Limin Lang, Shuyi Liang, Fenglin Zhang, Yiming Fu, Junfeng Wang, Kaixin Deng, Lina Wang, Ping Gao, Canjun Zhu, Gang Shu, Ruifan Wu, Qingyan Jiang, Songbo Wang
Vascular endothelial growth factor B (VEGFB) has been well demonstrated to play a crucial role in regulating vascular function by binding to the VEGF receptors (VEGFRs). However, the specific role of VEGFB and VEGFRs in pubertal mammary gland development remains unclear. In this study, we observed that blocking the VEGF receptors with Axitinib suppressed the pubertal mammary gland development. Meanwhile, the proliferation of mammary epithelial cells (HC11) was repressed by blocking the VEGF receptors with Axitinib...
March 10, 2024: International Journal of Biological Macromolecules