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Michael T. Green

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https://read.qxmd.com/read/30747564/the-feasibility-of-remotely-delivered-exercise-session-in-adults-with-alzheimer-disease-and-their-caregivers
#1
Lauren T Ptomey, Eric D Vidoni, Esteban Montenegro-Montenegro, Michael A Thompson, Joseph R Sherman, Anna M Gorczyca, J L Greene, Richard A Washburn, Joseph E Donnelly
Adults with Alzheimer's disease (AD) and their caregivers represent a segment of the population with low levels of moderate physical activity (MPA) and limited options for increasing MPA. The purpose of this study was to evaluate the feasibility of a group video conference approach for increasing MPA in adults with AD and their caregivers. Adults with AD and their caregivers attended 30-minute group exercise sessions 3x/wk for 12wks. Exercise sessions and support sessions were delivered in their homes on a tablet computer over video conferencing software...
February 12, 2019: Journal of Aging and Physical Activity
https://read.qxmd.com/read/30734619/a-facile-forward-genetic-screen-for-arabidopsis-autophagy-mutants-reveals-twenty-one-loss-of-function-mutations-disrupting-six-atg-genes
#2
Pierce G Young, Michael J Passalacqua, Kevin Chappell, Roxanna J Llinas, Bonnie Bartel
Macroautophagy is a process through which eukaryotic cells degrade large substrates including organelles, protein aggregates, and invading pathogens. Over 40 autophagy-related (ATG) genes have been identified through forward-genetic screens in yeast. Although homology-based analyses have identified conserved ATG genes in plants, only a few atg mutants have emerged from forward-genetic screens in Arabidopsis thaliana. We developed a screen that consistently recovers Arabidopsis atg mutations by exploiting mutants with defective LON2/At5g47040, a protease implicated in peroxisomal quality control...
February 8, 2019: Autophagy
https://read.qxmd.com/read/30715471/double-barrel-extracranial-intracranial-bypass-and-trapping-of-dolichoectatic-middle-cerebral-artery-aneurysms-3-dimensional-operative-video
#3
Sirin Gandhi, Ruth Lau Rodriguez, Halima Tabani, Jan-Karl Burkhardt, Arnau Benet, Michael T Lawton
A dolichoectatic intracranial vessel with multiple fusiform aneurysms on the same vessel segment is rare, and usually managed with a bypass with aneurysm trapping. This video demonstrates trapping and a double-barrel superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass to treat two fusiform aneurysms in a left dolichoectatic superior MCA trunk. A 46-year-old man with AIDS presented with aphasia and hemiparesis. IRB approval and patient consent were obtained. Both STA branches (frontal and parietal) were harvested...
January 30, 2019: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/30699061/linear-polyethylenimine-dna-nanoconstruct-for-corneal-gene-delivery
#4
Jason T Rodier, Ratnakar Tripathi, Michael K Fink, Ajay Sharma, Madhuri Korampally, Shubhra Gangopadhyay, Elizabeth A Giuliano, Prashant R Sinha, Rajiv R Mohan
PURPOSE: This study investigated the efficiency and potential toxicity of a linear 22-kDa polyethylenimine (PEI)-DNA nanoconstruct for delivering genes to corneal cells and the effects of PEI nitrogen-to-DNA phosphate (N:P) ratio on gene transfer efficiency in vitro and in vivo. METHODS: A gel retardation assay, zeta potential measurement, bright-field microscopy, transfection with green fluorescent protein (GFP), immunofluorescence, and enzyme-linked immunosorbent assay (ELISA) were used to characterize the physicochemical and biological properties and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH), and reactive oxygen species (ROS) assay for cytotoxicity of the linear PEI-DNA nanoconstruct using in vitro cultured primary human corneal fibroblast and in vivo mouse models...
