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JOURNAL ARTICLE
Hila Shamon, Roi Maor, Michael V Cove, Roland Kays, Jessie Adley, Peter D Alexander, David N Allen, Maximilian L Allen, Cara L Appel, Evan Barr, Erika L Barthelmess, Carolina Baruzzi, Kelli Bashaw, Guillaume Bastille-Rousseau, Madison E Baugh, Jerrold Belant, John F Benson, Bethany A Bespoyasny, Tori Bird, Daniel A Bogan, LaRoy S E Brandt, Claire E Bresnan, Jarred M Brooke, Frances E Buderman, Suzannah G Buzzell, Amanda E Cheeseman, M Colter Chitwood, Petros Chrysafis, Merri K Collins, D Parks Collins, Justin A Compton, L Mike Conner, Olivia G Cosby, Stephanie S Coster, Benjamin Crawford, Anthony P Crupi, Andrea K Darracq, Miranda L Davis, Brett A DeGregorio, Kimberly L Denningmann, Kyle D Dougherty, Ace Driver, Andrew J Edelman, E Hance Ellington, Susan N Ellis-Felege, Caroline N Ellison, Jean E Fantle-Lepczyk, Zach J Farris, Jorie Favreau, Pilar Fernandez, M Caitlin Fisher-Reid, Matthew C Fitzpatrick, Elizabeth A Flaherty, Tavis D Forrester, Sarah R Fritts, Travis Gallo, Brian D Gerber, Sean T Giery, Jessica L Glasscock, Alex D Gonatas, Anna C Grady, Austin M Green, Tremaine Gregory, Noel Griffin, Robert H Hagen, Christopher P Hansen, Lonnie P Hansen, Steven C Hasstedt, Haydée Hernández-Yáñez, Daniel J Herrera, Robert V Horan, Victoria L Jackson, Luanne Johnson, Mark J Jordan, Willaine Kahano, Joseph Kiser, Travis W Knowles, Molly M Koeck, Caroline Koroly, Kellie M Kuhn, Erin K Kuprewicz, Diana J R Lafferty, Scott D LaPoint, Marcus Lashley, Richard G Lathrop, Thomas E Lee, Christopher A Lepczyk, Damon B Lesmeister, Jason V Lombardi, Robert A Long, Robert C Lonsinger, Paula MacKay, Sean P Maher, David S Mason, Joshua J Millspaugh, Remington J Moll, Jessica B Moon, Alessio Mortelliti, Alexis M Mychajliw, Christopher M Nagy, Sean A Neiswenter, Dana L Nelson, Claire E Nemes, Clayton K Nielsen, Elizabeth Olson, M Teague O'Mara, Brian J O'Neill, Blake R Page, Elizabeth Parsons, Brent S Pease, Mary E Pendergast, Mike Proctor, Heather Quick, Christine C Rega-Brodsky, Michael S Rentz, Kylie Rezendes, Daric Rich, Derek R Risch, Andrea Romero, Brigit R Rooney, Christopher T Rota, Corey A Samples, Christopher M Schalk, Çağan H Sekercioğlu, Maksim Sergeyev, Austin B Smith, Daniel S Smith, Jinelle H Sperry, Jennifer L Stenglein, Michael K Stokes, Johnathon S Stutzman, Kimberly R Todd, John P Vanek, Wren Varga, Zachary M Wardle, Stephen L Webb, Nathaniel H Wehr, Laura S Whipple, Christopher A Whittier, Jane S Widness, Jacque Williamson, Andrew M Wilson, Alexander J Wolf, Marketa Zimova, Adam S Zorn, William J McShea
SNAPSHOT USA is a multicontributor, long-term camera trap survey designed to survey mammals across the United States. Participants are recruited through community networks and directly through a website application (https://www.snapshot-usa.org/). The growing Snapshot dataset is useful, for example, for tracking wildlife population responses to land use, land cover, and climate changes across spatial and temporal scales. Here we present the SNAPSHOT USA 2021 dataset, the third national camera trap survey across the US...
