M C Ramaboli, S Ocvirk, M Khan Mirzaei, B L Eberhart, M Valdivia-Garcia, A Metwaly, K Neuhaus, G Barker, J Ru, L T Nesengani, D Mahdi-Joest, A S Wilson, S K Joni, D C Layman, J Zheng, R Mandal, Q Chen, M R Perez, S Fortuin, B Gaunt, D Wishart, B Methé, D Haller, J V Li, L Deng, R Swart, S J D O'Keefe
Transition from traditional high-fiber to Western diets in urbanizing communities of Sub-Saharan Africa is associated with increased risk of non-communicable diseases (NCD), exemplified by colorectal cancer (CRC) risk. To investigate how urbanization gives rise to microbial patterns that may be amenable by dietary intervention, we analyzed diet intake, fecal 16 S bacteriome, virome, and metabolome in a cross-sectional study in healthy rural and urban Xhosa people (South Africa). Urban Xhosa individuals had higher intakes of energy (urban: 3,578 ± 455; rural: 2,185 ± 179 kcal/d), fat and animal protein...
April 20, 2024: Nature Communications