January 2019: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/30696104/gfp-fragment-reassembly-screens-for-the-functional-characterization-of-variants-of-uncertain-significance-in-protein-interaction-domains-of-the-brca1-and-brca2-genes
#5
Laura Caleca, Mara Colombo, Thomas van Overeem Hansen, Conxi Lázaro, Siranoush Manoukian, Michael T Parsons, Amanda B Spurdle, Paolo Radice
Genetic testing for BRCA1 and BRCA2 genes has led to the identification of many unique variants of uncertain significance (VUS). Multifactorial likelihood models that predict the odds ratio for VUS in favor or against cancer causality, have been developed, but their use is conditioned by the amount of necessary data, which are difficult to obtain if a variant is rare. As an alternative, variants mapping to the coding regions can be examined using in vitro functional assays. BRCA1 and BRCA2 proteins promote genome protection by interacting with different proteins...
January 28, 2019: Cancers
https://read.qxmd.com/read/30691655/fluorescence-based-methods-for-measuring-target-interference-by-crispr-cas-systems
#6
Phong T Phan, Michael Schelling, Chaoyou Xue, Dipali G Sashital
Type I, II, and V CRISPR-Cas systems are RNA-guided dsDNA targeting defense mechanisms found in bacteria and archaea. During CRISPR interference, Cas effectors use CRISPR-derived RNAs (crRNAs) as guides to bind complementary sequences in foreign dsDNA, leading to the cleavage and destruction of the DNA target. Mutations within the target or in the protospacer adjacent motif can reduce the level of CRISPR interference, although the level of defect is dependent on the type and position of the mutation, as well as the guide sequence of the crRNA...
2019: Methods in Enzymology
https://read.qxmd.com/read/30686506/contribution-of-rare-copy-number-variants-to-bipolar-disorder-risk-is-limited-to-schizoaffective-cases
#7
Alexander W Charney, Eli A Stahl, Elaine K Green, Chia-Yen Chen, Jennifer L Moran, Kimberly Chambert, Richard A Belliveau, Liz Forty, Katherine Gordon-Smith, Phil H Lee, Evelyn J Bromet, Peter F Buckley, Michael A Escamilla, Ayman H Fanous, Laura J Fochtmann, Douglas S Lehrer, Dolores Malaspina, Stephen R Marder, Christopher P Morley, Humberto Nicolini, Diana O Perkins, Jeffrey J Rakofsky, Mark H Rapaport, Helena Medeiros, Janet L Sobell, Lena Backlund, Sarah E Bergen, Anders Juréus, Martin Schalling, Paul Lichtenstein, James A Knowles, Katherine E Burdick, Ian Jones, Lisa A Jones, Christina M Hultman, Roy Perlis, Shaun M Purcell, Steven A McCarroll, Carlos N Pato, Michele T Pato, Ariana Di Florio, Nick Craddock, Mikael Landén, Jordan W Smoller, Douglas M Ruderfer, Pamela Sklar
BACKGROUND: Genetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type (SAB), bipolar I disorder (BD I), and bipolar II disorder (BD II) differ according to the prominence and timing of psychosis, mania, and depression. The genetic factors contributing to the combination of symptoms among these subtypes are poorly understood. METHODS: Rare large CNVs were analyzed in 6353 BD cases (3833 BD I [2676 with psychosis, 850 without psychosis, and 307 with unknown psychosis history], 1436 BD II, 579 SAB, and 505 BD not otherwise specified) and 8656 controls...
