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https://read.qxmd.com/read/30766882/lead-induced-ototoxicity-and-neurotoxicity-in-adult-guinea-pig
#1
Yanni Zhang, Qian Jiang, Shaobing Xie, Xuewen Wu, Jun Zhou, Hong Sun
Lead exposure causes or aggravates hearing damage to human or animal, but the detailed effects of lead exposure on auditory system including injury sites of the cochlea in mammal remain controversy. To investigate the effect of chronic lead exposure on auditory system, 40 adult guinea pigs with normal hearing were randomly divided into five groups. They were fed 2 mmol/L lead acetate in drinking water for 0, 15, 30, 60, and 90 days (n = 8), respectively. Lead concentrations in blood, cochlea, and brainstem were measured...
2019: BioMed Research International
https://read.qxmd.com/read/30743166/evaluation-of-hearing-in-pediatric-familial-mediterranean-fever-patients-during-attack-period-and-attack-free-period
#2
Asif Salimov, Umut Akyol, Bunyamin Cildir, Ezgi Deniz Batu, Seza Ozen
OBJECTIVES: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. It usually has a childhood onset and is characterized with recurrent attacks with irregular intervals. Few studies have been performed to investigate hearing in FMF patients ran with various tests and showed different results. In this study, first time in the literature, we aimed to evaluate and compare auditory functions in pediatric FMF patients during the attack periods and attack-free periods to see the possible effects of autoinflammation that was caused by FMF attacks...
February 1, 2019: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30709692/distortion-product-otoacoustic-emissions-sensitive-measures-of-tympanic-membrane-perforation-and-healing-processes-in-a-gerbil-model
#3
Wei Dong, Glenna Stomackin, Xiaohui Lin, Glen K Martin, Timothy T Jung
Distortion product otoacoustic emissions (DPOAEs) evoked by two pure tones carry information about the mechanisms that generate and shape them. Thus, DPOAEs hold promise for providing powerful noninvasive diagnostic details of cochlear operations, middle ear (ME) transmission, and impairments. DPOAEs are sensitive to ME function because they are influenced by ME transmission twice, i.e., by the inward-going primary tones in the forward direction and the outward traveling DPOAEs in the reverse direction. However, the effects of ME injuries on DPOAEs have not been systematically characterized...
January 23, 2019: Hearing Research
https://read.qxmd.com/read/30686544/progressive-hearing-damage-after-exposure-to-repeated-low-intensity-blasts-in-chinchillas
#4
Tao Chen, Kyle Smith, Shangyuan Jiang, Tianyu Zhang, Rong Z Gan
Hearing damage caused by blast waves is a frequent and common injury for Service members. However, most studies have focused on high-intensity blast exposures that are known to cause moderate to severe traumatic brain injury (TBI), and fewer studies have investigated the progressive hearing damage caused by low-intensity blast exposures (below mild TBI). In this paper, we report our recent study in chinchillas to investigate the auditory function changes over the time course after repetitive exposures to low-intensity blast...
January 17, 2019: Hearing Research
https://read.qxmd.com/read/30675896/characterization-of-the-early-pathology-of-cochlear-stereocilia-in-four-inbred-mouse-strains-with-progressive-hearing-loss
#5
Xiang Liu, Yi Xie, Shanshan Huang, Ang Xu, Mengmeng Zhao, Xiaoxia Kang, Aiwei Yan, Ping Li, Changzhu Jin, Fengchan Han
OBJECTIVE: Inbred strains of mice offer promising models for understanding the genetic basis of age-related hearing loss (AHL). NOD/LtJ, A/J, DBA/2J and C57BL/6J mice are classical models of age-related hearing loss and exhibit early onset of pathology of AHL. This study was carried out to characterize the early pathology of cochlear stereocilia in the four mouse strains with age-related hearing loss. METHODS: The structural features of stereocilia in NOD/LtJ, A/J, DBA/2J and C57BL/6J mice were observed by scanning electron microscopy (SEM) at age 2, 4, 6 or 8, and 10 or 12 weeks...