May 1, 2024: Ecology
#2
JOURNAL ARTICLE
James M Klugh, Thaddeus J Puzio, Michael W Wandling, Chelsea J Guy-Frank, Charles Green, Paulina B Sergot, Samuel J Prater, Julius Balogh, Christopher T Stephens, Charles E Wade, Lillian S Kao, John A Harvin
INTRODUCTION: Non-narcotic intravenous medications may be a beneficial adjunct to oral multimodal pain regimens (MMPRs) which reduce but do not eliminate opioid exposure and prescribing after trauma. We hypothesized that the addition of a sub-dissociative ketamine infusion (KI) to a standardized oral MMPR reduces inpatient opioid exposure. METHODS: Eligible adult trauma patients admitted to the intermediate or intensive care unit were randomized upon admission to our institutional MMPR per usual care (UC) or UC plus sub-dissociative KI for 24 to 72 hours after arrival...
May 1, 2024: Journal of Trauma and Acute Care Surgery
#3
JOURNAL ARTICLE
Ethan A Winkler, Joshua S Catapano, Lea Scherschinski, Ashia M Hackett, Michael T Lawton
Posterior inferior cerebellar artery (PICA) aneurysms account for 0.3% of all intracranial aneurysms, and they commonly present with a complex fusiform morphology that necessitates unique bypass strategies.1-5 An adolescent boy with a familial predisposition to aneurysmal subarachnoid hemorrhage was identified as harboring a fusiform aneurysm of the right distal PICA, characterized by 2 outflow branches. Our recommended treatment strategy involved a right far lateral craniotomy, followed by P1 PICA reanastomosis and P2 PICA reimplantation...
April 30, 2024: Operative Neurosurgery (Hagerstown, Md.)
#4
REVIEW
Ebony B Madden, Lucia A Hindorff, Vence L Bonham, Tabia Henry Akintobi, Esteban G Burchard, Kellan E Baker, Rene L Begay, John D Carpten, Nancy J Cox, Valentina Di Francesco, Denise A Dillard, Faith E Fletcher, Stephanie M Fullerton, Nanibaa' A Garrison, Catherine M Hammack-Aviran, Vanessa Y Hiratsuka, James E K Hildreth, Carol R Horowitz, Chanita A Hughes Halbert, Michael Inouye, Amber Jackson, Latrice G Landry, Rick A Kittles, Jeff T Leek, Nita A Limdi, Nicole C Lockhart, Elizabeth O Ofili, Eliseo J Pérez-Stable, Maya Sabatello, Loren Saulsberry, Lorjetta E Schools, Jennifer L Troyer, Benjamin S Wilfond, Genevieve L Wojcik, Judy H Cho, Sandra S-J Lee, Eric D Green
Health equity is the state in which everyone has fair and just opportunities to attain their highest level of health. The field of human genomics has fallen short in increasing health equity, largely because the diversity of the human population has been inadequately reflected among participants of genomics research. This lack of diversity leads to disparities that can have scientific and clinical consequences. Achieving health equity related to genomics will require greater effort in addressing inequities within the field...
April 29, 2024: Nature Genetics
#5
JOURNAL ARTICLE
Ethan A Winkler, Lea Scherschinski, Joshua S Catapano, Joseph D DiDomenico, Sahin Hanalioglu, Michael T Lawton
Brain arteriovenous malformations (AVMs) of the fourth ventricle represent a rare subtype associated with an aggressive natural course.1,2 In this case, a woman in her early 50s presented with dizziness. An AVM was diagnosed in the left superior cerebellar peduncle extending into the fourth ventricle. The AVM was supplied by superior cerebellar artery branches and classified as a Spetzler-Martin grade III and a Lawton-Young grade III, with a supplemented grade of 6.3,4 Being a single case report, institutional review board approval was not needed...
April 25, 2024: Operative Neurosurgery (Hagerstown, Md.)
#6
JOURNAL ARTICLE
Meirion Raymant, Yuliana Astuti, Laura Alvaro-Espinosa, Daniel Green, Valeria Quaranta, Gaia Bellomo, Mark Glenn, Vatshala Chandran-Gorner, Daniel H Palmer, Christopher Halloran, Paula Ghaneh, Neil C Henderson, Jennifer P Morton, Manuel Valiente, Ainhoa Mielgo, Michael C Schmid
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease for which better therapies are urgently needed. Fibroblasts and macrophages are heterogeneous cell populations able to enhance metastasis, but the role of a macrophage-fibroblast crosstalk in regulating their pro-metastatic functions remains poorly understood. Here we deconvolve how macrophages regulate metastasis-associated fibroblast (MAF) heterogeneity in the liver. We identify three functionally distinct MAF populations, among which the generation of pro-metastatic and immunoregulatory myofibroblastic-MAFs (myMAFs) critically depends on macrophages...