December 20, 2018: Biological Psychiatry
https://read.qxmd.com/read/30683880/shared-heritability-and-functional-enrichment-across-six-solid-cancers
#8
Xia Jiang, Hilary K Finucane, Fredrick R Schumacher, Stephanie L Schmit, Jonathan P Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B Kuchenbaecker, Joe Dennis, David V Conti, Graham Casey, Mia M Gaudet, Jeroen R Huyghe, Demetrius Albanes, Melinda C Aldrich, Angeline S Andrew, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Natalia N Antonenkova, Susanne M Arnold, Kristan J Aronson, Banu K Arun, Elisa V Bandera, Rosa B Barkardottir, Daniel R Barnes, Jyotsna Batra, Matthias W Beckmann, Javier Benitez, Sara Benlloch, Andrew Berchuck, Sonja I Berndt, Heike Bickeböller, Stephanie A Bien, Carl Blomqvist, Stefania Boccia, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Hiltrud Brauch, Hermann Brenner, James D Brenton, Mark N Brook, Joan Brunet, Hans Brunnström, Daniel D Buchanan, Barbara Burwinkel, Ralf Butzow, Gabriella Cadoni, Trinidad Caldés, Maria A Caligo, Ian Campbell, Peter T Campbell, Géraldine Cancel-Tassin, Lisa Cannon-Albright, Daniele Campa, Neil Caporaso, André L Carvalho, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Chu Chen, David C Christiani, Kathleen B M Claes, Frank Claessens, Judith Clements, J Margriet Collée, Marcia Cruz Correa, Fergus J Couch, Angela Cox, Julie M Cunningham, Cezary Cybulski, Kamila Czene, Mary B Daly, Anna deFazio, Peter Devilee, Orland Diez, Manuela Gago-Dominguez, Jenny L Donovan, Thilo Dörk, Eric J Duell, Alison M Dunning, Miriam Dwek, Diana M Eccles, Christopher K Edlund, Digna R Velez Edwards, Carolina Ellberg, D Gareth Evans, Peter A Fasching, Robert L Ferris, Triantafillos Liloglou, Jane C Figueiredo, Olivia Fletcher, Renée T Fortner, Florentia Fostira, Silvia Franceschi, Eitan Friedman, Steven J Gallinger, Patricia A Ganz, Judy Garber, José A García-Sáenz, Simon A Gayther, Graham G Giles, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Ellen L Goode, Marc T Goodman, Gary Goodman, Kjell Grankvist, Mark H Greene, Henrik Gronberg, Jacek Gronwald, Pascal Guénel, Niclas Håkansson, Per Hall, Ute Hamann, Freddie C Hamdy, Robert J Hamilton, Jochen Hampe, Aage Haugen, Florian Heitz, Rolando Herrero, Peter Hillemanns, Michael Hoffmeister, Estrid Høgdall, Yun-Chul Hong, John L Hopper, Richard Houlston, Peter J Hulick, David J Hunter, David G Huntsman, Gregory Idos, Evgeny N Imyanitov, Sue Ann Ingles, Claudine Isaacs, Anna Jakubowska, Paul James, Mark A Jenkins, Mattias Johansson, Mikael Johansson, Esther M John, Amit D Joshi, Radka Kaneva, Beth Y Karlan, Linda E Kelemen, Tabea Kühl, Kay-Tee Khaw, Elza Khusnutdinova, Adam S Kibel, Lambertus A Kiemeney, Jeri Kim, Susanne K Kjaer, Julia A Knight, Manolis Kogevinas, Zsofia Kote-Jarai, Stella Koutros, Vessela N Kristensen, Jolanta Kupryjanczyk, Martin Lacko, Stephan Lam, Diether Lambrechts, Maria Teresa Landi, Philip Lazarus, Nhu D Le, Eunjung Lee, Flavio Lejbkowicz, Heinz-Josef Lenz, Goska Leslie, Davor Lessel, Jenny Lester, Douglas A Levine, Li Li, Christopher I Li, Annika Lindblom, Noralane M Lindor, Geoffrey Liu, Fotios Loupakis, Jan Lubiński, Lovise Maehle, Christiane Maier, Arto Mannermaa, Loic Le Marchand, Sara Margolin, Taymaa May, Lesley McGuffog, Alfons Meindl, Pooja Middha, Austin Miller, Roger L Milne, Robert J MacInnis, Francesmary Modugno, Marco Montagna, Victor Moreno, Kirsten B Moysich, Lorelei Mucci, Kenneth Muir, Anna Marie Mulligan, Katherine L Nathanson, David E Neal, Andrew R Ness, Susan L