Read by QxMD icon Read


Christopher A Groh, Madelaine Faulkner, Shiffen Getabecha, Victoria Taffe, Gregory Nah, Kathi Sigona, Debbe McCall, Mellanie True Hills, Kathleen Sciarappa, Mark J Pletcher, Jeffrey E Olgin, Gregory M Marcus
BACKGROUND: Triggers for discrete atrial fibrillation (AF) events remain poorly studied and incompletely characterized. OBJECTIVE: The present study describes common triggers for AF and their relationships with patient characteristics. METHODS: We invited symptomatic, paroxysmal AF patients enrolled in the Health eHeart Study and through the patient-centered advocacy organization to complete a questionnaire regarding their AF triggers and cardiovascular risk factors...
January 30, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Thibaut Gentina, Sébastien Bailly, François Jounieaux, Christophe Verkindre, Pierre-Marie Broussier, Dominique Guffroy, Arnaud Prigent, Jean-Jacques Gres, Jamal Kabbani, Laurent Kedziora, Renaud Tamisier, Elodie Gentina, Jean-Louis Pépin
BACKGROUND: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea (OSA) but its effectiveness requires high adherence. We aimed to assess the impacts of the spouse's/partner's involvement and the quality of the couple's relationship on CPAP adherence. METHODS: In a multicenter prospective study conducted in France, patients reported their subjective views regarding their partner's engagement in their CPAP treatment and the quality of their marital relationship using the Quality of Marriage Index...
December 26, 2018: Sleep Medicine
Li Ge, Rena C Moon, Ha Nguyen, Luiz Gustavo de Quadros, Andre F Teixeira, Muhammad A Jawad
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. METHODS: A retrospective analysis was conducted using a prospectively maintained database of 649 patients who underwent LSG between November 1, 2013 and December 31, 2015 at our institution...
February 15, 2019: Surgical Endoscopy
Lu Bai, Chunying Sun, Huifen Zhai, Chen Chen, Xiaotian Hu, Xiulin Ye, Min Li, Yan Fang, Weimin Yang, Haoyan Wang, Shibo Sun
BACKGROUND: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. The goal of this study was to investigate if a relationship exists between OSA and Sestrin2. METHODS: We prospectively enrolled 71 subjects, and 16 patients of them with severe OSA completed 4 weeks of nasal continuous positive airway pressure (nCPAP) therapy...
February 15, 2019: Lung
Guanglei Ye, Bina Guo
This paper demonstrates a BSN-based portable monitor integrating micro sensors with mobile devices for monitoring and diagnosing obstructive sleep apnea syndrome (OSAS) at home. The system uses a micro hot-film flow sensor to detect respiratory flow, uses tri-axis micro accelerometer to detect body posture and motion intensity, and uses a micro photoelectric sensor to detect oxygen saturation of blood. The real-time vital signs are detected and transmitted wirelessly to a mobile device. The transmitted data are processed and analyzed in the mobile device and can be further transmitted to a remote medical center and physicians through mobile cellular networks or Internet for comprehensively analyzing, assessing, and diagnosing to the diseases...
January 30, 2019: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Luca Baldelli, Olga Addimanda, Marco Burattini, Giacomo Chiaro, Veronica Brusi, Elettra Pignotti, Riccardo Meliconi, Federica Provini
OBJECTIVES: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness". MATERIALS & METHODS: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations...
February 15, 2019: Brain and Behavior
Cinthia Amiñoso, María Gordillo-Marañón, Jaime Hernández, Jesús Solera
Glycogen storage disease type II, or Pompe disease, is an autosomal recessive disorder caused by deficiency of lysosomal acid alpha-glucosidase (GAA). We performed genetic analysis to confirm the diagnosis of Pompe disease in a 61-year-old patient with progressive weakness in extremities, severe Sleep Apnea-Hypopnea Syndrome, a significant reduction of alpha-glucosidase in liquid sample of peripheral blood and muscular biopsy diagnosis. GAA gene sequencing showed the patient is homozygous for the splice-site mutation c...
December 15, 2018: Neuromuscular Disorders: NMD
Thomas Penzel
No abstract text is available yet for this article.