January 24, 2019: Histology and Histopathology
https://read.qxmd.com/read/30666045/is-sensorineural-hearing-loss-related-to-chronic-rhinosinusitis-caused-by-outer-hair-cell-injury
#6
Xi Lin, Xin Shan, Shaolian Lin, Bo Shu, Yingge Wang, Wenhui Xiao
BACKGROUND Sensorineural hearing loss is caused by defects in the inner ear. In the present study, associations between chronic rhinosinusitis, outer hair cell injury, and sensorineural hearing loss were investigated. MATERIAL AND METHODS A total of 103 patients who met the inclusion criteria were recruited and allocated into a chronic rhinosinusitis group (n=82) and a simple deviated nasal septum group (n=21). Degree and type of hearing loss, including distortion product otoacoustic emissions, were used to assess the status of cochlear outer hair cells...
January 22, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30651130/a-randomized-controlled-trial-to-test-the-efficacy-of-trans-tympanic-injections-of-a-sodium-thiosulfate-gel-to-prevent-cisplatin-induced-ototoxicity-in-patients-with-head-and-neck-cancer
#7
Viannique Rolland, François Meyer, Matthieu J Guitton, Richard Bussières, Daniel Philippon, Isabelle Bairati, Mathieu Leclerc, Mathieu Côté
BACKGROUND: Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin. The objective of the trial was to test the efficacy of trans-tympanic injections of a STS gel to prevent cisplatin-induced ototoxicity. METHODS: Eligible participants were newly diagnosed patients with stage III or IV squamous cell carcinoma of the mouth, oropharynx, hypopharynx, or larynx and scheduled to be treated by concurrent chemoradiation (CCR)...
January 16, 2019: Journal of Otolaryngology—Head & Neck Surgery
https://read.qxmd.com/read/30618293/conventional-audiometry-extended-high-frequency-audiometry-and-dpoaes-in-youth-recreational-firearm-users
#8
Shana M Laffoon, Michael Stewart, Yunfang Zheng, Deanna K Meinke
To determine if conventional audiometry, EHFA, and pDPOAEs are useful as early indicators of cochlear damage from recreational firearm impulse noise exposure in youth firearm users. Quantitative cross-sectional descriptive pilot study. Descriptive statistics and MANOVA with post hoc Tukey Honestly Significant Difference test were used to compare pDPOAEs (1-10 kHz), conventional audiometry (0.25-8 kHz), and EHFA (10-16 kHz) in YFUs. 25 YFUs (n = 11 7-12 years; n = 14 13-17 years) with self-reported poor compliance with hearing protector device wear...
January 8, 2019: International Journal of Audiology
https://read.qxmd.com/read/30606168/implementation-and-evaluation-of-a-rural-community-based-pediatric-hearing-screening-program-integrating-in-person-and-tele-diagnostic-auditory-brainstem-response-abr
#9
Vidya Ramkumar, Roopa Nagarajan, Vanaja C Shankarnarayan, Selvakumar Kumaravelu, James W Hall
BACKGROUND: In an attempt to reach remote rural areas, this study explores a community-based, pediatric hearing screening program in villages, integrating two models of diagnostic ABR testing; one using a tele-medicine approach and the other a traditional in-person testing at a tertiary care hospital. METHODS: Village health workers (VHWs) underwent a five day training program on conducting Distortion Product Oto Acoustic Emissions (DPOAE) screening and assisting in tele-ABR...
January 3, 2019: BMC Health Services Research
https://read.qxmd.com/read/30587464/isotretinoin-s-action-against-cisplatin-induced-ototoxicity-in-rats
#10
Mehmet Akif Alan, Mehmet Akif Eryılmaz, Figen Kaymaz, Aysegul Suzer, Mitat Arıcıgil
Current data do not support the routine use of any agent to prevent cisplatin ototoxicity. Although there are various diseases in which derivatives of vitamin A are used due to their antioxidant effects, there is no study for prevention from ototoxicity. In this study, the protective effect of isotretinoin was investigated on cisplatin ototoxicity in rats. 21 Wistar Albino rats were divided randomly into 3 groups. Group I: cisplatin, Group II: cisplatin + isotretinoin and Group III was the control group. Hearing assessment of all rats was done with ABR and DPOAE tests before and after the procedure...