Neuhausen, Heli Nevanlinna, Polly A Newcomb, Lisa F Newcomb, Finn Cilius Nielsen, Liene Nikitina-Zake, Børge G Nordestgaard, Robert L Nussbaum, Kenneth Offit, Edith Olah, Ali Amin Al Olama, Olufunmilayo I Olopade, Andrew F Olshan, Håkan Olsson, Ana Osorio, Hardev Pandha, Jong Y Park, Nora Pashayan, Michael T Parsons, Tanja Pejovic, Kathryn L Penney, Wilbert H M Peters, Catherine M Phelan, Amanda I Phipps, Dijana Plaseska-Karanfilska, Miranda Pring, Darya Prokofyeva, Paolo Radice, Kari Stefansson, Susan J Ramus, Leon Raskin, Gad Rennert, Hedy S Rennert, Elizabeth J van Rensburg, Marjorie J Riggan, Harvey A Risch, Angela Risch, Monique J Roobol, Barry S Rosenstein, Mary Anne Rossing, Kim De Ruyck, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Matthew B Schabath, Johanna Schleutker, Marjanka K Schmidt, V Wendy Setiawan, Hongbing Shen, Erin M Siegel, Weiva Sieh, Christian F Singer, Martha L Slattery, Karina Dalsgaard Sorensen, Melissa C Southey, Amanda B Spurdle, Janet L Stanford, Victoria L Stevens, Sebastian Stintzing, Jennifer Stone, Karin Sundfeldt, Rebecca Sutphen, Anthony J Swerdlow, Eloiza H Tajara, Catherine M Tangen, Adonina Tardon, Jack A Taylor, M Dawn Teare, Manuel R Teixeira, Mary Beth Terry, Kathryn L Terry, Stephen N Thibodeau, Mads Thomassen, Line Bjørge, Marc Tischkowitz, Amanda E Toland, Diana Torres, Paul A Townsend, Ruth C Travis, Nadine Tung, Shelley S Tworoger, Cornelia M Ulrich, Nawaid Usmani, Celine M Vachon, Els Van Nieuwenhuysen, Ana Vega, Miguel Elías Aguado-Barrera, Qin Wang, Penelope M Webb, Clarice R Weinberg, Stephanie Weinstein, Mark C Weissler, Jeffrey N Weitzel, Catharine M L West, Emily White, Alice S Whittemore, H-Erich Wichmann, Fredrik Wiklund, Robert Winqvist, Alicja Wolk, Penella Woll, Michael Woods, Anna H Wu, Xifeng Wu, Drakoulis Yannoukakos, Wei Zheng, Shanbeh Zienolddiny, Argyrios Ziogas, Kristin K Zorn, Jacqueline M Lane, Richa Saxena, Duncan Thomas, Rayjean J Hung, Brenda Diergaarde, James McKay, Ulrike Peters, Li Hsu, Montserrat García-Closas, Rosalind A Eeles, Georgia Chenevix-Trench, Paul J Brennan, Christopher A Haiman, Jacques Simard, Douglas F Easton, Stephen B Gruber, Paul D P Pharoah, Alkes L Price, Bogdan Pasaniuc, Christopher I Amos, Peter Kraft, Sara Lindström
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg  = 0...
January 25, 2019: Nature Communications
https://read.qxmd.com/read/30678763/blood-pressure-assessment-in-adults-in-clinical-practice-and-clinic-based-research-jacc-scientific-expert-panel
#9
REVIEW
Paul Muntner, Paula T Einhorn, William C Cushman, Paul K Whelton, Natalie A Bello, Paul E Drawz, Beverly B Green, Daniel W Jones, Stephen P Juraschek, Karen L Margolis, Edgar R Miller, Ann Marie Navar, Yechiam Ostchega, Michael K Rakotz, Bernard Rosner, Joseph E Schwartz, Daichi Shimbo, George S Stergiou, Raymond R Townsend, Jeff D Williamson, Jackson T Wright, Lawrence J Appel
The accurate measurement of blood pressure (BP) is essential for the diagnosis and management of hypertension. Restricted use of mercury devices, increased use of oscillometric devices, discrepancies between clinic and out-of-clinic BP, and concerns about measurement error with manual BP measurement techniques have resulted in uncertainty for clinicians and researchers. The National Heart, Lung, and Blood Institute of the U.S. National Institutes of Health convened a working group of clinicians and researchers in October 2017 to review data on BP assessment among adults in clinical practice and clinic-based research...