April 27, 2024: Nature Communications
#7
JOURNAL ARTICLE
Alexandre R Zuntini, Tom Carruthers, Olivier Maurin, Paul C Bailey, Kevin Leempoel, Grace E Brewer, Niroshini Epitawalage, Elaine Françoso, Berta Gallego-Paramo, Catherine McGinnie, Raquel Negrão, Shyamali R Roy, Lalita Simpson, Eduardo Toledo Romero, Vanessa M A Barber, Laura Botigué, James J Clarkson, Robyn S Cowan, Steven Dodsworth, Matthew G Johnson, Jan T Kim, Lisa Pokorny, Norman J Wickett, Guilherme M Antar, Lucinda DeBolt, Karime Gutierrez, Kasper P Hendriks, Alina Hoewener, Ai-Qun Hu, Elizabeth M Joyce, Izai A B S Kikuchi, Isabel Larridon, Drew A Larson, Elton John de Lírio, Jing-Xia Liu, Panagiota Malakasi, Natalia A S Przelomska, Toral Shah, Juan Viruel, Theodore R Allnutt, Gabriel K Ameka, Rose L Andrew, Marc S Appelhans, Montserrat Arista, María Jesús Ariza, Juan Arroyo, Watchara Arthan, Julien B Bachelier, C Donovan Bailey, Helen F Barnes, Matthew D Barrett, Russell L Barrett, Randall J Bayer, Michael J Bayly, Ed Biffin, Nicky Biggs, Joanne L Birch, Diego Bogarín, Renata Borosova, Alexander M C Bowles, Peter C Boyce, Gemma L C Bramley, Marie Briggs, Linda Broadhurst, Gillian K Brown, Jeremy J Bruhl, Anne Bruneau, Sven Buerki, Edie Burns, Margaret Byrne, Stuart Cable, Ainsley Calladine, Martin W Callmander, Ángela Cano, David J Cantrill, Warren M Cardinal-McTeague, Mónica M Carlsen, Abigail J A Carruthers, Alejandra de Castro Mateo, Mark W Chase, Lars W Chatrou, Martin Cheek, Shilin Chen, Maarten J M Christenhusz, Pascal-Antoine Christin, Mark A Clements, Skye C Coffey, John G Conran, Xavier Cornejo, Thomas L P Couvreur, Ian D Cowie, Laszlo Csiba, Iain Darbyshire, Gerrit Davidse, Nina M J Davies, Aaron P Davis, Kor-Jent van Dijk, Stephen R Downie, Marco F Duretto, Melvin R Duvall, Sara L Edwards, Urs Eggli, Roy H J Erkens, Marcial Escudero, Manuel de la Estrella, Federico Fabriani, Michael F Fay, Paola de L Ferreira, Sarah Z Ficinski, Rachael M Fowler, Sue Frisby, Lin Fu, Tim Fulcher, Mercè Galbany-Casals, Elliot M Gardner, Dmitry A German, Augusto Giaretta, Marc Gibernau, Lynn J Gillespie, Cynthia C González, David J Goyder, Sean W Graham, Aurélie Grall, Laura Green, Bee F Gunn, Diego G Gutiérrez, Jan Hackel, Thomas Haevermans, Anna Haigh, Jocelyn C Hall, Tony Hall, Melissa J Harrison, Sebastian A Hatt, Oriane Hidalgo, Trevor R Hodkinson, Gareth D Holmes, Helen C F Hopkins, Christopher J Jackson, Shelley A James, Richard W Jobson, Gudrun Kadereit, Imalka M Kahandawala, Kent Kainulainen, Masahiro Kato, Elizabeth A Kellogg, Graham J King, Beata Klejevskaja, Bente B Klitgaard, Ronell R Klopper, Sandra Knapp, Marcus A Koch, James H Leebens-Mack, Frederic Lens, Christine J Leon, Étienne Léveillé-Bourret, Gwilym P Lewis, De-Zhu Li, Lan Li, Sigrid Liede-Schumann, Tatyana Livshultz, David Lorence, Meng Lu, Patricia Lu-Irving, Jaquelini Luber, Eve J Lucas, Manuel Luján, Mabel Lum, Terry D Macfarlane, Carlos Magdalena, Vidal F Mansano, Lizo E Masters, Simon J Mayo, Kristina McColl, Angela J McDonnell, Andrew E McDougall, Todd G B