November 2018: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/30579092/transplantation-of-human-limbus-derived-mesenchymal-stromal-cells-via-occipital-approach-improves-hearing-in-animal-auditory-neuropathy
#11
Hsin-Chien Chen, Chang-Min Liang, Chih-Hung Wang, Ming-Yuan Huang, Yuan-Yung Lin, Cheng-Ping Shih, Chao-Yin Kuo, Yi-Chun Lin, Hang-Kang Chen
OBJECTIVE: To develop a surgical approach for cell transplantation into mouse cochlear nerves via an intracranial route and investigate whether transplantation of human limbus-derived mesenchymal stromal cells (HL-MSCs) can improve hearing in this model of auditory neuropathy. METHODS: We used 8-week-old CBA/CaJ male mice and created ouabain-induced auditory neuropathy. The surgical approach passed through the cerebellum to reveal the superior semicircular canal and brainstem, allowing access to the auditory nerve...
November 15, 2018: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30579070/large-scale-otoscopic-and-audiometric-population-assessment-a-pilot-study
#12
Kenny H Chan, Susan Dreith, Kristin M Uhler, Veronica Tallo, Marilla Lucero, Joanne De Jesus, Eric Af Simões
OBJECTIVE: Large-scale otoscopic and audiometric assessment of populations is difficult due to logistic impracticalities, particularly in low- and middle-income countries (LMIC). We report a novel assessment methodology based on training local field workers, advances in audiometric testing equipment and cloud-based technology. METHODS: Prospective observational study in Bohol, Philippines. A U.S. otolaryngologist/audiologist team trained 5 local nurses on all procedures in a didactic and hands-on process...
November 30, 2018: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30570608/sens-401-effectively-reduces-severe-acoustic-trauma-induced-hearing-loss-in-male-rats-with-twice-daily-administration-delayed-up-to-96-hours
#13
Mathieu Petremann, Charlotte Romanet, Audrey Broussy, Christophe Tran Van Ba, Sonia Poli, Jonas Dyhrfjeld-Johnsen
HYPOTHESIS: SENS-401 (R-azasetron besylate) is effective against severe acoustic trauma-induced hearing loss. BACKGROUND: SENS-401 has calcineurin inhibiting properties and attenuates cisplatin-induced hearing loss in a rat model. Cisplatin-induced and acoustic trauma-induced hearing loss share common apoptotic pathways. METHODS: The dose-response relationship of SENS-401 (6.6 mg/kg BID, 13.2 mg/kg BID, 26.4 mg/kg QD) and treatment time-window (13...
December 17, 2018: Otology & Neurotology
https://read.qxmd.com/read/30559766/isoflurane-anesthesia-suppresses-distortion-product-otoacoustic-emissions-in-rats
#14
Adam M Sheppard, Deng-Ling Zhao, Richard Salvi
A commonly used anesthetic, isoflurane, can impair auditory function in a dose-dependent manner. However, in rats, isoflurane-induced auditory impairments have only been assessed with auditory brainstem responses; a measure which is unable to distinguish if changes originate from the central or peripheral auditory system. Studies performed in other species, such as mice and guinea-pigs, suggests auditory impairment stems from disrupted OHC amplification. Despite the wide use of the rat in auditory research, these observations have yet to be replicated in the rat animal model...
June 2018: Journal of Otology
https://read.qxmd.com/read/30541727/auditory-and-histopathological-effects-of-topical-mercurochrome-treatment-in-rats-with-tympanic-membrane-perforation
#15
Süleyman Korkmaz, Mehmet Emrah Ceylan, Gözde Ceylan, Abdullah Dalgıç, Sevinç İnan, Levent Olgun, Mehmet Ziya Özüer
OBJECTIVES: Topical treatment is first choice in the treatment of uncomplicated chronic otitis media. It was intended to assess auditory and histopathological safety of ototopical use of mercurochrome solution in rats with induced tympanic membrane perforation. MATERIALS AND METHODS: The study was conducted on 21 female Wistar-Albino rats which were randomly assigned into 3 groups. In all rats, perforation was performed at right tympanic membrane. Distortion product otoacoustic emissions (DPOAEs) measurements were performed at frequencies of 2000, 3000 and 4000 Hz (with L1/L2: 70 /70 dB at 2f1-f2 frequency; f2/f1 ratio: 1:22) before recovery from anesthesia and signal-to-noise ratio (SNR) were recorded...