January 6, 2019: Sleep Medicine
Farhan Shah, Karl A Franklin, Thorbjörn Holmlund, Eva Levring Jäghagen, Diana Berggren, Sture Forsgren, Per Stål
BACKGROUND: The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes. Recently we reported an absence and an abnormal isoform of two cytoskeletal proteins, desmin, and dystrophin, in upper airway muscles of healthy humans. These cytoskeletal proteins are considered vital for muscle function. We aimed to investigate for muscle cytoskeletal abnormalities in upper airways and its association with swallowing dysfunction and severity of sleep apnea...
February 14, 2019: Respiratory Research
Diego R Mazzotti, Brendan T Keenan, Diane C Lim, Daniel J Gottlieb, Jinyoung Kim, Allan I Pack
RATIONALE: Symptom subtypes have been described in clinical and population samples of obstructive sleep apnea (OSA) patients. It is unclear whether these subtypes have different cardiovascular consequences. OBJECTIVES: This study aimed to characterize OSA symptom subtypes and assess their association with prevalent and incident cardiovascular disease in the Sleep Heart Health Study. METHODS: Data from 1,207 OSA patients (apnea-hypopnea index [AHI]≥15 events/hour) were used to evaluate the existence of symptom subtypes using latent class analysis...
February 15, 2019: American Journal of Respiratory and Critical Care Medicine
Adeel Nazir Ahmad, Geraldine McLeod, Nada Al Zahrani, Haneen Al Zahrani
Sleep apnea is a potentially serious but under-diagnosed sleep disorder. Saudi Arabia has a high prevalence of hypertension, diabetes, obesity, and smoking, which are all major risk factors for sleep apnea. However, few studies report screening for sleep apnea in Saudi Arabia. A three-month prospective, questionnaire-based study, using the Berlin Questionnaire (BQ) and the Epworth Sleepiness Scale (ESS), screened 319 patients attending a family medicine clinic in Saudi Arabia for risk of sleep apnea. The results showed that when using the BQ and the ESS, 95 (29...
February 5, 2019: International Journal of Environmental Research and Public Health
Kuan-Li Wu, Chia-Yu Kuo, Yu-Chen Tsai, Jen-Yu Hung, Chau-Chyun Sheu, Chih-Jen Yang, Chung-Yao Hsu, Meng-Ni Wu, Ming-Ju Tsai
The association between sleep apnea (SA) and peripheral artery disease (PAD) remains debatable, and there is no clinical tool to predict incident PAD in SA patients. The CHADS₂ score has been found useful in predicting PAD risk. This study was designed to investigate the association between these diseases and the usefulness of CHADS₂ and CHA₂DS₂ASc scores in predicting subsequent PAD in SA patients. From a population-based database of one-million representative subjects, adult patients with SA diagnosis were enrolled as the suspected SA group, and those having SA diagnosis after polysomnography were further extracted as the probable SA group...
February 5, 2019: Journal of Clinical Medicine
Kathleen M Sarber, Stacey L Ishman, Reena Dhanda Patil
No abstract text is available yet for this article.
February 14, 2019: JAMA Otolaryngology—Head & Neck Surgery
Hao Wu, Qianwen Lv, Huina Zhang, Yanwen Qin, Fang Fang, Haili Sun, Yongxiang Wei
PURPOSE: We aimed to investigate the effect of obstructive sleep apnea (OSA) and apnea-hypopnea duration on endothelial, ventricular function, blood pressure, and inflammation in a rat model. METHODS: We established a novel rat model of OSA. Wistar rats were randomized to six groups according to 4-week different treatments: (1) OSA (apnea for 60 s in a 90-s window of breathing [60 s/90 s] with anesthesia), (2) OSA 30 s/90 s with anesthesia, (3) partial recovery (60 s/90 s for 2 weeks, followed by 15 s/90 s for 2 weeks with anesthesia), (4) complete recovery (60 s/90 s for 2 weeks with anesthesia, and then normal breathing for 2 weeks), (5) sham (normal breathing in the device with anesthesia), and (6) control group (normal breathing, normal cage, no anesthesia)...
