Yue Wei, Yan-Feng Zhou, Lili Xiao, Jian Qin, Hong Cheng, Haiqing Cai, Xing Chen, Yunfeng Zou, Li Yang, Haiying Zhang, Zhiyong Zhang, Xiaobo Yang
OBJECTIVE: Exposure to heavy metals has been reported to be associated with impaired cognitive function, but the underlying mechanisms remain unclear. This pilot study aimed to identify key heavy metal elements associated with cognitive function and further explore the potential mediating role of metal-related DNA methylation. METHODS: Blood levels of arsenic, cadmium, lead, copper, manganese, and zinc and genome-wide DNA methylations were separately detected in peripheral blood in 155 older adults...
April 25, 2024: Annals of Neurology