December 12, 2018: Journal of International Advanced Otology
https://read.qxmd.com/read/30510499/differences-in-stress-induced-modulation-of-the-auditory-system-between-wistar-and-lewis-rats
#16
Agnieszka J Szczepek, Gunnar P H Dietz, Uta Reich, Olga Hegend, Heidi Olze, Birgit Mazurek
Many aspects of stress-induced physiological and psychological effects have been characterized in people and animals. However, stress effects on the auditory system are less explored and their mechanisms are not well-understood, in spite of its relevance for a variety of diseases, including tinnitus. To expedite further research of stress-induced changes in the auditory system, here we compare the reactions to stress among Wistar and Lewis rats. The animals were stressed for 24 h, and subsequently we tested the functionality of the outer hair cells (OHCs) using distortion product otoacoustic emissions (DPOAEs) and auditory neurons using evoked auditory brainstem responses (ABR)...
2018: Frontiers in Neuroscience
https://read.qxmd.com/read/30484386/contrasting-effects-of-pressure-compensation-on-teoae-and-dpoae-in-children-with-negative-middle-ear-pressure
#17
Snezana A Filipović, Mark P Haggard, Helen Spencer, Goran Trajković
In children with normal cochlear acuity, middle ear fluid often abolishes otoacoustic emissions (OAEs), and negative middle ear pressure (NMEP) reduces them. No convincing evidence of beneficial pressure compensation on distortion product OAE (DPOAE) has yet been presented. Two studies aimed to document effects of NMEP on transient OAE (TEOAE) and DPOAE. In Study 1, TEOAE and DPOAE pass/fail responses were analyzed before and after pressure compensation in 50 consecutive qualifying referrals having NMEP from -100 to -299 daPa...
January 2018: Trends in Hearing
https://read.qxmd.com/read/30461415/early-indices-of-reduced-cochlear-function-in-young-adults-with-type-1-diabetes-revealed-by-dpoae-fine-structure
#18
Christopher Spankovich, Glenis R Long, Linda J Hood
BACKGROUND: The relationship between type-1 diabetes mellitus (DM) and cochlear dysfunction remains inconclusive. PURPOSE: The purpose of this study was to examine otoacoustic emissions (OAEs) in normal-hearing young adults with type-1 DM as compared with matched controls and identify potential covariates influencing OAE findings. RESEARCH DESIGN: Cross-sectional study. STUDY SAMPLE: N = 40 young adults aged 18-28 years including individuals with type-1 DM (n = 20) and age-gender matched controls (n = 20) with normal hearing sensitivity...
September 25, 2018: Journal of the American Academy of Audiology
https://read.qxmd.com/read/30455746/cochlear-dysfunction-and-microvascular-complications-in-patients-with-type-1-diabetes-mellitus
#19
João Soares Felício, Lilian de Souza d'Albuquerque Silva, Carlliane Lima E Lins Pinto Martins, João Felício Abrahão Neto, Manuela Nascimento de Lemos, Fabrício de Souza Resende, Wanderson Maia da Silva, Angélica Leite de Alcântara, Maria Clara Neres Iunes de Oliveira, Norberto Jorge Kzan de Souza Neto, Isabela Imbelloni Farias de Franco, Nathalie Abdallah Zahalan, Luísa Correa Janaú, Ana Carolina Contente Braga de Souza, Flavia Marques Santos, Natércia Neves Marques de Queiroz, Neyla Arroyo Lara Mourão, Márcia Costa Dos Santos, Karem Miléo Felício, Franciane Trindade Cunha de Melo
Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic kidney disease (DKD) and diabetic cardiac autonomic neuropathy (CAN). We performed a cross-sectional study with 37 type 1 DM patients without auditory symptoms, submitted to the study of Distortion Product Otoacoustic Emissions (DPOAEs) and screened for DKD and CAN...
2018: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/30440607/noise-induced-hearing-loss-in-mice-effects-of-high-and-low-levels-of-noise-trauma-in-cba-mice
#20
Reza M Amanipour, Xiaoxia Zhu, Guillaume Duvey, Sylvain Celanire, Joseph P Walton, Robert D Frisina
Acoustic trauma can induce temporary or permanent noise-induced hearing loss (NIHL). Noise exposed animal models allow us to study the effects of various noise trauma insults on the cochlea and auditory pathways. Here we studied the short-term and long-term functional changes occurring in the auditory system following exposure to two different noise traumas. Several measures of hearing function known to change following noise exposure were examined: Temporary (TTS) and permanent (PTS) threshold shifts were measured using auditory brainstem responses (ABR), outer hair cell function was examined using distortion product otoacoustic emissions (DPOAEs), and auditory temporal processing was assessed using a gap-in-noise (GIN) ABR paradigm...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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