Emma Monte, Takaaki Furihata, Guangwen Wang, Isaac Perea-Gil, Eric Wei, Hassan Chaib, Ramesh Nair, Julio Vicente Guevara, Rene Mares, Xun Cheng, Yan Zhuge, Katelyn Black, Ricardo Serrano, Orit Dagan-Rosenfeld, Peter Maguire, Mark Mercola, Ioannis Karakikes, Joseph C Wu, Michael P Snyder
BACKGROUND: There is growing evidence that pathogenic mutations do not fully explain hypertrophic (HCM) or dilated (DCM) cardiomyopathy phenotypes. We hypothesized that if a patient's genetic background was influencing cardiomyopathy this should be detectable as signatures in gene expression. We built a cardiomyopathy biobank resource for interrogating personalized genotype phenotype relationships in human cell lines. METHODS: We recruited 308 diseased and control patients for our cardiomyopathy stem cell biobank...
May 14, 2024: bioRxiv