January 29, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30667371/minimally-invasive-method-for-the-point-of-care-quantification-of-lymphatic-vessel-function
#10
Anna K Polomska, Steven T Proulx, Davide Brambilla, Daniel Fehr, Mathias Bonmarin, Simon Brändli, Mirko Meboldt, Christian Steuer, Tsvetina Vasileva, Nils Reinke, Jean-Christophe Leroux, Michael Detmar
Current clinical methods for the evaluation of lymphatic vessel function, crucial for early diagnosis and evaluation of treatment-response of several pathological conditions, in particular of post-surgical lymphedema, are based on complex and mainly qualitative imaging techniques. To address this unmet medical need, we established a simple strategy for the painless and quantitative assessment of cutaneous lymphatic function. We prepared a lymphatic-specific tracer formulation, consisting of the clinically approved near-infrared fluorescent dye, indocyanine green, and the solubilizing surfactant Kolliphor HS15...
January 22, 2019: JCI Insight
https://read.qxmd.com/read/30661607/construction-and-testing-of-an-atmospheric-pressure-transmission-mode-matrix-assisted-laser-desorption-ionisation-mass-spectrometry-imaging-ion-source-with-plasma-ionisation-enhancement
#11
Rory T Steven, Michael Shaw, Alex Dexter, Teresa Murta, Felicia M Green, Kenneth N Robinson, Ian S Gilmore, Zoltan Takats, Josephine Bunch
Matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) at atmospheric pressure (AP) is, with a few notable exceptions, overshadowed by its vacuum based forms and AP transmission mode (TM) MALDI-MS lacks the up-take its potential benefits might suggest. The reasons for this are not fully understood and it is clear further development is required to realise the flexibility and power of this ionisation method and geometry. Here we report the build of a new AP-TM-MALDI-MSI ion source with plasma ionisation enhancement...
March 21, 2019: Analytica Chimica Acta
https://read.qxmd.com/read/30658626/underutilized-and-undertheorized-the-use-of-hospitalization-for-ambulatory-care-sensitive-conditions-for-assessing-the-extent-to-which-primary-healthcare-services-are-meeting-needs-in-british-columbia-first-nation-communities
#12
Josée G Lavoie, Sabrina T Wong, Naser Ibrahim, John D O'Neil, Michael Green, Amanda Ward
BACKGROUND: Since the 1960s, the federal government has been providing or funding a selection of community-based primary healthcare (PHC) programs on First Nations reserves. A key question is whether local access to PHC can help address health inequities in First Nations on-reserve communities in British Columbia (BC). OBJECTIVES: This paper examines whether hospitalization for Ambulatory Care Sensitive Conditions (1) can be used as a proxy measure for the organization of PHC in First Nations reserve areas; and (2) is associated with premature mortality rates...
January 18, 2019: BMC Health Services Research
https://read.qxmd.com/read/30651952/endoscopy-in-2017-a-national-survey-of-practice-in-the-uk
#13
Lavanya Shenbagaraj, Siwan Thomas-Gibson, John Stebbing, Raphael Broughton, Michael Dron, Debbie Johnston, Tim Shaw, Hasan Nadim Haboubi, John T Green
Introduction: The Joint Advisory Group on Gastrointestinal Endoscopy (JAG), hosted by the Royal College of Physicians, London, oversees the quality assurance of endoscopy services across the UK. Additional questions focusing on the pressures faced by endoscopy units to meet targets were added to the 2017 annual Global Rating Scale (GRS) return. This provides a unique insight into endoscopy services across all nations of the UK involving the acute and non-acute Nation Health Service sector as well as the independent sector...
