Weiqiang Jing, Ganyu Wang, Zhiwei Cui, Xinyuan Li, Shuyan Zeng, Xin Jiang, Wushan Li, Bo Han, Nianzeng Xing, Yunxue Zhao, Shouzhen Chen, Benkang Shi
The immune landscape of bladder cancer progression is not fully understood, and effective therapies are lacking in advanced bladder cancer. Here, we visualized that bladder cancer cells recruited neutrophils by secreting interleukin-8 (IL-8); in turn, neutrophils played dual functions in bladder cancer, including hepatocyte growth factor (HGF) release and CCL3high PD-L1high super-immunosuppressive subset formation. Mechanistically, c-Fos was identified as the mediator of HGF up-regulating IL-8 transcription in bladder cancer cells, which was central to the positive feedback of neutrophil recruitment...
May 14, 2024: Proceedings of the National Academy of Sciences of the United States of America