McLay, Hannah McPherson, Rosa I Meneses, Vincent S F T Merckx, Fabián A Michelangeli, John D Mitchell, Alexandre K Monro, Michael J Moore, Taryn L Mueller, Klaus Mummenhoff, Jérôme Munzinger, Priscilla Muriel, Daniel J Murphy, Katharina Nargar, Lars Nauheimer, Francis J Nge, Reto Nyffeler, Andrés Orejuela, Edgardo M Ortiz, Luis Palazzesi, Ariane Luna Peixoto, Susan K Pell, Jaume Pellicer, Darin S Penneys, Oscar A Perez-Escobar, Claes Persson, Marc Pignal, Yohan Pillon, José R Pirani, Gregory M Plunkett, Robyn F Powell, Ghillean T Prance, Carmen Puglisi, Ming Qin, Richard K Rabeler, Paul E J Rees, Matthew Renner, Eric H Roalson, Michele Rodda, Zachary S Rogers, Saba Rokni, Rolf Rutishauser, Miguel F de Salas, Hanno Schaefer, Rowan J Schley, Alexander Schmidt-Lebuhn, Alison Shapcott, Ihsan Al-Shehbaz, Kelly A Shepherd, Mark P Simmons, André O Simões, Ana Rita G Simões, Michelle Siros, Eric C Smidt, James F Smith, Neil Snow, Douglas E Soltis, Pamela S Soltis, Robert J Soreng, Cynthia A Sothers, Julian R Starr, Peter F Stevens, Shannon C K Straub, Lena Struwe, Jennifer M Taylor, Ian R H Telford, Andrew H Thornhill, Ifeanna Tooth, Anna Trias-Blasi, Frank Udovicic, Timothy M A Utteridge, Jose C Del Valle, G Anthony Verboom, Helen P Vonow, Maria S Vorontsova, Jurriaan M de Vos, Noor Al-Wattar, Michelle Waycott, Cassiano A D Welker, Adam J White, Jan J Wieringa, Luis T Williamson, Trevor C Wilson, Sin Yeng Wong, Lisa A Woods, Roseina Woods, Stuart Worboys, Martin Xanthos, Ya Yang, Yu-Xiao Zhang, Meng-Yuan Zhou, Sue Zmarzty, Fernando O Zuloaga, Alexandre Antonelli, Sidonie Bellot, Darren M Crayn, Olwen M Grace, Paul J Kersey, Ilia J Leitch, Hervé Sauquet, Stephen A Smith, Wolf L Eiserhardt, Félix Forest, William J Baker
Angiosperms are the cornerstone of most terrestrial ecosystems and human livelihoods1,2 . A robust understanding of angiosperm evolution is required to explain their rise to ecological dominance. So far, the angiosperm tree of life has been determined primarily by means of analyses of the plastid genome3,4 . Many studies have drawn on this foundational work, such as classification and first insights into angiosperm diversification since their Mesozoic origins5-7 . However, the limited and biased sampling of both taxa and genomes undermines confidence in the tree and its implications...
April 24, 2024: Nature
#8
JOURNAL ARTICLE
Gerardo A Alvarez, Kelsey J Hebert, Michael C Britt, Cory M Resnick, Bonnie L Padwa, Mark A Green
For many surgical procedures, enhanced recovery after surgery (ERAS) protocols have improved patient outcomes, particularly postoperative nausea and vomiting. The purpose of this study was to evaluate postoperative nausea following orthognathic surgery after the implementation of an ERAS protocol. This retrospective cohort study included patients between 12 and 35 years old who underwent orthognathic surgery at Boston Children's Hospital from April 2018 to December 2022. Patients with syndromes or a hospital stay greater than 48 hours were excluded from the study...
