David Story, Kate Charlesworth, Glenn Ison, Alexandra Barratt
BACKGROUND: Pathology testing and diagnostic imaging together contribute 9% of healthcare's carbon footprint. Whilst the carbon footprint of pathology testing has been undertaken, to date, the carbon footprint of the four most common imaging modalities is unclear. METHODS: We performed a prospective life cycle assessment at two Australian university-affiliated health services of five imaging modalities: chest X-ray (CXR), mobile chest X-ray (MCXR), computerised tomography (CT), magnetic resonance imaging (MRI) and ultrasound (US)...
July 2022: The Lancet Regional Health. Western Pacific
#12
REVIEW
Marlena Klaic, Suzanne Kapp, Peter Hudson, Wendy Chapman, Linda Denehy, David Story, Jill J Francis
BACKGROUND: Implementation research may play an important role in reducing research waste by identifying strategies that support translation of evidence into practice. Implementation of healthcare interventions is influenced by multiple factors including the organisational context, implementation strategies and features of the intervention as perceived by people delivering and receiving the intervention. Recently, concepts relating to perceived features of interventions have been gaining traction in published literature, namely, acceptability, fidelity, feasibility, scalability and sustainability...
January 27, 2022: Implementation Science: IS
#13
Owen G James, Bhuvaneish T Selvaraj, Dario Magnani, Karen Burr, Peter Connick, Samantha K Barton, Navneet A Vasistha, David W Hampton, David Story, Robert Smigiel, Rafal Ploski, Peter J Brophy, Charles Ffrench-Constant, David A Lyons, Siddharthan Chandran
No abstract text is available yet for this article.
January 10, 2022: Developmental Cell
#14
JOURNAL ARTICLE
Zoeb Jiwaji, Sachin S Tiwari, Rolando X Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M Smith, Peta Greer, Matthew Ball, Peter C Kind, Paul M Matthews, Colin Smith, Owen Dando, Tara L Spires-Jones, Jeffrey A Johnson, Siddharthan Chandran, Giles E Hardingham
Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPTP301S tauopathy mice revealed that only Aß influenced expression of AD risk genes, but both pathologies precociously induced age-dependent changes, and had distinct but overlapping signatures found in human post-mortem AD astrocytes. Both Aß and Tau pathology induced an astrocyte signature involving repression of bioenergetic and translation machinery, and induction of inflammation pathways plus protein degradation/proteostasis genes, the latter enriched in targets of inflammatory mediator Spi1 and stress-activated cytoprotective Nrf2...
January 10, 2022: Nature Communications
#15
RANDOMIZED CONTROLLED TRIAL
Dharshi Karalapillai, Laurence Weinberg, Serpa Neto A, Philip Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones
BACKGROUND: Studies in critically ill patients suggest a relationship between mechanical power (an index of the energy delivered by the ventilator, which includes driving pressure, respiratory rate, tidal volume and inspiratory pressure) and complications. OBJECTIVE: We aimed to assess the association between intra-operative mechanical power and postoperative pulmonary complications (PPCs). DESIGN: Post hoc analysis of a large randomised clinical trial...
January 1, 2022: European Journal of Anaesthesiology
#16
JOURNAL ARTICLE
Samantha K Barton, Jenna M Gregory, Bhuvaneish T Selvaraj, Karina McDade, Christopher M Henstridge, Tara L Spires-Jones, Owen G James, Arpan R Mehta, David Story, Karen Burr, Dario Magnani, Adrian M Isaacs, Colin Smith, Siddharthan Chandran
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the extent to which this affects myelination and the relative contribution of this to disease pathogenesis is unclear. ALS autopsy research findings showing demyelination contrasts with the routine clinical-pathological workup of ALS cases where it is rare to see white matter abnormalities other than simple Wallerian degeneration secondary to widespread neuronal loss...
2021: Frontiers in Neuroscience
#17
JOURNAL ARTICLE
George Braitberg, Vasilios Nimorakiotakis, Celene Y L Yap, Violet Mukaro, Ronelle Welton, Anna Parker, Jonathan Knott, David Story
Despite recent reviews of best practice for the treatment of Australian venomous bites and stings, there is controversy about some aspects of care, particularly the use of antivenom. Our aim was to understand current attitudes and practice in the management of suspected snake envenoming. A single-stage, cross-sectional survey of Australian emergency care physicians who had treated snake envenomation in the previous 36 months was conducted. Hospital pharmacists were also invited to complete a survey about antivenom availability, usage, and wastage in Australian hospitals...
July 12, 2021: Toxins
#18
RANDOMIZED CONTROLLED TRIAL
Tomás B Corcoran, Paul S Myles, Andrew B Forbes, Allen C Cheng, Leon A Bach, Edmond O'Loughlin, Kate Leslie, Matthew T V Chan, David Story, Timothy G Short, Catherine Martin, Pauline Coutts, Kwok M Ho
BACKGROUND: The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection. METHODS: In this pragmatic, international, noninferiority trial, we randomly assigned 8880 adult patients who were undergoing nonurgent, noncardiac surgery of at least 2 hours' duration, with a skin incision length longer than 5 cm and a postoperative overnight hospital stay, to receive 8 mg of intravenous dexamethasone or matching placebo while under anesthesia...
May 6, 2021: New England Journal of Medicine
#19
JOURNAL ARTICLE
Owen G James, Bhuvaneish T Selvaraj, Dario Magnani, Karen Burr, Peter Connick, Samantha K Barton, Navneet A Vasistha, David W Hampton, David Story, Robert Smigiel, Rafal Ploski, Peter J Brophy, Charles Ffrench-Constant, David A Lyons, Siddharthan Chandran
Myelination is essential for central nervous system (CNS) formation, health, and function. Emerging evidence of oligodendrocyte heterogeneity in health and disease and divergent CNS gene expression profiles between mice and humans supports the development of experimentally tractable human myelination systems. Here, we developed human iPSC-derived myelinating organoids ("myelinoids") and quantitative tools to study myelination from oligodendrogenesis through to compact myelin formation and myelinated axon organization...
May 3, 2021: Developmental Cell
#20
JOURNAL ARTICLE
Arpan R Mehta, Jenna M Gregory, Owen Dando, Roderick N Carter, Karen Burr, Jyoti Nanda, David Story, Karina McDade, Colin Smith, Nicholas M Morton, Don J Mahad, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axonal function is a highly energy-demanding process, raising the question of whether MN cellular energetics is perturbed in ALS, and whether its recovery promotes axonal rescue. To address this, we undertook cellular and molecular interrogation of multiple patient-derived induced pluripotent stem cell lines and patient autopsy samples harbouring the most common ALS causing mutation, C9orf72...
February 2021: Acta Neuropathologica
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