January 2019: Frontline Gastroenterology
https://read.qxmd.com/read/30608872/-b-six-weeks-of-oral-i-echinacea-purpurea-i-supplementation-does-not-enhance-the-production-of-serum-erythropoietin-or-erythropoietic-status-in-recreationally-active-males-with-above-average-aerobic-fitness-b
#14
Tyler D Martin, Michael Stephen Green, Malcolm T Whitehead, Timothy P Scheett, Michael J Webster, Geoffrey M Hudson
The purpose of this study was to investigate the effect of six weeks of oral <i>Echinacea purpurea</i> supplementation on serum erythropoietin (EPO) and erythropoietic status. Twenty-four males (mean ± SE): age = 25.2 ± 1.4 yr, height = 178.1 ± 1.4 cm, body mass = 78.1 ± 1.6 kg, body fat = 12.7 ± 0.9 %, VO<sub>2max</sub> = 52.9 ± 0.9 mL·kg<sup>-1</sup>·min<sup>-1</sup> were randomly grouped using a matched-pair, double-blind design and self-administered 8,000 mg·d<sup>-1</sup> of either <i>Echinacea purpurea</i> (ECH) (<i>n</i> = 12) or placebo (PLA) (<i>n</i> = 12) for 42 consecutive days...
January 4, 2019: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://read.qxmd.com/read/30590667/cytomegalovirus-in-pediatric-hematopoietic-stem-cell-transplantation-a-case-based-panel-discussion-of-current-challenges
#15
Lara Danziger-Isakov, Janet Englund, Michael Green, Klara M Posfay-Barbe, Danielle M Zerr
Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590658/cytomegalovirus-in-pediatric-hematopoietic-stem-cell-transplantation-a-case-based-panel-discussion-of-current-challenges
#16
Lara Danziger-Isakov, Janet Englund, Michael Green, Klara M Posfay-Barbe, Danielle M Zerr
Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590645/cytomegalovirus-in-pediatric-hematopoietic-stem-cell-transplantation-a-case-based-panel-discussion-of-current-challenges
#17
Lara Danziger-Isakov, Janet Englund, Michael Green, Klara M Posfay-Barbe, Danielle M Zerr
Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590636/cytomegalovirus-in-pediatric-hematopoietic-stem-cell-transplantation-a-case-based-panel-discussion-of-current-challenges
#18
Lara Danziger-Isakov, Janet Englund, Michael Green, Klara M Posfay-Barbe, Danielle M Zerr
Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590625/cytomegalovirus-in-pediatric-hematopoietic-stem-cell-transplantation-a-case-based-panel-discussion-of-current-challenges
#19
Lara Danziger-Isakov, Janet Englund, Michael Green, Klara M Posfay-Barbe, Danielle M Zerr
Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30575980/thymectomy-may-not-be-associated-with-clinical-improvement-in-musk-myasthenia-gravis
#20
Katherine M Clifford, Lisa D Hobson-Webb, Michael Benatar, Ted M Burns, Carolina Barnett, Nicholas J Silvestri, James F Howard, Amy Visser, Brian A Crum, Richard Nowak, Rachel Beekman, Aditya Kumar, Katherine Ruzhansky, I-Hweii Amy Chen, Michael T Pulley, Shannon M Laboy, Melissa A Fellman, Diantha B Howard, Noah A Kolb, Shane M Greene, Mamatha Pasnoor, Mazen M Dimachkie, Richard J Barohn, Michael K Hehir
INTRODUCTION: A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)-antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest thymectomy may not be efficacious in anti-muscle-specific kinase (MuSK)-MG. METHODS: The therapeutic impact of thymectomy was evaluated from data collected for a multicenter, retrospective blinded review of rituximab in MuSK-MG. RESULTS: Baseline characteristics were similar between thymectomy (n = 26) and nonthymectomy (n = 29) groups, including treatment with rituximab (42% vs...
December 21, 2018: Muscle & Nerve
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