April 24, 2024: Journal of Craniofacial Surgery
#9
JOURNAL ARTICLE
Jonathan Z Pan, Zhanqiang Wang, Wei Sun, Peipei Pan, Wei Li, Yongtao Sun, Shoulin Chen, Amity Lin, Wulin Tan, Liangliang He, Jacob Greene, Virginia Yao, Lijun An, Rich Liang, Qifeng Li, Jessica Yu, Lingyi Zhang, Nikolaos Kyritsis, Xuan Duong Fernandez, Sara Moncivais, Esmeralda Mendoza, Pamela Fung, Gongming Wang, Xinhuan Niu, Qihang Du, Zhaoyang Xiao, Yuwen Chang, Peiyuan Lv, J Russell Huie, Abel Torres-Espin, Adam R Ferguson, Debra D Hemmerle, Jason F Talbott, Philip R Weinstein, Lisa U Pascual, Vineeta Singh, Anthony M DiGiorgio, Rajiv Saigal, William D Whetstone, Geoffrey T Manley, Sanjay S Dhall, Jacqueline C Bresnahan, Mervyn Maze, Xiangning Jiang, Neel S Singhal, Michael S Beattie, Hua Su, Zhonghui Guan
BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions...
April 2024: Clinical and Translational Medicine
#10
JOURNAL ARTICLE
Mark A Green, Michael C Britt, Sarah Flanagan
BACKGROUND: Supplemental bone grafting is regularly required before dental implant placement in patients with cleft lip and palate (CLP). PURPOSE: The study purpose was to measure and compare implant osseointegration and changes in graft dimensions following lateral incisor onlay cortical bone grafting in CLP and non-CLP patients. STUDY DESIGN, SETTING, SAMPLE: Retrospective cohort study composed of patients who presented to Boston Children's Hospital and underwent autogenous onlay cortical block bone grafting at lateral incisor sites from 2015 through 2023...
April 3, 2024: Journal of Oral and Maxillofacial Surgery
#11
JOURNAL ARTICLE
Colin R Zamecnik, Gavin M Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D Bair, Kristen J Wade, Christopher M Bartley, Kerry Kizer, Danillo G Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M Caspar, Jessica Alexander, Anne E Wapniarski, Rita P Loudermilk, Erica L Eggers, Kelsey C Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A Mann, Nicholas R Ragan, Adam Santaniello, Roland G Henry, Sergio E Baranzini, Scott S Zamvil, Joseph J Sabatino, Riley M Bove, Chu-Yueh Guo, Jeffrey M Gelfand, Richard Cuneo, H-Christian von Büdingen, Jorge R Oksenberg, Bruce A C Cree, Jill A Hollenbach, Ari J Green, Stephen L Hauser, Mitchell T Wallin, Joseph L DeRisi, Michael R Wilson
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster in approximately 10% of PwMS who share an autoantibody signature against a common motif that has similarity with many human pathogens...
April 19, 2024: Nature Medicine
#12
JOURNAL ARTICLE
Eleftheria Kampouri, Elizabeth M Krantz, Hu Xie, Sarah S Ibrahimi, Erika S Kiem, Mandeep K Sekhon, Emily C Liang, Andrew J Cowan, Andrew J Portuguese, Damian J Green, Aya Albittar, Jennifer J Huang, Jordan Gauthier, Ailyn C Pérez-Osorio, Keith R Jerome, Danielle Zerr, Michael J Boeckh, Joshua A Hill
Human herpesvirus-6B (HHV-6B) reactivation and disease are increasingly reported after CAR-T-cell therapy (CARTx). HHV-6 reactivation in the CAR-T-cell product was recently reported, raising questions about product and patient management. Due to overlapping manifestations with immune effector cell-associated neurotoxicity syndrome, diagnosing HHV-6B encephalitis is challenging. We provide two lines of evidence assessing the incidence and outcomes of HHV-6B after CARTx. First, in a prospective study with weekly HHV-6B testing for up to 12 weeks post-infusion, HHV-6B reactivation occurred in eight of 89 participants; three had chromosomally integrated HHV-6 and were excluded, resulting in a cumulative incidence of HHV-6B reactivation of 6% (95% confidence interval (CI), 2...