February 14, 2019: Sleep & Breathing, Schlaf & Atmung
Natalie Jo Hawes, Amanda T Wiggins, Deborah B Reed, Frances Hardin-Fanning
BACKGROUND: Farmers' work schedules can result in inconsistent sleep patterns which negatively impact health. PURPOSE: To explore the relationships between sleep, obesity, and depression in working, older farmers and their spouses. Covariates included body mass index (BMI), age, and gender. METHODS: Sleep quality, BMI, and depression were assessed in farmers (n = 1,394) 50 years and older. Bivariate associations among all covariates (i...
February 13, 2019: Public Health Nursing
Yousef Mohammad, Ahmed Almutlaq, Abdullah Al-Ruwaita, Amjad Aldrees, Abdulaziz Alsubaie, Fawaz Al-Hussain
OBJECTIVES: The onset of ischemic stroke symptoms has been established to have a diurnal variation, with a sizeable proportion (8-28%) occurring during sleep. Obstructive sleep apnea (OSA) has been established as an important risk factor for ischemic stroke. However, data on the relationship between OSA and wake-up stroke (WUS) has been scarce. The aim of our study is to determine the relationship between OSA and WUS. METHODS: This is a case-control study conducted on acute stroke patients who presented to one of two major medical centers in Riyadh of Saudi Arabia...
February 13, 2019: Neurological Sciences
Tatiana Albuquerque Gonçalves de Lima, Evandro Cabral de Brito, Robson Martins, Sandro Gonçalves de Lima, Rodrigo Pinto Pedrosa
OBJECTIVE: To evaluate quality of life in elderly patients with obstructive sleep apnea (OSA) who have a pacemaker. METHODS: This was a cross-sectional study involving elderly patients (≥ 60 years of age) with a pacemaker. The dependent variable was quality of life, as evaluated with the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Sociodemographic and clinical parameters, including anxiety and depression (Hospital Anxiety and Depression Scale score), as well as the presence of OSA (defined as an apnea-hypopnea index ≥ 15 events/h), were analyzed as independent variables...
February 11, 2019: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Xuechao Yang, Linfei Zhang, Huan Liu, Yongfeng Shao, Shijiang Zhang
Background Chronic intermittent hypoxia ( CIH ) is a distinct pathological mechanism of obstructive sleep apnea ( OSA ), which is recognized as an independent risk factor for cardiovascular diseases. The aims of this study were to ascertain whether CIH induces atrial fibrillation ( AF ), to determine whether cardiac sympathetic denervation ( CSD ) can prevent it and suppress blood pressure, and to explore the potential molecular mechanisms involved. Methods and Results Sixty Sprague-Dawley male rats were randomly divided into 4 groups: sham, CSD , CIH , CIH + CSD ...
February 19, 2019: Journal of the American Heart Association
Jacob C Lux, Devika Channaveerappa, Roshanak Aslebagh, Timothy A Heintz, Meredith McLerie, Brian K Panama, Costel C Darie
Obstructive sleep apnea (OSA) affects an estimated 20% of adults worldwide and has been associated with electrical and structural abnormalities of the atria, although the molecular mechanisms are not well understood. Here, we used two-dimensional polyacrylamide gel electrophoresis (2D PAGE) coupled with nanoliquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) to investigate the proteins that are dysregulated in the atria from severe and moderate apnea when compared to control. We found enzymes involved in the glycolysis, beta-oxidation, electron transport chain and Krebs cycle to be down-regulated...
February 12, 2019: Journal of Cellular and Molecular Medicine
David M Rosen, Vaishnavi Kundel, Michael Rueschman, Robert Kaplan, Na Guo, James G Wilson, Yuan-I Min, Susan Redline, Neomi Shah
PURPOSE: Evidence suggests that snoring is associated with increased risk for cardiovascular disease (CVD) events such as myocardial infarction and stroke. Limited data exists pertaining to this association among African Americans. We therefore examined the association between self-reported habitual snoring and incident CVD in the Jackson Heart Study (JHS), a population-based cohort study of African Americans. METHODS: Self-reported data on snoring and risk factors for CVD were collected at baseline (2000-2004)...
February 13, 2019: Sleep & Breathing, Schlaf & Atmung
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"