April 18, 2024: Blood
#13
JOURNAL ARTICLE
Clayton T Lamb, Sara Williams, Stan Boutin, Michael Bridger, Deborah Cichowski, Kristina Cornhill, Craig DeMars, Melanie Dickie, Bevan Ernst, Adam Ford, Michael P Gillingham, Laura Greene, Douglas C Heard, Mark Hebblewhite, Dave Hervieux, Mike Klaczek, Bruce N McLellan, R Scott McNay, Lalenia Neufeld, Barry Nobert, J Joshua Nowak, Agnès Pelletier, Aaron Reid, Anne-Marie Roberts, Mike Russell, Dale Seip, Caroline Seip, Carolyn Shores, Robin Steenweg, Shane White, Heiko U Wittmer, Mark Wong, Kathryn L Zimmerman, Robert Serrouya
Habitat loss is affecting many species, including the southern mountain caribou (Rangifer tarandus caribou) population in western North America. Over the last half century, this threatened caribou population's range and abundance have dramatically contracted. An integrated population model was used to analyze 51 years (1973-2023) of demographic data from 40 southern mountain caribou subpopulations to assess the effectiveness of population-based recovery actions at increasing population growth. Reducing potential limiting factors on threatened caribou populations offered a rare opportunity to identify the causes of decline and assess methods of recovery...
April 17, 2024: Ecological Applications
#14
JOURNAL ARTICLE
Brian T Fisher, Jesse Blumenstock, Craig L K Boge, Sydney Shuster, Alix E Seif, Michael Green, Marian G Michaels, Jessie L Alexander, Monica I Ardura, Tamara P Miller, Diego R Hijano, William J Muller, Jennifer E Schuster, Abby M Green, Daniel E Dulek, Adriana E Kajon, Lara Danziger-Isakov
BACKGROUND: Pediatric allogeneic hematopoietic cell transplant (allo-HCT) recipients are at risk for morbidity and mortality from human adenovirus (HAdV). HAdV can be detected in an asymptomatic state, referred to as infection or with signs or symptoms of illness, referred to as disease. Standardized case definitions are needed to distinguish infection from disease and allow for consistent reporting in both observational cohort studies and therapeutic clinical trials. METHODS: A working group of experts in virology, transplant infectious disease, and HCT was assembled to develop HAdV infection and disease definitions with the degree of certainty (i...
May 2024: Pediatric Transplantation
#15
JOURNAL ARTICLE
William B Ventres, Leslie A Stone, Kathleen T Rowland, Richard H Streiffer, Michael D Macechko, Julia A Roulier, Jeffrey M Borkan, Larry A Green
Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine, as interpreted by individual family physicians and medical educators in the USA and elsewhere around the world. In 'I: framing family medicine-history, values, and perspectives', the authors address the following themes: 'Notes on Storylines of Family Medicine' , 'Family medicine-the generalist specialty', 'Family medicine's achievements-a glass half full assessment', 'Family medicine's next 50 years-toward filling our glasses', 'Four enduring truths of family medicine', 'Names matter', 'Family medicine at its core' and 'The ecology of medical care...
April 12, 2024: Family Medicine and Community Health
#16
JOURNAL ARTICLE
Michael P Jeffrey, Lin Saleem, Chad W MacPherson, Thomas A Tompkins, Sandra T Clarke, Julia M Green-Johnson
Macrophage responses to activation are fluid and dynamic in their ability to respond appropriately to challenges, a role integral to host defence. While bacteria can influence macrophage differentiation and polarization into pro-inflammatory and alternatively activated phenotypes through direct interactions, many questions surround indirect communication mechanisms mediated through secretomes derived from gut bacteria, such as lactobacilli. We examined effects of secretome-mediated conditioning on THP-1 human monocytes, focusing on the ability of the Lacticaseibacillus rhamnosus R0011 secretome (LrS) to drive macrophage differentiation and polarization and prime immune responses to subsequent challenge with lipopolysaccharide (LPS)...
April 10, 2024: Scientific Reports
#17
JOURNAL ARTICLE
Lynda G Balneaves, Ashleigh Brown, Matthew Green, Erin Prosk, Lucile Rapin, Max Monahan-Ellison, Eva McMillan, Jonathan Zaid, Michael Dworkind, Cody Z Watling
BACKGROUND: There has been a precipitous decline in authorizations for medical cannabis since non-medical cannabis was legalized in Canada in 2018. This study examines the demographic and health- and medical cannabis-related factors associated with authorization as well as the differences in medical cannabis use, side effects, and sources of medical cannabis and information by authorization status. METHODS: Individuals who were taking cannabis for therapeutic purposes completed an online survey in early 2022...
April 8, 2024: BMC Medicine
#18
JOURNAL ARTICLE
Robert Kronstrand, Markus Roman, Henrik Green, Michael T Truver
Hexahydrocannabinol (HHC) was first reported in the EU in May 2022. HHC has three chiral carbon atoms, but only (6aR,9R,10aR)-HHC (9R-HHC) and (6aR,9S,10aR)-HHC (9S-HHC) have been encountered in HHC products. The goal of this study was to develop and validate a method for the quantitative analysis of 9R-HHC, 9S-HHC, 11-OH-9R-HHC, 9R-HHC-COOH, 9S-HHC-COOH, and 8-OH-9R-HHC. In addition, an objective was to investigate the immunochemical cross reactivity. Blood samples from DUID-cases screened positive for cannabis using ELISA and confirmed negative for tetrahydrocannabinol (THC), 11-hydroxy-THC, and THC-COOH were reanalyzed with a newly validated HHC method to investigate the presence of HHC and metabolites...
April 6, 2024: Journal of Analytical Toxicology
#19
JOURNAL ARTICLE
Alexander T Yahanda, Joyce Koueik, Laurie L Ackerman, P David Adelson, Gregory W Albert, Philipp R Aldana, Tord D Alden, Richard C E Anderson, David F Bauer, Tammy Bethel-Anderson, Karin Bierbrauer, Douglas L Brockmeyer, Joshua J Chern, Daniel E Couture, David J Daniels, Brian J Dlouhy, Susan R Durham, Richard G Ellenbogen, Ramin Eskandari, Herbert E Fuchs, Gerald A Grant, Patrick C Graupman, Stephanie Greene, Jeffrey P Greenfield, Naina L Gross, Daniel J Guillaume, Todd C Hankinson, Gregory G Heuer, Mark Iantosca, Bermans J Iskandar, Eric M Jackson, George I Jallo, James M Johnston, Bruce A Kaufman, Robert F Keating, Nickalus R Khan, Mark D Krieger, Jeffrey R Leonard, Cormac O Maher, Francesco T Mangano, Jonathan Martin, J Gordon McComb, Sean D McEvoy, Thanda Meehan, Arnold H Menezes, Michael S Muhlbauer, Brent R O'Neill, Greg Olavarria, John Ragheb, Nathan R Selden, Manish N Shah, Chevis N Shannon, Joshua S Shimony, Matthew D Smyth, Scellig S D Stone, Jennifer M Strahle, Mandeep S Tamber, James C Torner, Gerald F Tuite, Elizabeth C Tyler-Kabara, Scott D Wait, John C Wellons, William E Whitehead, Tae Sung Park, David D Limbrick, Raheel Ahmed
OBJECTIVE: Congenital anomalies of the atlanto-occipital articulation may be present in patients with Chiari malformation type I (CM-I). However, it is unclear how these anomalies affect the biomechanical stability of the craniovertebral junction (CVJ) and whether they are associated with an increased incidence of occipitocervical fusion (OCF) following posterior fossa decompression (PFD). The objective of this study was to determine the prevalence of condylar hypoplasia and atlas anomalies in children with CM-I and syringomyelia...
April 5, 2024: Journal of Neurosurgery. Pediatrics
#20
Rebecca Asiimwe, Brittney Knott, Morgan E Greene, Emma Wright, Markayla Bell, Daniel Epstein, Stefani D Yates, Matthew D Cheung, Michael V Gonzalez, Samantha Fry, Emily Boydston, Stephanie Clevenger, Jayme E Locke, James F George, Richard Burney, Nitin Arora, Virginia E Duncan, Holly E Richter, Deidre Gunn, Aharon G Freud, Shawn C Little, Paige M Porrett
UNLABELLED: Uterine natural killer cells (uNKs) are a tissue resident lymphocyte population that are critical for pregnancy success. Although mouse models have demonstrated that NK deficiency results in abnormal placentation and poor pregnancy outcomes, the generalizability of this knowledge to humans remains unclear. Here we identify uterus transplant (UTx) recipients as a human population with reduced endometrial NK cells and altered pregnancy phenotypes. We further show that the NK reduction in UTx is due to impaired transcriptional programming of NK tissue residency due to blockade of the transcription factor nuclear factor of activated T cells (NFAT)...
March 12, 2024: bioRxiv
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